Guillaume Lamotte
( out of 164 reviews )

Guillaume Lamotte, MD, MSc

Languages spoken: English, French

Clinical Locations

Imaging & Neurosciences Center

Salt Lake City
801-585-7575

  • Dr. Lamotte has a broad background in medicine and neurology with specialty training and expertise in movement disorders and autonomic disorders. He completed a neurology residency at the University Hospital of Caen in France and did a year of supplementary training in movement disorders during his first neurology residency. He then completed the clinician-scientist track between the National Institutes of Health (NIH) and Medstar Georgetown University Hospital as his second neurology residency in the United States. He worked under the guidance of Dr. David Goldstein in the autonomic medicine section at the NIH and developed his clinical skills in autonomic medicine through history taking and physical examinations, as well as exposure to autonomic function testing procedures. He gained experience in conducting clinical research in autonomic disorders focusing on autonomic nervous system dysfunction in synucleinopathies. He completed a clinical fellowship at the Mayo Clinic in Rochester, MN, where he had a broad exposure to various autonomic disorders in the clinic and autonomic laboratory. He is pursuing an academic career focused on clinical research in the fields of autonomic and movement disorders and is currently an assistant professor in neurology at the University of Utah, Salt Lake City, UT, where he sees patients with movement disorders and autonomic disorders.

    Specialties

    Board Certification

    American Board of Psychiatry & Neurology (Neurology)
    Educational Commission for Foreign Medical Graduates
    National Board of Medical Examiners
    United Council for Neurologic Subspecialties (Autonomic Disorders)

    Patient Rating

    4.9 /5
    ( out of 164 reviews )

    The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers.

    The scale on which responses are measured is 1 to 5 with 5 being the best score.

    Patient Comments

    Patient comments are gathered from our patient experience survey and displayed in their entirety.
    Patients are de-identified for confidentiality and patient privacy.

    February 25, 2024
    CLINICAL NEUROSCIENCES CENTER

    He listened to and answered all of my questions. Explained everything so I could understand. Ask me if I would like to follow up. Very pleased with my physician.

    February 23, 2024
    CLINICAL NEUROSCIENCES CENTER

    Dr. Lamotte and his assistant were fantastic. I can¿t tell you how many different doctors I have seen that have quickly dismissed me because my situation is complicated. He saw the whole picture and tried very hard to figure out if it¿s all connected. He was honest and let me know he may not be the best doctor to really treat the underlying disease but didn¿t leave me with that. He recommended two specialties and gave me referrals for both. I came away feeling encouraged and hopeful. It¿s been a long time since a doctor made me feel that way.

    February 23, 2024
    CLINICAL NEUROSCIENCES CENTER

    I felt the appointment was well worth the time and money.

    February 14, 2024
    CLINICAL NEUROSCIENCES CENTER

    Dr. Lamotte is a great doctor with excellent interpersonal skills. I would highly recommend him.

    February 14, 2024
    CLINICAL NEUROSCIENCES CENTER

    A great physician with high level knowledge and care

    February 10, 2024
    CLINICAL NEUROSCIENCES CENTER

    Anyone would be very fortunate to be under Dr. Lamotte¿s care.

    February 09, 2024
    CLINICAL NEUROSCIENCES CENTER

    I highly recommend Dr. Lamotte. He is kind and will take the time you need to discuss your situation. I also know that he intends to stay with me through this by regular check ups as needed. I am very pleased with Dr. Lamotte.

    January 29, 2024
    CLINICAL NEUROSCIENCES CENTER

    He is the smartest doctor.

    January 25, 2024
    CLINICAL NEUROSCIENCES CENTER

    Dr. Lamotte was knowledgeable and friendly. He had great insight into our problem and was frank about what we could expect. We trusted his expertise.

