Patricia R. Slev
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Patricia R. Slev, PhD

Languages spoken: English

  • Dr. Slev is the medical director of the Serological Hepatitis/Retrovirus Laboratory and Co-Director Immunogenetics at ARUP and an Associate Professor of Pathology at the University of Utah, School of Medicine. Dr. Slev's research interests are in immunogenetics and pathogen interactions, particularly HIV and viral hepatitis.

    Specialties

    • Pathology, Clinical

    Board Certification

    American Board of Clinical Chemistry (Sub: Clinical Chemistry)

  • Dr. Slev is the medical director of the Serological Hepatitis/Retrovirus Laboratory and Co-Director Immunogenetics at ARUP and an Associate Professor of Pathology at the University of Utah, School of Medicine. Dr. Slev's research interests are in immunogenetics and pathogen interactions, particularly HIV and viral hepatitis.

    Board Certification and Academic Information

    Academic Departments Pathology -Primary
    Board Certification
    American Board of Clinical Chemistry (Sub: Clinical Chemistry)

    Education history

    Fellowship Clinical Chemistry - University of Utah School of Medicine Fellow
    Biology - University of Utah Postdoctoral Fellow
    Doctoral Training Immunology, Laboratory Medicine - University of Florida Ph.D.
    Biology - Florida Atlantic University B.A.

