Josef T. Prchal
( out of 81 reviews )

Josef T. Prchal, MD

Languages spoken: Czech, English

Clinical Locations

Primary Location

Huntsman Cancer Institute - Cancer Research North

Clinic 2D/E, BMT/Hematology
2000 Circle of Hope
Salt Lake City , UT 84112
801-585-2626
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Veterans Administration Medical Center

Myeloproliferative Disorders Clinic
500 S Foothill Blvd
Salt Lake City , UT 84148
801-585-2626
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Josef Prchal MD is a physician scientist. He holds The Charles A. Nugent, M.D., and Margaret Nugent Endowed Professorship in Medicine/Hematology and is Adjunct Professor in Genetics at the University of Utah and Investigator at Huntsman Cancer Institute. In his clinics at the Huntsman Cancer Institute and at the VA Medical Center, he sees myeloproliferative neoplasms and benign red cell disorders. His research focuses on studies of anemias and erythrocytosis, on the molecular and clinical studies of polycythemia vera and essential thrombocythemia, mis-regulated responses to hypoxia including evolutionary Tibetan and other high altitude natives’ adaptation to high altitude. He published 432 peer-reviewed papers and 202 book chapters and reviews. He is the Editor of Williams Hematology, and the author of 4 Up-To-Date chapters. He is the recipient of several external professorships and numerous awards including Henry M. Stratton 2017 Award for Outstanding Contribution to the Fundamental Understanding of Broad Range of Red Cell Disorders from American Society of Hematology.

To schedule an appointment New Patients: 801-646-4122 Returning patients: 801-585-2626 or schedule through MyChart.

For questions regarding our clinical programs or for help identifying the right Hematology specialist for you or for your family member, please feel free to contact our Clinical Care Specialist at (801) 587-4630.

Specialties

Board Certification

American Board of Internal Medicine (Internal Medicine)
Royal College of Surgeons of Canada
Educational Commission for Foreign Medical Graduates
Royal College of Physicians and Surgeons of Canada
Licentiate of the Medical Council of Canada

Patient Rating

4.9 /5
( out of 81 reviews )

The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers.

The scale on which responses are measured is 1 to 5 with 5 being the best score.

Patient Comments

Patient comments are gathered from our patient experience survey and displayed in their entirety. For the convenience of our visitors, some patient comments have been translated from their original language into English while preserving their original meaning as accurately as possible. Patients are de-identified for confidentiality and patient privacy.

HUNTSMAN CANCER CENTER

Very good

HUNTSMAN CANCER CENTER

Good experience

HUNTSMAN CANCER CENTER

Dr. Prchal is an amazing individual. We feel lucky to have him caring for our father.

HUNTSMAN CANCER CENTER

very informitive

HUNTSMAN CANCER CENTER

I have been a patient for almost ten years--Dr. Prychal has always done well on all of these.

HUNTSMAN CANCER CENTER

Always a great experience with Dr. Prchal and his staff, including RNs!

HUNTSMAN CANCER CENTER

He is fantastic!

HUNTSMAN CANCER CENTER

Dr Prchal is an amazing man he started treating me 19 years ago and had no issues until a few months ago when my disorder went to the next level just as he said it could do that many years back he will do whatever he can to make sure you are living life the best you can without feeling sick I would trust him with my life without hesitation and this includes the whole staff at the Huntsman center and the Hospital

HUNTSMAN CANCER CENTER

He is extremely kind to me. He ensures that I understand him.

Josef Prchal MD is a physician scientist. He holds The Charles A. Nugent, M.D., and Margaret Nugent Endowed Professorship in Medicine/Hematology and is Adjunct Professor in Genetics at the University of Utah and Investigator at Huntsman Cancer Institute. In his clinics at the Huntsman Cancer Institute and at the VA Medical Center, he sees myeloproliferative neoplasms and benign red cell disorders. His research focuses on studies of anemias and erythrocytosis, on the molecular and clinical studies of polycythemia vera and essential thrombocythemia, mis-regulated responses to hypoxia including evolutionary Tibetan and other high altitude natives’ adaptation to high altitude. He published 432 peer-reviewed papers and 202 book chapters and reviews. He is the Editor of Williams Hematology, and the author of 4 Up-To-Date chapters. He is the recipient of several external professorships and numerous awards including Henry M. Stratton 2017 Award for Outstanding Contribution to the Fundamental Understanding of Broad Range of Red Cell Disorders from American Society of Hematology.

