Guillaume Lamotte

Guillaume Lamotte, MD, MSc

Languages spoken: English, French

Clinical Locations

Clinical Neurosciences Center

801-585-7575

  • Dr. Lamotte has a broad background in medicine and neurology with specialty training and expertise in movement disorders and autonomic disorders. He completed a neurology residency at the University Hospital of Caen in France and did a year of supplementary training in movement disorders during his first neurology residency. He then completed the clinician-scientist track between the National Institutes of Health (NIH) and Medstar Georgetown University Hospital as his second neurology residency in the United States.

    He worked under the guidance of Dr. David Goldstein in the autonomic medicine section at the NIH and developed his clinical skills in autonomic medicine through history taking and physical examinations, as well as exposure to autonomic function testing procedures. He gained experience in conducting clinical research in autonomic disorders focusing on autonomic nervous system dysfunction in synucleinopathies.

    He completed a clinical fellowship at the Mayo Clinic in Rochester, MN, where he had a broad exposure to various autonomic disorders in the clinic and autonomic laboratory. He is pursuing an academic career focused on clinical research in the fields of autonomic and movement disorders and is currently an assistant professor in neurology at the University of Utah, Salt Lake City, UT, where he sees patients with movement disorders and autonomic disorders. Forty percent of his time is dedicated to research where he focuses on autonomic dysfunction in synucleinopathies.

    Specialties

    Board Certification

    American Board of Psychiatry & Neurology (Neurology)
    Educational Commission for Foreign Medical Graduates
    National Board of Medical Examiners

  • Dr. Lamotte has a broad background in medicine and neurology with specialty training and expertise in movement disorders and autonomic disorders. He completed a neurology residency at the University Hospital of Caen in France and did a year of supplementary training in movement disorders during his first neurology residency. He then completed the clinician-scientist track between the National Institutes of Health (NIH) and Medstar Georgetown University Hospital as his second neurology residency in the United States.

    He worked under the guidance of Dr. David Goldstein in the autonomic medicine section at the NIH and developed his clinical skills in autonomic medicine through history taking and physical examinations, as well as exposure to autonomic function testing procedures. He gained experience in conducting clinical research in autonomic disorders focusing on autonomic nervous system dysfunction in synucleinopathies.

    He completed a clinical fellowship at the Mayo Clinic in Rochester, MN, where he had a broad exposure to various autonomic disorders in the clinic and autonomic laboratory. He is pursuing an academic career focused on clinical research in the fields of autonomic and movement disorders and is currently an assistant professor in neurology at the University of Utah, Salt Lake City, UT, where he sees patients with movement disorders and autonomic disorders. Forty percent of his time is dedicated to research where he focuses on autonomic dysfunction in synucleinopathies.

    Board Certification and Academic Information

    Academic Departments Neurology -Primary
    Board Certification
    American Board of Psychiatry & Neurology (Neurology)
    Educational Commission for Foreign Medical Graduates
    National Board of Medical Examiners

    Education history

    Fellowship Autonomic Disorders - Mayo Clinic Fellow
    Neurology - National Institutes of Health / MedStar Georgetown University Hospital Academic Chief Resident
    Residency Neurology (Clinician Scientist Track) - National Institutes of Health / MedStar Georgetown University Hospital Resident
    Internal Medicine - National Institutes of Health / MedStar Georgetown University Hospital Resident
    Graduate Training Neurosciences - University of Caen M.S.
    Movement Disorders - Groupe Hospitalier Pitié Salpêtrière, Paris, France Diploma
    Residency Neurology - University Hospital of Caen Basse Normandie Resident
    Medicine - University of Caen Basse-Normandie M.D.
    Graduate Training Anatomy - University of Caen Basse-Normandie M.S.
    Infectious Disease and Tropical Disease - University of Caen Basse-Normandie M.S.

