Specialties
Board Certification
|
National Board of Echocardiography
American Board of Internal Medicine (Sub: Cardiovascular Disease)
|
Board Certification and Academic Information
| Academic Departments |
Biochemistry
-Adjunct Associate Professor Internal Medicine -Associate Professor |
|---|---|
| Academic Divisions |
Cardiovascular Medicine
|
| Board Certification |
National Board of Echocardiography
American Board of Internal Medicine (Sub: Cardiovascular Disease)
|
Education history
| Undergraduate | Biology, Philosophy - Cornell University | B.A. |
|---|---|---|
| Professional Medical | Medicine, Neuroscience - Johns Hopkins University School of Medicine | M.D., Ph.D. |
| Internship | Internal Medicine - University of California, San Francisco | Intern |
| Residency | Internal Medicine, ABIM Research Pathway - University of California, San Francisco | Resident |
| Fellowship | Cardiovascular Diseases - Massachusetts General Hospital | Clinical Fellow |
| Research Fellow | Cardiovascular Research Center - Massachusetts General Hospital | Research Fellow |
| Research Fellow | Cardiology - Boston Children¿s Hospital | Research Fellow |
Selected Publications
Journal Article
- Eberhardt DR, Rekate EC, Masini YB, Duron HE, Mollinedo D, Velarde AM, Stucki D, Price T, Lee SHJ, Balderas E, Rai NK, Bratt AR, Balynas AM, Stubben CJ, Bia R, Maity S, Hartel N, Yin X, Corbin A, Kumari A, Nguyen DM, Shimura D, Nguyen VD, Vinod V, Chowdhury KH, Verdeguer F, Zvick J, Mimche PN, Boudina S, Drakos SG, Aromolaran AS, Franklin S, Garg V, Shaw RM, Holland WL, Summers SA, Pezzolesi MG, Rutter J, Evason KJ, Chaudhuri (2026). Excessive Ca(2+)-dependent ER-mitochondrial contact stabilization by EFHD1 drives liver injury. bioRxiv,
- Mia S, Siokatas G, Sidiropoulou R, Hoffman M, Fragkiadakis K, Markopoulou E, Elesawy MI, Roy R, Blair S, Kuwabara Y, Rapushi E, Chaudhuri D, Makarewich CA, Gao E, Koch WJ, Schilling JD, Molkentin JD, Marketou M, Drosatos (2025). Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling. Cell reports. Medicine, 102125.
- Rai NK, Eberhardt DR, Balynas AM, MacEwen MJS, Bratt AR, Sancak Y, Chaudhuri (2025). Mechanism of MCUB-Dependent Inhibition of Mitochondrial Calcium Uptake. Journal of cellular physiology, 240(4), e70033.
- Ajanel A, Andrianova I, Kowalczyk M, Menéndez-Pérez J, Bhatt SR, Portier I, Boone TC, Ballard-Kordeliski A, Kosaka Y, Chaudhuri D, Paul DS, Bergmeier W, Denorme F, Campbell R (2025). Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation. Circulation research, 137(4), 474-492.
- Barr RG, Lima JAC, Prince MR, Ambale Venkatesh B, Abraham T, Agarwal PP, Arora G, Balasubramanian A, Barjaktarevic I, Bello NA, Bluemke DA, Budoff MJ, Carr JC, Chaudhuri D, Cooper CB, Couper D, Finn JP, Freed BH, Han MK, Hansel NN, Hsu JJ, Kitzman DW, Krishnan JA, LaBounty TM, Lee YJ, Liu J, Lloyd SG, Markl M, Mukherjee M, Beussink-Nelson L, Ohar J, Ortega VE, Paine R 3rd, Peters SP, Schroeder JD, Shen W, Shepshelovich D, Sun Y, Vogel-Claussen J, Watson KE, Wells JM, Wieben O, Woodruff PG, Shah S (2025). SPIROMICS HF: Rationale, Design, and Reproducibility of Measures. Circulation. Heart failure, e012833.
