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Specialties
- Clinical and Diagnostic Immunology
- Coagulation
- Pathology, Clinical
Board Certification
American Board of Pathology (Clinical Path)American Board of Pathology (Sub: Molecular Genetic Pathology) -
Board Certification and Academic Information
Academic Departments Pathology -Assistant Professor (Clinical)
Board Certification American Board of Pathology (Clinical Path)American Board of Pathology (Sub: Molecular Genetic Pathology)Education history
Fellowship Special Coagulation - Mayo Clinic Clinical Fellow Fellowship Molecular Genetic Pathology - Washington University School of Medicine Clinical Fellow Residency Clinical Pathology - Mayo Clinic Resident Research Fellow Immunology - Mayo Clinic Senior Research Fellow Research Fellow Immunology - Mayo Clinic Research Fellow Professional Medical Diagnostic Clinical Immunology - Alexandria University Medical Research Institute Diploma Professional Medical Medicine - Alexandria University School of Medicine M.B.B.Ch. Selected Publications
Journal Article
- Shean RC, Hellwig S, Saadalla A, George TI, Rets AV (2025). High-sensitivity KIT D816V variation analysis by droplet digital polymerase chain reaction: The reference laboratory perspective. Am J Clin Pathol. (Read full article)
- Lozier B, Martins T, Slev P, Saadalla A (2025). Determination of Positivity Cutoff for an Automated Aspergillus fumigatus-Specific Immunoglobulin-G Assay in a National Reference Laboratory. J Appl Lab Med. (Read full article)
- Dadelahi A, Walker BS, Banerjee D, Mahler M, Saadalla A, Nandakumar V (2024). Is the 99th Percentile Cutoff Still Relevant? A Single-Center Assessment of Different Thresholds for Diagnosing Antiphospholipid Syndrome. J Appl Lab Med. (Read full article)
- Nelson HA, Martins TB, Saadalla A, Nandakumar V (2024). Evaluation of the clinical performance of anti-mutated citrullinated vimentin antibody and 14-3-3 eta testing in rheumatoid arthritis. Clin Chem Lab Med, 63(4), 790-796. (Read full article)
- Saadalla A, Novis CL, Banerjee D, Martins T, Holloway B, Ann Aure M, Mahler M, Nandakumar V (2024). Comparative assessment of the diagnostic performances of particle-based multianalyte technology and commercial ELISA for antiphospholipid autoantibody testing. Clin Chim Acta, 562, 119849. (Read full article)
- Saadalla A, Chen D, Stuart M, Pruthi R, Heikal N, Snyder M, Ashrani A, Seheult J (2024). The lupus anticoagulant titer is associated with elevated antiphosphatidylserine/prothrombin immunoglobulin-M isotype antibody levels. Int J Lab Hematol, 46(4), 695-704. (Read full article)
- Saadalla A, Jacela J, Poll R, Slev P (2023). Immunoassay Testing of Alpha-Gal Specific Immunoglobulin-E: Data from a National Reference Laboratory. J Appl Lab Med, 9(2), 262-272. (Read full article)
- Saadalla A, Nandakumar V (2024). Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses: A single center study. Clin Chim Acta, 554, 117761. (Read full article)
- Grande J, Jones TL, Sun Z, Chanana P, Jaiswal I, Leontovich A, Carapanceanu N, Carapanceanu V, Saadalla A, Osman A, Famuyide AO, Daftary GS, Khan Z, Khazaie K (2023). Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis. Biochim Biophys Acta Mol Basis Dis, 1869(7), 166784. (Read full article)
- Kanack AJ, Athale J, Leger RR, Saadalla A, Heikal NM, Chen D, Garcia DA, Singh R, Pruthi RK, Padmanabhan A (2023). "Autoimmune HIT" antibodies in diagnostic samples are a potential artifact and not associated with more severe outcomes. Blood Adv, 7(16), 4431-4434. (Read full article)
- Grande J, Jones TL, Sun Z, Chanana P, Jaiswal I, Leontovich A, Carapanceanu N, Carapanceanu V, Saadalla A, Osman A, Famuyide AO, Daftary GS, Khan Z, Khazaie K (2023). Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis. Biochim Biophys Acta Mol Basis Dis.