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  • Dr. Lamotte has a broad background in medicine and neurology with specialty training and expertise in movement disorders and autonomic disorders. He completed a neurology residency at the University Hospital of Caen in France and did a year of supplementary training in movement disorders during his first neurology residency. He then completed the clinician-scientist track between the National Institutes of Health (NIH) and Medstar Georgetown University Hospital as his second neurology residency in the United States. He worked under the guidance of Dr. David Goldstein in the autonomic medicine section at the NIH and developed his clinical skills in autonomic medicine through history taking and physical examinations, as well as exposure to autonomic function testing procedures. He gained experience in conducting clinical research in autonomic disorders focusing on autonomic nervous system dysfunction in synucleinopathies. He completed a clinical fellowship at the Mayo Clinic in Rochester, MN, where he had a broad exposure to various autonomic disorders in the clinic and autonomic laboratory. He is pursuing an academic career focused on clinical research in the fields of autonomic and movement disorders and is currently an assistant professor in neurology at the University of Utah, Salt Lake City, UT, where he sees patients with movement disorders and autonomic disorders.

    Board Certification and Academic Information

    Academic Departments Neurology -Primary
    Board Certification
    American Board of Psychiatry & Neurology (Neurology)
    Educational Commission for Foreign Medical Graduates
    National Board of Medical Examiners
    United Council for Neurologic Subspecialties (Autonomic Disorders)

    Education history

    Fellowship Autonomic Disorders - Mayo Clinic Fellow
    Neurology - National Institutes of Health / MedStar Georgetown University Hospital Academic Chief Resident
    Residency Neurology (Clinician Scientist Track) - National Institutes of Health / MedStar Georgetown University Hospital Resident
    Internal Medicine - National Institutes of Health / MedStar Georgetown University Hospital Resident
    Graduate Training Neurosciences - University of Caen M.S.
    Movement Disorders - Groupe Hospitalier Pitié Salpêtrière, Paris, France Diploma
    Residency Neurology - University Hospital of Caen Basse Normandie Resident
    Medicine - University of Caen Basse-Normandie M.D.
    Graduate Training Anatomy - University of Caen Basse-Normandie M.S.
    Infectious Disease and Tropical Disease - University of Caen Basse-Normandie M.S.

