Nicholas Alonzo Frost
( out of 152 reviews )

Nicholas Alonzo Frost, MD, PhD

Languages spoken: English

  • Dr. Frost is a board certified neurologist who sees patients with disorders of memory and cognition. His clinical and research interests focus on understanding mechanisms that contribute to disorders of cognition. His research focuses on how information relevant to complex behaviors including social interactions are encoded within the prefrontal cortex and disrupted in disease. His laboratory utilizes imaging and transcriptomic approaches to understand how heterogeneous populations of neurons function in concert to encode different types of behavioral information.

    Dr. Frost received his medical degree and graduate research training from the University of Maryland School of Medicine. There his research focused on developing super-resolution microscopy to image biological processes in living neurons. He then moved to San Francisco for further clinical training including an internship in internal medicine and residency in adult neurology at the University of California, San Francisco. Following residency he completed a research fellowship at UCSF focused on characterizing circuit-level endophenotypes underlying abnormal behavior in preclinical models of neurodevelopmental disorders.

    Specialties

    Board Certification

    American Board of Psychiatry & Neurology (Neurology)

    Patient Rating

    4.9 /5
    ( out of 152 reviews )

    The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers.

    The scale on which responses are measured is 1 to 5 with 5 being the best score.

    Patient Comments

    Patient comments are gathered from our patient experience survey and displayed in their entirety. For the convenience of our visitors, some patient comments have been translated from their original language into English while preserving their original meaning as accurately as possible. Patients are de-identified for confidentiality and patient privacy.

    January 25, 2025
    CLINICAL NEUROSCIENCES CENTER

    Dr. Frost is great he has helped me a lot

    January 23, 2025
    CLINICAL NEUROSCIENCES CENTER

    Dr. Frost is an excellent Doctor!

    January 16, 2025
    CLINICAL NEUROSCIENCES CENTER

    See previous comments. Gave me what I needed but had to wait too long between test and consultation.

    January 16, 2025
    CLINICAL NEUROSCIENCES CENTER

    Dr. Frost is an exceptionally talented Neurologist. His level of expertise in understanding the complexity of Alzheimer's disease and his ability to navigate the possible treatments to delay the progress of this disease gave me great confidence and hope. I have past experience on Boards of Health systems and can say that U Health, Dr. Frost, and his team are exceptional.

    December 26, 2024
    CLINICAL NEUROSCIENCES CENTER 1

    One of the nicest and most caring physicians we've ever met

    December 22, 2024
    CLINICAL NEUROSCIENCES CENTER 1

    Dr. Frost is very good at helping me I just wish it didn't take so long

    December 22, 2024
    CLINICAL NEUROSCIENCES CENTER 1

    Great

    December 09, 2024
    CLINICAL NEUROSCIENCES CENTER 1

    Dr Nicholas Frost addressed my condition or concern for Mild Cognitive Impairment. After studies with procedures and specialist appointments, it was said that diagnostically that I met criteria for diagnosis for Mild Cognitive Impairment. Etiogically, cognitive decline was seen since my last Neuropsych Evaluation and continued neurologic work up was warranted. Dr Frost's impression and plan showed consolidation was preserved making AD or LATE unlikely but LP would show more insight. Dr Frost presented professional and skilled characteristics to determine my future diagnosis. He expressed excellent knowledge to determine my issues and he was very thorough with testing and counseling. I WILL RESPECT HIS PROFESSIONAL INSIGHT WITH HOW I SHOULD MOVE FORWARD AND I AM LOOKING FORWARD TO HIS RECOMMENDATIONS.

    November 10, 2024
    CLINICAL NEUROSCIENCES CENTER

    I'm very lucky to have Dr. Frost as a provider and to live so close to U of U Medical Center.

  • Dr. Frost is a board certified neurologist who sees patients with disorders of memory and cognition. His clinical and research interests focus on understanding mechanisms that contribute to disorders of cognition. His research focuses on how information relevant to complex behaviors including social interactions are encoded within the prefrontal cortex and disrupted in disease. His laboratory utilizes imaging and transcriptomic approaches to understand how heterogeneous populations of neurons function in concert to encode different types of behavioral information.

    Dr. Frost received his medical degree and graduate research training from the University of Maryland School of Medicine. There his research focused on developing super-resolution microscopy to image biological processes in living neurons. He then moved to San Francisco for further clinical training including an internship in internal medicine and residency in adult neurology at the University of California, San Francisco. Following residency he completed a research fellowship at UCSF focused on characterizing circuit-level endophenotypes underlying abnormal behavior in preclinical models of neurodevelopmental disorders.

