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Patricia R. Slev, PhD

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Languages Spoken: English

Dr. Slev is the medical director of the Serological Hepatitis/Retrovirus Laboratory and Co-Director Immunogenetics at ARUP and an Associate Professor of Pathology at the University of Utah, School of Medicine. Dr. Slev's research interests are in immunogenetics and pathogen interactions, particularly HIV and viral hepatitis.

Specialties

  • Pathology, Clinical

Board Certification and Academic Information

Academic Departments Pathology - Associate Professor (Clinical)
Academic Divisions Clinical Pathology
Board Certification American Board of Clinical Chemistry (Sub: Clinical Chemistry)

Dr. Slev is the medical director of the Serological Hepatitis/Retrovirus Laboratory and Co-Director Immunogenetics at ARUP and an Associate Professor of Pathology at the University of Utah, School of Medicine. Dr. Slev's research interests are in immunogenetics and pathogen interactions, particularly HIV and viral hepatitis.

Academic Locations

ARUP Laboratories

801-583-2787

500 S Chipeta Way
ARUP Laboratories
Salt Lake City, UT  84108

Board Certification and Academic Information

Academic Departments Pathology - Associate Professor (Clinical)
Academic Divisions Clinical Pathology
Board Certification American Board of Clinical Chemistry (Sub: Clinical Chemistry)

Education History

Fellowship University of Utah School of Medicine
Clinical Chemistry
Fellow
Postdoctoral Fellowship University of Utah
Biology
Postdoctoral Fellow
Doctoral Training University of Florida
Immunology, Laboratory Medicine
Ph.D.
Undergraduate Florida Atlantic University
Biology
B.A.

