Corrine K. Welt

Corrine K. Welt, MD

Languages spoken: English

Clinical Locations

Utah Diabetes & Endocrinology Center

801-581-7761

  • Female reproductive disorders are devastating and their underlying etiologies may present additional medical problems within and beyond the reproductive years. My work has therefore focused on disorders of reproduction and their medical consequences. Polycystic ovary syndrome causes infertility because of its irregular menstrual cycles. It is also associated with risk for diabetes, high blood pressure, insulin resistance and high cholesterol. Hypothalamic amenorrhea, which can result from too much exercise or too little fat, causes infertility and bone loss. Women who go through menopause too early are at risk for bone loss and heart disease. My goal is to find markers and genetic risk factors that will help identify these problems early. If diagnosed early, the appropriate prevention and treatment measures can be put in place to alleviate infertility and avoid the associated medical consequences.

    Specialties

    Board Certification

    American Board of Internal Medicine (Sub: Endocrinology, Diabetes & Metabolism)

  • Female reproductive disorders are devastating and their underlying etiologies may present additional medical problems within and beyond the reproductive years. My work has therefore focused on disorders of reproduction and their medical consequences. Polycystic ovary syndrome causes infertility because of its irregular menstrual cycles. It is also associated with risk for diabetes, high blood pressure, insulin resistance and high cholesterol. Hypothalamic amenorrhea, which can result from too much exercise or too little fat, causes infertility and bone loss. Women who go through menopause too early are at risk for bone loss and heart disease. My goal is to find markers and genetic risk factors that will help identify these problems early. If diagnosed early, the appropriate prevention and treatment measures can be put in place to alleviate infertility and avoid the associated medical consequences.

    Board Certification and Academic Information

    Academic Departments Internal Medicine -Primary
    Board Certification
    American Board of Internal Medicine (Sub: Endocrinology, Diabetes & Metabolism)

    Education history

    Research Fellow Reproductive Endocrinology - Massachusetts General Hospital Research Fellow
    Internal Medicine - VA Boston Healthcare System Chief Resident
    Fellowship Endocrinology - Massachusetts General Hospital Clinical Fellow
    Internal Medicine - Brigham and Women's Hospital Resident
    Internship Internal Medicine - Brigham and Women's Hospital Intern
    Medicine - Cornell University Medical College M.D.
    Undergraduate Biochemistry - University of Wisconsin–Madison B.S.

    Selected Publications

    Journal Article

    1. McDonald IR, Welt CK, Dwyer AA (2022). Health-related quality of life in women with primary ovarian insufficiency: a scoping review of the literature and implications for targeted interventions. Hum Reprod.
    2. Sharma A, Krick B, Li Y, Summers SA, Playdon MC, Welt C (2022). The Use of Ceramides to Predict Metabolic Response to Metformin in Women With PCOS. J Endocr Soc, 6(11), bvac131.
    3. Day FR, Hinds DA, Tung JY, Stolk L, Styrkarsdottir U, Saxena R, Bjonnes A, Broer L, Dunger DB, Halldorsson BV, Lawlor DA, Laval G, Mathieson I, McCardle WL, Louwers Y, Meun C, Ring S, Scott RA, Sulem P, Uitterlinden AG, Wareham NJ, Thorsteinsdottir U, Welt C, Stefansson K, Laven JS, Ong KK, Perry JR (2015). Causal mechanisms and balancing selection inferred from genetic associations with the polycystic ovary syndrome. Nat Commun, 6, 8464-8470.
    4. Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH, Reproductive Medicine Network, Stener-Victorin E, Legro RS, Dunairf A (2015). Genomewide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun, 6, 7502-7514.
    5. Saxena R, Bjonnes AC, Georgopoulos NA, Koika V, Panidis D, Welt CK (2015). Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume. Hum Reprod, 30, 1697-1703.
    6. Pau CT, Keefe C, Duran J, Welt CK (2014). Metformin improves glucose effectiveness, not insulin sensitivity: predicting treatment response in women with polycystic ovary syndrome in an open-label, interventional study. J Clin Endocrinol Metab, 99(5), 1870-8.
    7. Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK (2013). Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 98(12), 4565-92.
    8. Kasippillai T, MacArthur DG, Kirby A, Thomas B, Lambalk CB, Daly MJ, Welt CK (2013). Mutations in eIF4ENIF1 are associated with primary ovarian insufficiency. J Clin Endocrinol Metab, 98(9), E1534-9.
    9. Saxena R, Welt CK (2013). Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes. Acta Diabetol, 50(3), 451-7.
    10. Welt CK, Styrkarsdottir U, Ehrmann DA, Thorleifsson G, Arason G, Gudmundsson JA, Ober C, Rosenfield RL, Saxena R, Thorsteinsdottir U, Crowley WF, Stefansson K (2012). Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab, 97(7), E1342-7.
    11. Caronia LM, Martin C, Welt CK, Sykiotis GP, Quinton R, Thambundit A, Avbelj M, Dhruvakumar S, Plummer L, Hughes VA, Seminara SB, Boepple PA, Sidis Y, Crowley WF Jr, Martin KA, Hall JE, Pitteloud N (2011). A genetic basis for functional hypothalamic amenorrhea. N Engl J Med, 364(3), 215-25.
    12. Powe CE, Allen M, Puopolo KM, Merewood A, Worden S, Johnson LC, Fleischman A, Welt CK (2010). Recombinant human prolactin for the treatment of lactation insufficiency. Clin Endocrinol (Oxf), 73(5), 645-53.
    13. Welt CK, Arason G, Gudmundsson JA, Adams J, Palsdottir H, Gudlaugsdottir G, Ingadottir G, Crowley WF (2006). Defining constant versus variable phenotypic features of women with polycystic ovary syndrome using different ethnic groups and populations. J Clin Endocrinol Metab, 91(11), 4361-8.
    14. Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS (2004). Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med, 351(10), 987-97.

    Review

    1. Welt CK (2008). Primary ovarian insufficiency: a more accurate term for premature ovarian failure. [Review]. Clin Endocrinol (Oxf), 68(4), 499-509.

    Case Report

    1. Iwama S, Welt CK, Romero CJ, Radovick S, Caturegli P (2013). Isolated prolactin deficiency associated with serum autoantibodies against prolactin-secreting cells. J Clin Endocrinol Metab, 98(10), 3920-5.
    2. Welt CK, Falorni A, Taylor AE, Martin KA, Hall JE (2005). Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol, and elevated inhibin B levels. J Clin Endocrinol Metab, 90(5), 3069-76.

  • Podcasts & News

    News

    The Scope Podcast