Jonathan Robert Genzen
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Jonathan Robert Genzen, MD, PhD, MBA

Languages spoken: English

  • Dr. Genzen is a Professor (Clinical) in the Department of Pathology at the University of Utah. He serves as Chief Medical Officer at ARUP Laboratories, where he is Medical Director of Automation and a Co-Medical Director of the Automated Core Laboratory. He is board certified in Clinical Pathology by the American Board of Pathology and is a Fellow of the American Society for Clinical Pathology. He is a member of the American Association for Clinical Chemistry and the Academy of Clinical Laboratory Physicians and Scientists.

    Dr. Genzen received both his Ph.D. and M.D. from the University of Chicago. He completed his clinical pathology residency at Yale-New Haven Hospital / Yale University in the Department of Laboratory Medicine, where he also conducted his postdoctoral research fellowship. Dr. Genzen’s clinical and research focus is on automated clinical chemistry, quality improvement, and process efficiency initiatives.

    Specialties

    • Pathology, Clinical

    Board Certification

    American Board of Pathology (Clinical Path)

  • Dr. Genzen is a Professor (Clinical) in the Department of Pathology at the University of Utah. He serves as Chief Medical Officer at ARUP Laboratories, where he is Medical Director of Automation and a Co-Medical Director of the Automated Core Laboratory. He is board certified in Clinical Pathology by the American Board of Pathology and is a Fellow of the American Society for Clinical Pathology. He is a member of the American Association for Clinical Chemistry and the Academy of Clinical Laboratory Physicians and Scientists.

    Dr. Genzen received both his Ph.D. and M.D. from the University of Chicago. He completed his clinical pathology residency at Yale-New Haven Hospital / Yale University in the Department of Laboratory Medicine, where he also conducted his postdoctoral research fellowship. Dr. Genzen’s clinical and research focus is on automated clinical chemistry, quality improvement, and process efficiency initiatives.

    Board Certification and Academic Information

    Academic Departments Pathology -Primary
    Board Certification
    American Board of Pathology (Clinical Path)

    Education history

    Graduate Training Joint Executive MBA Americas Program - Cornell University and Queen's University EMBA
    Yale University School of Medicine, Department of Laboratory Medicine Postdoctoral Research Fellow
    Residency Clinical Pathology - Yale-New Haven Hospital and VA Connecticut Healthcare System Resident
    University of Chicago, Committee on Neurobiology Ph.D.
    Professional Medical University of Chicago, Pritzker School of Medicine M.D.
    Biological Sciences / Neurobiology Concentration & International Studies - Northwestern University, College of Arts and Sciences B.A.