Selected Publications - Journal Articles

Journal Article

  1. Wesolowski LG, Chavez PR, Cardenas AM, Katayev A, Slev P, Valsamakis A, Wang YF, Yao JD, Dougherty C, Gillim-Ross L, Harmon C, Delaney KP et al (2020). Routine HIV Test Results in 6 US Clinical Laboratories Using the Recommended Laboratory HIV Testing Algorithm With Geenius HIV 1/2 Supplemental Assay. Sex Transm Dis, (Suppl 1:S13-S17).
  2. Theel ES, Slev P, Wheeler S, Couturier MR, Wong SJ, Kadkhoda K, et al (2020). The Role of Antibody Testing for SARS-CoV-2: is There One? J Clin Microbiol, in press.
  3. Profaizer T, Slev P (2020). Multiplex Droplet Digital PCR Assay for the Detection of T-Cell Receptor Excision Circles and Kappa-Deleting Recombination Excision Circles. Clinical Chemistry (Chicago), 1(66), 229-238.
  4. Ravkov EV, Charlton CM, Barker AP, Hill H, Peterson LK, Slev P, Tebo A, Voelkerding KV, Wittwer CT, Heikal N, Delgado JC, Lzr-Molnr E, Kumnovics A (2019). Evaluation of Mass Cytometry in the Clinical Laboratory. Cytometry B Clin Cytom, 96(4), 266-274.
  5. Kuo CY, Garcia-Lioret MI, Slev P, Bohnsack JF, Chen K (2017). Profound T-cell lymphopenia associated with prenatal exposure to purine antagonists detected by TREC newborn screening. J Allergy Clin Immunol, 5(1), 198-200.
  6. Apanius V, Penn D, Slev PR, Ruff LR, Potts WK (2018). The Nature of Selection on the Major Histocompatibility Complex. Crit Rev Immunol, 37(2-6), 75-120.
  7. Martins TB, Bandhauer ME, Wilcock DM, Hill HR, Slev PR (2016). Specific Immunoglobulin (Ig) G Reference Intervals for Common Food, Insect, and Mold Allergens. Ann Clin Lab Sci, 46(6), 635-638.
  8. Slev, PR (09/01/2016). The status of laboratory testing for the diagnosis of HIV infection. MLO Med Lab Obs, 48(9), 32.
  9. Chow SK, Atienza EE, Cook L, Prince H, Slev P, Lap-Nixon M, Jerome KR (2016). Comparison of Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum. Clin Vaccine Immunol, 23(8), 732-4.
  10. Slev, PR (03/01/2016). Laboratory Testing for HIV. Clinical Laboratory News.
  11. Ravkov E, Slev P, Heikal N (2015). Thymic output: Assessment of CD4+ Recent Thymic Emigrants and T-Cell Receptor Excision Circles in Infants. Cytometry B Clin Cytom, Epub ahead(print).
  12. Slev PR (2013). US preventive services task force HIV screening guidelines:a laboratory perspective. Clin Chem, 59(8), 1281-2.
  13. Slev PR (07/01/2013). HIV Universal Screening & Laboratory Diagnosis. Clin Leadersh Manag Rev, 27(2).
  14. Slev P (2012). The changing landscape of HIV diagnostics. MLO Med Lab Obs, 44(11), 8-10, 12, 14; quiz 16.
  15. Slev P (2012). Host genomics and HCV personalized medicine. Ann Clin Lab Sci, 42(4), 363-9.
  16. Melis R, Lewis T, Millson A, Lyon E, McMillin GA, Slev PR, Swensen J (2012). Copy Number Variation and Incomplete Linkage Disequilibrium Interfere with the HCP5 Genotyping Assay for Abacavir Hypersensitivity. Genet Test Mol Biomarkers, 16(9), 1111-4.
  17. Kubinak JL, Ruff JS, Hyzer CW, Slev PR, Potts WK (2012). Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types. Proc Natl Acad Sci U S A, 109(9), 3422-7.
  18. Melis R, Faun C, McMillin G, Lyon E, Shirts B, Hubley LM, Slev PR (2011). Simulaneous genotyping of rs1297860 and rs8099917 variants near the IL28B locus associated with HCV clearance and treatment response. J Mol Diagn, 13(4), 446-51.
  19. Pranzatelli MR, Slev PR, Tate ED, Travelstead AL, Colliver JA, Joseph SA (2011). Cerebrospinal fluid oligoclonal bands in childhood opsoclonus-myoclonus. Pediatr Neurol, 45(1), 27-33.
  20. Slev PR, Bunker AM, Owen WE, Roberts WL (2010). Pediatric reference intervals for random urine calcium, phosphorus and total protein. Pediatr Nephrol, 25(9), 1707-10.
  21. Slev PR (2009). A look at CDC 2006 HIV testing guidelines and rapid tests. Clinical Laboratory News. Clinical Laboratory News, 35, 14-16.
  22. Slev PR, Williams BG, Harville TO, Ashwood ER, Bornhorst JA (2008). Efficacy of the detection of the alpha1-antitrypsin "Z" deficiency variant by routine serum protein electrophoresis. Am J Clin Pathol, 130(4), 568-72.
  23. Slev PR, Laulu SL, Roberts WL (2008). Intermethod differences in results for total PSA, free PSA, and percentage of free PSA. Am J Clin Pathol, 129(6), 952-8.
  24. Laulu SL, Slev PR, Roberts WL (2007). Performance characteristics of 5 automated thyroglobulin autoantibody and thyroid peroxidase autoantibody assays. Clin Chim Acta, 376(1-2), 88-95.
  25. Slev PR, Nelson AC, Potts WK (2006). Sensory neurons with MHC-like peptide binding properties: disease consequences. Curr Opin Immunol, 18(5), 608-16.
  26. Slev PR, Rawlins ML, Roberts WL (2006). Performance characteristics of seven automated CA 15-3 assays. Am J Clin Pathol, 125(5), 752-7.
  27. Slev PR, Potts WK (2002). Disease consequences of pathogen adaptation. Curr Opin Immunol, 14(5), 609-14.
  28. Penn D, Schneider G, White K, Slev PR, Potts WK (2002). Female mice (Mus musculus domesticus) prefer the odor of uninfected males over males infected with influenza viruses. Ethology, 104, 685-694.
  29. Profaizer T, Slev P (). A multiplex, Droplet Digital PCR Assay for T-Cell Receptor Excision Circles and Kappa-Deleting Recombination Excision Circles. Clin Chem, in press.

Review

  1. Apanius V, Penn D, Slev PR, Ruff LR, Potts WK (1997). The nature of selection on the major histocompatibility complex. [Review]. Crit Rev Immunol, 17(2), 179-224.
  2. Potts WK, Slev PR (1995). Pathogen-based models favoring MHC genetic diversity. [Review]. Immunol Rev, 143, 181-97.

Book Chapter

  1. Hillyard DR, Slev PR (2015). Infectious Disease and Pharmacogenomics. In Deborah Leonard (Ed.), Molecular Pathology in Clinical Practice.
  2. Slev P (2009). HIV Methods. In Kaplan (Ed.), Clinical Chemistry; Theory, Analysis and Correlation. Pesce and Kazmierczak.