- Saadalla AM, Goldsmith SR, Neidich JA, Duncavage EJ, Parikh BA (2021). Immunoglobulin Variable Heavy Chain Somatic Hypermutation Testing in a Patient with Small Lymphocytic Lymphoma and Multiple Myeloma. J Appl Lab Med, 6(6), 1665-1670. (Read full article)
- Osman A, Yan B, Li Y, Pavelko KD, Quandt J, Saadalla A, Singh MP, Kazemian M, Gounari F, Khazaie K (2021). TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer. Nat Immunol. 2021 Aug 12. doi: 10.1038/s41590-021-00987-1. Epub ahead of print. PMID: 34385712. Nat Immunol.
- Saadalla A, Jara Aguirre J, Wockenfus AM, Kelley BR, Swanson RL, Howard MT, Karon BS (2020). Evaluation of automated synovial fluid total cell count and percent polymorphonuclear leukocytes on a Sysmex XN-1000 analyzer for identifying patients at risk of septic arthritis. Clin Chim Acta, 510, 416-420. (Read full article)
- Bishehsari F, Engen PA, Voigt RM, Swanson G, Shaikh M, Wilber S, Naqib A, Green SJ, Shetuni B, Forsyth CB, Saadalla A, Osman A, Hamaker BR, Keshavarzian A, Khazaie K (2019). Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis. Cell Mol Gastroenterol Hepatol, 9(2), 219-237. (Read full article)
- Saadalla A, Lima MM, Tsai F, Osman A, Singh MP, Linden DR, Dennis KL, Haeryfar SMM, Gurish MF, Gounari F, Khazaie K (2019). Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer. Front Immunol, 10, 2777. (Read full article)
- Puranik AS, Leaf IA, Jensen MA, Hedayat AF, Saad A, Kim KW, Saadalla AM, Woollard JR, Kashyap S, Textor SC, Grande JP, Lerman A, Simari RD, Randolph GJ, Duffield JS, Lerman LO (2018). Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney. Sci Rep, 8(1), 13948. (Read full article)
- Saadalla AM, Osman A, Gurish MF, Dennis KL, Blatner NR, Pezeshki A, McNagny KM, Cheroutre H, Gounari F, Khazaie K (2018). Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner. Proc Natl Acad Sci U S A, 115(7), 1588-1592. (Read full article)
- Khan MW, Saadalla A, Ewida AH, Al-Katranji K, Al-Saoudi G, Giaccone ZT, Gounari F, Zhang M, Frank DA, Khazaie K (2017). The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer. Cancer Immunol Immunother, 67(1), 13-23. (Read full article)
- Bishehsari F, Saadalla A, Khazaie K, Engen PA, Voigt RM, Shetuni BB, Forsyth C, Shaikh M, Vitaterna MH, Turek F, Keshavarzian A (2016). Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota. Int J Mol Sci, 17(12). (Read full article)
- Delaney AA, Khan Z, Zheng Y, Correa LF, Zanfagnin V, Shenoy CC, Schoolmeester JK, Saadalla AM, El-Nashar S, Famuyide AO, Subramaniam M, Hawse JR, Khazaie K, Daftary GS (2016). KLF10 Mediated Epigenetic Dysregulation of Epithelial CD40/CD154 Promotes Endometriosis. Biol Reprod, 95(3), 62. (Read full article)
- Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie K (2015). T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine. Cancer Immunol Res, 3(7), 806-14. (Read full article)
- Dennis KL, Wang Y, Blatner NR, Wang S, Saadalla A, Trudeau E, Roers A, Weaver CT, Lee JJ, Gilbert JA, Chang EB, Khazaie K (2013). Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res, 73(19), 5905-13. (Read full article)
Review
- Saadalla A, Seheult J, Pruthi RK, Chen D (2022). Von Willebrand Factor Multimer Analysis and Classification: A Comprehensive Review and Updates. [Review]. Semin Thromb Hemost, 49(6), 580-591. (Read full article)
Case Report
