Jonathan Robert Genzen
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Jonathan Robert Genzen, MD, PhD, MBA

Languages spoken: English

Dr. Genzen is a Professor (Clinical) in the Department of Pathology at the University of Utah. He serves as Chief Medical Officer at ARUP Laboratories, where he is Medical Director of Automation and a Co-Medical Director of the Automated Core Laboratory. He is board certified in Clinical Pathology by the American Board of Pathology and is a Fellow of the American Society for Clinical Pathology. He is a member of the American Association for Clinical Chemistry and the Academy of Clinical Laboratory Physicians and Scientists.

Dr. Genzen received both his Ph.D. and M.D. from the University of Chicago. He completed his clinical pathology residency at Yale-New Haven Hospital / Yale University in the Department of Laboratory Medicine, where he also conducted his postdoctoral research fellowship. Dr. Genzen’s clinical and research focus is on automated clinical chemistry, quality improvement, and process efficiency initiatives.

Specialties

  • Pathology, Clinical

Board Certification

American Board of Pathology (Clinical Path)

Dr. Genzen is a Professor (Clinical) in the Department of Pathology at the University of Utah. He serves as Chief Medical Officer at ARUP Laboratories, where he is Medical Director of Automation and a Co-Medical Director of the Automated Core Laboratory. He is board certified in Clinical Pathology by the American Board of Pathology and is a Fellow of the American Society for Clinical Pathology. He is a member of the American Association for Clinical Chemistry and the Academy of Clinical Laboratory Physicians and Scientists.

Dr. Genzen received both his Ph.D. and M.D. from the University of Chicago. He completed his clinical pathology residency at Yale-New Haven Hospital / Yale University in the Department of Laboratory Medicine, where he also conducted his postdoctoral research fellowship. Dr. Genzen’s clinical and research focus is on automated clinical chemistry, quality improvement, and process efficiency initiatives.

Board Certification and Academic Information

Academic Departments Pathology -Professor (Clinical)
Board Certification
American Board of Pathology (Clinical Path)

Education history

Undergraduate Biological Sciences / Neurobiology Concentration & International Studies - Northwestern University, College of Arts and Sciences B.A.
Professional Medical University of Chicago, Pritzker School of Medicine M.D.
Doctoral Training University of Chicago, Committee on Neurobiology Ph.D.
Residency Clinical Pathology - Yale-New Haven Hospital and VA Connecticut Healthcare System Resident
Research Fellow Yale University School of Medicine, Department of Laboratory Medicine Postdoctoral Research Fellow
Graduate Training Joint Executive MBA Americas Program - Cornell University and Queen's University EMBA

