Christopher O. Audu
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Christopher O. Audu, MD, PhD

Languages spoken: English

Clinical Locations

Primary Children's Hospital

Pediatric Vascular Surgery
Salt Lake City
801-662-2950

University of Utah Hospital

Vascular Surgery
Salt Lake City
801-585-7676

  • Christopher Audu MD, PhD, is an integrated residency-trained, adult and pediatric surgeon-scientist specializing in vascular surgery, medicinal chemistry, biophysical chemistry, immunology, and drug development as it relates to vascular disease and pathophysiology.

    Dr. Audu’s Clinical and Surgical Specialties Include:

    • Cerebrovascular disease
    • Upper extremity arterial and venous disease
    • Aortic pathology
    • Visceral artery disease
    • Aortoiliac occlusive disease
    • Peripheral arterial disease
    • Popliteal aneurysms
    • Popliteal entrapment syndrome
    • Iliac artery endofibrosis
    • Arteriovenous dialysis access
    • Pediatric vascular surgery

    Dr. Audu received his medical and graduate degrees (Chemistry) from Dartmouth. He then completed a 1-year preliminary internship in General Surgery at Dartmouth, and then a 7-year Integrated Vascular Surgery Residency at the University of Michigan.

    Dr. Audu’s Research Interests Include:

    • Immunology
    • Medicinal Chemistry
    • Biophysics
    • Epigenetic enzymes

    When working with every patient, Dr. Audu’s primary goal is to help fix vascular-related ailments in a manner that meets the patient's goals and needs within the scope of his expertise and practice. He strives to provide this patient-centered care by listening to each concern, gathering appropriate clinical information, and then making appropriate recommendations for care in a compassionate, competent way.

    In his spare time, Dr. Audu enjoys reading, creative writing, cooking, spending quality family time, hiking, road biking, and soccer.

    Specialties

  • Christopher Audu MD, PhD, is an integrated residency-trained, adult and pediatric surgeon-scientist specializing in vascular surgery, medicinal chemistry, biophysical chemistry, immunology, and drug development as it relates to vascular disease and pathophysiology.

    Dr. Audu’s Clinical and Surgical Specialties Include:

    • Cerebrovascular disease
    • Upper extremity arterial and venous disease
    • Aortic pathology
    • Visceral artery disease
    • Aortoiliac occlusive disease
    • Peripheral arterial disease
    • Popliteal aneurysms
    • Popliteal entrapment syndrome
    • Iliac artery endofibrosis
    • Arteriovenous dialysis access
    • Pediatric vascular surgery

    Dr. Audu received his medical and graduate degrees (Chemistry) from Dartmouth. He then completed a 1-year preliminary internship in General Surgery at Dartmouth, and then a 7-year Integrated Vascular Surgery Residency at the University of Michigan.

    Dr. Audu’s Research Interests Include:

    • Immunology
    • Medicinal Chemistry
    • Biophysics
    • Epigenetic enzymes

    When working with every patient, Dr. Audu’s primary goal is to help fix vascular-related ailments in a manner that meets the patient's goals and needs within the scope of his expertise and practice. He strives to provide this patient-centered care by listening to each concern, gathering appropriate clinical information, and then making appropriate recommendations for care in a compassionate, competent way.

    In his spare time, Dr. Audu enjoys reading, creative writing, cooking, spending quality family time, hiking, road biking, and soccer.

    Board Certification and Academic Information

    Academic Departments Surgery -Primary

    Education history

    Residency Integrated Vascular Surgery - University of Michigan Resident
    General Surgery - Dartmouth Hitchcock Medical Center Preliminary Resident
    Doctoral Training Chemistry - Dartmouth College Ph.D.
    Medicine - Geisel School of Medicine at Dartmouth M.D.
    Undergraduate Major: Chemistry; Minor: Mathematics - Purdue University B.Sc.
    Undergraduate Religious Education - Crossroads Bible College A.A.

