(
out of
81
reviews
)
Clinical Locations
Primary Location
Huntsman Cancer Institute - Cancer Research North
Clinic 2D/E, BMT/Hematology
2000 Circle of Hope
Salt Lake City
,
UT
84112
Veterans Administration Medical Center
Myeloproliferative Disorders Clinic
500 S Foothill Blvd
Salt Lake City
,
UT
84148
Board Certification
|
American Board of Internal Medicine (Internal Medicine)
Royal College of Surgeons of Canada
Educational Commission for Foreign Medical Graduates
Royal College of Physicians and Surgeons of Canada
Licentiate of the Medical Council of Canada
|
Patient Rating
4.9
/5
( out of
81 reviews
)
The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers. The scale on which responses are measured is 1 to 5 with 5 being the best score.
Patient comments are gathered from our patient experience survey and displayed in their entirety. For the convenience of our visitors, some patient comments have been translated from their original language into English while preserving their original meaning as accurately as possible. Patients are de-identified for confidentiality and patient privacy.
Board Certification and Academic Information
| Academic Departments |
Internal Medicine
-Professor Human Genetics -Adjunct Professor |
|---|---|
| Academic Divisions |
Hematology & Hematologic Malignancies
|
| Board Certification |
American Board of Internal Medicine (Internal Medicine)
Royal College of Surgeons of Canada
Educational Commission for Foreign Medical Graduates
Royal College of Physicians and Surgeons of Canada
Licentiate of the Medical Council of Canada
|
Education history
| Professional Medical | Charles University | M.D. |
|---|---|---|
| Fellowship | Biochemistry - Charles University School of Medicine | Postdoctoral Research Associate |
| Internship | Rotating Internship - University of Toronto, Dept of Medicine | Intern |
| Residency | Internal Medicine - University of Toronto, Dept of Medicine | Resident |
| Fellowship | Hematology/Oncology - University of Toronto, Department of Medicine | Fellow |
| Research Fellow | Research - City of Hope National Medical Center | Research Fellow |
| Residency | Pathology - University of Toronto, Department of Medicine | Resident |
| Fellowship | Laboratory and Clinical Hematology - Toronto General Hospital | Fellow |
Selected Publications
Journal Article
- Gordeuk VR, Shah BN, Zhang X, Thuma PE, Zulu S, Moono R, Reading NS, Song J, Zhang Y, Nouraie M, Campbell A, Minniti CP, Rana SR, Darbari DS, Kato GJ, Niu M, Castro OL, Machado R, Gladwin MT, Prchal J (2020). The CYB5R3c .350C>G and G6PD A alleles modify severity of anemia in malaria and sickle cell disease. American journal of hematology, 95(11), 1269-1279.
- Abou-Ismail MY, Prchal JT, Deininger MW, Parker CJ, Lim M (2021). Anticoagulation management post-transjugular intrahepatic portosystemic shunt in portal hypertension associated with myeloproliferative neoplasms. Blood coagulation & fibrinolysis, 32(8), 578-583.
- Kapralova K, Lanikova L, Lorenzo F, Song J, Horvathova M, Divoky V, Prchal J (2014). RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling. Blood, 123(3), 391-4.
- Dickinson RE, Milne P, Jardine L, Zandi S, Swierczek SI, McGovern N, Cookson S, Ferozepurwalla Z, Langridge A, Pagan S, Gennery A, Heiskanen-Kosma T, Hamalainen S, Seppanen M, Helbert M, Tholouli E, Gambineri E, Reykdal S, Gottfreethsson M, Thaventhiran JE, Morris E, Hirschfield G, Richter AG, Jolles S, Bacon CM, Hambleton S, Haniffa M, Bryceson Y, Allen C, Prchal JT, Dick JE, Bigley V, Collin (2014). The evolution of cellular deficiency in GATA2 mutation. Blood, 123(6), 863-74.
- Rondelli D, Goldberg JD, Isola L, Price LS, Shore TB, Boyer M, Bacigalupo A, Rambaldi A, Scarano M, Klisovic RB, Gupta V, Andreasson B, Mascarenhas J, Wetzler M, Vannucchi AM, Prchal JT, Najfeld V, Orazi A, Weinberg RS, Miller C, Barosi G, Silverman LR, Prosperini G, Marchioli R, Hoffman (2014). MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis. Blood, 124(7), 1183-91.
- Patel AB, Franzini A, Leroy E, Kim SJ, Pomicter AD, Genet L, Xiao M, Yan D, Ahmann JM, Agarwal AM, Clair P, Addada J, Lambert J, Salmon M, Gleich GJ, Cross NCP, Constantinescu SN, O'Hare T, Prchal JT, Deininger M (2019). JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera. Blood, 134(26), 2388-2398.
- Yacoub A, Mascarenhas J, Kosiorek H, Prchal JT, Berenzon D, Baer MR, Ritchie E, Silver RT, Kessler C, Winton E, Finazzi MC, Rambaldi A, Vannucchi AM, Leibowitz D, Rondelli D, Arcasoy MO, Catchatourian R, Vadakara J, Rosti V, Hexner E, Kremyanskaya M, Sandy L, Tripodi J, Najfeld V, Farnoud N, Papaemmanuil E, Salama M, Singer-Weinberg R, Rampal R, Goldberg JD, Barbui T, Mesa R, Dueck AC, Hoffman (2019). Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea. Blood, 134(18), 1498-1509.
