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Corrine K. Welt
( out of 14 reviews )

Corrine K. Welt, MD

Languages spoken: English

Clinical Locations

  • Female reproductive disorders are devastating and their underlying etiologies may present additional medical problems within and beyond the reproductive years. My work has therefore focused on disorders of reproduction and their medical consequences. Polycystic ovary syndrome causes infertility because of its irregular menstrual cycles. It is also associated with risk for diabetes, high blood pressure, insulin resistance and high cholesterol. Hypothalamic amenorrhea, which can result from too much exercise or too little fat, causes infertility and bone loss. Women who go through menopause too early are at risk for bone loss and heart disease. My goal is to find markers and genetic risk factors that will help identify these problems early. If diagnosed early, the appropriate prevention and treatment measures can be put in place to alleviate infertility and avoid the associated medical consequences.

    Board Certification

    American Board of Internal Medicine (Sub: Endocrinology, Diabetes & Metabolism)

    Patient Rating

    5.0 /5
    ( out of 14 reviews )

    The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers.

    The scale on which responses are measured is 1 to 5 with 5 being the best score.

    Patient Comments

    Patient comments are gathered from our patient experience survey and displayed in their entirety.
    Patients are de-identified for confidentiality and patient privacy.

    August 13, 2023
    UH HOSPITALS AND CLINICS

    I enjoy my annual vist with Dr. Welt. She is knowledgeable, polite, and concerned.

    August 05, 2023
    UH HOSPITALS AND CLINICS

    Dr. Welt has an amazing wealth of experience.

    April 17, 2023
    UH HOSPITALS AND CLINICS

    Dr. Welt was very good. She listened to everything I had to say. I feel she really cares. She explained everything very good in a way I understand.

    March 12, 2023
    UH HOSPITALS AND CLINICS

    She was very thorough and knowledgeable and didnt rush but took her time explaining everything.

    February 14, 2023
    UH HOSPITALS AND CLINICS

    We appreciated her ability to hear our concerns and understand the issue we are trying to figure out. She was kind and supportive.

    December 12, 2022
    UH HOSPITALS AND CLINICS

    I appreciated the amount of time Dr Welt spent with me. As a patient it is very challenging to have an untreated, rare diagnosis which has health implications across multiple disciplines. The providers who treat the diagnosis are aware of its far reaching health implications; but the individual departments where there is cross over don't seem to have the most up to date information; understandably so. I am hopeful that Dr Welt will agree to keep me on as a patient to proactively help manage symptoms until such time as I am able to complete treatment. It would be fantastic if there were a concerted effort to include a provider in the endocrinology department as part of the treatment team for vascular compressions:Nutcracker Syndrome, SMAS, PVI, and May Thurner as there seems to be significant overlap with endocrine disruption and the abdominal vascular compression diagnoses. If nothing else involvement with this Dept could drastically improve the prognosis for women's health

    November 14, 2022
    University Hospital

    Dr Welt was very kind and compassionate as well as knowledgeable and provided clear explanations

    October 03, 2022
    UH HOSPITALS AND CLINICS

    I left with more questions than answers, and not really feeling like I want to go back.

  • Female reproductive disorders are devastating and their underlying etiologies may present additional medical problems within and beyond the reproductive years. My work has therefore focused on disorders of reproduction and their medical consequences. Polycystic ovary syndrome causes infertility because of its irregular menstrual cycles. It is also associated with risk for diabetes, high blood pressure, insulin resistance and high cholesterol. Hypothalamic amenorrhea, which can result from too much exercise or too little fat, causes infertility and bone loss. Women who go through menopause too early are at risk for bone loss and heart disease. My goal is to find markers and genetic risk factors that will help identify these problems early. If diagnosed early, the appropriate prevention and treatment measures can be put in place to alleviate infertility and avoid the associated medical consequences.

    Board Certification and Academic Information

    Academic Departments Internal Medicine -Primary
    Academic Divisions Endocrinology
    Board Certification
    American Board of Internal Medicine (Sub: Endocrinology, Diabetes & Metabolism)

    Education history

    Research Fellow Reproductive Endocrinology - Massachusetts General Hospital Research Fellow
    Internal Medicine - VA Boston Healthcare System Chief Resident
    Fellowship Endocrinology - Massachusetts General Hospital Clinical Fellow
    Internal Medicine - Brigham and Women's Hospital Resident
    Internship Internal Medicine - Brigham and Women's Hospital Intern
    Medicine - Cornell University Medical College M.D.
    Undergraduate Biochemistry - University of Wisconsin–Madison B.S.