    Selected Publications

    Journal Article

    1. Balogun K, Slev PR (2022). Towards achieving the end of the HIV epidemic: Advances, challenges and scaling-up strategies. Clin Biochem, 117, 53-59. (Read full article)
    2. Nandakumar V, Profaizer T, Lozier BK, Elgort MG, Rychert J, Slev PR, Delgado JC (2021). Evaluation of a Novel Multiplex Platform for Simultaneous Detection of IgG Antibodies Against the 4 Main SARS-CoV-2 Antigens. J Appl Lab Med, 7(3), 698-710. (Read full article)
    3. Rychert J, Couturier MR, Elgort M, Lozier BK, Laulu S, Genzen JR, Straseski JA, Delgado JC, Slev PR (2020). Evaluation of 3 SARS-CoV-2 IgG Antibody Assays and Correlation with Neutralizing Antibodies. J Appl Lab Med, 6(3), 614-624. (Read full article)
    4. Walter A Schrading, Stacy A Trent, James H Paxton, Robert M Rodriguez 5, Morgan B Swanson, Nicholas M Mohr, David A Talan (2021). Project COVERED Emergency Department Network (Slev P, author in COVERED Emerg Dept Network). Vaccination rates and acceptance of SARS-CoV-2 vaccination among U.S. emergency department health care personnel. Acad Emerg Med, 28(4), 455-458.
    5. Victoria Zhang, Joesph Wiencek, Qing H Meng, Elitza S Theel, Nikolina Babic, Lusia Sepiashvili, Nicole D Pecora, Patricia Slev, Andrew Cameron, Danijela Konforte on behalf of the AACC COVID 19 Serologic Testing Task Force (2021). AACC Practical Recommendations for Implementing and Interpreting SARS-CoV-2 EUA and LDT Serologic Testing in Clinical Laboratories. Clin Chem.
    6. Rodriguez RM, Montroy JCC, Hoth KF, Talan DA, Harland KK, Eyck PT, Mower W, Krishnadasan A, SAntibanez S, Mohr N (2021). Project COVERED Emergency Network (Slev P, member & author COVERED Emergency Network). Ann Emerg Med.
    7. Mohr N, Harland K, Krishnadasan A, Eyck PT, Mower Wr, Wiley J, Chisolm-Straker M, Lim SC, McDonald CL, Kutty PK, Hesse E, Santibanez S, Talan DA (2020). PROJECT COVERED Emergency Department Network (Slev P author in COVERED Emergency Department Network). Diagnosed and Undiagnosed COVID-19 in US Emergency Department Healthcare Personnell– Cross-sectional Analysis. Ann Emerg Med, 20, 31455-4.
    8. Luetkens T, Metcalf R, Planelles V, Zheng Y, Larragoite ET, Spivak ES, Spivak AM, Steinbach M, Blaylock RC, Avila SV, Hankey KG, Martins TB, Slev PR, Mannuel HD, Sajadi M, Rapoport AP, Atanackovic D (2020). Successful transfer of anti-SARS-CoV-2 immunity using convalescent plasma in an MM patient with hypogammaglobulinemia and COVID-19. Blood Adv, 4(19), 4864-4868. (Read full article)
    9. Wesolowski LG, Chavez PR, Cardenas AM, Katayev A, Slev P, Valsamakis A, Wang YF, Yao JD, Dougherty C, Gillim-Ross L, Harmon C, Delaney KP et al (2020). Routine HIV Test Results in 6 US Clinical Laboratories Using the Recommended Laboratory HIV Testing Algorithm With Geenius HIV 1/2 Supplemental Assay. Sex Transm Dis, (Suppl 1:S13-S17).
    10. Theel ES, Slev P, Wheeler S, Couturier MR, Wong SJ, Kadkhoda K, et al (2020). The Role of Antibody Testing for SARS-CoV-2: is There One? J Clin Microbiol, in press.
    11. Profaizer T, Slev P (2020). Multiplex Droplet Digital PCR Assay for the Detection of T-Cell Receptor Excision Circles and Kappa-Deleting Recombination Excision Circles. 1(66), 229-238.
    12. Ravkov EV, Charlton CM, Barker AP, Hill H, Peterson LK, Slev P, Tebo A, Voelkerding KV, Wittwer CT, Heikal N, Delgado JC, Lzr-Molnr E, Kumnovics A (2019). Evaluation of Mass Cytometry in the Clinical Laboratory. Cytometry B Clin Cytom, 96(4), 266-274. (Read full article)
    13. Kuo CY, Garcia-Lioret MI, Slev P, Bohnsack JF, Chen K (2017). Profound T-cell lymphopenia associated with prenatal exposure to purine antagonists detected by TREC newborn screening. J Allergy Clin Immunol, 5(1), 198-200.
    14. Apanius V, Penn D, Slev PR, Ruff LR, Potts WK (2018). The Nature of Selection on the Major Histocompatibility Complex. Crit Rev Immunol, 37(2-6), 75-120. (Read full article)