- Simonson TS, Huff CD, Witherspoon DJ, Prchal JT, Jorde L (2015). Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans. Experimental physiology, 100(11), 1263-8.
- Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain D (2015). Metabolic aspects of high-altitude adaptation in Tibetans. Experimental physiology, 100(11), 1247-55.
- Ye Z, Liu CF, Lanikova L, Dowey SN, He C, Huang X, Brodsky RA, Spivak JL, Prchal JT, Cheng (2014). Differential sensitivity to JAK inhibitory drugs by isogenic human erythroblasts and hematopoietic progenitors generated from patient-specific induced pluripotent stem cells. Stem cells (Dayton, Ohio), 32(1), 269-78.
- Nussenzveig RH, Pham HT, Perkins SL, Prchal JT, Agarwal AM, Salama M (2016). Increased frequency of co-existing JAK2 exon-12 or MPL exon-10 mutations in patients with low JAK2(V617F) allelic burden. Leukemia & lymphoma, 57(6), 1429-35.
- Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG Jr, Koivunen P, Prchal J (2014). A genetic mechanism for Tibetan high-altitude adaptation. Nature genetics, 46(9), 951-6.
- Zhang X, Zhang W, Ma SF, Desai AA, Saraf S, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Abbasi T, Casanova NG, Steinberg MH, Baldwin CT, Sebastiani P, Prchal JT, Kittles R, Garcia JG, Machado RF, Gordeuk V (2014). Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation, 129(16), 1650-8.
- Swierczek S, Prchal J (2020). Clonal hematopoiesis in hematological disorders: Three different scenarios. Experimental hematology, 83, 57-65.
- Pomicter AD, Eiring AM, Senina AV, Zabriskie MS, Marvin JE, Prchal JT, O'Hare T, Deininger M (2015). Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm. Experimental hematology, 43(7), 537-45.e1-11.
- Reading NS, Sirdah MM, Tarazi IS, Prchal J (2014). Detection of nine Mediterranean beta-thalassemia mutations in Palestinians using three restriction enzyme digest panels: a reliable method for developing countries. Hemoglobin, 38(1), 39-43.
- Bahr TM, Henry E, Hulse W, Baer VL, Prchal JT, Bhutani VK, Christensen R (2020). Early Hyperbilirubinemia in Neonates with Down Syndrome. The Journal of pediatrics, 219, 140-145.
- Prchal J (2015). Genetic selection by high altitude: Beware of experiments at ambient conditions. Proceedings of the National Academy of Sciences of the United States of America, 112(33), 10080-1.
- Song J, Yoon D, Christensen RD, Horvathova M, Thiagarajan P, Prchal J (2015). HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis. Journal of molecular medicine (Berlin, Germany), 93(8), 857-66.
- Zhang X, Zhang W, Ma SF, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Nourai M, Wade MS, Prchal JT, Garcia JGN, Machado RF, Gordeuk V (2014). Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing. Blood cells, molecules & diseases, 52(1), 35-45.
- Tashi T, Feng T, Koul P, Amaru R, Hussey D, Lorenzo FR, RiLi G, Prchal J (2014). High altitude genetic adaptation in Tibetans: no role of increased hemoglobin-oxygen affinity. Blood cells, molecules & diseases, 53(1-2), 27-9.
- Sirdah M, Reading NS, Vankayalapati H, Prchal J (2021). A computational study of structural differences of binding of NADP+ and G6P substrates to G6PD Mediterraneanc.563T, G6PD A-c.202A/c.376G, G6PD Cairoc.404C and G6PD Gazac.536A mutations. Blood cells, molecules & diseases, 89, 102572.
- Christensen RD, Lambert DK, Henry E, Yaish HM, Prchal J (2015). End-tidal carbon monoxide as an indicator of the hemolytic rate. Blood cells, molecules & diseases, 54(3), 292-6.
- Sangle N, Cook J, Perkins S, Teman CJ, Bahler D, Hickman K, Wilson A, Prchal J, Salama M (2014). Myelofibrotic transformations of polycythemia vera and essential thrombocythemia are morphologically, biologically, and prognostically indistinguishable from primary myelofibrosis. Applied immunohistochemistry & molecular morphology, 22(9), 663-8.
- Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal JT, Lanikova (2019). Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1. Journal of cellular and molecular medicine, 23(11), 7785-7795.
- Sarangi S, Lanikova L, Kapralova K, Acharya S, Swierczek S, Lipton JM, Wolfe L, Prchal J (2014). The homozygous VHL(D126N) missense mutation is associated with dramatically elevated erythropoietin levels, consequent polycythemia, and early onset severe pulmonary hypertension. Pediatric blood & cancer, 61(11), 2104-6.
- Christensen RD, Nussenzveig RH, Reading NS, Agarwal AM, Prchal JT, Yaish H (2014). Variations in both alpha-spectrin (SPTA1) and beta-spectrin ( SPTB ) in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis. Neonatology, 105(1), 1-4.