Selected Publications

Journal Article

  1. Genzen JR, Miller LJ, Rets AV, Affolter K (2025). Laboratory-developed tests and in vitro diagnostics: A regulatory overview for anatomic pathology. American journal of clinical pathology, 163(5), 730-743.
  2. Shean RC, Genzen JR, Spies N (2025). Large Language Models Lack Sufficient Performance to Provide Definitive Regulatory Guidance. The journal of applied laboratory medicine,
  3. Manthei DM, Souers RJ, Melanson SEF, Genzen J (2025). Estimated Glomerular Filtration Rate Reporting From Whole Blood Creatinine: A Proficiency Testing Survey. Archives of pathology & laboratory medicine, 149(12), 1060-1061.
  4. Genzen JR, Moser K (2024). The FDA's proposed rule on laboratory-developed tests: what happens next?. Laboratory medicine,
  5. Smith L, Carricaburu LA, Genzen J (2024). The US FDA's proposed rule on laboratory-developed tests: Impacts on clinical laboratory testing. Practical laboratory medicine, 40, e00407.
  6. Merrill AE, Hackenmueller SA, Derdeyn C, Genzen J, Gruson D, Ludgate M, Mulchandani S, Parnas ML, Ranheim (2024). Beyond the Screen: Navigating Remote Work within Medicine. Clinical chemistry, 70(8), 1009-1016.
  7. Chambliss AB, Souers RJ, Genzen JR, Manthei D (2024). Reported Awareness and Use of Pyridoxal-5'-Phosphate Supplementation in Alanine Aminotransferase and Aspartate Aminotransferase Assay Reagents: A Survey by the College of American Pathologists Clinical Chemistry Committee. Archives of pathology & laboratory medicine,
  8. van Wijk XMR, Master SR, Genzen J (2024). FDA's Final Rule on Laboratory Developed Tests. Clinical chemistry, 70(9), 1192-1194.
  9. Brown HM, Farnsworth CW, Bryan A, Genzen JR, Gronowski A, Philips Deeter J, Yarbrough (2023). One Bad Apple Can Spoil the Bunch: The Impact of Contamination in the Clinical Laboratory. Clinical chemistry, 69(1), 9-16.
  10. Rychert J, Genzen J (2023). Modifications of FDA-cleared/approved tests. American journal of clinical pathology, 160(5), 542.
  11. Rychert J, Schmidt RL, Genzen J (2023). Laboratory-Developed Tests Account for a Small Minority of Tests Ordered in an Academic Hospital System. American journal of clinical pathology, 160(3), 297-302.
  12. Ondracek CR, Genzen JR, Lockwood CM, Das S, Kang P, Melanson SE (2023). Robust Response of the Clinical Laboratory to the COVID-19 Pandemic despite Significant Challenges. The journal of applied laboratory medicine, 8(6), 1160-1172.
  13. Hunsaker JJH, La'ulu SL, LaGrave D, Murphy W, Reichman HA, Snow TM, McMillin GA, Johnson-Davis KL, Genzen J (2022). Tobacco and Cannabis Use During Pregnancy. American journal of clinical pathology, 157(1), 146-152.
  14. Genzen JR, Nwosu A, Long T, Murphy H, Alter D (2022). An International Survey of Glucose-6-Phosphate Dehydrogenase Laboratory Reporting Practices: Implications for Tafenoquine Eligibility Assessment. Archives of pathology & laboratory medicine, 146(10), 1211-1217.
  15. Brown K, Duzan D, Fong K, Freeman VS, Genzen J, Goodyear N, Harrington SM, Taff T, Tanabe P (2022). ASCP Board of Certification Survey of Medical Laboratory Science Education 2020: Faculty. Laboratory medicine, 53, e159-e163.
  16. Brown K, Duzan D, Fong K, Freeman VS, Genzen J, Goodyear N, Harrington SM, Taff T, Tanabe P (2022). ASCP Board of Certification Survey of Medical Laboratory Science Education 2020: Programs. Laboratory medicine, 53, e154-e158.
  17. Johnson LM, Genzen JR, Algeciras-Schimnich A, Bornhorst J, Lambert-Messerlian (2022). PAPP-A Results Cannot Be Used to Accurately Estimate Gestational Age. The journal of applied laboratory medicine, 7, 1000-1002.
  18. Genzen JR, Rychert J, George T (2022). Integrity of SARS-CoV-2 Laboratory-Developed Tests. JAMA, 328(5), 478.
  19. Wyness SP, Snow TM, Villanueva M, Kunzler T, Seiter J, Genzen JR, Johnson L (2022). Impact of Unconjugated estriol (uE3) assay interference on prenatal screening tests. Clinica chimica acta; international journal of clinical chemistry, 536, 1-5.