To schedule an appointment New Patients: 801-646-4122 Returning patients: 801-585-2626 or schedule through MyChart.

For questions regarding our clinical programs or for help identifying the right Hematology specialist for you or for your family member, please feel free to contact our Clinical Care Specialist at (801) 587-4630.

Board Certification and Academic Information

Academic Departments Internal Medicine -Professor
Human Genetics -Adjunct Professor
Academic Divisions Hematology & Hematologic Malignancies
Board Certification
American Board of Internal Medicine (Internal Medicine)
Royal College of Surgeons of Canada
Educational Commission for Foreign Medical Graduates
Royal College of Physicians and Surgeons of Canada
Licentiate of the Medical Council of Canada

Education history

Professional Medical Charles University M.D.
Fellowship Biochemistry - Charles University School of Medicine Postdoctoral Research Associate
Internship Rotating Internship - University of Toronto, Dept of Medicine Intern
Residency Internal Medicine - University of Toronto, Dept of Medicine Resident
Fellowship Hematology/Oncology - University of Toronto, Department of Medicine Fellow
Research Fellow Research - City of Hope National Medical Center Research Fellow
Residency Pathology - University of Toronto, Department of Medicine Resident
Fellowship Laboratory and Clinical Hematology - Toronto General Hospital Fellow