    Selected Publications

    Journal Article

    1. van Wijk XMR, Master SR, Genzen JR (2024). FDA's Final Rule on Laboratory Developed Tests. Clin Chem, 70(9), 1192-1194. (Read full article)
    2. Merrill AE, Hackenmueller SA, Derdeyn C, Genzen J, Gruson D, Ludgate M, Mulchandani S, Parnas ML, Ranheim E (2024). Beyond the Screen: Navigating Remote Work within Medicine. Clin Chem, 70(8), 1009-1016. (Read full article)
    3. Chambliss AB, Souers RJ, Genzen JR, Manthei DM (2024). Reported Awareness and Use of Pyridoxal-5'-Phosphate Supplementation in Alanine Aminotransferase and Aspartate Aminotransferase Assay Reagents: A Survey by the College of American Pathologists Clinical Chemistry Committee. Arch Pathol Lab Med. (Read full article)
    4. Smith L, Carricaburu LA, Genzen JR (2024). The US FDA's proposed rule on laboratory-developed tests: Impacts on clinical laboratory testing. Pract Lab Med, 40, e00407. (Read full article)
    5. Genzen JR, Moser KA (2024). The FDA's proposed rule on laboratory-developed tests: what happens next? Lab Med. (Read full article)
    6. Rychert J, Genzen JR (2023). Modifications of FDA-cleared/approved tests. Am J Clin Pathol, 160(5), 542. (Read full article)
    7. Rychert J, Schmidt RL, Genzen JR (2023). Laboratory-Developed Tests Account for a Small Minority of Tests Ordered in an Academic Hospital System. Am J Clin Pathol, 160(3), 297-302. (Read full article)
    8. Ondracek CR, Genzen JR, Lockwood CM, Das S, Kang P, Melanson SEF (2023). Robust Response of the Clinical Laboratory to the COVID-19 Pandemic despite Significant Challenges. J Appl Lab Med, 8(6), 1160-1172. (Read full article)
    9. Brown HM, Farnsworth CW, Bryan A, Genzen JR, Gronowski A, Philips Deeter J, Yarbrough M (2022). One Bad Apple Can Spoil the Bunch: The Impact of Contamination in the Clinical Laboratory. Clin Chem, 69(1), 9-16. (Read full article)
    10. Genzen JR, Souers RJ, Pearson LN, Manthei DM, Chambliss AB, Shajani-Yi Z, Miller WG (2023). Reported Awareness and Adoption of 2021 Estimated Glomerular Filtration Rate Equations Among US Clinical Laboratories, March 2022. JAMA, 328(20), 2060-2062. (Read full article)
    11. Wyness SP, Snow TM, Villanueva M, Kunzler T, Seiter J, Genzen JR, Johnson LM (2022). Impact of Unconjugated estriol (uE3) assay interference on prenatal screening tests. Clin Chim Acta, 536, 1-5. (Read full article)
    12. Allison TR, Hunsaker JJH, Laulu SL, Genzen JR (2022). Evaluation of an adenosine deaminase (ADA) assay in serum, pleural, pericardial, peritoneal, and cerebrospinal fluids on the Roche cobas c501 analyzer. Clin Biochem, 109-110, 57-63. (Read full article)
    13. Erickson JA, Chiang FI, Walker CM, Genzen JR, Doyle K (2022). Comparison of two chromogranin A assays and investigation of nonlinear specimens. Pract Lab Med, 32, e00299. (Read full article)
    14. Genzen JR, Rychert J, George TI (2022). Integrity of SARS-CoV-2 Laboratory-Developed Tests. JAMA, 328(5), 478. (Read full article)
    15. Brown K, Duzan D, Fong K, Freeman VS, Genzen J, Goodyear N, Harrington SM, Taff T, Tanabe PA (2022). ASCP Board of Certification Survey of Medical Laboratory Science Education 2020: Programs. Lab Med, 53, e154-e158. (Read full article)
    16. Brown K, Duzan D, Fong K, Freeman VS, Genzen J, Goodyear N, Harrington SM, Taff T, Tanabe PA (2022). ASCP Board of Certification Survey of Medical Laboratory Science Education 2020: Faculty. Lab Med, 53, e159-e163. (Read full article)
    17. Johnson LM, Genzen JR, Algeciras-Schimnich A, Bornhorst J, Lambert-Messerlian G (2022). PAPP-A Results Cannot Be Used to Accurately Estimate Gestational Age. J Appl Lab Med, 7, 1000-1002. (Read full article)
    18. Genzen JR, Nwosu A, Long T, Murphy H, Alter DN (2022). An International Survey of Glucose-6-Phosphate Dehydrogenase Laboratory Reporting Practices: Implications for Tafenoquine Eligibility Assessment. Arch Pathol Lab Med, 146(10), 1211-1217. (Read full article)