  20. Allison TR, Hunsaker JJH, La'ulu SL, Genzen J (2022). Evaluation of an adenosine deaminase (ADA) assay in serum, pleural, pericardial, peritoneal, and cerebrospinal fluids on the Roche cobas c501 analyzer. Clinical biochemistry, 109-110, 57-63.
  21. Erickson JA, Chiang FI, Walker CM, Genzen JR, Doyle (2022). Comparison of two chromogranin A assays and investigation of nonlinear specimens. Practical laboratory medicine, 32, e00299.
  22. Genzen JR, Souers RJ, Pearson LN, Manthei DM, Chambliss AB, Shajani-Yi Z, Miller W (2022). Reported Awareness and Adoption of 2021 Estimated Glomerular Filtration Rate Equations Among US Clinical Laboratories, March 2022. JAMA, 328(20), 2060-2062.
  23. Jackson BR, Genzen J (2021). The Lab Must Go On. American journal of clinical pathology, 155(1), 4-11.
  24. Smy L, De Biase I, Genzen JR, Yuzyuk (2021). The nuclear magnetic resonance metabolic profile: Impact of fasting status. Clinical biochemistry, 87, 85-92.
  25. Pandya V, Hunsaker JJH, La'ulu SL, Genzen JR, Frank EL, Johnson LM, Rudolf J (2021). Excessively low cholesterol and triglyceride levels in an apparently healthy patient. Clinical biochemistry, 96, 78-81.
  26. Patel MK, El-Khoury JM, Simundic EA, Farnsworth CW, Broell F, Genzen JR, Amukele T (2021). Evolution of Blood Sample Transportation and Monitoring Technologies. Clinical chemistry, 67(6), 812-819.
  27. Haspel RL, Genzen JR, Wagner J, Fong K, Undergraduate Training in Genomics (UTRIG) Working Group., Wilcox R (2021). Call for improvement in medical school training in genetics: results of a national survey. Genetics in medicine, 23(6), 1151-1157.
  28. La'ulu SL, Turner DR, Zupan E, Genzen J (2021). Pretreatment of Body Fluid Specimens Using Hyaluronidase and Ultracentrifugation. Laboratory medicine, 52, 469-476.
  29. Calvaresi EC, La'ulu SL, Snow TM, Allison TR, Genzen J (2021). Plasma hemoglobin: A method comparison of six assays for hemoglobin and hemolysis index measurement. International journal of laboratory hematology, 43, 1145-1153.
  30. Rychert J, Couturier MR, Elgort M, Lozier BK, La'ulu S, Genzen JR, Straseski JA, Delgado JC, Slev P (2021). Evaluation of 3 SARS-CoV-2 IgG Antibody Assays and Correlation with Neutralizing Antibodies. The journal of applied laboratory medicine, 6(3), 614-624.
  31. Klutts JS, Genzen J (2021). Disparities and Bias in Pathology and Laboratory Medicine. The journal of applied laboratory medicine, 6(1), 3-6.
  32. Nelson HA, Genzen JR, Delgado JC, Rudolf J (2021). An Interference in an Automated HCO3- Assay Leads to an Unexpected IgG Monoclonal Gammopathy Diagnosis. The journal of applied laboratory medicine, 7, 622-625.
  33. Calvaresi EC, Genzen J (2020). Evaluating Percentage-Based Reporting of Glucose-6-Phosphate Dehydrogenase (G6PD) Enzymatic Activity. American journal of clinical pathology, 154(2), 248-254.
  34. Peedin AR, Genzen JR, Karp J (2020). Correlating Transfusion Medicine In-Service Examination Scores With Outcomes of the American Board of Pathology Transfusion Medicine Subspecialty Certifying Examination. American journal of clinical pathology, 153(4), 497-501.
  35. Haspel RL, Genzen JR, Wagner J, Lockwood CM, Fong K, Training Residents in Genomics (TRIG) Working Group (2020). Integration of Genomic Medicine in Pathology Resident Training. American journal of clinical pathology, 154(6), 784-791.
  36. Lakshmipathi J, Gao Y, Hu C, Stuart D, Genzen J, Ramkumar N, Kohan D (2020). Nephron-Specific Disruption of Polycystin-1 Induces Cyclooxygenase-2-Mediated Blood Pressure Reduction Independent of Cystogenesis. Journal of the American Society of Nephrology, 31(6), 1243-1254.
  37. Rychert J, Delgado JC, Genzen J (2020). Modification of In Vitro Diagnostic Devices: Leveling the Playing Field. Clinical chemistry, 66(6), 760-762.
  38. Naides SJ, Genzen JR, Abel G, Bashleben C, Ansari M (2020). Antinuclear Antibodies Testing Method Variability: A Survey of Participants in the College of American Pathologists' Proficiency Testing Program. The Journal of rheumatology, 47(12), 1768-1773.