    Selected Publications

    Journal Article

    1. Gibbons CH, Levine T, Adler C, Bellaire B, Wang N, Stohl J, Agarwal P, Aldridge GM, Barboi A, Evidente VGH, Galasko D, Geschwind MD, Gonzalez-Duarte A, Gil R, Gudesblatt M, Isaacson SH, Kaufmann H, Khemani P, Kumar R, Lamotte G, Liu AJ, McFarland NR, Miglis M, Reynolds A, Sahagian GA, Saint-Hillaire MH, Schwartzbard JB, Singer W, Soileau MJ, Vernino S, Yerstein O, Freeman R (2024). Skin Biopsy Detection of Phosphorylated α-Synuclein in Patients With Synucleinopathies. JAMA. (Read full article)
    2. Earl T, Jridi A, Thulin PC, Zorn M, McKee KE, Mitrovich K, Moretti P, Alshaikh J, Kassavetis P, Cortez MM, Lamotte G (2024). Effect of levodopa on postural blood pressure changes in Parkinson disease: a randomized crossover study. Clin Auton Res, 34(1), 117-124. (Read full article)
    3. Rasmussen TK, Borghammer P, Finnerup NB, Jensen TS, Hansen J, Knudsen K, Singer W, Lamotte G, Terkelsen AJ (2024). Functional and (123)I-MIBG scintigraphy assessment of cardiac adrenergic dysfunction in diabetes. Auton Neurosci, 252, 103155. (Read full article)
    4. Griffith G, Lamotte G, Mehta N, Fan P, Nikolich J, Springman V, Suttman E, Joslin E, Balfany K, Dunlap M, Kohrt WM, Christiansen CL, Melanson EL, Josbeno D, Chahine LM, Patterson CG, Corcos DM (2024). Chronotropic Incompetence During Exercise Testing as a Marker of Autonomic Dysfunction in Individuals with Early Parkinson's Disease. J Parkinsons Dis. (Read full article)
    5. Corcos DM, Lamotte G, Luthra NS, McKee KE (2023). Advice to People with Parkinson's in My Clinic: Exercise. J Parkinsons Dis. (Read full article)
    6. Lenka A, Lamotte G, Beach P (2023). Asymptomatic orthostatic hypotension in synucleinopathies: to treat or not to treat? Clin Auton Res. (Read full article)
    7. Lamotte G, Sandroni P (2022). Updates on the Diagnosis and Treatment of Peripheral Autonomic Neuropathies. Curr Neurol Neurosci Rep, 22(12), 823-837. (Read full article)
    8. Patterson CG, Joslin E, Gil AB, Spigle W, Nemet T, Chahine L, Christiansen CL, Melanson E, Kohrt WM, Mancini M, Josbeno D, Balfany K, Griffith G, Dunlap MK, Lamotte G, Suttman E, Larson D, Branson C, McKee KE, Goelz L, Poon C, Tilley B, Kang UJ, Tansey MG, Luthra N, Tanner CM, Haus JM, Fantuzzi G, McFarland NR, Gonzalez-Latapi P, Foroud T, Motl R, Schwarzschild MA, Simuni T, Marek K, Naito A, Lungu C, Corcos DM, SPARX3-PSG Investigators (2022). Study in Parkinson's disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial. Trials, 23(1), 855. (Read full article)
    9. Lamotte G, Lenka A (2022). Orthostatic Hypotension in Parkinson Disease: What Is New? Neurol Clin Pract, 12(5), e112-e115. (Read full article)
    10. Lenka A, Di Maria G, Lamotte G, Bahroo L, Jankovic J (2022). Practical pearls to improve the efficacy and tolerability of levodopa in Parkinson's disease. Expert Rev Neurother, 22(6), 489-498. (Read full article)
    11. Lamotte G, Coon EA, Suarez MD, Sandroni P, Benarroch E, Cutsforth-Gregory JK, Mauermann ML, Berini SE, Shouman K, Sletten D, Goodman BP, Low PA, Singer W (2021). Standardized Autonomic Testing in Patients With Probable Radiation-Induced Afferent Baroreflex Failure. Hypertension, 79(1), 50-56. (Read full article)
