Steffen Schmitz-Valckenberg,
MD
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Languages Spoken: English, German
Steffen Schmitz-Valckenberg, MD, specializes in clinical and surgical treatment of macular and retinal diseases, including age-related macular degeneration (AMD), and is an expert in high-resolution retinal imaging.
Dr. Schmitz-Valckenberg co-founded and directed the Grading of Digital Fundus Examination Reading Center at the University of Bonn, Germany, where he was the Department of Ophthalmology’s assistant medical director. As an expert in high-resolution retinal and fundus autofluorescence imaging, he has used various imaging techniques to map the stages of decline in AMD. Researchers worldwide use this mapping to measure outcomes during interventional clinical trials.
At Moran, Dr. Schmitz-Valckenberg is directing an ophthalmic image reading center that will play a key role in the Sharon Eccles Steele Center for Translational Medicine's drive to take a new therapy for a prevalent form of AMD into clinical trials.
Dr. Schmitz-Valckenberg holds a Jon M. Huntsman Presidential Chair at the University of Utah and is a prolific researcher with more than 165 publications and 120 peer-reviewed articles. His honors include being named by The Ophthalmologist to its Power List 2017: Top 50 Rising Stars.
Specialties
Board Certification and Academic Information
| Academic Departments | Ophthalmology/Visual Sciences
-
Professor |
| Board Certification | European Board of Ophthalmology Medical Association of North Rhine-Ophthalmology |
Steffen Schmitz-Valckenberg, MD, specializes in clinical and surgical treatment of macular and retinal diseases, including age-related macular degeneration (AMD), and is an expert in high-resolution retinal imaging.
Dr. Schmitz-Valckenberg co-founded and directed the Grading of Digital Fundus Examination Reading Center at the University of Bonn, Germany, where he was the Department of Ophthalmology’s assistant medical director. As an expert in high-resolution retinal and fundus autofluorescence imaging, he has used various imaging techniques to map the stages of decline in AMD. Researchers worldwide use this mapping to measure outcomes during interventional clinical trials.
At Moran, Dr. Schmitz-Valckenberg is directing an ophthalmic image reading center that will play a key role in the Sharon Eccles Steele Center for Translational Medicine's drive to take a new therapy for a prevalent form of AMD into clinical trials.
Dr. Schmitz-Valckenberg holds a Jon M. Huntsman Presidential Chair at the University of Utah and is a prolific researcher with more than 165 publications and 120 peer-reviewed articles. His honors include being named by The Ophthalmologist to its Power List 2017: Top 50 Rising Stars.
Academic Locations
John A. Moran Eye Center
801-581-2352
Board Certification and Academic Information
| Academic Departments | Ophthalmology/Visual Sciences
-
Professor |
| Board Certification | European Board of Ophthalmology Medical Association of North Rhine-Ophthalmology |
Research Interests
- Age-related Macular Degeneration
- Retinal Imaging
- Fundus Autofluorescence
- Molecular Imaging
- Structural-Functional Analysis Including Fundus-Controlled Perimetry
Education History
| Fellowship | University of Bonn Ophthalmology Fellow |
| Research Fellow | University College London Institute of Ophthalmology Research Fellow |
| Residency | University of Bonn Ophthalmology Resident |
| Professional Medical | Ruprecht-Karls-University Heidelberg Medicine M.D. |
Selected Publications - Journal Articles
Journal Article
- Holekamp N, Wykoff CC, Schmitz-Valckenberg S, Mons J, Souied EH, Lin H, Rabena MD, Cantrell RA, Henry EC, Tang F, Swaminathan B, Martin J, Ferrara D, Staurenghi G (2019). Natural History of Geographic Atrophy Secondary to Age-Related Macular Degeneration: Results from the Prospective Proxima A and B Clinical Trials. Ophthalmology, 127(6), 769-783.
- Knzel SH, Mller PT, Lindner M, Goerdt L, Nadal J, Schmid M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M, Pfau M (2020). Determinants of Quality of Life in Geographic Atrophy Secondary to Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci, 61(5), 63.
- Schmitz-Valckenberg S, Brasse K, Hoerauf H (2020). [Vitreous floaters]. Ophthalmologe, 117(5), 485-496.
