Karen E. James,
MD, MSCE
Languages Spoken: English
Dr. Karen James received her medical degree from Tufts University School of Medicine. She completed her Pediatrics residency at Golisano Children’s Hospital at the University of Rochester, and her Pediatric Rheumatology fellowship at the Children’s Hospital of Philadelphia.
She is currently an Instructor in Pediatric Rheumatology at the University of Utah School of Medicine and Primary Children’s Medical Center. As a pediatric rheumatologist, Dr. James’ clinical interests include vasculitis, systemic lupus erythematosus, dermatomyositis, autoinflammatory diseases and juvenile idiopathic arthritis. She also evaluates patients with musculoskeletal and joint pain. Her research focuses on diagnosis, treatment and outcomes of children diagnosed with vasculitis.
Clinical Locations
Specialties
Board Certification and Academic Information
| Academic Departments | Pediatrics
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Assistant Professor |
| Academic Divisions | Pediatric Rheumatology |
| Board Certification | American Board of Pediatrics (Pediatrics) American Board of Pediatrics (Sub: Peds Rheumatology) |
Dr. Karen James received her medical degree from Tufts University School of Medicine. She completed her Pediatrics residency at Golisano Children’s Hospital at the University of Rochester, and her Pediatric Rheumatology fellowship at the Children’s Hospital of Philadelphia.
She is currently an Instructor in Pediatric Rheumatology at the University of Utah School of Medicine and Primary Children’s Medical Center. As a pediatric rheumatologist, Dr. James’ clinical interests include vasculitis, systemic lupus erythematosus, dermatomyositis, autoinflammatory diseases and juvenile idiopathic arthritis. She also evaluates patients with musculoskeletal and joint pain. Her research focuses on diagnosis, treatment and outcomes of children diagnosed with vasculitis.
Academic Locations
Research Statement
I am an Instructor in Pediatric Rheumatology with a long-term goal of establishing an independent research career with a focus on improving care and outcomes for patients, especially pediatric patients, with vasculitis, focusing on ANCA associated vasculitis (AAV). I developed a research interest in AAV during my pediatric rheumatology fellowship at the Children’s Hospital of Philadelphia. In addition as a part of my fellowship program I completed a Master’s of Science in Clinical Epidemiology (MSCE) program and published two manuscripts describing the treatment and outcomes of AAV; the first was a single center review and the second utilized a large, multicenter administrative database. Through my MSCE training, I gained an invaluable introduction to several research tools including understanding complex study design and statistical analyses, as well as a basis in epidemiologic techniques for addressing confounding in retrospective and large databases. Currently, I am working on several projects aimed at better understanding outcomes in AAV to ultimately improve care. This includes utilizing the Utah Population Database, an extensive statewide database linking healthcare records, public health records and genealogies, to study the clinical and genetic epidemiology of AAV in a population-based cohort. I am also collaborating with other pediatric rheumatologists through the Childhood Arthritis and Rheumatology Research Alliance to develop consensus treatment plans (CTPs) for AAV in children. The goal of these CTPs is to decrease treatment variability, help identify the most effective treatment strategies, and ultimately pediatric vasculitis outcomes.
Board Certification and Academic Information
| Academic Departments | Pediatrics
-
Assistant Professor |
| Academic Divisions | Pediatric Rheumatology |
| Board Certification | American Board of Pediatrics (Pediatrics) American Board of Pediatrics (Sub: Peds Rheumatology) |
Education History
| Graduate Training | University of Pennsylvania Clinical Epidemiology M.S., 2017 |
| Fellowship | The Children’s Hospital of Philadelphia Rheumatology Fellow, 2016 |
| Residency | University of Rochester Medical Center, Golisano Children’s Hospital Pediatrics Resident, 2013 |
| Internship | University of Rochester Medical Center, Golisano Children’s Hospital Pediatrics Intern, 2011 |
| Professional Medical | Tufts University School of Medicine Medicine M.D., 2010 |
| Undergraduate | Cornell University College of Arts and Sciences Biology with concentration in Microbiology B.A., 2006 |
Selected Publications - Journal Articles
Journal Article
- Vielleux MJ, Swartwood S, Nguyen D, James KE, Barbeau B, Bonkowsky JL (2022). SARS-CoV-2 Infection and Increased Risk for Pediatric Stroke. Pediatr Neurol.
- Carter-Febres M, Lozano-Chinga M, Thomsen W, Treemarcki EB, James KE, Fluchel M (2022). Variation of Diagnostic Approaches and Treatment Practices for HLH/MAS Among Pediatric Subspecialists. . J Pediatr.
- Chen A, Mammen C, Guzman J, Al-Abadi E, Benseler SM, Berard RA, Gerstbacher D, Heshin-Bekenstein M, Kim S, Klein-Gitelman M, Chavan PP, James KE, Martin N, McErlane F, Myrup C, Noone DG, Raghuram J, Shenoi S, Sivaraman V, Tanner T, Yeung RSM, Cabral DA, Morishita KA, for ARChiVe Investigators within the PedVas Initiative (2022). Wide variation in glucocorticoid dosing in paediatric ANCA-associated vasculitis with renal disease: a paediatric vasculitis initiative study. Clin Exp Rheumatol, 40(4), 841-848.
- Chen A, Mammen C, Guzman J, Al-Abadi E, Benseler SM, Berard RA, Gerstbacher D, Heshin-Bekenstein M, Kim S, Klein-Gitelman M, Chavan PP, James KE, Martin N, McErlane F, Myrup C, Noone DG, Raghuram J, Shenoi S, Sivaraman V, Tanner T, Yeung RSM, Cabral DA, Morishita KA for ARChiVe Investigators within the PedVas Initiative (2022). Wide variation in glucocorticoid dosing in paediatric ANCA-associated vasculitis with renal disease: a paediatric vasculitis initiative study. . Clin Exp Rheumatol, 40(4), 841-848.