    12. Castillo-Pinto C, Lamotte G, Mehta A, Sonti R, Di Maria G, Ruiz D, Kumar PN, Stemer AB, Denny MC (2020). Healthcare Worker With Large Vessel Acute Ischemic Stroke Likely Related to Mild SARS-CoV-2 Infection. Neurohospitalist, 12(1), 48-56. (Read full article)
    13. Goldstein DS, Isonaka R, Lamotte G, Kaufmann H (2021). Different phenoconversion pathways in pure autonomic failure with versus without Lewy bodies. Clin Auton Res, 31(6), 677-684. (Read full article)
    14. Lamotte G, Shouman K, Benarroch EE (2021). Stress and central autonomic network. Auton Neurosci, 235, 102870. (Read full article)
    15. Laureno R, Lamotte G (2022). The midline cerebellar lesion in experimental Wernicke disease. Neurol India, 69(6), 1624. (Read full article)
    16. Lamotte G, Sandroni P, Cutsforth-Gregory JK, Berini SE, Benarroch EE, Shouman K, Mauermann ML, Anderson J, Low PA, Singer W, Coon EA (2021). Clinical presentation and autonomic profile in Ross syndrome. J Neurol, 268(10), 3852-3860. (Read full article)
    17. Lamotte G, Sandroni P (2021). A practical approach to peripheral autonomic neuropathies. Curr Opin Neurol, 34(5), 638-647. (Read full article)
    18. Lamotte G, Takahashi M, Wu T, Sullivan P, Cherup J, Holmes C, Goldstein DS (2021). Do indices of baroreflex failure and peripheral noradrenergic deficiency predict the magnitude of orthostatic hypotension in Lewy body diseases? Clin Auton Res, 31(4), 543-551. (Read full article)
    19. Lamotte G (2021). Central pontine myelinolysis secondary to rapid correction of hyponatremia historical perspective with Doctor Robert Laureno. Neurol Sci, 42(8), 3479-3483. (Read full article)
    20. Lamotte G, Coon EA, Suarez MD, Sandroni P, Benarroch EE, Cutsforth-Gregory JK, Mauermann ML, Berini SE, Shouman K, Sletten D, Goodman BP, Low PA, Singer W (2021). Natural History of Afferent Baroreflex Failure in Adults. Neurology, 97(2), e136-e144. (Read full article)
    21. Goldstein DS, Sullivan P, Holmes C, Lamotte G, Lenka A, Sharabi Y (2021). Differential abnormalities of cerebrospinal fluid dopaminergic versus noradrenergic indices in synucleinopathies. J Neurochem, 158(2), 554-568. (Read full article)
    22. Shouman K, Vanichkachorn G, Cheshire WP, Suarez MD, Shelly S, Lamotte GJ, Sandroni P, Benarroch EE, Berini SE, Cutsforth-Gregory JK, Coon EA, Mauermann ML, Low PA, Singer W (2021). Autonomic dysfunction following COVID-19 infection: an early experience. Clin Auton Res, 31(3), 385-394. (Read full article)
    23. Lenka A, Mittal SO, Lamotte G, Pagan FL (2020). A Pragmatic Approach to the Perioperative Management of Parkinson's Disease. Can J Neurol Sci, 48(3), 299-307. (Read full article)
    24. Lamotte G, Benarroch EE (2021). What Is the Clinical Correlation of Cardiac Noradrenergic Denervation in Parkinson Disease? Neurology, 96(16), 748-753. (Read full article)
    25. Lenka A, Lamotte G, Goldstein DS (2021). Cardiac 18F-Dopamine PET Distinguishes PD with Orthostatic Hypotension from Parkinsonian MSA. Mov Disord Clin Pract, 8(4), 582-586. (Read full article)
    26. Lamotte G, Lenka A (2021). Brainstem Predominant Posterior Reversible Encephalopathy Syndrome. Neurol India, 69(2), 536-537. (Read full article)