Selected Publications

Journal Article

  1. Gordeuk VR, Shah BN, Zhang X, Thuma PE, Zulu S, Moono R, Reading NS, Song J, Zhang Y, Nouraie M, Campbell A, Minniti CP, Rana SR, Darbari DS, Kato GJ, Niu M, Castro OL, Machado R, Gladwin MT, Prchal J (2020). The CYB5R3c .350C>G and G6PD A alleles modify severity of anemia in malaria and sickle cell disease. American journal of hematology, 95(11), 1269-1279.
  2. Abou-Ismail MY, Prchal JT, Deininger MW, Parker CJ, Lim M (2021). Anticoagulation management post-transjugular intrahepatic portosystemic shunt in portal hypertension associated with myeloproliferative neoplasms. Blood coagulation & fibrinolysis, 32(8), 578-583.
  3. Kapralova K, Lanikova L, Lorenzo F, Song J, Horvathova M, Divoky V, Prchal J (2014). RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling. Blood, 123(3), 391-4.
  4. Dickinson RE, Milne P, Jardine L, Zandi S, Swierczek SI, McGovern N, Cookson S, Ferozepurwalla Z, Langridge A, Pagan S, Gennery A, Heiskanen-Kosma T, Hamalainen S, Seppanen M, Helbert M, Tholouli E, Gambineri E, Reykdal S, Gottfreethsson M, Thaventhiran JE, Morris E, Hirschfield G, Richter AG, Jolles S, Bacon CM, Hambleton S, Haniffa M, Bryceson Y, Allen C, Prchal JT, Dick JE, Bigley V, Collin (2014). The evolution of cellular deficiency in GATA2 mutation. Blood, 123(6), 863-74.
  5. Rondelli D, Goldberg JD, Isola L, Price LS, Shore TB, Boyer M, Bacigalupo A, Rambaldi A, Scarano M, Klisovic RB, Gupta V, Andreasson B, Mascarenhas J, Wetzler M, Vannucchi AM, Prchal JT, Najfeld V, Orazi A, Weinberg RS, Miller C, Barosi G, Silverman LR, Prosperini G, Marchioli R, Hoffman (2014). MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis. Blood, 124(7), 1183-91.
  6. Patel AB, Franzini A, Leroy E, Kim SJ, Pomicter AD, Genet L, Xiao M, Yan D, Ahmann JM, Agarwal AM, Clair P, Addada J, Lambert J, Salmon M, Gleich GJ, Cross NCP, Constantinescu SN, O'Hare T, Prchal JT, Deininger M (2019). JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera. Blood, 134(26), 2388-2398.
  7. Yacoub A, Mascarenhas J, Kosiorek H, Prchal JT, Berenzon D, Baer MR, Ritchie E, Silver RT, Kessler C, Winton E, Finazzi MC, Rambaldi A, Vannucchi AM, Leibowitz D, Rondelli D, Arcasoy MO, Catchatourian R, Vadakara J, Rosti V, Hexner E, Kremyanskaya M, Sandy L, Tripodi J, Najfeld V, Farnoud N, Papaemmanuil E, Salama M, Singer-Weinberg R, Rampal R, Goldberg JD, Barbui T, Mesa R, Dueck AC, Hoffman (2019). Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea. Blood, 134(18), 1498-1509.
  8. Simonson TS, Huff CD, Witherspoon DJ, Prchal JT, Jorde L (2015). Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans. Experimental physiology, 100(11), 1263-8.
  9. Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain D (2015). Metabolic aspects of high-altitude adaptation in Tibetans. Experimental physiology, 100(11), 1247-55.
  10. Ye Z, Liu CF, Lanikova L, Dowey SN, He C, Huang X, Brodsky RA, Spivak JL, Prchal JT, Cheng (2014). Differential sensitivity to JAK inhibitory drugs by isogenic human erythroblasts and hematopoietic progenitors generated from patient-specific induced pluripotent stem cells. Stem cells (Dayton, Ohio), 32(1), 269-78.
  11. Nussenzveig RH, Pham HT, Perkins SL, Prchal JT, Agarwal AM, Salama M (2016). Increased frequency of co-existing JAK2 exon-12 or MPL exon-10 mutations in patients with low JAK2(V617F) allelic burden. Leukemia & lymphoma, 57(6), 1429-35.
  12. Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG Jr, Koivunen P, Prchal J (2014). A genetic mechanism for Tibetan high-altitude adaptation. Nature genetics, 46(9), 951-6.
  13. Zhang X, Zhang W, Ma SF, Desai AA, Saraf S, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Abbasi T, Casanova NG, Steinberg MH, Baldwin CT, Sebastiani P, Prchal JT, Kittles R, Garcia JG, Machado RF, Gordeuk V (2014). Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation, 129(16), 1650-8.
  14. Swierczek S, Prchal J (2020). Clonal hematopoiesis in hematological disorders: Three different scenarios. Experimental hematology, 83, 57-65.
  15. Pomicter AD, Eiring AM, Senina AV, Zabriskie MS, Marvin JE, Prchal JT, O'Hare T, Deininger M (2015). Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm. Experimental hematology, 43(7), 537-45.e1-11.
