Frederic C. Clayton
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Frederic C. Clayton, MD

Languages spoken: English

  • Dr. Clayton's recent work has focused on the immunologic aspects of allergic diseases.

    Specialties

    • Pathology, Anatomical

    Board Certification

    American Board of Pathology (Sub: Anatomic Path)

  • Dr. Clayton's recent work has focused on the immunologic aspects of allergic diseases.

    Board Certification and Academic Information

    Academic Departments Pathology -Professor
    Board Certification
    American Board of Pathology (Sub: Anatomic Path)

    Education history

    Undergraduate Rice University B.A.
    Professional Medical Medicine - Washington University M.D.
    Internship Anatomic & Clinical Pathology - Stanford University Medical Center Intern
    Residency Anatomic Pathology - Stanford University Medical Center Resident
    Fellowship Surgical Pathology - University of Minnesota Hospitals Fellow
    Fellowship Anatomic Pathology - M.D. Anderson Cancer Center Fellow
    Residency Clinical Pathology - University of Utah School of Medicine Resident

    Selected Publications

    Journal Article

    1. Dong ZM, Lin E, Wechsler ME, Weller PF, Klion AD, Bochner BS, Delker DA, Hazel MW, Fairfax K, Khoury P, Akuthota P, Merkel PA, Dyer AM, Langford C, Specks U, Gleich GJ, Chinchilli VM, Raby B, Yandell M, Clayton (2020). Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features. The American journal of pathology, 190(7), 1438-1448. (Read full publication)
    2. Swanson EA, March JK, Clayton F, Couturier MR, Arcega R, Smith R, Evason K (2018). Epithelial Inclusions in Gallbladder Specimens Mimic Parasite Infection: Histologic and Molecular Examination of Reported Cystoisospora belli Infection in Gallbladders of Immunocompetent Patients. The American journal of surgical pathology, 42(10), 1346-1352. (Read full publication)
    3. Peterson KA, Yoshigi M, Hazel MW, Delker DA, Lin E, Krishnamurthy C, Consiglio N, Robson J, Yandell M, Clayton (2018). RNA sequencing confirms similarities between PPI-responsive oesophageal eosinophilia and eosinophilic oesophagitis. Alimentary pharmacology & therapeutics, 48(2), 219-225. (Read full publication)
    4. Saffari H, Peterson KA, Leiferman KM, Stabin MG, Krstyen JJ, Clayton FC, Pease LF 3rd, Yap JT, Hoffman JM, Gleich G (2020). Oral Administration of 99mTechnetium-Labeled Heparin in Eosinophilic Esophagitis. Mayo Clinic proceedings, 95(3), 449-458. (Read full publication)
    5. Clayton F, Peterson (2018). Eosinophilic Esophagitis: Pathophysiology and Definition. Gastrointestinal endoscopy clinics of North America, 28(1), 1-14. (Read full publication)
    6. Peterson KA, Gleich GJ, Limaye NS, Crispin H, Robson J, Fang J, Saffari H, Clayton F, Leiferman K (2019). Eosinophil granule major basic protein 1 deposition in eosinophilic esophagitis correlates with symptoms independent of eosinophil counts. Diseases of the esophagus, 32(11), (Read full publication)
    7. Li L, Luo C, Song Z, Reyes-Vargas E, Clayton F, Huang J, Jensen P, Chen (2018). Association of anti-HER2 antibody with graphene oxide for curative treatment of osteosarcoma. Nanomedicine, 14(2), 581-593. (Read full publication)
    8. Eroh GD, Clayton FC, Florell SR, Cassidy PB, Chirife A, Marón CF, Valenzuela LO, Campbell MS, Seger J, Rowntree VJ, Leachman S (2017). Cellular and ultrastructural characterization of the grey-morph phenotype in southern right whales (Eubalaena australis). PloS one, 12(2), e0171449. (Read full publication)