    Selected Publications

    Journal Article

    1. Santosa KB, Kayward L, Matusko N, Jagsi R, Audu CO, Kwakye G, Waljee JF, Sandhu G (2021). Incivility, Work Withdrawal, and Organizational Commitment Among US Surgeons. Ann Surg, 277(3), 416-422. (Read full article)
    2. Sharma SB, Melvin WJ, Audu CO, Bame M, Rhoads N, Wu W, Kanthi Y, Knight JS, Adili R, Holinstat MA, Wakefield TW, Henke PK, Moore BB, Gallagher KA, Obi AT (2022). The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation. Blood, 141(7), 725-742. (Read full article)
    3. Audu CO, Melvin WJ, Joshi AD, Wolf SJ, Moon JY, Davis FM, Barrett EC, Mangum KD, Deng H, Xing X, Wasikowski R, Tsoi LC, Sharma SB, Bauer TM, Shadiow J, Corriere MA, Obi AT, Kunkel SL, Levi B, Moore BB, Gudjonsson JE, Smith AM, Gallagher KA (2022). Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair. Cell Mol Immunol, 19(11), 1251-1262. (Read full article)
    4. Wolf SJ, Audu CO, Joshi A, denDekker A, Melvin WJ, Davis FM, Xing X, Wasikowski R, Tsoi LC, Kunkel SL, Gudjonsson JE, ORiordan MX, Kahlenberg JM, Gallagher KA (2022). IFN-κ is critical for normal wound repair and is decreased in diabetic wounds. JCI Insight, 7(9). (Read full article)
    5. Deng H, Konopka CJ, Prabhu S, Sarkar S, Medina NG, Fayyaz M, Arogundade OH, Vidana Gamage HE, Shahoei SH, Nall D, Youn Y, Dobrucka IT, Audu CO, Joshi A, Melvin WJ, Gallagher KA, Selvin PR, Nelson ER, Dobrucki LW, Swanson KS, Smith AM (2022). Dextran-Mimetic Quantum Dots for Multimodal Macrophage Imaging In Vivo, Ex Vivo, and In Situ. ACS Nano, 16(2), 1999-2012. (Read full article)
    6. Audu CO, Dardik A (2021). Nutrition in the management of peripheral arterial disease: should we pay more attention to what our patients eat? JVS Vasc Sci, 3, 15-16. (Read full article)
    7. Melvin WJ, Audu CO, Davis FM, Sharma SB, Joshi A, DenDekker A, Wolf S, Barrett E, Mangum K, Zhou X, Bame M, Ruan A, Obi A, Kunkel SL, Moore BB, Gallagher KA (2021). Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2. Proc Natl Acad Sci U S A, 118(38). (Read full article)
    8. Davis FM, Tsoi LC, Melvin WJ, denDekker A, Wasikowski R, Joshi AD, Wolf S, Obi AT, Billi AC, Xing X, Audu C, Moore BB, Kunkel SL, Daugherty A, Lu HS, Gudjonsson JE, Gallagher KA (2020). Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms. J Exp Med, 218(6). (Read full article)
    9. Kemp MT, Rivard SJ, Anderson S, Audu CO, Barrett M, Fry BT, Lane M, Vu JV, Young BAC, Englesbe M, Sandhu G, Coleman DM (2020). Trainee Wellness and Safety in the Context of COVID-19: The Experience of One Institution. Acad Med, 96(5), 655-660. (Read full article)
    10. Davis FM, denDekker A, Joshi AD, Wolf SJ, Audu C, Melvin WJ, Mangum K, Riordan MO, Kunkel SL, Gallagher KA (2020). Palmitate-TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing. Eur J Immunol, 50(12), 1929-1940. (Read full article)
    11. Davis FM, Tsoi LC, Wasikowski R, denDekker A, Joshi A, Wilke C, Deng H, Wolf S, Obi A, Huang S, Billi AC, Robinson S, Lipinski J, Melvin WJ, Audu CO, Weidinger S, Kunkel SL, Smith A, Gudjonsson JE, Moore BB, Gallagher KA (2020). Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair. JCI Insight, 5(17). (Read full article)
    12. Davis FM, denDekker A, Kimball A, Joshi AD, El Azzouny M, Wolf SJ, Obi AT, Lipinski J, Gudjonsson JE, Xing X, Plazyo O, Audu C, Melvin WJ, Singer K, Henke PK, Moore BB, Burant C, Kunkel SL, Gallagher KA (2020). Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair. J Immunol, 204(9), 2503-2513. (Read full article)
    13. Audu CO, Coleman DM (2019). Prioritizing personal well-being during vascular surgery training. Semin Vasc Surg, 32(1-2), 23-26. (Read full article)
    14. Audu CO, Columbo JA, Sun SJ, Perri JL, Goodney PP, Stone DH, Nolan BW, Suckow BD (2018). Variation in timing and type of groin wound complications highlights the need for uniform reporting standards. J Vasc Surg, 69(2), 532-543. (Read full article)
    15. Audu CO, Boniakowski AE, Robinson S, Dasika NL, Wakefield T, Coleman DM (2016). Internal iliac venous aneurysm associated with pelvic venous insufficiency. J Vasc Surg Venous Lymphat Disord, 5(2), 257-260. (Read full article)
    16. Guo B, Audu CO, Cochran JC, Mierke DF, Pellegrini M (2014). Protein engineering of the N-terminus of NEMO: structure stabilization and rescue of IKKβ binding. Biochemistry, 53(43), 6776-85. (Read full article)
    17. Audu CO, Plati JJ, Pellegrini M, Mierke DF (2014). Engineering a soluble parathyroid hormone GPCR mimetic. Proteins, 82(7), 1370-5. (Read full article)
    18. Audu CO, Cochran JC, Pellegrini M, Mierke DF (2013). Recombinant production of TEV cleaved human parathyroid hormone. J Pept Sci, 19(8), 504-10. (Read full article)
    19. Audu CO, OHara B, Pellegrini M, Wang L, Atwood WJ, Mierke DF (2012). Reining in polyoma virus associated nephropathy: design and characterization of a template mimicking BK viral coat protein cellular binding. Biochemistry, 51(41), 8092-9. (Read full article)
    20. Scott WL, Audu CO, Dage JL, Goodwin LA, Martynow JG, Platt LK, Smith JG, Strong AT, Wickizer K, Woerly EM, ODonnell MJ (2008). Distributed Drug Discovery, Part 3: using D(3) methodology to synthesize analogs of an anti-melanoma compound. J Comb Chem, 11(1), 34-43. (Read full article)
    21. Scott WL, Alsina J, Audu CO, Babaev E, Cook L, Dage JL, Goodwin LA, Martynow JG, Matosiuk D, Royo M, Smith JG, Strong AT, Wickizer K, Woerly EM, Zhou Z, ODonnell MJ (2008). Distributed Drug Discovery, Part 2: global rehearsal of alkylating agents for the synthesis of resin-bound unnatural amino acids and virtual D(3) catalog construction. J Comb Chem, 11(1), 14-33. (Read full article)

    Review

    1. Audu CO, Gordon AE, Obi AT, Wakefield TW, Henke PK (2019). Inflammatory biomarkers in deep venous thrombosis organization, resolution, and post-thrombotic syndrome. [Review]. J Vasc Surg Venous Lymphat Disord, 8(2), 299-305. (Read full article)
    2. Audu CO, Wakefield TW, Coleman DM (2019). Pediatric deep venous thrombosis. [Review]. J Vasc Surg Venous Lymphat Disord, 7(3), 452-462. (Read full article)