  16. Reading NS, Sirdah MM, Tarazi IS, Prchal J (2014). Detection of nine Mediterranean beta-thalassemia mutations in Palestinians using three restriction enzyme digest panels: a reliable method for developing countries. Hemoglobin, 38(1), 39-43.
  17. Bahr TM, Henry E, Hulse W, Baer VL, Prchal JT, Bhutani VK, Christensen R (2020). Early Hyperbilirubinemia in Neonates with Down Syndrome. The Journal of pediatrics, 219, 140-145.
  18. Prchal J (2015). Genetic selection by high altitude: Beware of experiments at ambient conditions. Proceedings of the National Academy of Sciences of the United States of America, 112(33), 10080-1.
  19. Song J, Yoon D, Christensen RD, Horvathova M, Thiagarajan P, Prchal J (2015). HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis. Journal of molecular medicine (Berlin, Germany), 93(8), 857-66.
  20. Zhang X, Zhang W, Ma SF, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Nourai M, Wade MS, Prchal JT, Garcia JGN, Machado RF, Gordeuk V (2014). Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing. Blood cells, molecules & diseases, 52(1), 35-45.
  21. Tashi T, Feng T, Koul P, Amaru R, Hussey D, Lorenzo FR, RiLi G, Prchal J (2014). High altitude genetic adaptation in Tibetans: no role of increased hemoglobin-oxygen affinity. Blood cells, molecules & diseases, 53(1-2), 27-9.
  22. Sirdah M, Reading NS, Vankayalapati H, Prchal J (2021). A computational study of structural differences of binding of NADP+ and G6P substrates to G6PD Mediterraneanc.563T, G6PD A-c.202A/c.376G, G6PD Cairoc.404C and G6PD Gazac.536A mutations. Blood cells, molecules & diseases, 89, 102572.
  23. Christensen RD, Lambert DK, Henry E, Yaish HM, Prchal J (2015). End-tidal carbon monoxide as an indicator of the hemolytic rate. Blood cells, molecules & diseases, 54(3), 292-6.
  24. Sangle N, Cook J, Perkins S, Teman CJ, Bahler D, Hickman K, Wilson A, Prchal J, Salama M (2014). Myelofibrotic transformations of polycythemia vera and essential thrombocythemia are morphologically, biologically, and prognostically indistinguishable from primary myelofibrosis. Applied immunohistochemistry & molecular morphology, 22(9), 663-8.
  25. Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal JT, Lanikova (2019). Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1. Journal of cellular and molecular medicine, 23(11), 7785-7795.
  26. Sarangi S, Lanikova L, Kapralova K, Acharya S, Swierczek S, Lipton JM, Wolfe L, Prchal J (2014). The homozygous VHL(D126N) missense mutation is associated with dramatically elevated erythropoietin levels, consequent polycythemia, and early onset severe pulmonary hypertension. Pediatric blood & cancer, 61(11), 2104-6.
  27. Christensen RD, Nussenzveig RH, Reading NS, Agarwal AM, Prchal JT, Yaish H (2014). Variations in both alpha-spectrin (SPTA1) and beta-spectrin ( SPTB ) in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis. Neonatology, 105(1), 1-4.
  28. Nussenzveig RH, Christensen RD, Prchal JT, Yaish HM, Agarwal A (2014). Novel alpha-spectrin mutation in trans with alpha-spectrin causing severe neonatal jaundice from hereditary spherocytosis. Neonatology, 106(4), 355-7.
  29. Christensen RD, Malleske DT, Lambert DK, Baer VL, Prchal JT, Denson LE, Gerday E, Weaver Lewis KA, Shepherd J (2016). Measuring End-Tidal Carbon Monoxide of Jaundiced Neonates in the Birth Hospital to Identify Those with Hemolysis. Neonatology, 109(1), 1-5.
  30. Thiagarajan P, Parker CJ, Prchal J (2021). How Do Red Blood Cells Die?. Frontiers in physiology, 12, 655393.
  31. Lanikova L, Babosova O, Prchal J (2019). Experimental Modeling of Myeloproliferative Neoplasms. Genes, 10(10),
  32. Xu G, van Bruggen R, Gualtieri CO, Moradin N, Fois A, Vallerand D, De Sa Tavares Russo M, Bassenden A, Lu W, Tam M, Lesage S, Girouard H, Avizonis DZ, Deblois G, Prchal JT, Stevenson M, Berghuis A, Muir T, Rabinowitz J, Vidal SM, Fodil N, Gros (2020). Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia. Cell reports, 32(12), 108170.