Abstract

  1. Martins TB, Wilcock DM, First R, Slev PR, Hill HR (2017). Evaluation of A Basophil Activation Flow Cytometric Assay As An Alternative to Oral Food Challenge for Determining Peanut Allergy. [Abstract]. Western Research Conference.
  2. Kish-Trier E, Ravkov, Barker A, Couturier M, Delgado J, Heikal N Hill H, Lazar-Molnar E, Peterson LK, Slev PR, Tebo A, Voelkerding K, Kumanovics A (2017). A Preliminary Evaluation of a Mass Cytometry Instrument at ARUP Laboratories. MSACL 2017. [Abstract].
  3. Ravkov E, Slev P, Heikal N (2015). Correlation between Thymic Emigrants and T-cell Receptor Excision Circles in Newborn Screening for SCID. [Abstract]. AMLI, Seattle, WA.
  4. Nikolic D, Lesourd S, Slev P, Bornhorst J (2015). Comparison of the sensitivity of a type-specific and a combined Immunoassay against HSV-1 and HSV-2. [Abstract]. Association of Clinical Scientists, Annual Meeting, Salt Lake City, Utah.
  5. Chow SK, Atienza E, Cook L, Prince H, Slev P, Jerome K (2015). Comparison of Commercial and In-House Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum Specimens. [Abstract]. Clinical Virology Symposium, Daytona Beach, FL.
  6. Ardon O, Blackley J, Griffiths S, Slev PR (2013). Comparison of the AVIOQ HTLV I/II Microelisa System to MP Diagnostics (MPD) HTLV I/II Elisa 4.0 assay for detection of HTLV I/II [Abstract]. Clinical Virology Symposium, Daytona, FL.
  7. Ardon O, Blackley J, Griffiths S, Slev PR (2013). Evaluation of multispot for detection of HIV-1 and HIV-2 infection [Abstract]. Clinical Virology Symposium, Daytona, FL.
  8. Fauron C, Slev P (2012). Evaluation of the Bio-Rad GS HIV combo Ag/Ab EIA Assay [Abstract]. Clinical Virology Symposium, Daytona, FL.
  9. Melis R, Lewis T, McMillin G, Lyon E, Slev PR, Swensen J (2011). CNV and incomplete linkage diseqilibrium interference with the HCP5 genotyping assay for Abacavir hypsensitivity. [Abstract]. Association for Molecular Pathology.
  10. Melis R, Fauron C, McMillin G, Lyon E, Hubley LM, Slev PR (2011). Genotype Frequency of Two Polymorphisms Associated with Clearance and Treatment Response in Different Ethnic Groups. [Abstract]. Clinical Virology Symposium (CVS) Annual Meeting, Daytona Beach, FL.
  11. Melis R, Lewis T, McMillin G, Lyon E, Slev PR, Swensen, J (2011). CNV and incomplete linkage disequillibrium interference with the HCP5 genotyping assay for Abacavir hypersensitivity. [Abstract]. Association for Molecular Patology (AMP) Annual Meeting, Grapevine, Texas.
  12. Melis R, Fauron C, McMillin G, Lyon E, Slev P (2010). Rapid detection of two variants near the IL28B locus associated with HCV clearance and treatment response. AACC National Meeting, Anaheim California. [Abstract].
  13. Pyne M, Roberts R, Griffiths S, Bradley R, Slev PR (2010). Evaluation of the ADVIA Centaur® HIV 1/O/2 Enchanced (EHIV) Assay. 2010 HIV Diagnostics Conference, Orlando Florida. [Abstract].
  14. Melis R, Millson A McMillin G, Lyon E, Slev PR (2010). A Rapid Screening Assay for Prediction of Hypersensitivity reaction to Abacavir. Clinical Virology Symposium, Daytona Florida. [Abstract].
  15. Slev PR (2009). Estimating Hepatitis Delta Virus Prevalence Using Serologic Laboratory Results. Clinical Virology Symposium, Daytona, Florida. [Abstract].
  16. Slev PR, Williams B, Ashwood ER, Bornhorst JA (2007). Evaluation of the Detection of a1-antitrypsin Deficiency Variants by Routine Serum Protein Electrophoresis. AACC National Meeting, San Diego, California. [Abstract].
  17. Erickson A, Slev PR, Ashwood ER (July 2007). Reference Interval and Performance Characteristics of an Enzyme-Linked Immunosorbent Assay for Quantifying Soluable Mesothelin Related Peptides AACC National Meeting, San Diego, California. [Abstract].
  18. Slev PR (2006). Performance characteristics of Five Automated Immunoassays for anti-Tg and anti-TPO. [Abstract].
  19. Slev PR (2005). Performance characteristics of Seven Automated CA 15-3 Methods. [Abstract].

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