    9. COREOS Collaborators:., Ma C, Schoepfer AM, Dellon ES, Bredenoord AJ, Chehade M, Collins MH, Feagan BG, Furuta GT, Gupta SK, Hirano I, Jairath V, Katzka DA, Pai RK, Rothenberg ME, Straumann A, Aceves SS, Alexander JA, Arva NC, Atkins D, Biedermann L, Blanchard C, Cianferoni A, Ciriza de Los Rios C, Clayton F, Davis CM, de Bortoli N, Dias JA, Falk GW, Genta RM, Ghaffari G, Gonsalves N, Greuter T, Hopp R, Hsu Blatman KS, Jensen ET, Johnston D, Kagalwalla AF, Larsson HM, Leung J, Louis H, Masterson JC, Menard-Katcher C, Menard-Katcher PA, Moawad FJ, Muir AB, Mukkada VA, Penagini R, Pesek RD, Peterson K, Putnam PE, Ravelli A, Savarino EV, Schlag C, Schreiner P, Simon D, Smyrk TC, Spergel JM, Taft TH, Terreehorst I, Vanuytsel T, Venter C, Vieira MC, Vieth M, Vlieg-Boerstra B, von Arnim U, Walker MM, Wechsler JB, Woodland P, Woosley JT, Yang GY, Zevit N, Safroneeva (2022). Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS). The Journal of allergy and clinical immunology, 149(2), 659-670. (Read full publication)
    10. Ma C, Schoepfer AM, Safroneeva E, COREOS Collaborators (2021). A Summary of the Meetings of the Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) International Multidisciplinary Consensus. Gastroenterology, 161(3), 778-784. (Read full publication)
    11. Ma C, Schoepfer AM, Safroneeva E, COREOS Collaborators., COREOS Collaborators (2021). Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS): An International Multidisciplinary Consensus. Gastroenterology, 161(3), 748-755. (Read full publication)
    12. Peterson K, Clayton F, Qeadan F, Gorman D, Robson J, Allen-Brady K, Fang J (2022). Esophageal Eosinophilia Is Common Among Relatives of Eosinophilic Esophagitis Patients. Clinical gastroenterology and hepatology, 20(5), e957-e963. (Read full publication)
    13. Boylan KE, Kanth P, Delker D, Hazel MW, Boucher KM, Affolter K, Clayton F, Evason KJ, Jedrzkiewicz J, Pletneva M, Samowitz W, Swanson E, Bronner M (2023). Three pathologic criteria for reproducible diagnosis of colonic sessile serrated lesion versus hyperplastic polyp. Human pathology, 137, 25-35. (Read full publication)
    14. Warren KJ, Deering-Rice C, Huecksteadt T, Trivedi S, Venosa A, Reilly C, Sanders K, Clayton F, Wyatt TA, Poole JA, Heller NM, Leung D, Paine R 3r (2023). Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance. Biology of sex differences, 14(1), 2. (Read full publication)
    15. Bowen AR, Duffy KL, Clayton FC, Andtbacka RH, Florell S (2015). Benign melanocytic lymph node deposits in the setting of giant congenital melanocytic nevi: the large congenital nodal nevus. Journal of cutaneous pathology, 42(11), 832-9. (Read full publication)
    16. Allen-Brady K, Clayton F, Hazel MW, Stevens J, Pyne AL, Pletneva MA, Cessna M, Stubben C, Robson J, Fang J, Peterson K (2025). Overlap of Genomic and Transcriptomic Genes Identified in Familial Eosinophilic Esophagitis. Gastroenterology, 168(6), 1101-1113.e18. (Read full publication)

    Case Report

    1. Gutnik L, Goold E, Madsen J, Clayton F, Varghese T, Glasgow (2021). Primary Esophageal Angiosarcoma. The Annals of thoracic surgery, 111(5), e365-e367. (Read full publication)

    Letter

    1. Kator S, Zurko J, Webb BJ, Balatico MA, Clayton F, Palmer CA, Konopa K, Motyckova G, Ford CD, Ostronoff (2020). Disseminated toxoplasmosis and haemophagocytic lymphohistiocytosis following chimeric antigen receptor T-cell therapy. British journal of haematology, 189(1), e4-e6. (Read full publication)
    2. Poole A, Girard N, Clayton F, Tantravahi S (2017). Rapid onset of hemophagocytic lymphohistiocytosis in a patient with refractory chronic lymphocytic leukemia treated with ibrutinib. Leukemia & lymphoma, 58(5), 1258-1261. (Read full publication)