- Wintergerst MWM, Gorgi Zadeh S, Wiens V, Thiele S, Schmitz-Valckenberg S, Holz FG, Finger RP, Schultz T (2020). Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography. Scientific Reports, 10(1), 7395.
- Pfau M, Emde LV, Dysli C, Mller PT, Thiele S, Lindner M, Schmid M, Rubin DL, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2020). Determinants of Cone- And Rod-Function in Geographic Atrophy: AI-based Structure-Function Correlation. Am J Ophthalmol, epub.
- Pfau M, Emde LV, Dysli C, Mller PT, Thiele S, Lindner M, Schmid M, Rubin DL, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2020). Determinants of cone- and rod-function in geographic atrophy: AI-based structure-function correlation. (Epub ahead of print) Am J Ophthalmol.
- Thiele S, Nadal J, Pfau M, Samannshausen M, Fleckenstein M, Holz FG, Schmid M, Schmitz-Valckenberg S (2020). Prognostic Value of Intermediate Age-Related Macular Degeneration Phenotypes for Geographic Atrophy Progression. Br J Ophthalmol, epub.
- Schmitz-Valckenberg S, Khlewein L, Waldstein SM, Spital G, Ziemssen F, Liakopoulos S (2020). Second Opinion in Retinal Imaging. Ophthalmologe, 117(4), 326-330.
- Schmitz-Valckenberg S, Khlewein L, Waldstein SM, Spital G, Ziemssen F, Liakopoulos S (2020). [Second opinion in retinal imaging]. Ophthalmologe, 117(4), 326-330.
- Pfau M, Mller PT, Knzel SH, von der Emde L, Lindner M, Thiele S, Dysli C, Nadal J, Schmid M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M (2019). Type 1 Choroidal Neovascularization Is Associated with Reduced Localized Progression of Atrophy in Age-Related Macular Degeneration. Ophthalmol Retina, 4(3), 238-248.
- Liakopoulos S, Spital G, Brinkmann CK, Schick T, Ziemssen F, Voegeler J, Koch M, Kirchhof B, Holz FG, Pauleikhoff D, Schmitz-Valckenberg S (2020). ORCA Study: Real-World Versus Reading Centre Assessment of Disease Activity of Neovascular Age-Related Macular Degeneration (nAMD). British Journal of Ophthalmology, epub.
- Thiele S, Nadal J, Pfau M, Samannshausen M, von der Emde L, Fleckenstein M, Holz FG, Schmid M, Schmitz-Valckenberg S, Molecular Diagnostic of Age-related Macular Degeneration Study Group (2019). Prognostic Value of Retinal Layers in Comparison with Other Risk Factors for Conversion of Intermediate Age-related Macular Degeneration. Ophthalmol Retina, 4(1), 31-40.
- von der Emde L, Thiele S, Pfau M, Nadal J, Meyer J, Mller PT, Schmid M, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2019). Assessment of Exudative Activity of Choroidal Neovascularization in Age-Related Macular Degeneration by OCT Angiography. Ophthalmologica, 243(2), 120-128.
- Pfau M, Mller PL, von der Emde L, Lindner M, Mller PT, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2018). MESOPIC AND DARK-ADAPTED TWO-COLOR FUNDUS-CONTROLLED PERIMETRY IN GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION. Retina, 40(1), 169-180.
- Holekamp N, Wykoff CC, Schmitz-Valckenberg S, Mons J, Souied EH, Lin H, Rabena MD, Cantrell RA, Henry EC, Tang F, Swaminathan B, Martin J, Ferrara D, Staurenghi G (2019). Natural History of Geographic Atrophy Secondary to Age-Related Macular Degeneration: Results From the Prospective Proxima A and B Clinical Trials. Trans Am Acad Ophthalmol Otolaryngol, 127(6), 769-783.
- Terheyden JH, Finger RP, Schmitz-Valckenberg S, Agostini H, Dahlke C, Kuehlewein L, Lang GE, Pauleikhoff D, Wolf A, Boettger MK, Luhmann UFO, Asmus F, Holz FG, MACUSTAR-Konsortium (2019). [Development and validation of novel clinical endpoints in intermediate age-related macular degeneration in MACUSTAR]. Ophthalmologe, 116(12), 1186-1193.