- Mitchell G, Javan H, Nickel I, Valdez S, Palatinus JA, Szulik M, Eberhardt D, Franklin S, Chaudhuri D, Skliar M, Ripoll CV, Pierce J, Selzman C (2025). Intravenous acellular human amniotic fluid prevents ischemic cardiac remodeling. Scientific reports, 15(1), 44725.
- Visker JR, Cluntun AA, Velasco-Silva JN, Eberhardt DR, Cedeno-Rosario L, Shankar TS, Hamouche R, Ling J, Kwak H, Hillas JY, Aist I, Tseliou E, Navankasattusas S, Chaudhuri D, Ducker GS, Drakos SG, Rutter (2024). Enhancing mitochondrial pyruvate metabolism ameliorates ischemic reperfusion injury in the heart. JCI insight, 9(17),
- Atomwise AIMS Progra (2024). AI is a viable alternative to high throughput screening: a 318-target study. Scientific reports, 14(1), 7526.
- Cluntun AA, Visker JR, Velasco-Silva JN, Lang MJ, Cedeño-Rosario L, Shankar TS, Hamouche R, Ling J, Kim JE, Toshniwal AG, Low HK, Cunningham CN, Carrington J, Catrow JL, Pearce Q, Jeong MY, Bott AJ, Narbona-Pérez ÁJ, Stanley CE, Li Q, Eberhardt DR, Morgan JT, Yadav T, Wells CE, Ramadurai DKA, Swiatek WI, Chaudhuri D, Rothstein JD, Muoio DM, Paulo JA, Gygi SP, Baker SA, Navankasattusas S, Cox JE, Funai K, Drakos SG, Rutter J, Ducker G (2024). Direct mitochondrial import of lactate supports resilient carbohydrate oxidation. bioRxiv,
- Johnson JM, Peterlin AD, Balderas E, Sustarsic EG, Maschek JA, Lang MJ, Jara-Ramos A, Panic V, Morgan JT, Villanueva CJ, Sanchez A, Rutter J, Lodhi IJ, Cox JE, Fisher-Wellman KH, Chaudhuri D, Gerhart-Hines Z, Funai (2023). Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis. Science advances, 9(8), eade7864.
- Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O'Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin (2023). SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation. Basic research in cardiology, 118(1), 20.
- Balderas E, Lee SHJ, Shankar TS, Yin X, Balynas AM, Kyriakopoulos CP, Selzman CH, Drakos SG, Chaudhuri (2023). Mitochondria possess a large, non-selective ionic current that is enhanced during cardiac injury. bioRxiv,
- Balderas E, Eberhardt DR, Lee S, Pleinis JM, Sommakia S, Balynas AM, Yin X, Parker MC, Maguire CT, Cho S, Szulik MW, Bakhtina A, Bia RD, Friederich MW, Locke TM, Van Hove JLK, Drakos SG, Sancak Y, Tristani-Firouzi M, Franklin S, Rodan AR, Chaudhuri (2022). Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment. Nature communications, 13(1), 2769.
Review
- Eberhardt DR, Chaudhuri (2026). Mitochondrial Calcium Signaling in Hepatocyte Health and Disease. Cold Spring Harbor perspectives in biology, 18(3),
- Balderas E, Lee SHJ, Rai NK, Mollinedo DM, Duron HE, Chaudhuri (2024). Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease. Physiology (Bethesda, Md.), 39(5), 0.
- Lee SH, Duron HE, Chaudhuri (2023). Beyond the TCA cycle: new insights into mitochondrial calcium regulation of oxidative phosphorylation. Biochemical Society transactions, 51(4), 1661-1673.
Book Chapter
- Balderas E, Sommakia S, Eberhardt D, Lee S, Chaudhuri (2023). The structural era of the mitochondrial calcium uniporter. 12-1 to 12-22.
Editorial
- Balderas E, Chaudhuri (2023). Absence (of the uniporter) makes the heart grow fonder: The cardiac response to injury adapts after prolonged EMRE inhibition. Journal of molecular and cellular cardiology, 181, 31-32.