  33. Shrimali NM, Agarwal S, Kaur S, Bhattacharya S, Bhattacharyya S, Prchal JT, Guchhait (2021). ¿-Ketoglutarate Inhibits Thrombosis and Inflammation by Prolyl Hydroxylase-2 Mediated Inactivation of Phospho-Akt. EBioMedicine, 73, 103672.
  34. Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT, Guchhait (2021). Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: A lesson in inflammatory response to inspired hypoxia. EBioMedicine, 68, 103418.
  35. Gangaraju R, Song J, Kim SJ, Tashi T, Reeves BN, Sundar KM, Thiagarajan P, Prchal J (2020). Thrombotic, inflammatory, and HIF-regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia. Blood advances, 4(6), 1115-1130.
  36. Chan XY, Volkova E, Eoh J, Black R, Fang L, Gorashi R, Song J, Wang J, Elliott MB, Barreto-Ortiz SF, Chen J, Lin BL, Santhanam L, Cheng L, Lee FS, Prchal JT, Gerecht (2021). HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics. iScience, 24(4), 102246.
  37. Feusier JE, Arunachalam S, Tashi T, Baker MJ, VanSant-Webb C, Ferdig A, Welm BE, Rodriguez-Flores JL, Ours C, Jorde LB, Prchal JT, Mason C (2021). Large-Scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers. Blood cancer discovery, 2(3), 226-237.
  38. Bahr TM, Agarwal AM, Meznarich JA, Prince WL, Wait TWP, Prchal JT, Christensen R (2021). Thirty-five males with severe (Class 1) G6PD deficiency (c.637G>T) in a North American family of European ancestry. Blood cells, molecules & diseases, 92, 102625.
  39. Mascarenhas J, Kosiorek HE, Prchal JT, Rambaldi A, Berenzon D, Yacoub A, Harrison CN, McMullin MF, Vannucchi AM, Ewing J, O'Connell CL, Kiladjian JJ, Mead AJ, Winton EF, Leibowitz DS, De Stefano V, Arcasoy MO, Kessler CM, Catchatourian R, Rondelli D, Silver RT, Bacigalupo A, Nagler A, Kremyanskaya M, Levine MF, Arango Ossa JE, McGovern E, Sandy L, Salama ME, Najfeld V, Tripodi J, Farnoud N, Penson AV, Weinberg RS, Price L, Goldberg JD, Barbui T, Marchioli R, Tognoni G, Rampal RK, Mesa RA, Dueck AC, Hoffman (2022). A randomized phase 3 trial of interferon-¿ vs hydroxyurea in polycythemia vera and essential thrombocythemia. Blood, 139(19), 2931-2941.
  40. Kralova B, Sochorcova L, Song J, Jahoda O, Hlusickova Kapralova K, Prchal JT, Divoky V, Horvathova (2022). Developmental changes in iron metabolism and erythropoiesis in mice with human gain-of-function erythropoietin receptor. American journal of hematology, 97(10), 1286-1299.
  41. Amaru R, Song J, Reading NS, Gordeuk VR, Prchal J (2023). "What We Know and What We Do Not Know about Evolutionary Genetic Adaptation to High Altitude Hypoxia in Andean Aymaras". Genes, 14(3),
  42. Song J, Kim SJ, Gollamudi J, Thiagarajan P, Prchal J (2023). Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression. Blood advances, 7(5), 712-717.
  43. Song J, Sundar KM, Horvathova M, Gangaraju R, Indrak K, Christensen RD, Genzor S, Lundby C, Divoky V, Ganz T, Prchal J (2023). Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis. American journal of hematology,
  44. Prchal JT, Semenza G (2023). On either side of homeostasis: EPAS1 gain and loss of function mutations. Haematologica,
  45. Kragesteen BK, Giladi A, David E, Halevi S, Geirsdóttir L, Lempke OM, Li B, Bapst AM, Xie K, Katzenelenbogen Y, Dahl SL, Sheban F, Gurevich-Shapiro A, Zada M, Phan TS, Avellino R, Wang SY, Barboy O, Shlomi-Loubaton S, Winning S, Markwerth PP, Dekalo S, Keren-Shaul H, Kedmi M, Sikora M, Fandrey J, Korneliussen TS, Prchal JT, Rosenzweig B, Yutkin V, Racimo F, Willerslev E, Gur C, Wenger RH, Amit (2023). The transcriptional and regulatory identity of erythropoietin producing cells. Nature medicine, 29(5), 1191-1200.
  46. Shah BN, Zhang X, Sergueeva AI, Miasnikova GY, Ganz T, Prchal JT, Gordeuk V (2023). Increased transferrin protects from thrombosis in Chuvash erythrocytosis. American journal of hematology,
  47. Zhang X, Song J, Shah BN, Han J, Hassan T, Miasniakova G, Sergueeva A, Nekhai S, Machado RF, Gladwin MT, Saraf SL, Prchal JT, Gordeuk V (2023). Gene expression changes in sickle cell reticulocytes and their clinical associations. Scientific reports, 13(1), 12864.
  48. Trunk AD, Patel SS, Prchal JT, Sborov DW, Zander AR, Lee C (2023). Allogeneic stem cell transplant for multiple myeloma & myelofibrosis with split-dose busulfan, fludarabine & cyclophosphamide. Leukemia research reports, 20, 100388.