- Gorelik M, Chung SA, Ardalan K, Binstadt BA, Friedman K, Hayward K, Imundo LF, Lapidus SK, Kim S, Son MB, Sule S, Tremoulet AH, Van Mater H, Yildirim-Toruner C, Langford CA, Maz M, Abril A, Guyatt G, Archer AM, Conn DL, Full KA, Grayson PC, Ibarra MF, Merkel PA, Rhee RL, Seo P, Stone JH, Sundel RP, Vitobaldi OI, Warner A, Byram K, Dua AB, Husainat N, James KE, Kalot M, Lin YC, Springer JM, Turgunbaev M, Villa-Forte A, Turner AS, Mustafa RA (2022). 2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease. Arthritis Rheumatol, 74(4), 586-596.
- James KE, Kalot MA, Husainat NM, Dua AB, Byram K, Springer JM, Lin YC, Turgunbaev M, Villa-Forte A, Gorelik M, Abril A, Langford C, Maz M, Chung SA, Mustafa RA (2021). Kawasaki Disease: A Systematic Review and Meta-Analysis of Benefits and Harms of Common Treatments. ACR Open Rheumatol, 3(10), 671-683.
- Chung SA, Langford CA, Maz M, Abril A, Gorelik M, Guyatt G, Archer AM, Conn DL, Full KA, Grayson PC, Ibarra MF, Imundo LF, Kim S, Merkel PA, Rhee RL, Seo P, Stone JH, Sule S, Sundel RP, Vitobaldi OI, Warner A, Byram K, Dua AB, Husainat N, James KE, Kalot MA, Lin YC, Springer JM, Turgunbaev M, Villa-Forte A, Turner AS, Mustafa RA (2021). 2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Care Res (Hoboken), 73(8), 1088-1105.
- Chung SA, Gorelik M, Langford CA, Maz M, Abril A, Guyatt G, Archer AM, Conn DL, Full KA, Grayson PC, Ibarra MF, Imundo LF, Kim S, Merkel PA, Rhee RL, Seo P, Stone JH, Sule S, Sundel RP, Vitobaldi OI, Warner A, Byram K, Dua AB, Husainat N, James KE, Kalot M, Lin YC, Springer JM, Turgunbaev M, Villa-Forte A, Turner AS, Mustafa RA (2021). 2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Polyarteritis Nodosa. Arthritis Rheumatol, 73(8), 1384-1393.
- Maz M, Chung SA, Abril A, Langford CA, Gorelik M, Guyatt G, Archer AM, Conn DL, Full KA, Grayson PC, Ibarra MF, Imundo LF, Kim S, Merkel PA, Rhee RL, Seo P, Stone JH, Sule S, Sundel RP, Vitobaldi OI, Warner A, Byram K, Dua AB, Husainat N, James KE, Kalot MA, Lin YC, Springer JM, Turgunbaev M, Villa-Forte A, Turner AS, Mustafa RA (2021). 2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis. Arthritis Rheumatol, 73(8), 1349-1365.
- Dua AB, Husainat NM, Kalot MA, Byram K, Springer JM, James KE, Chang Lin Y, Turgunbaev M, Villa-Forte A, Abril A, Langford C, Maz M, Chung SA, Mustafa RA (2021). Giant Cell Arteritis: A Systematic Review and Meta-Analysis of Test Accuracy and Benefits and Harms of Common Treatments. ACR Open Rheumatol, 3(7), 429-441.
- Springer JM, Kalot MA, Husainat NM, Byram KW, Dua AB, James KE, Chang Lin Y, Turgunbaev M, Villa-Forte A, Abril A, Langford C, Maz M, Chung SA, Mustafa RA (2021). Granulomatosis With Polyangiitis and Microscopic Polyangiitis: A Systematic Review and Meta-Analysis of Benefits and Harms of Common Treatments. ACR Open Rheumatol, 3(3), 196-205.
- Lin YC, Kalot MA, Husainat NM, Byram K, Dua AB, James KE, Springer JM, Turgunbaev M, Villa-Forte A, Abril A, Langford C, Maz M, Chung SA, Mustafa RA (2021). Polyarteritis Nodosa: A Systematic Review of Test Accuracy and Benefits and Harms of Common Treatments. ACR Open Rheumatol, 3(2), 91-100.
- Dua AB, Kalot MA, Husainat NM, Byram K, Springer JM, James KE, Chang Lin Y, Turgunbaev M, Villa-Forte A, Abril A, Langford C, Maz M, Chung SA, Mustafa RA (2021). Takayasu Arteritis: a Systematic Review and Meta-Analysis of Test Accuracy and Benefits and Harms of Common Treatments. ACR Open Rheumatol, 3(2), 80-90.
- Springer JM, Kalot MA, Husainat NM, Byram KW, Dua AB, James KE, Chang Lin Y, Turgunbaev M, Villa-Forte A, Abril A, Langford CA, Maz M, Chung SA, Mustafa RA (2021). Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review and Meta-Analysis of Test Accuracy and Benefits and Harms of Common Treatments. ACR Open Rheumatol, 3(2), 101-110.
- Peterson RG, Xiao R, James KE, Katcoff H, Fisher BT, Weiss PF (2020). Variation in Treatment of Children Hospitalized With New-Onset Systemic Juvenile Idiopathic Arthritis in the US. Arthritis Care Res (Hoboken), 73, 1714-1721.