    Selected Publications

    Journal Article

    1. Lamotte G, Coon EA, Suarez MD, Sandroni P, Benarroch E, Cutsforth-Gregory JK, Mauermann ML, Berini SE, Shouman K, Sletten D, Goodman BP, Low PA, Singer W (2021). Standardized Autonomic Testing in Patients With Probable Radiation-Induced Afferent Baroreflex Failure. Hypertension, 79(1), 50-56.
    2. Castillo-Pinto C, Lamotte G, Mehta A, Sonti R, Di Maria G, Ruiz D, Kumar PN, Stemer AB, Denny MC (2020). Healthcare Worker With Large Vessel Acute Ischemic Stroke Likely Related to Mild SARS-CoV-2 Infection. Neurohospitalist, 12(1), 48-56.
    3. Goldstein DS, Isonaka R, Lamotte G, Kaufmann H (2021). Different phenoconversion pathways in pure autonomic failure with versus without Lewy bodies. Clin Auton Res, 31(6), 677-684.
    4. Lamotte G, Shouman K, Benarroch EE (2021). Stress and central autonomic network. Auton Neurosci, 235, 102870.
    5. Laureno R, Lamotte G (2022). The midline cerebellar lesion in experimental Wernicke disease. Neurol India, 69(6), 1624.
    6. Lamotte G, Sandroni P, Cutsforth-Gregory JK, Berini SE, Benarroch EE, Shouman K, Mauermann ML, Anderson J, Low PA, Singer W, Coon EA (2021). Clinical presentation and autonomic profile in Ross syndrome. J Neurol, 268(10), 3852-3860.
    7. Lamotte G, Sandroni P (2021). A practical approach to peripheral autonomic neuropathies. Curr Opin Neurol, 34(5), 638-647.
    8. Lamotte G, Takahashi M, Wu T, Sullivan P, Cherup J, Holmes C, Goldstein DS (2021). Do indices of baroreflex failure and peripheral noradrenergic deficiency predict the magnitude of orthostatic hypotension in Lewy body diseases? Clin Auton Res, 31(4), 543-551.
    9. Lamotte G (2021). Central pontine myelinolysis secondary to rapid correction of hyponatremia historical perspective with Doctor Robert Laureno. Neurol Sci, 42(8), 3479-3483.
    10. Lamotte G, Coon EA, Suarez MD, Sandroni P, Benarroch EE, Cutsforth-Gregory JK, Mauermann ML, Berini SE, Shouman K, Sletten D, Goodman BP, Low PA, Singer W (2021). Natural History of Afferent Baroreflex Failure in Adults. Neurology, 97(2), e136-e144.
    11. Goldstein DS, Sullivan P, Holmes C, Lamotte G, Lenka A, Sharabi Y (2021). Differential abnormalities of cerebrospinal fluid dopaminergic versus noradrenergic indices in synucleinopathies. J Neurochem, 158(2), 554-568.
    12. Shouman K, Vanichkachorn G, Cheshire WP, Suarez MD, Shelly S, Lamotte GJ, Sandroni P, Benarroch EE, Berini SE, Cutsforth-Gregory JK, Coon EA, Mauermann ML, Low PA, Singer W (2021). Autonomic dysfunction following COVID-19 infection: an early experience. Clin Auton Res, 31(3), 385-394.
    13. Lenka A, Mittal SO, Lamotte G, Pagan FL (2020). A Pragmatic Approach to the Perioperative Management of Parkinson's Disease. Can J Neurol Sci, 48(3), 299-307.
    14. Lamotte G, Benarroch EE (2021). What Is the Clinical Correlation of Cardiac Noradrenergic Denervation in Parkinson Disease? Neurology, 96(16), 748-753.
    15. Lenka A, Lamotte G, Goldstein DS (2021). Cardiac 18F-Dopamine PET Distinguishes PD with Orthostatic Hypotension from Parkinsonian MSA. Mov Disord Clin Pract, 8(4), 582-586.
    16. Lamotte G, Lenka A (2021). Brainstem Predominant Posterior Reversible Encephalopathy Syndrome. Neurol India, 69(2), 536-537.
    17. Lamotte G, Holmes C, Sullivan P, Lenka A, Goldstein DS (2020). Cardioselective peripheral noradrenergic deficiency in Lewy body synucleinopathies. Ann Clin Transl Neurol, 7(12), 2450-2460.
    18. Castillo-Pinto C, Lamotte G, et al (2020). Healthcare Worker With Large Vessel Acute Ischemic Stroke Likely Related to Mild SARS-CoV-2 Infection. Neurohospitalist.
    19. Lamotte G, Holmes C, Wu T, Goldstein DS (2019). Long-term trends in myocardial sympathetic innervation and function in synucleinopathies. Parkinsonism Relat Disord, 67, 27-33.
    20. Lamotte G, Holmes C, Sullivan P, Goldstein DS (2018). Substantial renal conversion of L-threo-3,4-dihydroxyphenylserine (droxidopa) to norepinephrine in patients with neurogenic orthostatic hypotension. Clin Auton Res, 29(1), 113-117.
    21. Laureno R, Lamotte G, Mark AS (2018). Sequential MRI in pontine and extrapontine myelinolysis following rapid correction of hyponatremia. BMC Res Notes, 11(1), 707.
    22. Lamotte G (2018). Author response: Mystery Case: A case of fulminant encephalopathy in a 69-year-old woman. Neurology, 90(15), 714.
    23. Lamotte G, Farzal Z, Zimmerman WD, Han S, de Brito P, Mayson D (2017). Clinical Reasoning: Monocular vision loss, ophthalmoplegia, and strokes in a 61-year-old man with diabetes mellitus. Neurology, 89(24), e276-e281.
    24. Lamotte G, Williams C (2017). Mystery Case: A case of fulminant encephalopathy in a 69-year-old woman. Neurology, 89(9), e109-e114.
    25. Lamotte G, Shah RC, Lazarov O, Corcos DM (2016). Exercise Training for Persons with Alzheimer's Disease and Caregivers: A Review of Dyadic Exercise Interventions. J Mot Behav, 49(4), 365-377.
    26. Lamotte G, Agostini D (2015). Erratum to: Cardiac 123I-MIBG scintigraphy: A window into the brain in Parkinsonism? J Nucl Cardiol, 24(1), 111.
    27. Lamotte G, Morello R, Lebasnier A, Agostini D, Bouvard G, De La Sayette V, Defer GL (2016). Influence of education on cognitive performance and dopamine transporter binding in dementia with Lewy bodies. Clin Neurol Neurosurg, 146, 138-43.
    28. Lebasnier A, Lamotte G, Manrique A, Peyronnet D, Bouvard G, Defer G, Agostini D (2015). Potential diagnostic value of regional myocardial adrenergic imaging using (123)I-MIBG SPECT to identify patients with Lewy body diseases. Eur J Nucl Med Mol Imaging, 42(7), 1043-51.
    29. Lamotte G, Morello R, Lebasnier A, Agostini D, Defer GL (2015). Accuracy and cutoff values of delayed heart to mediastinum ratio with (123)I-metaiodobenzylguanidine cardiac scintigraphy for Lewy body disease diagnoses. BMC Neurol, 15, 83.
    30. Lamotte G, Skender E, Rafferty MR, David F, Sadowsky S, Corcos DM (2015). Effects of progressive resistance exercise training on the motor and non-motor features of Parkinson’s disease: a review. 4, 11-27.
    31. Lamotte G, Rafferty MR, Prodoehl J, Kohrt WM, Comella CL, Simuni T, Corcos DM (2014). Effects of endurance exercise training on the motor and non-motor features of Parkinson's disease: a review. J Parkinsons Dis, 5(1), 21-41.