- Spaide RF, Jaffe GJ, Sarraf D, Freund KB, Sadda SR, Staurenghi G, Waheed NK, Chakravarthy U, Rosenfeld PJ, Holz FG, Souied EH, Cohen SY, Querques G, Ohno-Matsui K, Boyer D, Gaudric A, Blodi B, Baumal CR, Li X, Coscas GJ, Brucker A, Singerman L, Luthert P, Schmitz-Valckenberg S, Schmidt-Erfurth U, Grossniklaus HE, Wilson DJ, Guymer R, Yannuzzi LA, Chew EY, Csaky K, Mons JM, Pauleikhoff D, Tadayoni R, Fujimoto J (2019). Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data: Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group. (Epub ahead of print) Ophthalmology.
- Callizo J, Ziemssen F, Bertelmann T, Feltgen N, Vgeler J, Koch M, Eter N, Liakopoulos S, Schmitz-Valckenberg S, Spital G (2019). Real-World Data: Ranibizumab Treatment For Retinal Vein Occlusion In The OCEAN Study. Clin Ophthalmol, 13, 2167-2179.
- Pielen A, Feltgen N, Hattenbach LO, Hoerauf H, Bertelmann T, Quiering C, Vgeler J, Priglinger S, Lang GE, Schmitz-Valckenberg S, Wolf A, Rehak M (2019). Ranibizumab Pro Re nata versus Dexamethasone in the Management of Ischemic Retinal Vein Occlusion: Post-hoc Analysis from the COMRADE Trials. Curr Eye Res, 1-11.
- Guymer RH, Rosenfeld PJ, Curcio CA, Holz FG, Staurenghi G, Freund KB, Schmitz-Valckenberg S, Sparrow J, Spaide RF, Tufail A, Chakravarthy U, Jaffe GJ, Csaky K, Sarraf D, Mons JM, Tadayoni R, Grunwald J, Bottoni F, Liakopoulos S, Pauleikhoff D, Pagliarini S, Chew EY, Viola F, Fleckenstein M, Blodi BA, Lim TH, Chong V, Lutty J, Bird AC, Sadda SR (2019). Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 4. (Epub ahead of print) Ophthalmology.
- Pfau M, von der Emde L, Dysli C, Thiele S, Mller PT, Lindner M, Nadal J, Schmid M, Schmitz-Valckenberg S, Holz FG, Fleckenstein M (2019). Light Sensitivity Within Areas of Geographic Atrophy Secondary to Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci, 60(12), 3992-4001.
- Fleckenstein M, Thiele S, Pfau M, Schmitz-Valckenberg S, Holz FG (2019). [Dry Age-Related Macular Degeneration - Epidemiology and Classification]. Klin Monatsbl Augenheilkd, 236(9), 1068-1075.
- Gale RP, Pearce I, Eter N, Ghanchi F, Holz FG, Schmitz-Valckenberg S, Balaskas K, Burton BJL, Downes SM, Eleftheriadis H, George S, Gilmour D, Hamilton R, Lotery AJ, Patel N, Prakash P, Santiago C, Thomas S, Varma D, Walters G, Williams M, Wolf A, Zakri RH, Igwe F, Ayan F (2019). Anatomical and functional outcomes following switching from aflibercept to ranibizumab in neovascular age-related macular degeneration in Europe: SAFARI study. (Epub ahead of print) Br J Ophthalmol.
- Pfau M, Lindner M, Goerdt L, Thiele S, Nadal J, Schmid M, Schmitz-Valckenberg S, Sadda SR, Holz FG, Fleckenstein M, Fundus Autofluorescence in Age-Related Macular Degeneration Study Group (2018). PROGNOSTIC VALUE OF SHAPE-DESCRIPTIVE FACTORS FOR THE PROGRESSION OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION. Retina, 39(8), 1527-1540.
- von der Emde L, Pfau M, Dysli C, Thiele S, Mller PT, Lindner M, Schmid M, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2019). Artificial intelligence for morphology-based function prediction in neovascular age-related macular degeneration. Sci Rep, 9(1), 11132.
- Meyer JH, Larsen PP, Strack C, Harmening WM, Krohne TU, Holz FG, Schmitz-Valckenberg S (2019). Optical coherence tomography angiography (OCT-A) in an animal model of laser-induced choroidal neovascularization. Exp Eye Res, 184, 162-171.