    15. Martins TB, Bandhauer ME, Wilcock DM, Hill HR, Slev PR (2016). Specific Immunoglobulin (Ig) G Reference Intervals for Common Food, Insect, and Mold Allergens. Ann Clin Lab Sci, 46(6), 635-638. (Read full article)
    16. Slev, PR (09/01/2016). The status of laboratory testing for the diagnosis of HIV infection. MLO Med Lab Obs, 48(9), 32.
    17. Chow SK, Atienza EE, Cook L, Prince H, Slev P, Lap-Nixon M, Jerome KR (2016). Comparison of Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum. Clin Vaccine Immunol, 23(8), 732-4. (Read full article)
    18. Slev, PR (03/01/2016). Laboratory Testing for HIV.
    19. Ravkov E, Slev P, Heikal N (2015). Thymic output: Assessment of CD4+ Recent Thymic Emigrants and T-Cell Receptor Excision Circles in Infants. Cytometry B Clin Cytom, Epub ahead(print).
    20. Slev PR (2013). US preventive services task force HIV screening guidelines:a laboratory perspective. Clin Chem, 59(8), 1281-2. (Read full article)
    21. Slev PR (07/01/2013). HIV Universal Screening & Laboratory Diagnosis. Clin Leadersh Manag Rev, 27(2).
    22. Slev P (2012). The changing landscape of HIV diagnostics. MLO Med Lab Obs, 44(11), 8-10, 12, 14; quiz 16. (Read full article)
    23. Slev P (2012). Host genomics and HCV personalized medicine. Ann Clin Lab Sci, 42(4), 363-9. (Read full article)
    24. Melis R, Lewis T, Millson A, Lyon E, McMillin GA, Slev PR, Swensen J (2012). Copy Number Variation and Incomplete Linkage Disequilibrium Interfere with the HCP5 Genotyping Assay for Abacavir Hypersensitivity. Genet Test Mol Biomarkers, 16(9), 1111-4. (Read full article)
    25. Kubinak JL, Ruff JS, Hyzer CW, Slev PR, Potts WK (2012). Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types. Proc Natl Acad Sci U S A, 109(9), 3422-7. (Read full article)
    26. Melis R, Faun C, McMillin G, Lyon E, Shirts B, Hubley LM, Slev PR (2011). Simulaneous genotyping of rs1297860 and rs8099917 variants near the IL28B locus associated with HCV clearance and treatment response. J Mol Diagn, 13(4), 446-51.
    27. Pranzatelli MR, Slev PR, Tate ED, Travelstead AL, Colliver JA, Joseph SA (2011). Cerebrospinal fluid oligoclonal bands in childhood opsoclonus-myoclonus. Pediatr Neurol, 45(1), 27-33. (Read full article)
    28. Slev PR, Bunker AM, Owen WE, Roberts WL (2010). Pediatric reference intervals for random urine calcium, phosphorus and total protein. Pediatr Nephrol, 25(9), 1707-10. (Read full article)
    29. Slev PR (2009). A look at CDC 2006 HIV testing guidelines and rapid tests. Clinical Laboratory News. 35, 14-16.
    30. Slev PR, Williams BG, Harville TO, Ashwood ER, Bornhorst JA (2008). Efficacy of the detection of the alpha1-antitrypsin "Z" deficiency variant by routine serum protein electrophoresis. Am J Clin Pathol, 130(4), 568-72. (Read full article)
    31. Slev PR, Laulu SL, Roberts WL (2008). Intermethod differences in results for total PSA, free PSA, and percentage of free PSA. Am J Clin Pathol, 129(6), 952-8. (Read full article)
    32. Laulu SL, Slev PR, Roberts WL (2007). Performance characteristics of 5 automated thyroglobulin autoantibody and thyroid peroxidase autoantibody assays. Clin Chim Acta, 376(1-2), 88-95. (Read full article)
    33. Slev PR, Nelson AC, Potts WK (2006). Sensory neurons with MHC-like peptide binding properties: disease consequences. Curr Opin Immunol, 18(5), 608-16. (Read full article)
    34. Slev PR, Rawlins ML, Roberts WL (2006). Performance characteristics of seven automated CA 15-3 assays. Am J Clin Pathol, 125(5), 752-7. (Read full article)
    35. Slev PR, Potts WK (2002). Disease consequences of pathogen adaptation. Curr Opin Immunol, 14(5), 609-14. (Read full article)
    36. Penn D, Schneider G, White K, Slev PR, Potts WK (2002). Female mice (Mus musculus domesticus) prefer the odor of uninfected males over males infected with influenza viruses. Ethology, 104, 685-694.