    27. Lamotte G, Holmes C, Sullivan P, Lenka A, Goldstein DS (2020). Cardioselective peripheral noradrenergic deficiency in Lewy body synucleinopathies. Ann Clin Transl Neurol, 7(12), 2450-2460. (Read full article)
    28. Castillo-Pinto C, Lamotte G, et al (2020). Healthcare Worker With Large Vessel Acute Ischemic Stroke Likely Related to Mild SARS-CoV-2 Infection. Neurohospitalist.
    29. Lamotte G, Holmes C, Wu T, Goldstein DS (2019). Long-term trends in myocardial sympathetic innervation and function in synucleinopathies. Parkinsonism Relat Disord, 67, 27-33. (Read full article)
    30. Lamotte G, Holmes C, Sullivan P, Goldstein DS (2018). Substantial renal conversion of L-threo-3,4-dihydroxyphenylserine (droxidopa) to norepinephrine in patients with neurogenic orthostatic hypotension. Clin Auton Res, 29(1), 113-117. (Read full article)
    31. Laureno R, Lamotte G, Mark AS (2018). Sequential MRI in pontine and extrapontine myelinolysis following rapid correction of hyponatremia. BMC Res Notes, 11(1), 707. (Read full article)
    32. Lamotte G (2018). Author response: Mystery Case: A case of fulminant encephalopathy in a 69-year-old woman. Neurology, 90(15), 714. (Read full article)
    33. Lamotte G, Farzal Z, Zimmerman WD, Han S, de Brito P, Mayson D (2017). Clinical Reasoning: Monocular vision loss, ophthalmoplegia, and strokes in a 61-year-old man with diabetes mellitus. Neurology, 89(24), e276-e281. (Read full article)
    34. Lamotte G, Williams C (2017). Mystery Case: A case of fulminant encephalopathy in a 69-year-old woman. Neurology, 89(9), e109-e114. (Read full article)
    35. Lamotte G, Shah RC, Lazarov O, Corcos DM (2016). Exercise Training for Persons with Alzheimer's Disease and Caregivers: A Review of Dyadic Exercise Interventions. J Mot Behav, 49(4), 365-377. (Read full article)
    36. Lamotte G, Agostini D (2015). Erratum to: Cardiac 123I-MIBG scintigraphy: A window into the brain in Parkinsonism? J Nucl Cardiol, 24(1), 111. (Read full article)
    37. Lamotte G, Morello R, Lebasnier A, Agostini D, Bouvard G, De La Sayette V, Defer GL (2016). Influence of education on cognitive performance and dopamine transporter binding in dementia with Lewy bodies. Clin Neurol Neurosurg, 146, 138-43. (Read full article)
    38. Lebasnier A, Lamotte G, Manrique A, Peyronnet D, Bouvard G, Defer G, Agostini D (2015). Potential diagnostic value of regional myocardial adrenergic imaging using (123)I-MIBG SPECT to identify patients with Lewy body diseases. Eur J Nucl Med Mol Imaging, 42(7), 1043-51. (Read full article)
    39. Lamotte G, Morello R, Lebasnier A, Agostini D, Defer GL (2015). Accuracy and cutoff values of delayed heart to mediastinum ratio with (123)I-metaiodobenzylguanidine cardiac scintigraphy for Lewy body disease diagnoses. BMC Neurol, 15, 83. (Read full article)
    40. Lamotte G, Skender E, Rafferty MR, David F, Sadowsky S, Corcos DM (2015). Effects of progressive resistance exercise training on the motor and non-motor features of Parkinson’s disease: a review. 4, 11-27.
    41. Lamotte G, Rafferty MR, Prodoehl J, Kohrt WM, Comella CL, Simuni T, Corcos DM (2014). Effects of endurance exercise training on the motor and non-motor features of Parkinson's disease: a review. J Parkinsons Dis, 5(1), 21-41. (Read full article)