- Saadalla A, Seheult J, Ladwig P, Tange J, Leger R, Kohlhagen M, Ashrani A, Murray D (2020). Sialic acid-bearing paraproteins are implicated in heparin-like coagulopathy in patients with myeloma. Blood, 136(17), 1988-1992. (Read full article)
- Saadalla AM, Singh A, Barnidge D, Kohlhagen M, Merlini G, Falk RH, Murray D (2019). High sensitivity M-protein detection in a case of light-chain cardiac amyloidosis without evidence of plasma cell dyscrasia. Am J Hematol, 94(5), 619-621. (Read full article)
Letter
- Saadalla A, Stuart M, Ashrani A, Pruthi R, Morava E, Chen D, Seheult J (2022). In special coagulation, think horses not zebras: A clotted sample from a patient with congenital disorder of glycosylation. [Letter to the editor]. Int J Lab Hematol, 45(1), e6-e9. (Read full article)
Abstract
- Lozier B, Martins T, Slev P, Saadalla A (08/17/2024). 37th Annual AMLI meeting in Nashville TN. Determination of Positivity Cutoff for Aspergillus Fumigatus Specific Immunoglobulin-G Using the ImmunoCAP Assay [Abstract]. (Epub ahead of print)
- Saadalla, A, Chen, D, Pruthi, R K, Heikal, N, Snyder, M, Ashrani, A A, Seheult, JN (2022). The Lupus Anticoagulant Titer Is Associated with Elevated Anti-Phosphatidyl-Serine/Prothrombin Antibody Levels [Abstract]. 140((Supplement 1)), 2669–2670.
- Kanack, A, Leger, R, Saadalla, A, Heikal, N, Chen, D, Chen, D, Garcia, D, Pruthi, R K, Padmanabhan, A (2022). “Autoimmune HIT”, a Potential Diagnostic Artifact Due to Remnant Heparin in HIT Samples, Is Not Associated with More Severe Outcomes [Abstract]. 140(Supplement 1), 1963–1964.
- Saadalla, A, Leger, R, Ashrani, A A, Pruthi, R K, Chen, D, Padmanabhan, A, Heikal, N (2021). No Diagnostic Utility of Zero Heparin Control Buffer in Serotonin Release Assay: Findings from a Validation Study. [Abstract]. Blood(138), 3227.
- Saadalla, A, Cao, Y, Evenson, M, Corliss, M, Neidich, J, Heusel, J, Schroeder, M (2022). PS4 utilization for PIK3CA variants implicated in disorders of somatic mosaicism. [Abstract]. Volumes 260–261(Supplement 1).
- Cao Y, Bell B, Evenson M, Corliss M, Kahle J, Saadalla A, Schroeder M, Krysiak K, Amarillo I, Heusel J, Neidich N (2022). Co-existence of two activating variants in somatic overgrowth & vascular anomalies: 7 years' findings at a single center [Abstract]. Volumes 260–261(Supplement 1).
- Saadalla, A, Stroup, B, Parikh, B (2021). VariantDirect: An extraction-free screening approach to detect circulating SARS-CoV-2 virus strains from pooled specimens. [Abstract]. 156(Supplement_1), S19-S20.
- Osman A, Saadalla A, Quand J, Gounari F, Pavelko K, Khazaie K (2018). Canonical Wnt signaling in Treg contributes to colon cancer [Abstract]. 200(1 Supplement), 57.51.
- Osman A, Saadalla A, Gounari F, Turek F, Keshavarzian A, Rakshit K, Matveyenko A, Khazaie K (2018). Circadian Clock disruption promotes TH17 Inflammation and Colon Cancer [Abstract]. 200(1 Supplement), 57.44.
- Jones TL, Senoy CC, Zheng Y, Saadalla AM, Khazaie K, Daftary GS (2017). Inflammation and fibrosis mediate distinct phenotypic progression in endometriosis [Abstract]. 24, 206A.
Video/Film/CD/Web/Podcast
- Saadalla A (2020). Atypical hemolytic uremic syndrome [Web]. Department of Laboratory Medicine and Pathology Pathways: Case of the Month: Mayo Clinic.
- Saadalla A (2019). Lipoprotein-X [Web]. Department of Laboratory Medicine and Pathology Pathways: Case of the Month: Mayo Clinic.
- Saadalla A (2018). POEMS syndrome [Web]. Department of Laboratory Medicine and Pathology Pathways: Case of the Month: Mayo Clinic.