- Gattoussi S, Buitendijk GHS, Peto T, Leung I, Schmitz-Valckenberg S, Oishi A, Wolf S, Dek G, Delcourt C, Klaver CCW, Korobelnik JF, European Eye Epidemiology E3 consortium (2018). The European Eye Epidemiology spectral-domain optical coherence tomography classification of macular diseases for epidemiological studies. Acta Ophthalmol, 97(4), 364-371.
- Grassmann F, Harsch S, Brandl C, Kiel C, Nrnberg P, Toliat MR, Fleckenstein M, Pfau M, Schmitz-Valckenberg S, Holz FG, Chew EY, Swaroop A, Ratnapriya R, Klein ML, Mulyukov Z, Zamiri P, Weber BHF (2019). Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration. (Epub ahead of print) JAMA Ophthalmol.
- Lindner M, Pfau M, Czauderna J, Goerdt L, Schmitz-Valckenberg S, Holz FG, Fleckenstein M (2018). Determinants of Reading Performance in Eyes with Foveal-Sparing Geographic Atrophy. Ophthalmol Retina, 3(3), 201-210.
- Brasse K, Schmitz-Valckenberg S, Jnemann A, Roider J, Hoerauf H (2018). [YAG laser vitreolysis for treatment of symptomatic vitreous opacities]. 116(1), 73-84.
- Finger RP, Schmitz-Valckenberg S, Schmid M, Rubin GS, Dunbar H, Tufail A, Crabb DP, Binns A, Snchez CI, Margaron P, Normand G, Durbin MK, Luhmann UFO, Zamiri P, Cunha-Vaz J, Asmus F, Holz FG, onbehalfoftheMACUSTARconsortium (2018). MACUSTAR: Development and Clinical Validation of Functional, Structural, and Patient-Reported Endpoints in Intermediate Age-Related Macular Degeneration. Ophthalmologica, 241(2), 61-72.
- Fang PP, Domdei N, Herrmann P, Schmitz-Valckenberg S, Holz FG, Harmening WM, Krohne TU (2017). MINIMAL OPTICAL COHERENCE TOMOGRAPHY B-SCAN DENSITY FOR RELIABLE DETECTION OF INTRARETINAL AND SUBRETINAL FLUID IN MACULAR DISEASES. Retina, 39(1), 150-156.
- Ziemssen F, Wachtlin J, Kuehlewein L, Gamulescu MA, Bertelmann T, Feucht N, Voegeler J, Koch M, Liakopoulos S, Schmitz-Valckenberg S, Spital G, OCEAN study group (2018). Intravitreal Ranibizumab Therapy for Diabetic Macular Edema in Routine Practice: Two-Year Real-Life Data from a Non-interventional, Multicenter Study in Germany. Diabetes Ther, 9(6), 2271-2289.
- Pfau M, Lindner M, Gliem M, Steinberg JS, Thiele S, Finger RP, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2018). Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen. Eye (Lond), 32(12), 1819-1830.
- Feltgen N, Hattenbach LO, Bertelmann T, Callizo J, Rehak M, Wolf A, Berk H, Eter N, Lang GE, Pielen A, Schmitz-Valckenberg S, Quiering C, Rose U, Hoerauf H, COMRADE Study Group (2018). Comparison of ranibizumab versus dexamethasone for macular oedema following retinal vein occlusion: 1-year results of the COMRADE extension study. Acta Ophthalmol, 96(8), e933-e941.
- Berger M, Schmid M, Welchowski T, Schmitz-Valckenberg S, Beyersmann J (2018). Subdistribution hazard models for competing risks in discrete time. (Epub ahead of print)
- Brinkmann CK, Chang P, Schick T, Heimes B, Vgeler J, Haegele B, Kirchhof B, Holz FG, Pauleikhoff D, Ziemssen F, Liakopoulos S, Spital G, Schmitz-Valckenberg S (2018). Initial diagnosis and indication for anti-vascular endothelial growth factor therapy in retinal diseases. Ophthalmologe.
- Mller PL, Pfau M, Mauschitz MM, Mller PT, Birtel J, Chang P, Gliem M, Schmitz-Valckenberg S, Fleckenstein M, Holz FG, Herrmann P (2018). Comparison of Green Versus Blue Fundus Autofluorescence in ABCA4-Related Retinopathy. Transl Vis Sci Technol, 7(5), 13.
