Abdulrahman Saadalla
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Abdulrahman Saadalla, MBBCh

Languages spoken: Arabic, English

Specialties

  • Coagulation
  • Pathology, Clinical
  • Clinical and Diagnostic Immunology

Board Certification

American Board of Pathology (Clinical Path)
American Board of Pathology (Sub: Molecular Genetic Pathology)

Board Certification and Academic Information

Academic Departments Pathology -Assistant Professor (Clinical)
Board Certification
American Board of Pathology (Clinical Path)
American Board of Pathology (Sub: Molecular Genetic Pathology)

Education history

Professional Medical Medicine - Alexandria University School of Medicine M.B.B.Ch.
Professional Medical Diagnostic Clinical Immunology - Alexandria University Medical Research Institute Diploma
Research Fellow Immunology - Mayo Clinic Research Fellow
Research Fellow Immunology - Mayo Clinic Senior Research Fellow
Residency Clinical Pathology - Mayo Clinic Resident
Fellowship Molecular Genetic Pathology - Washington University School of Medicine Clinical Fellow
Fellowship Special Coagulation - Mayo Clinic Clinical Fellow

Selected Publications

Journal Article

  1. Shean RC, Spies NC, Saadalla (2026). Estimation of serum tryptase reference intervals via an indirect method reveal age- and sex-dependent upper limits. The Journal of allergy and clinical immunology,
  2. Lozier B, Martins T, Slev P, Saadalla (2025). Determination of Positivity Cutoff for an Automated Aspergillus fumigatus-Specific Immunoglobulin-G Assay in a National Reference Laboratory. The journal of applied laboratory medicine,
  3. Shean RC, Hellwig S, Saadalla A, George TI, Rets A (2025). High-sensitivity KIT D816V variation analysis by droplet digital polymerase chain reaction: The reference laboratory perspective. American journal of clinical pathology,
  4. Peterson LK, Nandakumar V, Valentine JF, Delgado JC, Saadalla A (2025). The Utility of the Immunoglobulin A Flag Used in Celiac Disease Serology Testing on a Particle-Based Multianalyte Technology Platform. Clinical chemistry, 71(7), 818-820.
  5. Profaizer T, Saadalla A, Nandakumar (2025). Validation for soluble C5b-9 detection and comparative analysis of three quantification methods. Journal of immunological methods, 541, 113882.
  6. Dadelahi A, Walker BS, Banerjee D, Mahler M, Saadalla A, Nandakumar (2024). Is the 99th Percentile Cutoff Still Relevant? A Single-Center Assessment of Different Thresholds for Diagnosing Antiphospholipid Syndrome. The journal of applied laboratory medicine,
  7. Nelson HA, Martins TB, Saadalla A, Nandakumar (2024). Evaluation of the clinical performance of anti-mutated citrullinated vimentin antibody and 14-3-3 eta testing in rheumatoid arthritis. Clinical chemistry and laboratory medicine, 63(4), 790-796.
  8. Saadalla A, Novis CL, Banerjee D, Martins T, Holloway B, Ann Aure M, Mahler M, Nandakumar (2024). Comparative assessment of the diagnostic performances of particle-based multianalyte technology and commercial ELISA for antiphospholipid autoantibody testing. Clinica chimica acta; international journal of clinical chemistry, 562, 119849.
  9. Saadalla A, Chen D, Stuart M, Pruthi R, Heikal N, Snyder M, Ashrani A, Seheult (2024). The lupus anticoagulant titer is associated with elevated antiphosphatidylserine/prothrombin immunoglobulin-M isotype antibody levels. International journal of laboratory hematology, 46(4), 695-704.
  10. Saadalla A, Jacela J, Poll R, Slev (2024). Immunoassay Testing of Alpha-Gal Specific Immunoglobulin-E: Data from a National Reference Laboratory. The journal of applied laboratory medicine, 9(2), 262-272.
  11. Saadalla A, Nandakumar (2024). Anti-phosphatidyl-serine/prothrombin (aPS/PT) antibodies are superior predictors of LAC presence and APS diagnoses: A single center study. Clinica chimica acta; international journal of clinical chemistry, 554, 117761.
  12. Grande J, Jones TL, Sun Z, Chanana P, Jaiswal I, Leontovich A, Carapanceanu N, Carapanceanu V, Saadalla A, Osman A, Famuyide AO, Daftary GS, Khan Z, Khazaie K (2023). Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis. Biochimica et biophysica acta. Molecular basis of disease,
  13. Kanack AJ, Athale J, Leger RR, Saadalla A, Heikal NM, Chen D, Garcia DA, Singh R, Pruthi RK, Padmanabhan (2023). "Autoimmune HIT" antibodies in diagnostic samples are a potential artifact and not associated with more severe outcomes. Blood advances, 7(16), 4431-4434.
