Ryan A. Metcalf,
MD, CQA

Languages Spoken: English
Dr. Metcalf is the Medical Director of the Transfusion Medicine Service at University of Utah Health and Inpatient Chief Value Officer for the Department of Pathology at the University of Utah. He completed a residency in Anatomic and Clinical Pathology and a fellowship in Transfusion Medicine at Stanford University and is board certified in these disciplines. He also has expertise in quality management and is a Certified Quality Auditor.
Dr. Metcalf practices transfusion medicine and his specific interests include data-driven approaches to patient blood management, quality management, and innovation. He was previously Assistant Professor at the University of Washington where he helped build a new FDA-registered hospital-based transfusion service laboratory. He was recruited to the University of Utah and ARUP Laboratories in 2017. His research interests include the use of machine learning to predict patient blood management outcomes and data visualization to identify root causes from complex clinical data. He is a member of the AABB Clinical Transfusion Medicine Committee, the AABB Patient Blood Management Standards Committee, and the College of American Pathologists (CAP) Transfusion, Apheresis, and Cellular Therapy Committee.
Specialties
Board Certification and Academic Information
Academic Departments | Pathology
-
Assistant Professor (Clinical) |
Academic Divisions | Clinical Pathology |
Board Certification | American Board of Pathology (Anatomic & Clinical) American Board of Pathology (Sub: Blood Banking/Transfusion Medicine) National Board of Medical Examiners |
Dr. Metcalf is the Medical Director of the Transfusion Medicine Service at University of Utah Health and Inpatient Chief Value Officer for the Department of Pathology at the University of Utah. He completed a residency in Anatomic and Clinical Pathology and a fellowship in Transfusion Medicine at Stanford University and is board certified in these disciplines. He also has expertise in quality management and is a Certified Quality Auditor.
Dr. Metcalf practices transfusion medicine and his specific interests include data-driven approaches to patient blood management, quality management, and innovation. He was previously Assistant Professor at the University of Washington where he helped build a new FDA-registered hospital-based transfusion service laboratory. He was recruited to the University of Utah and ARUP Laboratories in 2017. His research interests include the use of machine learning to predict patient blood management outcomes and data visualization to identify root causes from complex clinical data. He is a member of the AABB Clinical Transfusion Medicine Committee, the AABB Patient Blood Management Standards Committee, and the College of American Pathologists (CAP) Transfusion, Apheresis, and Cellular Therapy Committee.
Academic Locations
ARUP
801-585-6217
Board Certification and Academic Information
Academic Departments | Pathology
-
Assistant Professor (Clinical) |
Academic Divisions | Clinical Pathology |
Board Certification | American Board of Pathology (Anatomic & Clinical) American Board of Pathology (Sub: Blood Banking/Transfusion Medicine) National Board of Medical Examiners |
Education History
Fellowship | Stanford University School of Medicine Transfusion Medicine Fellow |
Residency | Stanford University School of Medicine Anatomic and Clinical Pathology Resident |
Professional Medical | University of California, Davis School of Medicine Medicine M.D. |
Fellowship | Stanford University School of Medicine Pathology Predoctoral Fellow |
Undergraduate | University of California, Santa Barbara Cell and Developmental Biology B.S. |
Selected Publications - Journal Articles
Journal Article
- Metcalf RA, Goodfellow J, Cail K, Blaylock R, Kawamoto K, Enniss T, Galaviz C, Lim M, Reddy S, Sharma V, Wanner N (2021). Electronic clinical decision support: evidence that default settings influence end user behavior. Transfusion.
- Moore RA, Schmidt RL, Metcalf RA (2021). The Impact of the Sample Time of Secondary Bacterial Culture on the Risk of Exposure to Contaminated Platelet Components: A Mathematical Analysis. Transfusion.
- Luetkens T, Metcalf RA, Planelles V, Zheng Y, Larragoite ET, Spivak E, Spivak AM, Steinbach M, Blaylock RC, Avila SV, Hankey K, Martins TB, Slev PR, Mannuel HD, Sajadi M, Rapoport AP, and Atanackovic D (2020). Successful transfer of anti-SARS-CoV-2 immunity using convalescent plasma in a multiple myeloma patient with hypogammaglobulinemia and COVID-19 . Blood Adv.
- Corean J, White SK, Schmidt RL, Walker BS, Fisher MA, Metcalf RA (2020). The incremental benefit of anaerobic culture for controlling bacterial risk in platelets: a systematic review and meta-analysis. Vox Sang.
- Walker BS, White SK, Schmidt RL, Metcalf RA (2020). Residual bacterial detection rates following primary culture as determined by secondary culture and rapid testing in platelet components: a systematic review and meta-analysis. Transfusion.