- Nussenzveig RH, Christensen RD, Prchal JT, Yaish HM, Agarwal A (2014). Novel alpha-spectrin mutation in trans with alpha-spectrin causing severe neonatal jaundice from hereditary spherocytosis. Neonatology, 106(4), 355-7.
- Christensen RD, Malleske DT, Lambert DK, Baer VL, Prchal JT, Denson LE, Gerday E, Weaver Lewis KA, Shepherd J (2016). Measuring End-Tidal Carbon Monoxide of Jaundiced Neonates in the Birth Hospital to Identify Those with Hemolysis. Neonatology, 109(1), 1-5.
- Thiagarajan P, Parker CJ, Prchal J (2021). How Do Red Blood Cells Die?. Frontiers in physiology, 12, 655393.
- Lanikova L, Babosova O, Prchal J (2019). Experimental Modeling of Myeloproliferative Neoplasms. Genes, 10(10),
- Xu G, van Bruggen R, Gualtieri CO, Moradin N, Fois A, Vallerand D, De Sa Tavares Russo M, Bassenden A, Lu W, Tam M, Lesage S, Girouard H, Avizonis DZ, Deblois G, Prchal JT, Stevenson M, Berghuis A, Muir T, Rabinowitz J, Vidal SM, Fodil N, Gros (2020). Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia. Cell reports, 32(12), 108170.
- Shrimali NM, Agarwal S, Kaur S, Bhattacharya S, Bhattacharyya S, Prchal JT, Guchhait (2021). ¿-Ketoglutarate Inhibits Thrombosis and Inflammation by Prolyl Hydroxylase-2 Mediated Inactivation of Phospho-Akt. EBioMedicine, 73, 103672.
- Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT, Guchhait (2021). Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia. EBioMedicine, 68, 103418.
- Gangaraju R, Song J, Kim SJ, Tashi T, Reeves BN, Sundar KM, Thiagarajan P, Prchal J (2020). Thrombotic, inflammatory, and HIF-regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia. Blood advances, 4(6), 1115-1130.
- Chan XY, Volkova E, Eoh J, Black R, Fang L, Gorashi R, Song J, Wang J, Elliott MB, Barreto-Ortiz SF, Chen J, Lin BL, Santhanam L, Cheng L, Lee FS, Prchal JT, Gerecht (2021). HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics. iScience, 24(4), 102246.
- Feusier JE, Arunachalam S, Tashi T, Baker MJ, VanSant-Webb C, Ferdig A, Welm BE, Rodriguez-Flores JL, Ours C, Jorde LB, Prchal JT, Mason C (2021). Large-Scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers. Blood cancer discovery, 2(3), 226-237.
- Bahr TM, Agarwal AM, Meznarich JA, Prince WL, Wait TWP, Prchal JT, Christensen R (2021). Thirty-five males with severe (Class 1) G6PD deficiency (c.637G>T) in a North American family of European ancestry. Blood cells, molecules & diseases, 92, 102625.
- Mascarenhas J, Kosiorek HE, Prchal JT, Rambaldi A, Berenzon D, Yacoub A, Harrison CN, McMullin MF, Vannucchi AM, Ewing J, O'Connell CL, Kiladjian JJ, Mead AJ, Winton EF, Leibowitz DS, De Stefano V, Arcasoy MO, Kessler CM, Catchatourian R, Rondelli D, Silver RT, Bacigalupo A, Nagler A, Kremyanskaya M, Levine MF, Arango Ossa JE, McGovern E, Sandy L, Salama ME, Najfeld V, Tripodi J, Farnoud N, Penson AV, Weinberg RS, Price L, Goldberg JD, Barbui T, Marchioli R, Tognoni G, Rampal RK, Mesa RA, Dueck AC, Hoffman (2022). A randomized phase 3 trial of interferon-¿ vs hydroxyurea in polycythemia vera and essential thrombocythemia. Blood, 139(19), 2931-2941.
- Kralova B, Sochorcova L, Song J, Jahoda O, Hlusickova Kapralova K, Prchal JT, Divoky V, Horvathova (2022). Developmental changes in iron metabolism and erythropoiesis in mice with human gain-of-function erythropoietin receptor. American journal of hematology, 97(10), 1286-1299.
- Amaru R, Song J, Reading NS, Gordeuk VR, Prchal J (2023). "What We Know and What We Do Not Know about Evolutionary Genetic Adaptation to High Altitude Hypoxia in Andean Aymaras". Genes, 14(3),
- Song J, Kim SJ, Gollamudi J, Thiagarajan P, Prchal J (2023). Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression. Blood advances, 7(5), 712-717.
