Allison F. Carey,
MD, PhD
Languages Spoken: English
Dr. Carey is a physician-scientist who received her M.D. and Ph.D. degrees from Yale School of Medicine. She completed her doctoral training with John Carlson, gaining critical insights into how the olfactory system of the Anopheles gambiae mosquito detects human blood-meal hosts, a key step in the malaria transmission cycle. After a Roux fellowship at the Pasteur Institute, Dr. Carey completed her residency training in clinical pathology at Massachusetts General Hospital. She then joined Sarah Fortune’s research group at the Harvard T.H. Chan School of Public Health, where she developed expertise in another globally significant pathogen, Mycobacterium tuberculosis. At the University of Utah, Dr. Carey runs a research group with a focus on mycobacterial genetics and is a pathologist at ARUP Laboratories.
Specialties
Board Certification and Academic Information
| Academic Departments | Pathology
-
Assistant Professor |
| Academic Divisions | Clinical Pathology |
| Board Certification | American Board of Pathology (Clinical Path) |
Dr. Carey is a physician-scientist who received her M.D. and Ph.D. degrees from Yale School of Medicine. She completed her doctoral training with John Carlson, gaining critical insights into how the olfactory system of the Anopheles gambiae mosquito detects human blood-meal hosts, a key step in the malaria transmission cycle. After a Roux fellowship at the Pasteur Institute, Dr. Carey completed her residency training in clinical pathology at Massachusetts General Hospital. She then joined Sarah Fortune’s research group at the Harvard T.H. Chan School of Public Health, where she developed expertise in another globally significant pathogen, Mycobacterium tuberculosis. At the University of Utah, Dr. Carey runs a research group with a focus on mycobacterial genetics and is a pathologist at ARUP Laboratories.
Academic Locations
Emma Eccles Jones Research Building
801-585-5872
(801) 585-7376
Research Statement
My lab’s goal is to understand how bacterial genetic diversity impacts clinically relevant phenotypes such as antibiotic resistance and vaccine escape. Our focus is pathogenic mycobacteria, including Mycobacterium tuberculosis, the causative agent of tuberculosis, and atypical mycobacteria, which can cause chronic infections in the immunocompromised. We use a combination of experimental and computational approaches, including functional genomics, bacterial population genetics, and high-throughput phenotyping. Our long-term goal is to use this knowledge to inform the development of improved diagnostics, antibiotics, and vaccines.
Board Certification and Academic Information
| Academic Departments | Pathology
-
Assistant Professor |
| Academic Divisions | Clinical Pathology |
| Board Certification | American Board of Pathology (Clinical Path) |
Education History
| Fellowship | Massachusetts General Hospital Clinical Pathology Research and Clinical Fellow, 2018 |
| Chief Resident | Massachusetts General Hospital Clinical Pathology Chief Resident, 2015 |
| Residency | Massachusetts General Hospital Clinical Pathology Resident, 2014 |
| Postdoctoral Fellowship | Pasteur Institute Parasitology Postdoctoral Fellow, 2012 |
| Professional Medical | Yale University School of Medicine Neuroscience M.D., Ph.D., 2010 |
| Undergraduate | Pennsylvania State University Biochemistry and Molecular Biology, Animal Bioscience B.S., 2002 |
| Post Graduate Training | Harvard T.H. Chan School of Public Health Microbiology Postdoctoral Fellow, |
Selected Publications - Journal Articles
Journal Article
- Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL (2018). Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques. PLoS Pathog, 14(10), e1007305.
- Carey AF, Rock JM, Krieger IV, Chase MR, Fernandez-Suarez M, Gagneux S, Sacchettini JC, Ioerger TR, Fortune SM (2018). TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities. PLoS Pathog, 14(3), e1006939.
- Bargieri DY, Thiberge S, Tay CL, Carey AF, Rantz A, Hischen F, Lorthiois A, Straschil U, Singh P, Singh S, Triglia T, Tsuboi T, Cowman A, Chitnis C, Alano P, Baum J, Pradel G, Lavazec C, Mnard R (2016). Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes. Cell Host Microbe, 20(5), 618-630.
- Martin CJ, Carey AF, Fortune SM (2015). A bug's life in the granuloma. Semin Immunopathol, 38(2), 213-20.
- Carey AF, Singer M, Bargieri D, Thiberge S, Frischknecht F, Mnard R, Amino R (2014). Calcium dynamics of Plasmodium berghei sporozoite motility. Cell Microbiol, 16(5), 768-83.
- Carey AF, Mnard R, Bargieri DY (2012). Scoring sporozoite motility. Methods Mol Biol, 923, 371-83.
- Carey AF, Carlson JR (2011). Insect olfaction from model systems to disease control. Proc Natl Acad Sci U S A, 108(32), 12987-95.
- Carey AF, Wang G, Su CY, Zwiebel LJ, Carlson JR (2010). Odorant reception in the malaria mosquito Anopheles gambiae. Nature, 464(7285), 66-71.
- Wang G, Carey AF, Carlson JR, Zwiebel LJ (2010). Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae. Proc Natl Acad Sci U S A, 107(9), 4418-23.