    19. Hunsaker JJH, Laulu SL, LaGrave D, Murphy W, Reichman HA, Snow TM, McMillin GA, Johnson-Davis KL, Genzen JR (2021). Tobacco and Cannabis Use During Pregnancy. Am J Clin Pathol, 157(1), 146-152. (Read full article)
    20. Nelson HA, Genzen JR, Delgado JC, Rudolf JW (2021). An Interference in an Automated HCO3- Assay Leads to an Unexpected IgG Monoclonal Gammopathy Diagnosis. J Appl Lab Med, 7, 622-625. (Read full article)
    21. Pandya V, Hunsaker JJH, Laulu SL, Genzen JR, Frank EL, Johnson LM, Rudolf JW (2021). Excessively low cholesterol and triglyceride levels in an apparently healthy patient. Clin Biochem, 96, 78-81. (Read full article)
    22. Haspel RL, Genzen JR, Wagner J, Fong K, Undergraduate Training in Genomics UTRIG Working Group, Wilcox RL (2021). Call for improvement in medical school training in genetics: results of a national survey. Genet Med, 23(6), 1151-1157. (Read full article)
    23. Patel MK, El-Khoury JM, Simundic EA, Farnsworth CW, Broell F, Genzen JR, Amukele TK (2020). Evolution of Blood Sample Transportation and Monitoring Technologies. Clin Chem, 67(6), 812-819. (Read full article)
    24. Rychert J, Couturier MR, Elgort M, Lozier BK, Laulu S, Genzen JR, Straseski JA, Delgado JC, Slev PR (2020). Evaluation of 3 SARS-CoV-2 IgG Antibody Assays and Correlation with Neutralizing Antibodies. J Appl Lab Med, 6(3), 614-624. (Read full article)
    25. Laulu SL, Turner DR, Zupan E, Genzen JR (2021). Pretreatment of Body Fluid Specimens Using Hyaluronidase and Ultracentrifugation. Lab Med, 52, 469-476. (Read full article)
    26. Calvaresi EC, Laulu SL, Snow TM, Allison TR, Genzen JR (2021). Plasma hemoglobin: A method comparison of six assays for hemoglobin and hemolysis index measurement. Int J Lab Hematol, 43, 1145-1153. (Read full article)
    27. Klutts JS, Genzen JR (2020). Disparities and Bias in Pathology and Laboratory Medicine. J Appl Lab Med, 6(1), 3-6. (Read full article)
    28. Jackson BR, Genzen JR (2020). The Lab Must Go On. Am J Clin Pathol, 155(1), 4-11. (Read full article)
    29. Smy L, De Biase I, Genzen JR, Yuzyuk T (2020). The nuclear magnetic resonance metabolic profile: Impact of fasting status. Clin Biochem, 87, 85-92. (Read full article)
    30. Naides SJ, Genzen JR, Abel G, Bashleben C, Ansari MQ (2020). Antinuclear Antibodies Testing Method Variability: A Survey of Participants in the College of American Pathologists' Proficiency Testing Program. J Rheumatol, 47(12), 1768-1773. (Read full article)
    31. Haspel RL, Genzen JR, Wagner J, Lockwood CM, Fong K, Training Residents in Genomics TRIG Working Group (2020). Integration of Genomic Medicine in Pathology Resident Training. Am J Clin Pathol, 154(6), 784-791. (Read full article)
    32. Calvaresi EC, Genzen JR (2020). Evaluating Percentage-Based Reporting of Glucose-6-Phosphate Dehydrogenase (G6PD) Enzymatic Activity. Am J Clin Pathol, 154(2), 248-254. (Read full article)
    33. Roundy CS, Lin DC, Klopping PJ, Ence AT, Krezel AC, Genzen JR (2019). Specimen Temperature Detection on a Clinical Laboratory Pre-Analytic Automation Track: Implications for Direct-from-Track Total Laboratory Automation (TLA) Systems. SLAS Technol, 25(3), 293-299. (Read full article)
    34. Rychert J, Delgado JC, Genzen JR (2020). Modification of In Vitro Diagnostic Devices: Leveling the Playing Field. Clin Chem, 66(6), 760-762. (Read full article)
    35. Lakshmipathi J, Gao Y, Hu C, Stuart D, Genzen J, Ramkumar N, Kohan DE (2020). Nephron-Specific Disruption of Polycystin-1 Induces Cyclooxygenase-2-Mediated Blood Pressure Reduction Independent of Cystogenesis. J Am Soc Nephrol, 31(6), 1243-1254. (Read full article)
    36. Peedin AR, Genzen JR, Karp JK (2019). Correlating Transfusion Medicine In-Service Examination Scores With Outcomes of the American Board of Pathology Transfusion Medicine Subspecialty Certifying Examination. Am J Clin Pathol, 153(4), 497-501. (Read full article)