- Song J, Sundar KM, Horvathova M, Gangaraju R, Indrak K, Christensen RD, Genzor S, Lundby C, Divoky V, Ganz T, Prchal J (2023). Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis. American journal of hematology,
- Prchal JT, Semenza G (2023). On either side of homeostasis: EPAS1 gain and loss of function mutations. Haematologica,
- Kragesteen BK, Giladi A, David E, Halevi S, Geirsdóttir L, Lempke OM, Li B, Bapst AM, Xie K, Katzenelenbogen Y, Dahl SL, Sheban F, Gurevich-Shapiro A, Zada M, Phan TS, Avellino R, Wang SY, Barboy O, Shlomi-Loubaton S, Winning S, Markwerth PP, Dekalo S, Keren-Shaul H, Kedmi M, Sikora M, Fandrey J, Korneliussen TS, Prchal JT, Rosenzweig B, Yutkin V, Racimo F, Willerslev E, Gur C, Wenger RH, Amit (2023). The transcriptional and regulatory identity of erythropoietin producing cells. Nature medicine, 29(5), 1191-1200.
- Shah BN, Zhang X, Sergueeva AI, Miasnikova GY, Ganz T, Prchal JT, Gordeuk V (2023). Increased transferrin protects from thrombosis in Chuvash erythrocytosis. American journal of hematology,
- Zhang X, Song J, Shah BN, Han J, Hassan T, Miasniakova G, Sergueeva A, Nekhai S, Machado RF, Gladwin MT, Saraf SL, Prchal JT, Gordeuk V (2023). Gene expression changes in sickle cell reticulocytes and their clinical associations. Scientific reports, 13(1), 12864.
- Trunk AD, Patel SS, Prchal JT, Sborov DW, Zander AR, Lee C (2023). Allogeneic stem cell transplant for multiple myeloma & myelofibrosis with split-dose busulfan, fludarabine & cyclophosphamide. Leukemia research reports, 20, 100388.
- Yoo JJ, Cohen HJ, Artz AS, Price E, Fill JA, Prchal J, Sapp S, Barnhart H, from the Partnership for Anemia Clinical and Translational Trials in the Elderly (PACTTE (2023). Biomarkers of erythropoiesis response to intravenous iron in a crossover pilot study in unexplained anemia of the elderly. Hematology (Amsterdam, Netherlands), 28(1), 1-8.
- Talpaz M, Prchal J, Afrin L, Arcasoy M, Hamburg S, Clark J, Kornacki D, Colucci P, Verstovsek (2022). Safety and Efficacy of Ruxolitinib in Patients with Myelofibrosis and Low Platelet Counts (50 - 100¿×¿10(9)/L): Final Analysis of an Open-Label Phase 2 Study. Clinical lymphoma, myeloma & leukemia, 22(5), 336-346.
- Bretz CA, Divoky V, Prchal J, Kunz E, Simmons AB, Wang H, Hartnett M (2018). Erythropoietin Signaling Increases Choroidal Macrophages and Cytokine Expression, and Exacerbates Choroidal Neovascularization. Scientific reports, 8(1), 2161.
- Kovacsovics-Bankowski M, Kelley TW, Efimova O, Kim SJ, Wilson A, Swierczek S, Prchal (2016). Changes in peripheral blood lymphocytes in polycythemia vera and essential thrombocythemia patients treated with pegylated-interferon alpha and correlation with JAK2(V617F) allelic burden. Experimental hematology & oncology, 5, 28.
- Price E, Artz AS, Barnhart H, Sapp S, Chelune G, Ershler WB, Walston JD, Gordeuk VR, Berger NA, Reuben D, Prchal J, Rao SV, Roy CN, Supiano MA, Schrier SL, Cohen H (2014). A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL. Blood cells, molecules & diseases, 53(4), 221-30.
- Prchal JT, Lichtman M (2024). Measurement of red cell, plasma, and blood volume: A perspective. American journal of hematology, 99(1), 9-11.
- Song J, Lanikova L, Kim SJ, Papadopoulos N, Meznarich J, Constantinescu SN, Parsegov B, Prchal JF, Prchal J (2024). Novel germline JAK2(R715T) mutation causing PV-like erythrocytosis in 3 generations. Amelioration by Ropeg-Interferon. American journal of hematology, 99(7), 1220-1229.
- Prchal JT, Burtscher M, Kim SJ, Wille M, Amaru R, Song (2026). Do Andean Aymara High-Altitude-Enriched Genetic Variants Protect Europeans Against Acute Mountain Sickness?. Acta physiologica (Oxford, England), 242(2), e70154.
- Shrimali NM, Ghosh R, Bhardwaj K, Tsewang C, Thinlas T, Koul P, Prchal JT, Guchhait (2026). Elevated Protein S Provides Evidence against Hypoxia-Induced Hypercoagulation in Tibetan Highlanders with PHD2D4E;C127S Polymorphisms. Thrombosis and haemostasis, 126(2), 223-226.
- Tashi T, Shih LY, Yo YT, Sullivan A, Chueh HY, Kuo MC, Smith A, Kim SJ, Parsegov B, Reeves BN, Song J, Prchal J (2026). Ropeginterferon alfa-2b has minimal transplacental passage and breastmilk secretion in pregnant MPN patients. Blood advances,
- Lanikova L, Hrckulak D, Zimolova V, Lorenzo FR, Song J, Vecerkova K, Babosova O, Berkova L, Korinek V, Elliott S, Prchal J (2026). Autosomal Dominant Erythrocytosis Caused by Non-Renal Erythropoietin (EPO) Due to EPO c.-136 G>A Germline Mutation. American journal of hematology,
- Reeves BN, Song J, Leier A, Smith A, Kim SJ, Chen SL, Tashi T, Prchal J (2025). Metformin alleviates side effects and supports the resumption of interferon therapy in polycythemia vera and essential thrombocythemia. Haematologica,
- Song J, Amaru R, Prchal J (2025). High altitude: A forgotten cause of pulmonary oedema. Lung India, 42(5), 389-390.