    Board Certification and Academic Information

    Academic Departments Neurology -Assistant Professor
    Board Certification
    American Board of Psychiatry & Neurology (Neurology)

    Education history

    Research Fellow R25 Research Fellowship in circuit disorders underlying abnormal behavior - University of California, San Francisco Postdoctoral Fellow
    Residency Neurology - University of California, San Francisco Resident
    Internship Internal Medicine - University of California, San Francisco Intern
    Professional Medical Neuroscience - University of Maryland School of Medicine M.D., Ph.D.
    Undergraduate Biochemistry, Spanish - Florida State University B.S., B.A.

    Selected Publications

    Journal Article

    1. Walker H, Frost NA (2024). Protocol for the generation of single-nuclei RNA-seq libraries and quantification of heterogeneous cell types activated during social interaction. STAR Protoc, 5(4), 103395. (Read full article)
    2. Walker H, Frost NA (2023). Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction. iScience. (Read full article)
    3. Walker H, Frost NA (2024). Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction. iScience, 27(7), 110355. (Read full article)
    4. Shin D, Kim CN, Ross J, Hennick KM, Wu SR, Paranjape N, Leonard R, Wang JC, Keefe MG, Pavlovic BJ, Donohue KC, Moreau C, Wigdor EM, Larson HH, Allen DE, Cadwell CR, Bhaduri A, Popova G, Bearden CE, Pollen AA, Jacquemont S, Sanders SJ, Haussler D, Wiita AP, Frost NA, Sohal VS, Nowakowski TJ (2024). Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders. Cell Stem Cell, 31(3), 421-432.e8. (Read full article)
    5. Frost NA, Donohue KC, Sohal V (2023). Context-invariant socioemotional encoding by prefrontal ensembles. bioRxiv. (Read full article)
    6. Frost NA, Haggart A, Sohal VS (2021). Dynamic patterns of correlated activity in the prefrontal cortex encode information about social behavior. PLoS Biol, May 3;19(5), e3001235.
    7. MacGillavry HD, Kerr JM, Kassner J, Frost NA, Blanpied TA (2015). Shank-cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses. Eur J Neurosci, 43(2), 179-93. (Read full article)
    8. Lu HE, MacGillavry HD, Frost NA, Blanpied TA (2014). Multiple spatial and kinetic subpopulations of CaMKII in spines and dendrites as resolved by single-molecule tracking PALM. J Neurosci, 34(22), 7600-10. (Read full article)
    9. Jensen CS, Watanabe S, Rasmussen HB, Schmitt N, Olesen SP, Frost NA, Blanpied TA, Misonou H (2014). Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons. J Biol Chem, 289(15), 10566-81. (Read full article)
    10. Parikh RV, Frost NA, Green A, Dandu M (2014). A Leathery Lining. J Gen Intern Med, 29(1), 243.
    11. Lieberman JA, Frost NA, Hoppert M, Fernandes PJ, Vogt SL, Raivio TL, Blanpied TA, Donnenberg MS (2012). Outer membrane targeting, ultrastructure, and single molecule localization of the enteropathogenic Escherichia coli type IV pilus secretin BfpB. J Bacteriol, 194(7), 1646-58. (Read full article)
    12. Frost NA, Lu HE, Blanpied TA (2012). Optimization of cell morphology measurement via single-molecule tracking PALM. PLoS One, 7(5), e36751. (Read full article)
    13. Frost NA, Kerr JM, Lu HE, Blanpied TA (2010). A network of networks: cytoskeletal control of compartmentalized function within dendritic spines. Curr Opin Neurobiol, 20(5), 578-87. (Read full article)
    14. Frost NA, Shroff H, Kong H, Betzig E, Blanpied TA (2010). Single-molecule discrimination of discrete perisynaptic and distributed sites of actin filament assembly within dendritic spines. Neuron, 67(1), 86-99. (Read full article)
    15. Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M (2009). PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. Am J Physiol Renal Physiol, 297(6), F1560-5. (Read full article)
    16. Gerdes MJ, Myakishev M, Frost NA, Rishi V, Moitra J, Acharya A, Levy MR, Park SW, Glick A, Yuspa SH, Vinson C (2006). Activator protein-1 activity regulates epithelial tumor cell identity. Cancer Res, 66(15), 7578-88. (Read full article)

    Book Chapter

    1. Frost NA, MacGillavry HD, Lu HE, Blanpied TA (2014). Live-cell PALM of intracellular proteins in neurons. In Nägerl U, Triller A (Eds.), Nanoscale Imaging of Synapses. Neuromethods (84, pp. 93-123). New York, NY: Humana Press.