Elizabeth A. Middleton,
MD
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Languages Spoken: English
Specialties
Board Certification and Academic Information
| Academic Departments | Internal Medicine
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Assistant Professor |
| Academic Divisions | Pulmonary |
| Board Certification | American Board of Internal Medicine American Board of Internal Medicine (Sub: Critical Care Medicine) American Board of Internal Medicine (Sub: Pulmonary Disease) |
Academic Locations
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Assistant Professor |
| Academic Divisions | Pulmonary |
| Board Certification | American Board of Internal Medicine American Board of Internal Medicine (Sub: Critical Care Medicine) American Board of Internal Medicine (Sub: Pulmonary Disease) |
Education History
| Fellowship | University of Utah Pulmonary/Critical Care Medicine Fellow, 2015 |
| Chief Resident | University of Utah Internal Medicine Chief Medical Resident, 2011 |
| Residency | University of Utah Internal Medicine Resident, 2010 |
| Professional Medical | University of Utah Medicine M.D., 2007 |
| Undergraduate | University of Utah Behavioral and Health Sciences B.S., 2002 |
Selected Publications - Journal Articles
Journal Article
- Schwertz H, Rowley JW, Portier I, Middleton EA, Tolley ND, Campbell RA, Eustes AS, Chen K, Rondina MT (2021). Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5. Autophagy, 1-17.
- Campbell RA, Hisada Y, Denorme F, Grover SP, Bouck EG, Middleton EA, Wolberg AS, Rondina MT, Mackman N (2021). Comparison of the coagulopathies associated with COVID-19 and sepsis. Res Pract Thromb Haemost, 5(4), e12525.
- Self WH, Stewart TG, Wheeler AP, El Atrouni W, Bistran-Hall AJ, Casey JD, Cataldo VD, Chappell JD, Cohn CS, Collins JB, Denison MR, de Wit M, Dixon SL, Duggal A, Edwards TL, Fontaine MJ, Ginde AA, Harkins MS, Harrington T, Harris ES, Hoda D, Ipe TS, Jaiswal SJ, Johnson NJ, Jones AE, Laguio-Vila M, Lindsell CJ, Mallada J, Mammen MJ, Metcalf RA, Middleton EA, Mucha S, ONeal HR Jr, Pannu SR, Pulley JM, Qiao X, Raval JS, Rhoads JP, Schrager H, Shanholtz C, Shapiro NI, Schrantz SJ, Thomsen I, Vermillion KK, Bernard GR, Rice TW, Passive Immunity Trial for Our Nation PassITON Investigators (2021). Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults. Trials, 22(1), 221.
- Eustes AS, Campbell RA, Middleton EA, Tolley ND, Manne BK, Montenont E, Rowley JW, Krauel K, Blair A, Guo L, Kosaka Y, Medeiros-de-Moraes IM, Lacerda M, Hottz ED, Neto HCF, Zimmerman GA, Weyrich AS, Petrey A, Rondina MT (2021). Heparanase expression and activity are increased in platelets during clinical sepsis. J Thromb Haemost, 19(5), 1319-1330.
- Liou TG, Adler FR, Cahill BC, Cox DR, Cox JE, Grant GJ, Hanson KE, Hartsell SC, Hatton ND, Helms MN, Jensen JL, Kartsonaki C, Li Y, Leung DT, Marvin JE, Middleton EA, Osburn-Staker SM, Packer KA, Shakir SM, Sturrock AB, Tardif KD, Warren KJ, Waddoups LJ, Weaver LJ, Zimmerman E, Paine R 3rd (2020). SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection. Physiol Rep, 9(4), e14761.
- Petrey AC, Qeadan F, Middleton EA, Pinchuk IV, Campbell RA, Beswick EJ (2020). Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex. J Leukoc Biol, 109(1), 55-66.
- Trivedi S, Labuz D, Anderson CP, Araujo CV, Blair A, Middleton EA, Jensen O, Tran A, Mulvey MA, Campbell RA, Hale JS, Rondina MT, Leung DT (2020). Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis. Elife, 9.
- Denorme F, Manne BK, Portier I, Petrey AC, Middleton EA, Kile BT, Rondina MT, Campbell RA (2020). COVID-19 patients exhibit reduced procoagulant platelet responses. J Thromb Haemost, 18(11), 3067-3073.
- Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA (2020). Platelet gene expression and function in patients with COVID-19. Blood, 136(11), 1317-1329.
- Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC (2020). Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 136(10), 1169-1179.
- Manne BK, Bhatlekar S, Middleton EA, Weyrich AS, Borst O, Rondina MT (2020). Phospho-inositide-dependent kinase 1 regulates signal dependent translation in megakaryocytes and platelets. J Thromb Haemost, 18(5), 1183-1196.
- Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT (2019). Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood, 134(12), 911-923.