    37. Brown K, Fenn JP, Fong K, Freeman V, Genzen J, Goodyear N, Lunz Houston M, Taff T, Tanabe P (2019). ASCP Board of Certification Survey of Medical Laboratory Science Education Programs. Lab Med, 50(4), e70-e74. (Read full article)
    38. Brown K, Parker Fenn J, Fong K, Freeman V, Genzen J, Goodyear N, Lunz Houston M, Taff T, Tanabe P (2019). ASCP Board of Certification Survey of Medical Laboratory Science Faculty. Lab Med, 50(4), e75-e81. (Read full article)
    39. Maharjan AS, Wyness SP, Ray JA, Willcox TL, Seiter JD, Genzen JR (2019). Detection and characterization of estradiol (E2) and unconjugated estriol (uE3) immunoassay interference due to anti-bovine alkaline phosphatase (ALP) antibodies. Pract Lab Med, 17, e00131. (Read full article)
    40. Hunsaker JJH, Wyness SP, Needham LL, Genzen JR (2019). Evaluation of L-index interference limits on Roche cobas c502 and c702 immunoturbidimetric assays using endogenously lipemic specimens and intralipid spiking. Clin Biochem, 70, 18-23. (Read full article)
    41. Genzen JR (2019). Regulation of Laboratory-Developed Tests. Am J Clin Pathol, 152(2), 122-131. (Read full article)
    42. Mohlman JS, Genzen JR, Weiss RL, Schmidt RL (2018). Reliability and Validity of Proposed Risk Stratification Methods for Laboratory Developed Tests. Lab Med, 50(2), 194-201. (Read full article)
    43. Needham LL, Smy L, Lee MA, Kunzler TM, Genzen JR (2018). Phlebotomy tube interference with nuclear magnetic resonance (NMR) lipoprotein subclass analysis. Clin Chim Acta, 488, 235-241. (Read full article)
    44. Genzen JR, Laulu SL, Wyness SP, Scholes KL, Signorelli HN, Greer RW (2018). Identifying and Eliminating Laboratory Contamination by Topical Testosterone Therapeutics. Clin Chem, 65(1), 67-73. (Read full article)
    45. Lu J, Genzen JR, Grenache DG (2018). Development of an enzymatic assay to measure lactate in perchloric acid-precipitated cerebrospinal fluid. Clin Chim Acta, 483, 142-144. (Read full article)
    46. Owen WE, Hunsaker JJH, Genzen JR (2018). Alpha-fetoprotein in pericardial, peritoneal, and pleural fluids: A body fluid matrix evaluation. Clin Biochem, 56, 109-112. (Read full article)
    47. Hunsaker JJH, Laulu SL, Wyness SP, Genzen JR (2018). Lipemic interference of ceruloplasmin assays - An evaluation of lipid removal methods. Clin Chim Acta, 480, 71-78. (Read full article)
    48. Genzen JR, Murray DL, Abel G, Meng QH, Baltaro RJ, Rhoads DD, Delgado JC, Souers RJ, Bashleben C, Keren DF, Ansari MQ (2017). Screening and Diagnosis of Monoclonal Gammopathies: An International Survey of Laboratory Practice. Arch Pathol Lab Med, 142(4), 507-515. (Read full article)
    49. Genzen JR, Burnham CD, Felder RA, Hawker CD, Lippi G, Peck Palmer OM (2017). Challenges and Opportunities in Implementing Total Laboratory Automation. Clin Chem, 64(2), 259-264. (Read full article)
    50. Lin DC, Genzen JR (2017). Concordance analysis of paired cancer antigen (CA) 15-3 and 27.29 testing. Breast Cancer Res Treat, 167(1), 269-276. (Read full article)
    51. Genzen JR, Mohlman JS, Lynch JL, Squires MW, Weiss RL (2017). Laboratory-Developed Tests: A Legislative and Regulatory Review. Clin Chem, 63(10), 1575-1584. (Read full article)
    52. Taylor JR, Thompson PJ, Genzen JR, Hickner J, Marques MB (2016). Opportunities to Enhance Laboratory Professionals' Role On the Diagnostic Team. Lab Med, 48(1), 97-103. (Read full article)
    53. Rhoads DD, Genzen JR, Bashleben CP, Faix JD, Ansari MQ (2016). Prevalence of Traditional and Reverse-Algorithm Syphilis Screening in Laboratory Practice: A Survey of Participants in the College of American Pathologists Syphilis Serology Proficiency Testing Program. Arch Pathol Lab Med, 141(1), 93-97. (Read full article)