    Editorial

    1. Lamotte G, Goldstein DS (2022). What new can we learn from cardiac sympathetic neuroimaging in synucleinopathies? Clin Auton Res.
    2. Lamotte G, Millar Vernetti P (2021). Inhibition of the norepinephrine transporter to treat neurogenic orthostatic hypotension: is this the end of the story? Clin Auton Res, 31(6), 645-647.
    3. Lamotte G, Boes CJ, Low PA, Coon EA (2021). The expanding role of the cold pressor test: a brief history. Clin Auton Res, 31(2), 153-155.
    4. Lamotte G, Becker B (2020). Toward biomarker-based clinical subtyping of Parkinson disease. Neurology, 95(11), 461-462.
    5. Guillaume L, Denis A (2015). Cardiac 123I-MIBG scintigraphy: A window into the brain in Parkinsonism? J Nucl Cardiol, 24(1), 108-110.

    Letter

    1. Zahid A, Coon EA, Lamotte G (2021). "No man is an island"-unique pattern of anhidrosis with islands of preserved sweat in Ross syndrome. [Letter to the editor]. Neurol Sci, 42(12), 5399-5400.
    2. Cutsforth-Gregory JK, Benarroch EE, Lamotte G (2021). Platypnea-orthodeoxia syndrome mimicking postural orthostatic tachycardia syndrome. [Letter to the editor]. Clin Auton Res, 31(4), 573-576.
    3. Lamotte G, Sandroni P (2021). A case of Ross syndrome associated with systemic sclerosis. [Letter to the editor]. Clin Auton Res, 31(3), 463-465.
    4. Lamotte G, Benarroch EE, Coon EA (2021). Paroxysmal hypothermia and hyperhidrosis with exacerbation after COVID-19 Infection. [Letter to the editor]. Clin Auton Res, 31(2), 327-329.
    5. Chochol MD, Kataria L, ORourke MC, Lamotte G (2019). Clozapine-Associated Myoclonus and Stuttering Secondary to Smoking Cessation and Drug Interaction: A Case Report. [Letter to the editor]. J Clin Psychopharmacol, 39(3), 275-277.
    6. Lamotte G, Laballe R, Dupuy B (2014). Bilateral eyelid retraction, loss of vision, ophthalmoplegia: an atypical triad in anti-GQ1b syndrome. [Letter to the editor]. Rev Neurol (Paris), 170(6-7), 469-70.
    7. Lamotte G, Caillot A, Di Palma C, Lechapt-Zalcman E, Benateau H, Cogez J (2014). Intramedullary metastasis of a cutaneous squamous cell carcinoma. [Letter to the editor]. Rev Neurol (Paris), 170(3), 230-2.
    8. Lamotte G, Danaila TC, Jaillon-Rivire V, Hitier M, Defer GL (2013). Paraneoplastic opsoclonus myoclonus with autoantibodies to glutamic acid decarboxylase. [Letter to the editor]. Rev Neurol (Paris), 170(1), 50-1.
    9. Lamotte G, Cogez J, Viader F (2012). Interferon-β-1a-induced psychosis in a patient with multiple sclerosis. [Letter to the editor]. Psychiatry Clin Neurosci, 66(5), 462.

    Other

    1. Lamotte G, Rafferty MR, Prodoehl J, Kohrt WM, Comella CL, Simuni T, Corcos DM (2015). Effects of Endurance Exercise Training on The Motor and Non-Motor Features of Parkinson's Disease: A Review. J Parkinsons Dis (5(3), p. 621). Netherlands.
    2. Lamotte G, Rafferty MR, Prodoehl J, Kohrt WM, Comella CL, Simuni T, Corcos DM (2015). Effects of Endurance Exercise Training on The Motor and Non-Motor Features of Parkinson's Disease: A Review. J Parkinsons Dis (5(4), p. 993). Netherlands.