    Selected Publications

    Journal Article

    1. McDonald IR, Welt CK, Dwyer AA (2022). Health-related quality of life in women with primary ovarian insufficiency: a scoping review of the literature and implications for targeted interventions. Hum Reprod. (Read full article)
    2. Sharma A, Krick B, Li Y, Summers SA, Playdon MC, Welt C (2022). The Use of Ceramides to Predict Metabolic Response to Metformin in Women With PCOS. J Endocr Soc, 6(11), bvac131. (Read full article)
    3. Day FR, Hinds DA, Tung JY, Stolk L, Styrkarsdottir U, Saxena R, Bjonnes A, Broer L, Dunger DB, Halldorsson BV, Lawlor DA, Laval G, Mathieson I, McCardle WL, Louwers Y, Meun C, Ring S, Scott RA, Sulem P, Uitterlinden AG, Wareham NJ, Thorsteinsdottir U, Welt C, Stefansson K, Laven JS, Ong KK, Perry JR (2015). Causal mechanisms and balancing selection inferred from genetic associations with the polycystic ovary syndrome. Nat Commun, 6, 8464-8470.
    4. Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH, Reproductive Medicine Network, Stener-Victorin E, Legro RS, Dunairf A (2015). Genomewide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun, 6, 7502-7514.
    5. Saxena R, Bjonnes AC, Georgopoulos NA, Koika V, Panidis D, Welt CK (2015). Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume. Hum Reprod, 30, 1697-1703.
    6. Pau CT, Keefe C, Duran J, Welt CK (2014). Metformin improves glucose effectiveness, not insulin sensitivity: predicting treatment response in women with polycystic ovary syndrome in an open-label, interventional study. J Clin Endocrinol Metab, 99(5), 1870-8. (Read full article)
    7. Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK (2013). Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 98(12), 4565-92. (Read full article)
    8. Kasippillai T, MacArthur DG, Kirby A, Thomas B, Lambalk CB, Daly MJ, Welt CK (2013). Mutations in eIF4ENIF1 are associated with primary ovarian insufficiency. J Clin Endocrinol Metab, 98(9), E1534-9. (Read full article)
    9. Saxena R, Welt CK (2013). Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes. Acta Diabetol, 50(3), 451-7. (Read full article)
    10. Welt CK, Styrkarsdottir U, Ehrmann DA, Thorleifsson G, Arason G, Gudmundsson JA, Ober C, Rosenfield RL, Saxena R, Thorsteinsdottir U, Crowley WF, Stefansson K (2012). Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab, 97(7), E1342-7. (Read full article)
    11. Caronia LM, Martin C, Welt CK, Sykiotis GP, Quinton R, Thambundit A, Avbelj M, Dhruvakumar S, Plummer L, Hughes VA, Seminara SB, Boepple PA, Sidis Y, Crowley WF Jr, Martin KA, Hall JE, Pitteloud N (2011). A genetic basis for functional hypothalamic amenorrhea. N Engl J Med, 364(3), 215-25. (Read full article)
    12. Powe CE, Allen M, Puopolo KM, Merewood A, Worden S, Johnson LC, Fleischman A, Welt CK (2010). Recombinant human prolactin for the treatment of lactation insufficiency. Clin Endocrinol (Oxf), 73(5), 645-53. (Read full article)
    13. Welt CK, Arason G, Gudmundsson JA, Adams J, Palsdottir H, Gudlaugsdottir G, Ingadottir G, Crowley WF (2006). Defining constant versus variable phenotypic features of women with polycystic ovary syndrome using different ethnic groups and populations. J Clin Endocrinol Metab, 91(11), 4361-8. (Read full article)
    14. Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS (2004). Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med, 351(10), 987-97. (Read full article)

    Review

    1. Welt CK (2008). Primary ovarian insufficiency: a more accurate term for premature ovarian failure. [Review]. Clin Endocrinol (Oxf), 68(4), 499-509. (Read full article)

    Case Report

    1. Iwama S, Welt CK, Romero CJ, Radovick S, Caturegli P (2013). Isolated prolactin deficiency associated with serum autoantibodies against prolactin-secreting cells. J Clin Endocrinol Metab, 98(10), 3920-5. (Read full article)
    2. Welt CK, Falorni A, Taylor AE, Martin KA, Hall JE (2005). Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol, and elevated inhibin B levels. J Clin Endocrinol Metab, 90(5), 3069-76. (Read full article)