- Walker BS, Schmidt RL, Fisher MA, White SK, Blaylock RC, Metcalf RA (2020). The comparative safety of bacterial risk control strategies for platelet components: A simulation study. Transfusion.
- Pagano MB, Allen ES, Dunbar NM, Goel R, Harm S, Hopkins CK, Jacobsen J, Lokhandwala PM, Metcalf RA, Raval JS, Schwartz J, Spinella PC, Storch E, Cohn CS (2020). Current Advances in Transfusion Medicine: A 2019 review of selected topics from the AABB Clinical Transfusion Medicine Committee. Transfusion.
- White SK, Schmidt RL, Walker BS, Metcalf RA (2020). Bacterial contamination rate of platelet components by primary culture: A systematic review and meta-analysis. Transfusion.
- Lim MY, Pagano MB, Metcalf RA (2020). Things we do for no reason: routinely prescribing transfusion premedication to prevent acute transfusion reactions. Journal of Hospital Medicine.
- Metcalf RA, White S, Potter S, Barney R, Hunter C, White M, Enniss T, Galaviz C, Reddy S, Wanner N, Schmidt RL, Blaylock R (2019). The association of inpatient blood utilization and diagnosis related group weight: implications for risk-adjusted benchmarking. Transfusion, 59(7), 2316-2323.
- Gavva C, Barroso J, Gernsheimer T, Metcalf RA, Warner P, Pagano MB (2019). Response to Random Apheresis Platelets versus HLA-Selected Platelets versus Pooled Platelets in HLA-sensitized Patients. Transfusion, 59(7), 2276-2281.
- Pagano MB, Katchatag B, Khoobyari S, Van Gerwen M, Sen N, Haley R, Gernsheimer T, Hess JR, Metcalf RA (2019). Evaluating Safety and Cost-Effectiveness of Platelets Stored in Additive Solution (PAS-F) as a Hemolysis Risk Mitigation Strategy. Transfusion, 59(4), 1246-1251.
- Metcalf RA, Calvaresi E, Tonna JE, Blaylock R, Pearson L (2019). Severe Hemolysis Following Extracorporeal Right Ventricular Assist Device Placement. Transfusion, 59(4), 1178-1179.
- Murphy C, Parakh R, Metcalf RA, Pagano MB (2018). Transfusion Associated Chest Pain. Transfusion.
- Metcalf RA, Khan J, Andrews J, Mayock D, Billimoria Z, Pagano MB (2018). Severe ABO Hemolytic Disease of the Newborn Requiring Exchange Transfusion. J Pediatr Hematol Oncol.
- Metcalf RA, Pagano MB, Hess JR, Reyes J, Perkins JD, Montenovo MI (2018). A Data-Driven Patient Blood Management Strategy in Liver Transplantation. Vox Sang.
- Corean J, Al-Tigar R, Pysher T, Blaylock R, Metcalf RA (2018). Quality improvement after multiple fatal transfusion-transmitted bacterial infections. Am J Clin Pathol, 149(4), 293-299.
- Hess JR, Ramos PJ, Sen NE, Cruz-Cody VG, Tuott EE, Louzon MJ, Bulger EM, Arbabi S, Pagano MB, Metcalf RA (2018). Quality management of a massive transfusion protocol. Transfusion.
- Mays, JA, Greene DN, Metcalf RA, Pagano MB (2018). Transfusion support for transgender men of childbearing age. Transfusion.
- Pagano MB, Metcalf RA, Hess JR, Reyes J, Perkins JD, Montenovo MI (2018). A high plasma: red blood cell transfusion ratio during liver transplantation is associated with decreased blood utilization. Vox Sang.
- Hess JR, Hayden BK, Cruz-Cody VG, Louzon MJ, Tuott EE, Sen NE, Gary R, Ramos PJ, Daniel-Johnson JA, Metcalf RA, Pagano MB (2017). Building a new transfusion service. Am J Clin Pathol.
- Metcalf RA, Bakhtary S, Goodnough LT, Andrews J (2016). Clinical Pattern in Hypotensive Transfusion Reactions. Anesth Analg, 123(2), 268-73.
- Metcalf RA, Baker SA, Goodnough LT, Shah N (2016). Transportation Cooler Interventions Reduce Plasma and RBC Product Wastage. Am J Clin Pathol, 146(1), 18-24.
- Hartmann S, Winkelmann R, Metcalf RA, Treetipsatit J, Warnke RA, Natkunam Y, Hansmann ML (2015). Immunoarchitectural patterns of progressive transformation of germinal centers with and without nodular lymphocyte-predominant Hodgkin lymphoma. Hum Pathol, 46(11), 1655-61.