    Review

    1. Lamotte G, Singer W (2023). Synucleinopathies. [Review]. Handb Clin Neurol, 196, 175-202. (Read full article)

    Book Chapter

    1. Guillaume Lamotte, Norman L Foster (2023). Appropriate Use of Biomarkers in Suspected Neurodegenerative Diseases. In Donna J. Cross, Karina Mosci, Satoshi Minoshima (Eds.), Molecular Imaging of Neurodegenerative Disorders (1). Springer.

    Editorial

    1. Lamotte G (2023). Recent updates in autonomic research: new insights into vagal nerve activity during exercise, cardiac autonomic neuropathy and silent myocardial infarction in diabetes, and timing of orthostatic blood pressure change and future risk of dementia. Clin Auton Res, 33(6), 619-621. (Read full article)
    2. Lamotte G, Kaufmann H, Jordan J (2022). The Clinical Autonomic Research journal 2022 and onward. Clin Auton Res, 33(1), 1-2. (Read full article)
    3. Baker JR, Bourne KM, Lamotte G (2023). Recent updates in autonomic research: a focus on new technologies with high-resolution procedures to study sympathetic nerve activity, plasma proteomic profiling in POTS, and non-invasive neuromodulation with focused ultrasound. Clin Auton Res, 33(1), 11-14. (Read full article)
    4. Lamotte G, Cheshire WP (2022). Do not forget about caregivers in autonomic medicine! Clin Auton Res, 32(6), 403-404. (Read full article)
    5. Lamotte G, Kaufmann H (2022). Movement disorder society criteria for the diagnosis of multiple system atrophy-what's new? Clin Auton Res, 32(3), 163-165. (Read full article)
    6. Lamotte G, Goldstein DS (2022). What new can we learn from cardiac sympathetic neuroimaging in synucleinopathies? Clin Auton Res. (Read full article)
    7. Lamotte G, Millar Vernetti P (2021). Inhibition of the norepinephrine transporter to treat neurogenic orthostatic hypotension: is this the end of the story? Clin Auton Res, 31(6), 645-647. (Read full article)
    8. Lamotte G, Boes CJ, Low PA, Coon EA (2021). The expanding role of the cold pressor test: a brief history. Clin Auton Res, 31(2), 153-155. (Read full article)
    9. Lamotte G, Becker B (2020). Toward biomarker-based clinical subtyping of Parkinson disease. Neurology, 95(11), 461-462. (Read full article)
    10. Guillaume L, Denis A (2015). Cardiac 123I-MIBG scintigraphy: A window into the brain in Parkinsonism? J Nucl Cardiol, 24(1), 108-110. (Read full article)

    Letter

    1. Zahid A, Coon EA, Lamotte G (2021). "No man is an island"-unique pattern of anhidrosis with islands of preserved sweat in Ross syndrome. [Letter to the editor]. Neurol Sci, 42(12), 5399-5400. (Read full article)
    2. Cutsforth-Gregory JK, Benarroch EE, Lamotte G (2021). Platypnea-orthodeoxia syndrome mimicking postural orthostatic tachycardia syndrome. [Letter to the editor]. Clin Auton Res, 31(4), 573-576. (Read full article)
    3. Lamotte G, Sandroni P (2021). A case of Ross syndrome associated with systemic sclerosis. [Letter to the editor]. Clin Auton Res, 31(3), 463-465. (Read full article)
    4. Lamotte G, Benarroch EE, Coon EA (2021). Paroxysmal hypothermia and hyperhidrosis with exacerbation after COVID-19 Infection. [Letter to the editor]. Clin Auton Res, 31(2), 327-329. (Read full article)
    5. Chochol MD, Kataria L, ORourke MC, Lamotte G (2019). Clozapine-Associated Myoclonus and Stuttering Secondary to Smoking Cessation and Drug Interaction: A Case Report. [Letter to the editor]. J Clin Psychopharmacol, 39(3), 275-277. (Read full article)
    6. Lamotte G, Laballe R, Dupuy B (2014). Bilateral eyelid retraction, loss of vision, ophthalmoplegia: an atypical triad in anti-GQ1b syndrome. [Letter to the editor]. Rev Neurol (Paris), 170(6-7), 469-70. (Read full article)
    7. Lamotte G, Caillot A, Di Palma C, Lechapt-Zalcman E, Benateau H, Cogez J (2014). Intramedullary metastasis of a cutaneous squamous cell carcinoma. [Letter to the editor]. Rev Neurol (Paris), 170(3), 230-2. (Read full article)
    8. Lamotte G, Danaila TC, Jaillon-Rivire V, Hitier M, Defer GL (2013). Paraneoplastic opsoclonus myoclonus with autoantibodies to glutamic acid decarboxylase. [Letter to the editor]. Rev Neurol (Paris), 170(1), 50-1. (Read full article)
    9. Lamotte G, Cogez J, Viader F (2012). Interferon-β-1a-induced psychosis in a patient with multiple sclerosis. [Letter to the editor]. Psychiatry Clin Neurosci, 66(5), 462. (Read full article)

    Other

    1. Lamotte G, Rafferty MR, Prodoehl J, Kohrt WM, Comella CL, Simuni T, Corcos DM (2015). Effects of Endurance Exercise Training on The Motor and Non-Motor Features of Parkinson's Disease: A Review. J Parkinsons Dis (5(4), p. 993). Netherlands. (Read full article)

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