- Yu MS, Yu LH, Huang SH, Tsai TH, Lin AJ, Prchal JT, Chen MC, Lee K (2025). Real-world characteristics and treatment patterns in essential thrombocythemia: a population-based cross-sectional study in Taiwan between 2020 and 2021. Therapeutic advances in hematology, 16, 20406207251359651.
- Ghosh R, Joshi G, Shrimali NM, Bhardwaj K, Chorol T, Thinlas T, Koul PA, Prchal JT, Guchhait (2025). Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIF¿:IFN axis. PLoS pathogens, 21(6), e1013296.
- Song J, Han S, Amaru R, Lanikova L, Quispe T, Kim D, Crawford JE, Kim SJ, Lee Y, Prchal J (2025). Alternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin. Nature communications, 16(1), 1766.
Review
- Iolascon A, Bianchi P, Andolfo I, Russo R, Barcellini W, Fermo E, Toldi G, Ghirardello S, Rees D, Van Wijk R, Kattamis A, Gallagher PG, Roy N, Taher A, Mohty R, Kulozik A, De Franceschi L, Gambale A, De Montalembert M, Forni GL, Harteveld CL, Prchal J, SWG of red cell and iron of EHA and EuroBloodNe (2021). Recommendations for diagnosis and treatment of methemoglobinemia. American journal of hematology, 96(12), 1666-1678.
- Stein BL, Gotlib J, Arcasoy M, Nguyen MH, Shah N, Moliterno A, Jamieson C, Pollyea DA, Scott B, Wadleigh M, Levine R, Komrokji R, Klisovic R, Gundabolu K, Kropf P, Wetzler M, Oh ST, Ribeiro R, Paschal R, Mohan S, Podoltsev N, Prchal J, Talpaz M, Snyder D, Verstovsek S, Mesa R (2015). Historical views, conventional approaches, and evolving management strategies for myeloproliferative neoplasms. Journal of the National Comprehensive Cancer Network, 13(4), 424-34.
- Bose P, Xiao Z, Hasselbalch HC, Prchal JT, Duan M, Yacoub A, Rampal R, Kiladjian JJ, Hobbs GS, Tashi T, Shimoda K, Kirito K, Gill H, Hou HA, Lee SE, Huang J, Li B, Qin A, Yu LH, Mascarenhas JO, Mesa R (2025). Highlights from MPN Asia 2025: Advances in Molecular Pathogenesis and Therapeutic Strategies in Myeloproliferative Neoplasms. Current hematologic malignancy reports, 20(1), 9.
Case Report
- Boonyawat B, Dhanraj S, Al Abbas F, Zlateska B, Grunenbaum E, Roifman CM, Steele L, Meyn S, Blanchette V, Scherer SW, Swierczek S, Prchal J, Zhu Q, Torgerson TR, Ochs HD, Dror (2013). Combined de-novo mutation and non-random X-chromosome inactivation causing Wiskott-Aldrich syndrome in a female with thrombocytopenia. Journal of clinical immunology, 33(7), 1150-5.
- Christensen RD, Yaish HM, Wiedmeier SE, Reading NS, Pysher TJ, Palmer CA, Prchal J (2013). Neonatal death suspected to be from sepsis was found to be kernicterus with G6PD deficiency. Pediatrics, 132(6), e1694-8.
- Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Yost CC, Li P, Reading NS, Prchal JT, Christensen R (2020). A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity. Neonatology, 117(4), 532-535.
Editorial
- Prchal JT, Gordeuk V (2021). HIF-2 inhibitor, erythrocytosis, and pulmonary hypertension. Blood, 137(18), 2424-2425.
- Mascarenhas J, Mesa R, Prchal J, Hoffman (2014). Optimal therapy for polycythemia vera and essential thrombocythemia can only be determined by the completion of randomized clinical trials. Haematologica, 99(6), 945-9.
- Song J, Tashi T, Prchal J (2019). Editorial Comment on: Inhibition of Suicidal Erythrocyte Death by Chronic Hypoxia by Tang et al. (From: Tang F, Feng L, Li R, Wang W, Liu H, Yang Q, Ge R-L. High Alt Med Biol 2019;20:112-119; DOI: 10.1089/ham.2017.0159). High altitude medicine & biology, 20(2), 120-121.
- Song J, Christensen RD, Thiagarajan P, Prchal J (2021). Does neocytolysis exist after descent from high altitude?. Acta physiologica (Oxford, England), 233(3), e13713.
- Prchal JT, Reeves B (2023). EnvIRONment modifies polycythemia vera. Blood, 141(17), 2042-2044.