    Review

    1. Slev PR (2021). Severe Acute Respiratory Syndrome Coronavirus 2 Serology Testing - A Laboratory Primer. [Review]. Clin Lab Med, 42(1), 1-13. (Read full article)
    2. Apanius V, Penn D, Slev PR, Ruff LR, Potts WK (1997). The nature of selection on the major histocompatibility complex. [Review]. Crit Rev Immunol, 17(2), 179-224. (Read full article)
    3. Potts WK, Slev PR (1995). Pathogen-based models favoring MHC genetic diversity. [Review]. Immunol Rev, 143, 181-97. (Read full article)

    Book Chapter

    1. Hillyard DR, Slev PR (2015). Infectious Disease and Pharmacogenomics. In Deborah Leonard (Ed.), Molecular Pathology in Clinical Practice.
    2. Slev P (2009). HIV Methods. In Kaplan (Ed.), Clinical Chemistry; Theory, Analysis and Correlation. Pesce and Kazmierczak.

    Abstract

    1. Martins TB, Wilcock DM, First R, Slev PR, Hill HR (2017). Evaluation of A Basophil Activation Flow Cytometric Assay As An Alternative to Oral Food Challenge for Determining Peanut Allergy. [Abstract]. Western Research Conference.
    2. Kish-Trier E, Ravkov, Barker A, Couturier M, Delgado J, Heikal N Hill H, Lazar-Molnar E, Peterson LK, Slev PR, Tebo A, Voelkerding K, Kumanovics A (2017). A Preliminary Evaluation of a Mass Cytometry Instrument at ARUP Laboratories. MSACL 2017. [Abstract].
    3. Ravkov E, Slev P, Heikal N (2015). Correlation between Thymic Emigrants and T-cell Receptor Excision Circles in Newborn Screening for SCID. [Abstract]. AMLI, Seattle, WA.
    4. Nikolic D, Lesourd S, Slev P, Bornhorst J (2015). Comparison of the sensitivity of a type-specific and a combined Immunoassay against HSV-1 and HSV-2. [Abstract]. Association of Clinical Scientists, Annual Meeting, Salt Lake City, Utah.
    5. Chow SK, Atienza E, Cook L, Prince H, Slev P, Jerome K (2015). Comparison of Commercial and In-House Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum Specimens. [Abstract]. Clinical Virology Symposium, Daytona Beach, FL.
    6. Ardon O, Blackley J, Griffiths S, Slev PR (2013). Comparison of the AVIOQ HTLV I/II Microelisa System to MP Diagnostics (MPD) HTLV I/II Elisa 4.0 assay for detection of HTLV I/II [Abstract]. Clinical Virology Symposium, Daytona, FL.
    7. Ardon O, Blackley J, Griffiths S, Slev PR (2013). Evaluation of multispot for detection of HIV-1 and HIV-2 infection [Abstract]. Clinical Virology Symposium, Daytona, FL.
    8. Fauron C, Slev P (2012). Evaluation of the Bio-Rad GS HIV combo Ag/Ab EIA Assay [Abstract]. Clinical Virology Symposium, Daytona, FL.
    9. Melis R, Lewis T, McMillin G, Lyon E, Slev PR, Swensen J (2011). CNV and incomplete linkage diseqilibrium interference with the HCP5 genotyping assay for Abacavir hypsensitivity. [Abstract]. Association for Molecular Pathology.
    10. Melis R, Fauron C, McMillin G, Lyon E, Hubley LM, Slev PR (2011). Genotype Frequency of Two Polymorphisms Associated with Clearance and Treatment Response in Different Ethnic Groups. [Abstract]. Clinical Virology Symposium (CVS) Annual Meeting, Daytona Beach, FL.
    11. Melis R, Lewis T, McMillin G, Lyon E, Slev PR, Swensen, J (2011). CNV and incomplete linkage disequillibrium interference with the HCP5 genotyping assay for Abacavir hypersensitivity. [Abstract]. Association for Molecular Patology (AMP) Annual Meeting, Grapevine, Texas.
    12. Melis R, Fauron C, McMillin G, Lyon E, Slev P (2010). Rapid detection of two variants near the IL28B locus associated with HCV clearance and treatment response. AACC National Meeting, Anaheim California. [Abstract].
    13. Pyne M, Roberts R, Griffiths S, Bradley R, Slev PR (2010). Evaluation of the ADVIA Centaur® HIV 1/O/2 Enchanced (EHIV) Assay. 2010 HIV Diagnostics Conference, Orlando Florida. [Abstract].
    14. Melis R, Millson A McMillin G, Lyon E, Slev PR (2010). A Rapid Screening Assay for Prediction of Hypersensitivity reaction to Abacavir. Clinical Virology Symposium, Daytona Florida. [Abstract].
    15. Slev PR (2009). Estimating Hepatitis Delta Virus Prevalence Using Serologic Laboratory Results. Clinical Virology Symposium, Daytona, Florida. [Abstract].
    16. Slev PR, Williams B, Ashwood ER, Bornhorst JA (2007). Evaluation of the Detection of a1-antitrypsin Deficiency Variants by Routine Serum Protein Electrophoresis. AACC National Meeting, San Diego, California. [Abstract].
    17. Erickson A, Slev PR, Ashwood ER (July 2007). Reference Interval and Performance Characteristics of an Enzyme-Linked Immunosorbent Assay for Quantifying Soluable Mesothelin Related Peptides AACC National Meeting, San Diego, California. [Abstract].
    18. Slev PR (2006). Performance characteristics of Five Automated Immunoassays for anti-Tg and anti-TPO. [Abstract].
    19. Slev PR (2005). Performance characteristics of Seven Automated CA 15-3 Methods. [Abstract].