    54. Hunsaker JJH, Wyness SP, Snow TM, Genzen JR (2016). Clinical performance evaluation of total protein measurement by digital refractometry and characterization of non-protein solute interferences. Pract Lab Med, 6, 14-24. (Read full article)
    55. Wyness SP, Hunsaker JJH, Snow TM, Genzen JR (2016). Evaluation and analytical validation of a handheld digital refractometer for urine specific gravity measurement. Pract Lab Med, 5, 65-74. (Read full article)
    56. Blanchard MG, Kittikulsuth W, Nair AV, de Baaij JH, Latta F, Genzen JR, Kohan DE, Bindels RJ, Hoenderop JG (2015). Regulation of Mg2+ Reabsorption and Transient Receptor Potential Melastatin Type 6 Activity by cAMP Signaling. J Am Soc Nephrol, 27(3), 804-13. (Read full article)
    57. Johnson-Davis KL, Sadler AJ, Genzen JR (2015). A Retrospective Analysis of Urine Drugs of Abuse Immunoassay True Positive Rates at a National Reference Laboratory. J Anal Toxicol, 40(2), 97-107. (Read full article)
    58. Genzen JR, Hunsaker JJ, Nelson LS, Faine BA, Krasowski MD (2015). N-acetylcysteine interference of Trinder-based assays. Clin Biochem, 49(1-2), 100-4. (Read full article)
    59. Krasowski MD, Savage J, Ehlers A, Maakestad J, Schmidt GA, Laulu S, Rasmussen NN, Strathmann FG, Genzen JR (2015). Ordering of the Serum Angiotensin-Converting Enzyme Test in Patients Receiving Angiotensin-Converting Enzyme Inhibitor Therapy: An Avoidable but Common Error. Chest, 148(6), 1447-1453. (Read full article)
    60. Signorelli H, Straseski JA, Genzen JR, Walker BS, Jackson BR, Schmidt RL (2015). Benchmarking to Identify Practice Variation in Test Ordering: A Potential Tool for Utilization Management. Lab Med, 46(4), 356-64. (Read full article)
    61. Owen WE, Thatcher ML, Crabtree KJ, Greer RW, Strathmann FG, Straseski JA, Genzen JR (2015). Body fluid matrix evaluation on a Roche cobas 8000 system. Clin Biochem, 48(13-14), 911-4. (Read full article)
    62. Scholes KL, Ence AT, Strathmann FG, Genzen JR (2015). Identification and characterization of EDTA test strip interfering substances using a digital color detector. Clin Lab, 61(7), 785-791.
    63. Owen WE, Caron JE, Genzen JR (2015). Liver function testing on the Abaxis Piccolo Xpress: Use in Ebola virus disease protocols. Clin Chim Acta, 446, 119-27. (Read full article)
    64. Scholes KL, Laulu SL, Ence AT, Logan HL, Parker RL, Strathmann FG, Genzen JR (2015). Evaluation of test strips for the rapid identification of ethylenediaminetetraacetic acid (EDTA) specimens. Lab Med, 46(2), 97-108. (Read full article)
    65. Schmidt RL, Kordy MA, Genzen JR, Straseski JA, Greene DN, Lehman CM (2014). A mathematical procedure to estimate the impact of a change in method on discordance or misclassification at a decision limit in laboratory method comparison studies. Clin Chim Acta, 440, 23-30. (Read full article)
    66. Laulu SL, Straseski JA, Schmidt RL, Genzen JR (2014). Thrombin-mediated degradation of parathyroid hormone in serum tubes. Clin Chim Acta, 437, 191-6. (Read full article)
    67. Kang H, Kerloch A, Rotival M, Xu X, Zhang Q, DSouza Z, Kim M, Scholz JC, Ko JH, Srivastava PK, Genzen JR, Cui W, Aitman TJ, Game L, Melvin JE, Hanidu A, Dimock J, Zheng J, Souza D, Behera AK, Nabozny G, Cook HT, Bassett JH, Williams GR, Li J, Vignery A, Petretto E, Behmoaras J (2014). Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. Cell Rep, 8(4), 1210-24. (Read full article)
    68. Genzen JR (2014). Hypercalcemic crisis due to vitamin D toxicity. Lab Med, 45(2), 147-50. (Read full article)
    69. Genzen JR, Gosselin JT, Wilson TC, Racila E, Krasowski MD (2013). Analysis of vitamin D status at two academic medical centers and a national reference laboratory: result patterns vary by age, gender, season, and patient location. BMC Endocr Disord, 13, 52. (Read full article)
    70. Genzen JR (2013). An Overview of United States Physician Training, Certification, and Career Pathways in Clinical Pathology (Laboratory Medicine). EJIFCC, 24(1), 21-9. (Read full article)