- Iolascon A, Andolfo I, Russo R, Barcellini W, Fermo E, Toldi G, Ghirardello S, Rees D, Van Wijk R, Kattamis A, Gallagher PG, Roy N, Taher A, Mohty R, Kulozik A, De Franceschi L, Gambale A, De Montalembert M, Forni GL, Harteveld CL, Prchal J, Bianchi (2021). Summary of Joint European Hematology Association (EHA) and EuroBloodNet Recommendations on Diagnosis and Treatment of Methemoglobinemia. HemaSphere, 5(12), e660.
Letter
- Kim SJ, Song J, Reading NS, Lautersztain J, Kutlar A, Agarwal AM, Coetzer TL, Prchal J (2021). Novel mechanism of hereditary pyropoikilocytosis phenotype due to co-inheritance of ß globin and ¿ spectrin mutations. American journal of hematology, 96(5), E150-E154.
- Reeves BN, Kim SJ, Song J, Wilson KJ, Henderson MW, Key NS, Pawlinski R, Prchal J (2021). Tissue Factor Activity Is Increased in Neutrophils from JAK2 V617F-mutated Essential Thrombocythemia and Polycythemia Vera Patients. American journal of hematology, 97(2), E37-E40.
- Meznarich JA, Rets A, Agarwal AM, Christensen RD, Reading NS, Kuypers FA, Prchal J (2021). Novel, de novo, beta-globin variant with decreased oxygen affinity (HBB:c.317T>A, "Hemoglobin St. George") in a healthy child with low oxygen saturations and anemia. American journal of hematology, 96(12), E448-E450.
- Gangaraju R, Carroll AJ, Prchal J (2019). Response to interferon treatment in essential thrombocythemia with inv(3)(q21q26). Annals of hematology,
- Salama ME, Swierczek SI, Tashi T, Warby CA, Reading NS, Prchal J (2014). Calreticulin mutated prefibrotic-stage myelofibrosis and PMF represent an independent clone from coexisting CLL. Blood, 124(10), 1691-2.
- Sergueeva AI, Miasnikova GY, Polyakova LA, Nouraie M, Prchal JT, Gordeuk V (2015). Complications in children and adolescents with Chuvash polycythemia. Blood, 125(2), 414-5.
- Zhang X, Song J, Shah BN, Nekhai S, Miasnikova G, Sergueeva A, Prchal JT, Gordeuk V (2020). Peripheral blood mononuclear cells show prominent gene expression by erythroid progenitors in diseases characterized by heightened erythropoiesis. British journal of haematology, 190(1), e42-e45.
- Gordeuk VR, Miasnikova GY, Sergueeva AI, Lorenzo FR, Zhang X, Song J, Stockton DW, Prchal J (2020). Thrombotic risk in congenital erythrocytosis due to up-regulated hypoxia sensing is not associated with elevated hematocrit. Haematologica, 105(3), e87-e90.
- Wang L, Swierczek SI, Drummond J, Hickman K, Kim SJ, Walker K, Doddapaneni H, Muzny DM, Gibbs RA, Wheeler DA, Prchal J (2014). Whole-exome sequencing of polycythemia vera revealed novel driver genes and somatic mutation shared by T cells and granulocytes. Leukemia, 28(4), 935-8.
- Wang L, Swierczek SI, Lanikova L, Kim SJ, Hickman K, Walker K, Wang K, Drummond J, Doddapaneni H, Reid JG, Muzny DM, Gibbs RA, Wheeler DA, Prchal J (2014). The relationship of JAK2(V617F) and acquired UPD at chromosome 9p in polycythemia vera. Leukemia, 28(4), 938-41.
- Swierczek S, Lima LT, Tashi T, Kim SJ, Gregg XT, Prchal J (2015). Presence of polyclonal hematopoiesis in females with Ph-negative myeloproliferative neoplasms. Leukemia, 29(12), 2432-4.
- Mascarenhas J, Kosiorek H, Prchal J, Yacoub A, Berenzon D, Baer MR, Ritchie E, Silver RT, Kessler C, Winton E, Finazzi MC, Rambaldi A, Vannucchi AM, Leibowitz D, Rondelli D, Arcasoy MO, Catchatourian R, Vadakara J, Rosti V, Hexner E, Kremyanskaya M, Sandy L, Tripodi J, Najfeld V, Farnoud N, Salama ME, Weinberg RS, Rampal R, Goldberg JD, Mesa R, Dueck AC, Hoffman (2019). A prospective evaluation of pegylated interferon alfa-2a therapy in patients with polycythemia vera and essential thrombocythemia with a prior splanchnic vein thrombosis. Leukemia, 33(12), 2974-2978.
- Lichtman MA, Prchal J (2024). Measurement of red cell, plasma and blood volume: Essential components of diagnostic and research studies of oxygen transport. Blood cells, molecules & diseases, 105, 102819.
- Sergeev I, Prchal JT, Nouraie SM, Shah BN, Zhang X, Sergueeva A, Miasnikova G, Ganz T, Gordeuk V (2025). VHL, transferrin, and erythropoietin in the regulation of hepcidin. HemaSphere, 9(12), e70271.
Other
- Zhang X, Song J, Shah BN, Han J, Hassan T, Miasniakova G, Sergueeva A, Nekhai S, Machado RF, Gladwin MT, Saraf SL, Prchal JT, Gordeuk V (2023). Publisher Correction: Gene expression changes in sickle cell reticulocytes and their clinical associations. Scientific reports, 13(1), 15225.