  39. Roundy CS, Lin DC, Klopping PJ, Ence AT, Krezel AC, Genzen J (2020). Specimen Temperature Detection on a Clinical Laboratory Pre-Analytic Automation Track: Implications for Direct-from-Track Total Laboratory Automation (TLA) Systems. SLAS technology, 25(3), 293-299.
  40. Genzen J (2019). Regulation of Laboratory-Developed Tests. American journal of clinical pathology, 152(2), 122-131.
  41. Hunsaker JJH, Wyness SP, Needham LL, Genzen J (2019). Evaluation of L-index interference limits on Roche cobas c502 and c702 immunoturbidimetric assays using endogenously lipemic specimens and intralipid spiking. Clinical biochemistry, 70, 18-23.
  42. Genzen JR, La'ulu SL, Wyness SP, Scholes KL, Signorelli HN, Greer R (2019). Identifying and Eliminating Laboratory Contamination by Topical Testosterone Therapeutics. Clinical chemistry, 65(1), 67-73.
  43. Needham LL, Smy L, Lee MA, Kunzler TM, Genzen J (2019). Phlebotomy tube interference with nuclear magnetic resonance (NMR) lipoprotein subclass analysis. Clinica chimica acta; international journal of clinical chemistry, 488, 235-241.
  44. Brown K, Parker Fenn J, Fong K, Freeman V, Genzen J, Goodyear N, Lunz Houston M, Taff T, Tanabe (2019). ASCP Board of Certification Survey of Medical Laboratory Science Faculty. Laboratory medicine, 50(4), e75-e81.
  45. Mohlman JS, Genzen JR, Weiss RL, Schmidt R (2019). Reliability and Validity of Proposed Risk Stratification Methods for Laboratory Developed Tests. Laboratory medicine, 50(2), 194-201.
  46. Brown K, Fenn JP, Fong K, Freeman V, Genzen J, Goodyear N, Lunz Houston M, Taff T, Tanabe (2019). ASCP Board of Certification Survey of Medical Laboratory Science Education Programs. Laboratory medicine, 50(4), e70-e74.
  47. Maharjan AS, Wyness SP, Ray JA, Willcox TL, Seiter JD, Genzen J (2019). Detection and characterization of estradiol (E2) and unconjugated estriol (uE3) immunoassay interference due to anti-bovine alkaline phosphatase (ALP) antibodies. Practical laboratory medicine, 17, e00131.
  48. Genzen JR, Murray DL, Abel G, Meng QH, Baltaro RJ, Rhoads DD, Delgado JC, Souers RJ, Bashleben C, Keren DF, Ansari M (2018). Screening and Diagnosis of Monoclonal Gammopathies: An International Survey of Laboratory Practice. Archives of pathology & laboratory medicine, 142(4), 507-515.
  49. Lin DC, Genzen J (2018). Concordance analysis of paired cancer antigen (CA) 15-3 and 27.29 testing. Breast cancer research and treatment, 167(1), 269-276.
  50. Owen WE, Hunsaker JJH, Genzen J (2018). Alpha-fetoprotein in pericardial, peritoneal, and pleural fluids: A body fluid matrix evaluation. Clinical biochemistry, 56, 109-112.
  51. Genzen JR, Burnham CD, Felder RA, Hawker CD, Lippi G, Peck Palmer O (2018). Challenges and Opportunities in Implementing Total Laboratory Automation. Clinical chemistry, 64(2), 259-264.
  52. Lu J, Genzen JR, Grenache D (2018). Development of an enzymatic assay to measure lactate in perchloric acid-precipitated cerebrospinal fluid. Clinica chimica acta; international journal of clinical chemistry, 483, 142-144.
  53. Hunsaker JJH, La'ulu SL, Wyness SP, Genzen J (2018). Lipemic interference of ceruloplasmin assays - An evaluation of lipid removal methods. Clinica chimica acta; international journal of clinical chemistry, 480, 71-78.
  54. Rhoads DD, Genzen JR, Bashleben CP, Faix JD, Ansari M (2017). Prevalence of Traditional and Reverse-Algorithm Syphilis Screening in Laboratory Practice: A Survey of Participants in the College of American Pathologists Syphilis Serology Proficiency Testing Program. Archives of pathology & laboratory medicine, 141(1), 93-97.
  55. Genzen JR, Mohlman JS, Lynch JL, Squires MW, Weiss R (2017). Laboratory-Developed Tests: A Legislative and Regulatory Review. Clinical chemistry, 63(10), 1575-1584.
  56. Taylor JR, Thompson PJ, Genzen JR, Hickner J, Marques M (2017). Opportunities to Enhance Laboratory Professionals' Role On the Diagnostic Team. Laboratory medicine, 48(1), 97-103.