  49. Yoo JJ, Cohen HJ, Artz AS, Price E, Fill JA, Prchal J, Sapp S, Barnhart H, from the Partnership for Anemia Clinical and Translational Trials in the Elderly (PACTTE (2023). Biomarkers of erythropoiesis response to intravenous iron in a crossover pilot study in unexplained anemia of the elderly. Hematology (Amsterdam, Netherlands), 28(1), 1-8.
  50. Talpaz M, Prchal J, Afrin L, Arcasoy M, Hamburg S, Clark J, Kornacki D, Colucci P, Verstovsek (2022). Safety and Efficacy of Ruxolitinib in Patients with Myelofibrosis and Low Platelet Counts (50 - 100¿×¿10(9)/L): Final Analysis of an Open-Label Phase 2 Study. Clinical lymphoma, myeloma & leukemia, 22(5), 336-346.
  51. Bretz CA, Divoky V, Prchal J, Kunz E, Simmons AB, Wang H, Hartnett M (2018). Erythropoietin Signaling Increases Choroidal Macrophages and Cytokine Expression, and Exacerbates Choroidal Neovascularization. Scientific reports, 8(1), 2161.
  52. Kovacsovics-Bankowski M, Kelley TW, Efimova O, Kim SJ, Wilson A, Swierczek S, Prchal (2016). Changes in peripheral blood lymphocytes in polycythemia vera and essential thrombocythemia patients treated with pegylated-interferon alpha and correlation with JAK2(V617F) allelic burden. Experimental hematology & oncology, 5, 28.
  53. Price E, Artz AS, Barnhart H, Sapp S, Chelune G, Ershler WB, Walston JD, Gordeuk VR, Berger NA, Reuben D, Prchal J, Rao SV, Roy CN, Supiano MA, Schrier SL, Cohen H (2014). A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL. Blood cells, molecules & diseases, 53(4), 221-30.
  54. Prchal JT, Lichtman M (2024). Measurement of red cell, plasma, and blood volume: A perspective. American journal of hematology, 99(1), 9-11.
  55. Song J, Lanikova L, Kim SJ, Papadopoulos N, Meznarich J, Constantinescu SN, Parsegov B, Prchal JF, Prchal J (2024). Novel germline JAK2(R715T) mutation causing PV-like erythrocytosis in 3 generations. Amelioration by Ropeg-Interferon. American journal of hematology, 99(7), 1220-1229.
  56. Prchal JT, Burtscher M, Kim SJ, Wille M, Amaru R, Song (2026). Do Andean Aymara High-Altitude-Enriched Genetic Variants Protect Europeans Against Acute Mountain Sickness?. Acta physiologica (Oxford, England), 242(2), e70154.
  57. Shrimali NM, Ghosh R, Bhardwaj K, Tsewang C, Thinlas T, Koul P, Prchal JT, Guchhait (2026). Elevated Protein S Provides Evidence against Hypoxia-Induced Hypercoagulation in Tibetan Highlanders with PHD2D4E;C127S Polymorphisms. Thrombosis and haemostasis, 126(2), 223-226.
  58. Tashi T, Shih LY, Yo YT, Sullivan A, Chueh HY, Kuo MC, Smith A, Kim SJ, Parsegov B, Reeves BN, Song J, Prchal J (2026). Ropeginterferon alfa-2b has minimal transplacental passage and breastmilk secretion in pregnant MPN patients. Blood advances,
  59. Lanikova L, Hrckulak D, Zimolova V, Lorenzo FR, Song J, Vecerkova K, Babosova O, Berkova L, Korinek V, Elliott S, Prchal J (2026). Autosomal Dominant Erythrocytosis Caused by Non-Renal Erythropoietin (EPO) Due to EPO c.-136 G>A Germline Mutation. American journal of hematology,
  60. Reeves BN, Song J, Leier A, Smith A, Kim SJ, Chen SL, Tashi T, Prchal J (2025). Metformin alleviates side effects and supports the resumption of interferon therapy in polycythemia vera and essential thrombocythemia. Haematologica,
  61. Song J, Amaru R, Prchal J (2025). High altitude: A forgotten cause of pulmonary oedema. Lung India, 42(5), 389-390.
  62. Yu MS, Yu LH, Huang SH, Tsai TH, Lin AJ, Prchal JT, Chen MC, Lee K (2025). Real-world characteristics and treatment patterns in essential thrombocythemia: a population-based cross-sectional study in Taiwan between 2020 and 2021. Therapeutic advances in hematology, 16, 20406207251359651.
  63. Ghosh R, Joshi G, Shrimali NM, Bhardwaj K, Chorol T, Thinlas T, Koul PA, Prchal JT, Guchhait (2025). Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIF¿:IFN axis. PLoS pathogens, 21(6), e1013296.
  64. Song J, Han S, Amaru R, Lanikova L, Quispe T, Kim D, Crawford JE, Kim SJ, Lee Y, Prchal J (2025). Alternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin. Nature communications, 16(1), 1766.