Very good
Good experience
Dr. Prchal is an amazing individual. We feel lucky to have him caring for our father.
very informitive
I have been a patient for almost ten years--Dr. Prychal has always done well on all of these.
Always a great experience with Dr. Prchal and his staff, including RNs!
He is fantastic!
Dr Prchal is an amazing man he started treating me 19 years ago and had no issues until a few months ago when my disorder went to the next level just as he said it could do that many years back he will do whatever he can to make sure you are living life the best you can without feeling sick I would trust him with my life without hesitation and this includes the whole staff at the Huntsman center and the Hospital
He is extremely kind to me. He ensures that I understand him.
He is terrific. He is an expert in this area and tries to provide both the best up to date treatment and information to the patient.
There's nobody in the world better at dealing with ET than Dr. Prchal and I appreciate him being here.
Dr Prchal has restored my faith in the healthcare.
Dr Prchal is the finest researcher/clinician I've ever experienced. I'm grateful for the 8 years of extended life I've received because of his knowledge and concern - and, after the many years of tests, procedures and various courses of chemotherapy, he has become a dear friend.
Dr. Prchal is amazing he helped save my life
Dr Prchal ia an outstanding physician.
Issue has yet to be resolved.
He's kind.
Great Doctor. Goes above and beyond to help you understand a complex subject. Great bedside manner.
Dr Prchal has always provided me with the very best of care.
Dr. Prchal was determined to sign me up for a clinical trial and didnt want to talk about my symptoms, labs or other testing. He would not receive questions. He was abrupt and talked over everyone else. He doesnt to listen to the patient, he just pitches what hes already made up his mind to do. It was a useless appointment that I had very high hopes for.
Dr Prchal is one of the best hematologist experts - Im blessed to be his patient! He is a professional, very knowlegeable, caring and friendly.
Dr Prchal is a truly capable professional with excellent in-depth knowledge and courtesy to give me exceptional (outstanding) care! Im blessed to be his patient!
Dr Prchal always makes sure I understand about my meds and will listen to my concerns.
Outstanding physician!
15 years of positive experience, 4 trials, kept me alive.
Dr. Prchal is wonderful. Always very kind and attentive.
Dr Prchal is the kindest most caring Dr I've ever met
Dr Prchal is an amazing doctor. He answered all my questions and provided me with all the information I needed to decide about clinical trials for Myelofibrosis.
Always will spend time to explain everything
These are complicated, multi-determined issues. Dr Prchal and Brynn did a wonderful job of talking about everything.
Dr Prchal and NP Vadeboncoeur provide OUTSTANDING care, are extremely knowledgeable, and very thorough.
The best way to communicate with your Doctor. it saved me 250 mile round trip to visit with the Doctor.
All went well
Love Dr Prchal
Excellent discussion about COVID vaccine availability and my diagnosis. My husband is included in discussions as an active participant. On my own I did not have a procrit injection even though anemia numbers were down because I don't like the possible side effects and I did think I felt that much better. Dr. Prchal was supportive of my decisions I decided on my own to postpone procrit injenctions to 7 weeks--no change in my hemocrit numbers... and I don't like possible side effecrts.
Wry knowledgeable and friendly! Excellent doctor!!!!
Knowledgeable and caring physician. He and his team took the time needed to explain my cancer and my treatment options.
If you have a MPN disease he is one of the top doctors, he listens and is very kind and compassionate, I drive to see him 7 hours well worth the trip, I wish I found him earlier.
It's his way or get out
Very caring and understanding. Explains things in detail and makes sure you are comfortable and confident in your treatments. He takes the to listen to my concerns.
Dr. Prchal knows his stuff and explained everything clearly and carefully.
We really like Dr. Prchal, he always explains things very clearly and volunteers to keep our daughter informed - she's a VP of a top advertising company specializing in medical insurance
Have been seeing him for many years and he always helps in giving me options that I can understand to except or not except. This in important to me.
I love Dr. Prchal
Dr Prchal was kind, engaging, knowledgeable and professional. I appreciated his encouraging words, his thorough review of my condition and treatment options and his informative recommendations for next steps.
I so appreciate having someone of Dr Prchal's ability, concern and warmth available to care for me.
A great examvery pleased
Dr Prchal is very knowledgeable, congenial and patient. And he obviously cares about his patients.
The Best
Prchal always makes sure you clearly understand his findings and diagnosis - including acknowledgment of the unknowns
outstanding
They agreed to let me record the appointment, which I found VERY helpful. The doctor gave me many answers and suggestions and I didn't have to stop to write things down because of the recording.
He explains my medication and listens to me. He asks questions about the cost of my chemo drug . He is concerned about me.
very thorough
Respected my decision not to take procrit shots when anemia is just below the concern.Immediately picked up on my observation that a skin cancer had been discovered on my shoulder and that I was going for treatment. Told me to watch this because skin cancers can be a side effect of my medication and to tell dermatologist of this.
We are waiting for test results.
Very Good!
Excellent doc
very caring and thorough
He is excellent at explaining a complex issue in a very concise manner.