  14. Grande J, Jones TL, Sun Z, Chanana P, Jaiswal I, Leontovich A, Carapanceanu N, Carapanceanu V, Saadalla A, Osman A, Famuyide AO, Daftary GS, Khan Z, Khazaie (2023). Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis. Biochimica et biophysica acta. Molecular basis of disease, 1869(7), 166784.
  15. Saadalla A, Stuart M, Ashrani A, Pruthi R, Morava E, Chen D, Seheult (2023). In special coagulation, think horses not zebras: A clotted sample from a patient with congenital disorder of glycosylation. International journal of laboratory hematology, 45(1), e6-e9.
  16. Saadalla AM, Goldsmith SR, Neidich JA, Duncavage EJ, Parikh BA (2021). Immunoglobulin Variable Heavy Chain Somatic Hypermutation Testing in a Patient with Small Lymphocytic Lymphoma and Multiple Myeloma. J Appl Lab Med, 6(6), 1665-1670.
  17. Osman A, Yan B, Li Y, Pavelko KD, Quandt J, Saadalla A, Singh MP, Kazemian M, Gounari F, Khazaie K (2021). TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer. Nat Immunol. 2021 Aug 12. doi: 10.1038/s41590-021-00987-1. Epub ahead of print. PMID: 34385712. Nature immunology,
  18. Saadalla A, Jara Aguirre J, Wockenfus AM, Kelley BR, Swanson RL, Howard MT, Karon B (2020). Evaluation of automated synovial fluid total cell count and percent polymorphonuclear leukocytes on a Sysmex XN-1000 analyzer for identifying patients at risk of septic arthritis. Clinica chimica acta; international journal of clinical chemistry, 510, 416-420.
  19. Saadalla A, Seheult J, Ladwig P, Tange J, Leger R, Kohlhagen M, Ashrani A, Murray (2020). Sialic acid-bearing paraproteins are implicated in heparin-like coagulopathy in patients with myeloma. Blood, 136(17), 1988-1992.
  20. Bishehsari F, Engen PA, Voigt RM, Swanson G, Shaikh M, Wilber S, Naqib A, Green SJ, Shetuni B, Forsyth CB, Saadalla A, Osman A, Hamaker BR, Keshavarzian A, Khazaie (2020). Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis. Cellular and molecular gastroenterology and hepatology, 9(2), 219-237.
  21. Saadalla A, Lima MM, Tsai F, Osman A, Singh MP, Linden DR, Dennis KL, Haeryfar SMM, Gurish MF, Gounari F, Khazaie (2019). Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer. Frontiers in immunology, 10, 2777.
  22. Saadalla AM, Singh A, Barnidge D, Kohlhagen M, Merlini G, Falk RH, Murray (2019). High sensitivity M-protein detection in a case of light-chain cardiac amyloidosis without evidence of plasma cell dyscrasia. American journal of hematology, 94(5), 619-621.
  23. Puranik AS, Leaf IA, Jensen MA, Hedayat AF, Saad A, Kim KW, Saadalla AM, Woollard JR, Kashyap S, Textor SC, Grande JP, Lerman A, Simari RD, Randolph GJ, Duffield JS, Lerman L (2018). Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney. Scientific reports, 8(1), 13948.
  24. Saadalla AM, Osman A, Gurish MF, Dennis KL, Blatner NR, Pezeshki A, McNagny KM, Cheroutre H, Gounari F, Khazaie (2018). Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner. Proceedings of the National Academy of Sciences of the United States of America, 115(7), 1588-1592.
  25. Khan MW, Saadalla A, Ewida AH, Al-Katranji K, Al-Saoudi G, Giaccone ZT, Gounari F, Zhang M, Frank DA, Khazaie (2018). The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer. Cancer immunology, immunotherapy, 67(1), 13-23.
  26. Bishehsari F, Saadalla A, Khazaie K, Engen PA, Voigt RM, Shetuni BB, Forsyth C, Shaikh M, Vitaterna MH, Turek F, Keshavarzian (2016). Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota. International journal of molecular sciences, 17(12),
  27. Delaney AA, Khan Z, Zheng Y, Correa LF, Zanfagnin V, Shenoy CC, Schoolmeester JK, Saadalla AM, El-Nashar S, Famuyide AO, Subramaniam M, Hawse JR, Khazaie K, Daftary G (2016). KLF10 Mediated Epigenetic Dysregulation of Epithelial CD40/CD154 Promotes Endometriosis. Biology of reproduction, 95(3), 62.
  28. Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie (2015). T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine. Cancer immunology research, 3(7), 806-14.
  29. Dennis KL, Wang Y, Blatner NR, Wang S, Saadalla A, Trudeau E, Roers A, Weaver CT, Lee JJ, Gilbert JA, Chang EB, Khazaie (2013). Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells. Cancer research, 73(19), 5905-13.