  57. Blanchard MG, Kittikulsuth W, Nair AV, de Baaij JH, Latta F, Genzen JR, Kohan DE, Bindels RJ, Hoenderop J (2016). Regulation of Mg2+ Reabsorption and Transient Receptor Potential Melastatin Type 6 Activity by cAMP Signaling. Journal of the American Society of Nephrology, 27(3), 804-13.
  58. Genzen JR, Hunsaker JJ, Nelson LS, Faine BA, Krasowski M (2016). N-acetylcysteine interference of Trinder-based assays. Clinical biochemistry, 49(1-2), 100-4.
  59. Johnson-Davis KL, Sadler AJ, Genzen J (2016). A Retrospective Analysis of Urine Drugs of Abuse Immunoassay True Positive Rates at a National Reference Laboratory. Journal of analytical toxicology, 40(2), 97-107.
  60. Hunsaker JJH, Wyness SP, Snow TM, Genzen J (2016). Clinical performance evaluation of total protein measurement by digital refractometry and characterization of non-protein solute interferences. Practical laboratory medicine, 6, 14-24.
  61. Wyness SP, Hunsaker JJH, Snow TM, Genzen J (2016). Evaluation and analytical validation of a handheld digital refractometer for urine specific gravity measurement. Practical laboratory medicine, 5, 65-74.
  62. Krasowski MD, Savage J, Ehlers A, Maakestad J, Schmidt GA, La'ulu S, Rasmussen NN, Strathmann FG, Genzen J (2015). Ordering of the Serum Angiotensin-Converting Enzyme Test in Patients Receiving Angiotensin-Converting Enzyme Inhibitor Therapy: An Avoidable but Common Error. Chest, 148(6), 1447-1453.
  63. Owen WE, Thatcher ML, Crabtree KJ, Greer RW, Strathmann FG, Straseski JA, Genzen J (2015). Body fluid matrix evaluation on a Roche cobas 8000 system. Clinical biochemistry, 48(13-14), 911-4.
  64. Owen WE, Caron JE, Genzen J (2015). Liver function testing on the Abaxis Piccolo Xpress: Use in Ebola virus disease protocols. Clinica chimica acta; international journal of clinical chemistry, 446, 119-27.
  65. Schmidt RL, Kordy MA, Genzen JR, Straseski JA, Greene DN, Lehman C (2015). A mathematical procedure to estimate the impact of a change in method on discordance or misclassification at a decision limit in laboratory method comparison studies. Clinica chimica acta; international journal of clinical chemistry, 440, 23-30.
  66. Scholes KL, Ence AT, Strathmann FG, Genzen JR (2015). Identification and characterization of EDTA test strip interfering substances using a digital color detector. Clinical laboratory, 61(7), 785-791.
  67. Signorelli H, Straseski JA, Genzen JR, Walker BS, Jackson BR, Schmidt R (2015). Benchmarking to Identify Practice Variation in Test Ordering: A Potential Tool for Utilization Management. Laboratory medicine, 46(4), 356-64.
  68. Scholes KL, La'ulu SL, Ence AT, Logan HL, Parker RL, Strathmann FG, Genzen J (2015). Evaluation of test strips for the rapid identification of ethylenediaminetetraacetic acid (EDTA) specimens. Laboratory medicine, 46(2), 97-108.
  69. La'ulu SL, Straseski JA, Schmidt RL, Genzen J (2014). Thrombin-mediated degradation of parathyroid hormone in serum tubes. Clinica chimica acta; international journal of clinical chemistry, 437, 191-6.
  70. Genzen J (2014). Hypercalcemic crisis due to vitamin D toxicity. Laboratory medicine, 45(2), 147-50.
  71. Kang H, Kerloc'h A, Rotival M, Xu X, Zhang Q, D'Souza Z, Kim M, Scholz JC, Ko JH, Srivastava PK, Genzen JR, Cui W, Aitman TJ, Game L, Melvin JE, Hanidu A, Dimock J, Zheng J, Souza D, Behera AK, Nabozny G, Cook HT, Bassett JH, Williams GR, Li J, Vignery A, Petretto E, Behmoaras (2014). Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. Cell reports, 8(4), 1210-24.
  72. Genzen JR, Gosselin JT, Wilson TC, Racila E, Krasowski M (2013). Analysis of vitamin D status at two academic medical centers and a national reference laboratory: result patterns vary by age, gender, season, and patient location. BMC endocrine disorders, 13, 52.
  73. Genzen J (2013). An Overview of United States Physician Training, Certification, and Career Pathways in Clinical Pathology (Laboratory Medicine). EJIFCC, 24(1), 21-9.