Was declared cured of leukemia..great day
He's a very knowledgeable, brilliant physician who has a difficult time relating his plan to the patient. I would still recommend him based on his knowledge and expertise.
I have been seeing Dr Prchal for about 16 years. He has been an excellent doctor and given excellent care.
Dr. Prchal is always professional, knowledgeable, and caring. Excellent.
I felt much better when I left.
Noticed biopsy scab on shoulder. Mentioned that the type of skin cancer can be a side effect of medication and the possibility that may Indicate a change of drugs. My dermatology physician mentioned that he has had other patients of Dr.Prchal
Ongoing condition is being monitored and meds being adjusted as necessary.
Dr. Prachal is wonderful and we trust his judgment completely.
awesome
Terrific
Always look forward to seeing our dr. He is very highly recommended
I was rushed and felt like I was an inconvenience . I believe Dr was only in room maybe five minutes or less after making a 10 hour round-trip driving for this appointment . I left confused and very disappointed .
Great and caring
Smart as a whip and kind, a great doctor
Seemed very knowledgeable and caring..
He gives the impression that he really knows his stuff and is always very pleasant. Usually he takes all the time he needs to explain his recommendations. On my last visit he seemed pressed for time.
Dr Prchal is very interested in my health. He takes time to explain and answers questions in a way I understand.
Dr. Prchal is very thorough. He leaves no stone unturned when finding a proper diagnosis.
Dr. Prchal is a great physician.
great experience
Very helpful and informative
This experience has been far-and-above better than any I've received at my previous provider in houston; I am very confident in the doctor's expertise and level of care
Dr. Prchal was informative, attentive, and eager to help my son and myself with our medical condition. He was pleasant to talk with and I am confident he will be able to help us.
He cares about me
Dr. Prchal explained my labs to me and answered my questions in language I understood.
Dr Prchal is an amazing doctor and I value his opinions and suggestions regarding my condition. He is extremely sensitive, supportive and knowledgeable and truly understands his practice so well. I wouldn't want to go to any other doctor.
I feel blessed to have Dr Prchal and his staff to care for me.
VERY GOOD
Doctor Prachal is wonderful!
He is caring and extremely knowlegeble
Dr. Prchal is an expert in his field and I don't believe that there is a better or more knowledgeable Doctor than him anywhere. I have been a patient of his since January 2017. He is a great man.
Amazing doctor!
outstanding in his field treating PV
The best Oncologist live had. Listens very well and explains procedures and issue extremely well. Great Doctor.
He is amazing and did such a great job taking time to explain things
He was very kind and understanding
What a marvelous and devoted medical man! So glad we met. I look forward to seeing his capable hands at my treatment sessions.
Dr. Prchal was concerned about one of my symptoms. He scheduled me to return the next week.-.
Dr Prchal has always gone above and beyond. I will forever be grateful for him. Feel he saved my life. And, he strives to educate me on my rare blood disorder, reminds me I need to educate all other doctors who can (and have) treated very innappropriate, caused harm. I need to explain, not blindly trust lower caliber doctors, and if there are issues, get back to huntsman level providers for appropriate care.
Excellent
I have been a patient of Dr. Prchal's for almost 10 years..we have always had a good response from him.
excellent
After I filled out the last Huntsman survey, I was contacted by Dr. Prchal on a Sunday afternoon to discuss a concern. I'm not accustomed to, not do I expect, that kind of concern.
I have know Dr. Prchal for over 20 years, he is fantastic, explains things well, expresses genuine concern, and is top in his field.
He has been my Dr. for 15 years and has kept me alive with trial drugs.
My life saving Dr. for 15 years now. No superlitives good enough
A kind, knowledgeable, and interesting human being, who is interested in his patients.
I am fortunate to have him as my Dr. He is wonderful!
Dr.Prchal is wonderful. would never go to any one else. Kind, empathetic, concerned, caring
Dr. Prchal is the very best for my illness. If something arises the needs further assistance, he will have specialist there to assist almost immediately.
The best Dr. I have ever had. He is amazing in his knowledge, care, and practice
Always a pleasure speaking with Dr Prchal. He is so incredibly helpful and an expert in his field. Most appreciative of his insights into my condition.
Dr. Prchal has treated me for 15 years. I have the highest of confidence in his care.
fabulous
I am always so impressed with every person I interact with at the hospital. I always receive amazing care.
Dr spoke to my niece who is a nurse and focused on her he answered my questions but to her
He is SO knowlegable
It's always a pleasure to visit with Dr Prchal'his knowledge is something he openly shares making sure I understand my disease and receive the best treatment.
A ray of sunshine, knowledge and expertise! Dr. Prchal is a "master." He shows genuine interest in his patients as individuals.
He is amazing and I am grateful to be his patient. I had a difficulty with scheduling only. It has been resolved...
A very caring and knowledgeable doctor. Depression he listens to your concerns and calms your fears.
I'm very fortunate to have such a capable and knowlegeable doctor like Dr. Josef T. Prchal take care of me. I try to follow his comments and suggestion closely. Dr. Prchal is excellent and great! Many thanks for everything, Dr. Prchal! Sincerely with appreciation, [NAME REMOVED]