Review

  1. Saadalla A, Seheult J, Pruthi RK, Chen (2023). Von Willebrand Factor Multimer Analysis and Classification: A Comprehensive Review and Updates. Seminars in thrombosis and hemostasis, 49(6), 580-591.

Abstract

  1. Saadalla A, Nandakumar (2024). 37th Annual AMLI meeting in Nashville TN. Is the 99th Percentile Cut-off Still Relevant? A Single-Center Assessment of Different Thresholds for Diagnosing Antiphospholipid Syndrome.
  2. Munnich B ,Brown B ,Saadalla A , Cote A ,Fehniger T ,Rawala S, Krysiak K (2023). Microfilter enrichment of Hodgkin and Reed-Sternberg (HRS) cells. 278, Pages S1-S34.
  3. Saadalla, A., Chen, D., Pruthi, R. K., Heikal, N., Snyder, M., Ashrani, A. A., Seheult, JN (2022). The Lupus Anticoagulant Titer Is Associated with Elevated Anti-Phosphatidyl-Serine/Prothrombin Antibody Levels. 140((Supplement 1)), 2669¿2670.
  4. Kanack, A., Leger, R. , Saadalla, A., Heikal, N., Chen, D., Chen, D., Garcia, D., Pruthi, R. K., Padmanabhan, A (2022). “Autoimmune HIT”, a Potential Diagnostic Artifact Due to Remnant Heparin in HIT Samples, Is Not Associated with More Severe Outcomes. 140(Supplement 1), 1963¿1964..
  5. Saadalla, A., Leger, R., Ashrani, A. A., Pruthi, R. K., Chen, D., Padmanabhan, A., & Heikal, N (2022). No Diagnostic Utility of Zero Heparin Control Buffer in Serotonin Release Assay: Findings from a Validation Study. Blood(138), 3227.
  6. Saadalla, A., Cao, Y., Evenson, M., Corliss, M., Neidich, J., Heusel, J., Schroeder, (2022). PS4 utilization for PIK3CA variants implicated in disorders of somatic mosaicism. . Volumes 260¿261(Supplement 1),
  7. Cao Y , Bell B, Evenson M, Corliss M, Kahle J, Saadalla A, Schroeder M, Krysiak K, Amarillo I, Heusel J, Neidich (2022). Co-existence of two activating variants in somatic overgrowth & vascular anomalies: 7 years' findings at a single center. Volumes 260¿261(Supplement 1),
  8. Saadalla, A., Stroup, B., Parikh, B (2021). VariantDirect: An extraction-free screening approach to detect circulating SARS-CoV-2 virus strains from pooled specimens. 156(Supplement_1), S19-S20.
  9. Osman A, Saadalla A, Quand J, Gounari F, Pavelko K, Khazaie (2018). Canonical Wnt signaling in Treg contributes to colon cancer. 200(1 Supplement), 57.51.
  10. Osman A, Saadalla A, Gounari F, Turek F, Keshavarzian A, Rakshit K, Matveyenko A, Khazaie (2018). Circadian Clock disruption promotes TH17 Inflammation and Colon Cancer. 200(1 Supplement), 57.44.
  11. Jones TL, Senoy CC, Zheng Y, Saadalla AM, Khazaie K, Daftary G (2017). Inflammation and fibrosis mediate distinct phenotypic progression in endometriosis. 24, 206A.
  12. Lozier B, Martins T, Slev P, Saadalla 37th Annual AMLI meeting in Nashville TN. Determination of Positivity Cutoff for Aspergillus Fumigatus Specific Immunoglobulin-G Using the ImmunoCAP Assay.

Video/Film/CD/Web/Podcast

  1. Saadalla (2020). Atypical hemolytic uremic syndrome.
  2. Saadalla (2019). Lipoprotein-X.
  3. Saadalla (2018). POEMS syndrome.