Review

  1. Iolascon A, Bianchi P, Andolfo I, Russo R, Barcellini W, Fermo E, Toldi G, Ghirardello S, Rees D, Van Wijk R, Kattamis A, Gallagher PG, Roy N, Taher A, Mohty R, Kulozik A, De Franceschi L, Gambale A, De Montalembert M, Forni GL, Harteveld CL, Prchal J, SWG of red cell and iron of EHA and EuroBloodNe (2021). Recommendations for diagnosis and treatment of methemoglobinemia. American journal of hematology, 96(12), 1666-1678.
  2. Stein BL, Gotlib J, Arcasoy M, Nguyen MH, Shah N, Moliterno A, Jamieson C, Pollyea DA, Scott B, Wadleigh M, Levine R, Komrokji R, Klisovic R, Gundabolu K, Kropf P, Wetzler M, Oh ST, Ribeiro R, Paschal R, Mohan S, Podoltsev N, Prchal J, Talpaz M, Snyder D, Verstovsek S, Mesa R (2015). Historical views, conventional approaches, and evolving management strategies for myeloproliferative neoplasms. Journal of the National Comprehensive Cancer Network, 13(4), 424-34.
  3. Bose P, Xiao Z, Hasselbalch HC, Prchal JT, Duan M, Yacoub A, Rampal R, Kiladjian JJ, Hobbs GS, Tashi T, Shimoda K, Kirito K, Gill H, Hou HA, Lee SE, Huang J, Li B, Qin A, Yu LH, Mascarenhas JO, Mesa R (2025). Highlights from MPN Asia 2025: Advances in Molecular Pathogenesis and Therapeutic Strategies in Myeloproliferative Neoplasms. Current hematologic malignancy reports, 20(1), 9.

Case Report

  1. Boonyawat B, Dhanraj S, Al Abbas F, Zlateska B, Grunenbaum E, Roifman CM, Steele L, Meyn S, Blanchette V, Scherer SW, Swierczek S, Prchal J, Zhu Q, Torgerson TR, Ochs HD, Dror (2013). Combined de-novo mutation and non-random X-chromosome inactivation causing Wiskott-Aldrich syndrome in a female with thrombocytopenia. Journal of clinical immunology, 33(7), 1150-5.
  2. Christensen RD, Yaish HM, Wiedmeier SE, Reading NS, Pysher TJ, Palmer CA, Prchal J (2013). Neonatal death suspected to be from sepsis was found to be kernicterus with G6PD deficiency. Pediatrics, 132(6), e1694-8.
  3. Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Yost CC, Li P, Reading NS, Prchal JT, Christensen R (2020). A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity. Neonatology, 117(4), 532-535.

Editorial

  1. Prchal JT, Gordeuk V (2021). HIF-2 inhibitor, erythrocytosis, and pulmonary hypertension. Blood, 137(18), 2424-2425.
  2. Mascarenhas J, Mesa R, Prchal J, Hoffman (2014). Optimal therapy for polycythemia vera and essential thrombocythemia can only be determined by the completion of randomized clinical trials. Haematologica, 99(6), 945-9.
  3. Song J, Tashi T, Prchal J (2019). Editorial Comment on: Inhibition of Suicidal Erythrocyte Death by Chronic Hypoxia by Tang et al. (From: Tang F, Feng L, Li R, Wang W, Liu H, Yang Q, Ge R-L. High Alt Med Biol 2019;20:112-119; DOI: 10.1089/ham.2017.0159). High altitude medicine & biology, 20(2), 120-121.
  4. Song J, Christensen RD, Thiagarajan P, Prchal J (2021). Does neocytolysis exist after descent from high altitude?. Acta physiologica (Oxford, England), 233(3), e13713.
  5. Prchal JT, Reeves B (2023). EnvIRONment modifies polycythemia vera. Blood, 141(17), 2042-2044.
  6. Iolascon A, Andolfo I, Russo R, Barcellini W, Fermo E, Toldi G, Ghirardello S, Rees D, Van Wijk R, Kattamis A, Gallagher PG, Roy N, Taher A, Mohty R, Kulozik A, De Franceschi L, Gambale A, De Montalembert M, Forni GL, Harteveld CL, Prchal J, Bianchi (2021). Summary of Joint European Hematology Association (EHA) and EuroBloodNet Recommendations on Diagnosis and Treatment of Methemoglobinemia. HemaSphere, 5(12), e660.