- Metcalf RA, Wang L, Deos PH, Chock E, Warnke RA, Natkunam Y (2015). Extracavitary Primary Effusion Lymphoma Presenting in a Lymph Node Without Lymphomatous Effusions. Hum Pathol (N Y), 2(2), 36-41.
- Treetipsatit J, Metcalf RA, Warnke RA, Natkunam Y (2015). Large B-cell lymphoma with T-cell-rich background and nodules lacking follicular dendritic cell meshworks: description of an insufficiently recognized variant. Hum Pathol, 46(1), 74-83.
- Metcalf RA, Monabati A, Vyas M, Roncador G, Gualco G, Bacchi CE, Younes SF, Natkunam Y, Freud AG (2014). Myeloid cell nuclear differentiation antigen is expressed in a subset of marginal zone lymphomas and is useful in the differential diagnosis with follicular lymphoma. Hum Pathol, 45(8), 1730-6.
- Metcalf RA, Bashey S, Wysong A, Kim J, Kim YH, Gratzinger D (2013). Intravascular ALK-negative anaplastic large cell lymphoma with localized cutaneous involvement and an indolent clinical course: toward recognition of a distinct clinicopathologic entity. Am J Surg Pathol, 37(4), 617-23.
- Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF (2012). Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev, 26(18), 2075-87.
- Metcalf RA, Zhao S, Anderson MW, Lu ZS, Galperin I, Marinelli RJ, Cherry AM, Lossos IS, Natkunam Y (2010). Characterization of D-cyclin proteins in hematolymphoid neoplasms: lack of specificity of cyclin-D2 and D3 expression in lymphoma subtypes. Mod Pathol, 23(3), 420-33.
- Karafin MS, Becker JL, Berg M, DeSimone R, Draper N, Hudgins J, Metcalf RA, Pagano MB, Park YA, Rossmann SN, Schwartz J, Souers R, Thomas L, Uhl L, Ramsey GE (2020). Heterogeneity in approaches for switching from universal to patient ABO type-specific blood components during massive hemorrhage: An international survey and review of the literature. Arch Pathol Lab Med.
- Moore RA, Schmidt RL, Metcalf RA (2021). In reply: Window periods for secondary bacterial culture of platelets according to FDA Guidance. Transfusion.
- Silva O, Charu V, Ewalt MD, Metcalf RA, Zhao S, Castellanos EM, Orellana E, Natkunam Y, Luna-Fineman S (2021). Classic Hodgkin Lymphoma in Guatemalan Children of Age Less than Six Years: Analysis of Immune Regulatory Pathways and the Tumor Microenvironment. Leuk Lymphoma.
- Cohn CS, Estcourt L, Grossman BJ, Pagano MB, Allen ES, Bloch E, Casadevall A, Devine DV, Dunbar NM, Foroutan F, Gniadek TJ, Goel R, Gorlin J, Joyner MJ, Metcalf RA, Raval JS, Rice TW, Shaz BH, Vassallo RR, Winters JL, Beaudoin G, Tobian AAR (2021). COVID-19 convalescent plasma: interim recommendations from the AABB. Transfusion.
- Self WH, Stewart TG, Wheeler AP, Atrouni WE, Bistran-Hall AJ, Casey JD, Cataldo VD, Chappell JD, Cohn CS, Collins JB, Denison MR, de Wit M, Dixon SL, Duggal A, Edwards TL, Fontaine MJ, Ginde AA, Harkins MS, Harrington T, Harris ES, Hoda D, Ipe TS, Jaiswal SJ, Johnson NJ, Jones AE, Laguio-Vila M, Lindsell CJ, Mallada J, Mammen MJ, Metcalf RA, Middleton EA, Mucha S, ONeal HR, Pannu SR, Pulley JM, Qiao X, Raval JS, Rhoads JP, Schrager H, Shanholtz C, Shapiro NI, Schrantz SJ, Thomsen I, Vermillion KK, Bernard GR, Rice TW (2021). Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults. Trials.
Video/Film/CD/Web/Podcast
- Metcalf RA (2020). Convalescent Plasma Therapy. LabMind Podcast hosted by Dr. Brian Jackson. [Podcast]. ARUP Laboratories.
- Metcalf RA (2020). Patient Blood Management [Video]. Clinical Chemistry Pearls.
- Metcalf RA (2017). Blood Utilization and The Transfusion Committee [Web]. Clincial Chemistry Pearls of Laboratory Medicine..