Book Chapter

  1. Genzen JR, Hawker CD, Burnham CA, Wittwer C (2020). Automation in the clinical laboratory.
  2. Block DR, Genzen J (2020). Diagnostic body fluid testing.
  3. Hawker CD, Genzen J (2018). Chapter 19. Automation in the clinical laboratory. 370.
  4. Block DR, Genzen J (2016). Diagnostic body fluid testing.
  5. Genzen J (2016). Clinical protein and immunofixation electrophoresis.
  6. Genzen JR, Bordey (2008). Ependymal cells and the neurogenic niche.

Editorial

  1. Genzen J (2022). The Verifying Accurate Leading-edge IVCT Development Act: Potential impact on diagnostic testing in the United States. International journal of laboratory hematology, 44 Suppl 1, 9-10.
  2. Genzen J (2020). Wiping the Slate Clean-Assessing Clinical Laboratory Contamination Risk. Clinical chemistry, 66(9), 1128-1130.

Letter

  1. Genzen JR, Souers RJ, Pearson LN, Manthei DM, Chambliss AB, Shajani-Yi Z, Miller W (2023). An Update on Reported Adoption of 2021 CKD-EPI Estimated Glomerular Filtration Rate Equations. Clinical chemistry, 69(10), 1197-1199.
  2. Willrich MAV, Long TA, Bashleben C, Fink SL, Rudolf JW, Peterson D, Wener MH, Baltaro RJ, Genzen JR, Ansari MQ, Rhoads DD, Linden M (2020). Performance of perpendicular drop versus tangent skimming gating of M-protein in proficiency testing challenges. Clinical chemistry and laboratory medicine, 59(1), e19-e22.
  3. McCarthy MW, Genzen JR, Wilkin TJ, Singh H (2015). Use of a commercial HIV co-receptor tropism assay in clinical practice. AIDS patient care and STDs, 29(2), 53-4.