    Book Chapter

    1. Block DR, Genzen JR (2020). Diagnostic body fluid testing. In Clarke W, Marzinke M (Eds.), Contemporary Practice in Clinical Chemistry (4th Edition). Cambridge, MA: Academic Press.
    2. Genzen JR, Hawker CD, Burnham CA, Wittwer CT (2020). Automation in the clinical laboratory. In Rifai N, Horvath AR, Wittwer CT (Eds.), Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics (7th Edition). St Louis: Elsevier.
    3. Hawker CD, Genzen JR (2018). Chapter 19. Automation in the clinical laboratory. In Rifai N, Horvath R, Wittwer C. (Eds.), Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (6th Edition, p. 370). St. Louis, MO: Elsevier.
    4. Block DR, Genzen JR (2016). Diagnostic body fluid testing. In Clarke, W (Eds.), Contemporary Practice in Clinical Chemistry (3rd Edition). Washington, DC: AACC Press.
    5. Genzen JR (2016). Clinical protein and immunofixation electrophoresis. In Linden MA, McKenna RW (Eds.), Plasma Cell Neoplasms: A Morphologic, Cytogenetic, and Immunophenotypic Approach. Cham, Switzerland: Springer International Publishing.
    6. Genzen JR, Bordey A (2008). Ependymal cells and the neurogenic niche. In Bonfanti L (Ed.), Postnatal and Adult Neurogenesis. Research Signpost.

    Editorial

    1. Genzen JR (2022). The Verifying Accurate Leading-edge IVCT Development Act: Potential impact on diagnostic testing in the United States. Int J Lab Hematol, 44 Suppl 1, 9-10. (Read full article)
    2. Genzen JR (2020). Wiping the Slate Clean-Assessing Clinical Laboratory Contamination Risk. Clin Chem, 66(9), 1128-1130. (Read full article)

    Letter

    1. Genzen JR, Souers RJ, Pearson LN, Manthei DM, Chambliss AB, Shajani-Yi Z, Miller WG (2023). An Update on Reported Adoption of 2021 CKD-EPI Estimated Glomerular Filtration Rate Equations. [Letter to the editor]. Clin Chem, 69(10), 1197-1199. (Read full article)
    2. Willrich MAV, Long TA, Bashleben C, Fink SL, Rudolf JW, Peterson D, Wener MH, Baltaro RJ, Genzen JR, Ansari MQ, Rhoads DD, Linden MA (2020). Performance of perpendicular drop versus tangent skimming gating of M-protein in proficiency testing challenges. [Letter to the editor]. Clin Chem Lab Med, 59(1), e19-e22. (Read full article)
    3. McCarthy MW, Genzen JR, Wilkin TJ, Singh HK (2014). Use of a commercial HIV co-receptor tropism assay in clinical practice. [Letter to the editor]. AIDS Patient Care STDS, 29(2), 53-4. (Read full article)