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Abdulrahman Saadalla

Abdulrahman Saadalla, MBBCh

Languages spoken: Arabic, English
  • Specialties

    • Pathology, Clinical

    Board Certification

    American Board of Pathology (Clinical Path)
    American Board of Pathology (Sub: Molecular Genetic Pathology)
  • Board Certification and Academic Information

    Academic Departments Pathology -Primary
    Board Certification
    American Board of Pathology (Clinical Path)
    American Board of Pathology (Sub: Molecular Genetic Pathology)

    Education history

    Fellowship Special Coagulation - Mayo Clinic Clinical Fellow
    Molecular Genetic Pathology - Washington University School of Medicine Clinical Fellow
    Residency Clinical Pathology - Mayo Clinic Resident
    Immunology - Mayo Clinic Senior Research Fellow
    Research Fellow Immunology - Mayo Clinic Research Fellow
    Diagnostic Clinical Immunology - Alexandria University Medical Research Institute Diploma
    Professional Medical Medicine - Alexandria University School of Medicine M.B.B.Ch.

    Selected Publications

    Journal Article

    1. Grande J, Jones TL, Sun Z, Chanana P, Jaiswal I, Leontovich A, Carapanceanu N, Carapanceanu V, Saadalla A, Abu Osman A, Famuyide AO, Daftary G, Khan Z and Khazaie K (2023). Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis. Biochim Biophys Acta Mol Basis Dis.
    2. Kanack AJ, Athale J, Leger RRSaadalla A, Heikal NM, Chen D, Garcia DA, Singh R, Pruthi RK, Padmanabhan A (2023). "Autoimmune HIT" antibodies in diagnostic samples are a potential artifact and not associated with more severe outcomes. Blood Adv.
    3. Saadalla AM, Goldsmith SR, Neidich JA, Duncavage EJ, Parikh BA (2021). Immunoglobulin Variable Heavy Chain Somatic Hypermutation Testing in a Patient with Small Lymphocytic Lymphoma and Multiple Myeloma. J Appl Lab Med, 6(6), 1665-1670. (Read full article)
    4. Osman A, Yan B, Li Y, Pavelko KD, Quandt J, Saadalla A, Singh MP, Kazemian M, Gounari F, Khazaie K (2021). TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer. Nat Immunol. 2021 Aug 12. doi: 10.1038/s41590-021-00987-1. Epub ahead of print. PMID: 34385712. Nat Immunol.
    5. Saadalla A, Jara Aguirre J, Wockenfus AM, Kelley BR, Swanson RL, Howard MT, Karon BS (2020). Evaluation of automated synovial fluid total cell count and percent polymorphonuclear leukocytes on a Sysmex XN-1000 analyzer for identifying patients at risk of septic arthritis. Clin Chim Acta, 510, 416-420. (Read full article)
    6. Bishehsari F, Engen PA, Voigt RM, Swanson G, Shaikh M, Wilber S, Naqib A, Green SJ, Shetuni B, Forsyth CB, Saadalla A, Osman A, Hamaker BR, Keshavarzian A, Khazaie K (2019). Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis. Cell Mol Gastroenterol Hepatol, 9(2), 219-237. (Read full article)
    7. Saadalla A, Lima MM, Tsai F, Osman A, Singh MP, Linden DR, Dennis KL, Haeryfar SMM, Gurish MF, Gounari F, Khazaie K (2019). Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer. Front Immunol, 10, 2777. (Read full article)
    8. Puranik AS, Leaf IA, Jensen MA, Hedayat AF, Saad A, Kim KW, Saadalla AM, Woollard JR, Kashyap S, Textor SC, Grande JP, Lerman A, Simari RD, Randolph GJ, Duffield JS, Lerman LO (2018). Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney. Sci Rep, 8(1), 13948. (Read full article)
    9. Saadalla AM, Osman A, Gurish MF, Dennis KL, Blatner NR, Pezeshki A, McNagny KM, Cheroutre H, Gounari F, Khazaie K (2018). Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner. Proc Natl Acad Sci U S A, 115(7), 1588-1592. (Read full article)
    10. Khan MW, Saadalla A, Ewida AH, Al-Katranji K, Al-Saoudi G, Giaccone ZT, Gounari F, Zhang M, Frank DA, Khazaie K (2017). The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer. Cancer Immunol Immunother, 67(1), 13-23. (Read full article)
    11. Bishehsari F, Saadalla A, Khazaie K, Engen PA, Voigt RM, Shetuni BB, Forsyth C, Shaikh M, Vitaterna MH, Turek F, Keshavarzian A (2016). Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota. Int J Mol Sci, 17(12). (Read full article)
    12. Delaney AA, Khan Z, Zheng Y, Correa LF, Zanfagnin V, Shenoy CC, Schoolmeester JK, Saadalla AM, El-Nashar S, Famuyide AO, Subramaniam M, Hawse JR, Khazaie K, Daftary GS (2016). KLF10 Mediated Epigenetic Dysregulation of Epithelial CD40/CD154 Promotes Endometriosis. Biol Reprod, 95(3), 62. (Read full article)
    13. Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie K (2015). T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine. Cancer Immunol Res, 3(7), 806-14. (Read full article)
    14. Dennis KL, Wang Y, Blatner NR, Wang S, Saadalla A, Trudeau E, Roers A, Weaver CT, Lee JJ, Gilbert JA, Chang EB, Khazaie K (2013). Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer Res, 73(19), 5905-13. (Read full article)

    Review

    1. Saadalla A, Seheult J, Pruthi RK, Chen D (2023). Von Willebrand Factor Multimer Analysis and Classification: A Comprehensive Review and Updates,  Seminars in Thrombosis and Hemostasis. . [Review]. Semin Thromb Hemost.

    Case Report

    1. Saadalla A, Seheult J, Ladwig P, Tange J, Leger R, Kohlhagen M, Ashrani A, Murray D (2020). Sialic acid-bearing paraproteins are implicated in heparin-like coagulopathy in patients with myeloma. Blood, 136(17), 1988-1992. (Read full article)
    2. Saadalla AM, Singh A, Barnidge D, Kohlhagen M, Merlini G, Falk RH, Murray D (2019). High sensitivity M-protein detection in a case of light-chain cardiac amyloidosis without evidence of plasma cell dyscrasia. Am J Hematol, 94(5), 619-621. (Read full article)

    Letter

    1. Saadalla A, Stuart M, Ashrani A, Pruthi R, Morava E, Chen D, Seheult J (2022).  In special coagulation, think horses not zebras: A clotted sample from a patient with congenital disorder of glycosylation [Letter to the editor]. Int J Lab Hematol.