- Paul C, Krug P, Muller HH, Wachtlin J, Mennel S, Muller S, Schmitz-Valckenberg S, Bertelmann T, Schumann RG (2018). Comparison of the horizontal diameter to a modeled area of traction in eyes with vitreomacular traction: is the diameter close enough to the truth? Graefes Arch Clin Exp Ophthalmol, 256(10), 1817-1822.
- Pfau M, Lindner M, Steinberg JS, Thiele S, Brinkmann CK, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2018). Visual field indices and patterns of visual field deficits in mesopic and dark-adapted two-colour fundus-controlled perimetry in macular diseases. Br J Ophthalmol, 102(8), 1054-1059.
- Paul C, Heun C, Mller HH, Hoerauf H, Feltgen N, Wachtlin J, Kaymak H, Mennel S, Koss MJ, Fauser S, Maier MM, Schumann RG, Mueller S, Chang P, Schmitz-Valckenberg S, Kazerounian S, Szurman P, Lommatzsch A, Bertelmann T (2018). Calculating the individual probability of successful ocriplasmin treatment in eyes with VMT syndrome: a multivariable prediction model from the EXPORT study. Br J Ophthalmol, 102(8), 1092-1097.
- Welker SG, Pfau M, Heinemann M, Schmitz-Valckenberg S, Holz FG, Finger RP (2018). Retest Reliability of Mesopic and Dark-Adapted Microperimetry in Patients With Intermediate Age-Related Macular Degeneration and Age-Matched Controls. Invest Ophthalmol Vis Sci, 59(4), AMD152-AMD159.
- Mller PL, Pfau M, Mller PT, Nadal J, Schmid M, Lindner M, de Sisternes L, Sthr H, Weber BHF, Neuhaus C, Herrmann P, Schmitz-Valckenberg S, Holz FG, Fleckenstein M (2018). Choroidal Flow Signal in Late-Onset Stargardt Disease and Age-Related Macular Degeneration: An OCT-Angiography Study. Invest Ophthalmol Vis Sci, 59(4), AMD122-AMD131.
- Lindner M, Kosanetzky S, Pfau M, Nadal J, Gordt LA, Schmitz-Valckenberg S, Schmid M, Holz FG, Fleckenstein M (2018). Local Progression Kinetics of Geographic Atrophy in Age-Related Macular Degeneration Are Associated With Atrophy Border Morphology. Invest Ophthalmol Vis Sci, 59(4), AMD12-AMD18.
- Thiele S, Pfau M, Larsen PP, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2018). Multimodal Imaging Patterns for Development of Central Atrophy Secondary to Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci, 59(4), AMD1-AMD11.
- Sassmannshausen M, Steinberg JS, Fimmers R, Pfau M, Thiele S, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2018). Structure-Function Analysis in Patients With Intermediate Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci, 59(3), 1599-1608.
- Hattenbach LO, Feltgen N, Bertelmann T, Schmitz-Valckenberg S, Berk H, Eter N, Lang GE, Rehak M, Taylor SR, Wolf A, Weiss C, Paulus EM, Pielen A, Hoerauf H (2018). Head-to-head comparison of ranibizumab PRN versus single-dose dexamethasone for branch retinal vein occlusion (COMRADE-B). Acta Ophthalmol, 96(1), e10-e18.
- von der Emde L, Pfau M, Thiele S, Mller PT, Hassenrik R, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2018). Mesopic and Dark-Adapted Two-Color Fundus-Controlled Perimetry in Choroidal Neovascularization Secondary to Age-Related Macular Degeneration. Transl Vis Sci Technol, 8(1), 7.
Conference Proceedings
Case Report
- Raber FP, Reinking K, Schmitz-Valckenberg S, Althaus K, Kaut O, Witry M, Lang GE (2020). Successful Systemic Lysis Therapy in Acute Retinal Arterial Occlusions. Klin Monatsbl Augenheilkd, 237(6), 772-779.
Global Impact
Education History
| Fellowship | University of Bonn Ophthalmology Fellow |
| Research Fellow | University College London Institute of Ophthalmology Research Fellow |
| Residency | University of Bonn Ophthalmology Resident |
| Professional Medical | Ruprecht-Karls-University Heidelberg Medicine M.D. |