Letter

  1. Kim SJ, Song J, Reading NS, Lautersztain J, Kutlar A, Agarwal AM, Coetzer TL, Prchal J (2021). Novel mechanism of hereditary pyropoikilocytosis phenotype due to co-inheritance of ß globin and ¿ spectrin mutations. American journal of hematology, 96(5), E150-E154.
  2. Reeves BN, Kim SJ, Song J, Wilson KJ, Henderson MW, Key NS, Pawlinski R, Prchal J (2021). Tissue Factor Activity Is Increased in Neutrophils from JAK2 V617F-mutated Essential Thrombocythemia and Polycythemia Vera Patients. American journal of hematology, 97(2), E37-E40.
  3. Meznarich JA, Rets A, Agarwal AM, Christensen RD, Reading NS, Kuypers FA, Prchal J (2021). Novel, de novo, beta-globin variant with decreased oxygen affinity (HBB:c.317T>A, "Hemoglobin St. George") in a healthy child with low oxygen saturations and anemia. American journal of hematology, 96(12), E448-E450.
  4. Gangaraju R, Carroll AJ, Prchal J (2019). Response to interferon treatment in essential thrombocythemia with inv(3)(q21q26). Annals of hematology,
  5. Salama ME, Swierczek SI, Tashi T, Warby CA, Reading NS, Prchal J (2014). Calreticulin mutated prefibrotic-stage myelofibrosis and PMF represent an independent clone from coexisting CLL. Blood, 124(10), 1691-2.
  6. Sergueeva AI, Miasnikova GY, Polyakova LA, Nouraie M, Prchal JT, Gordeuk V (2015). Complications in children and adolescents with Chuvash polycythemia. Blood, 125(2), 414-5.
  7. Zhang X, Song J, Shah BN, Nekhai S, Miasnikova G, Sergueeva A, Prchal JT, Gordeuk V (2020). Peripheral blood mononuclear cells show prominent gene expression by erythroid progenitors in diseases characterized by heightened erythropoiesis. British journal of haematology, 190(1), e42-e45.
  8. Gordeuk VR, Miasnikova GY, Sergueeva AI, Lorenzo FR, Zhang X, Song J, Stockton DW, Prchal J (2020). Thrombotic risk in congenital erythrocytosis due to up-regulated hypoxia sensing is not associated with elevated hematocrit. Haematologica, 105(3), e87-e90.
  9. Wang L, Swierczek SI, Drummond J, Hickman K, Kim SJ, Walker K, Doddapaneni H, Muzny DM, Gibbs RA, Wheeler DA, Prchal J (2014). Whole-exome sequencing of polycythemia vera revealed novel driver genes and somatic mutation shared by T cells and granulocytes. Leukemia, 28(4), 935-8.
  10. Wang L, Swierczek SI, Lanikova L, Kim SJ, Hickman K, Walker K, Wang K, Drummond J, Doddapaneni H, Reid JG, Muzny DM, Gibbs RA, Wheeler DA, Prchal J (2014). The relationship of JAK2(V617F) and acquired UPD at chromosome 9p in polycythemia vera. Leukemia, 28(4), 938-41.
  11. Swierczek S, Lima LT, Tashi T, Kim SJ, Gregg XT, Prchal J (2015). Presence of polyclonal hematopoiesis in females with Ph-negative myeloproliferative neoplasms. Leukemia, 29(12), 2432-4.
  12. Mascarenhas J, Kosiorek H, Prchal J, Yacoub A, Berenzon D, Baer MR, Ritchie E, Silver RT, Kessler C, Winton E, Finazzi MC, Rambaldi A, Vannucchi AM, Leibowitz D, Rondelli D, Arcasoy MO, Catchatourian R, Vadakara J, Rosti V, Hexner E, Kremyanskaya M, Sandy L, Tripodi J, Najfeld V, Farnoud N, Salama ME, Weinberg RS, Rampal R, Goldberg JD, Mesa R, Dueck AC, Hoffman (2019). A prospective evaluation of pegylated interferon alfa-2a therapy in patients with polycythemia vera and essential thrombocythemia with a prior splanchnic vein thrombosis. Leukemia, 33(12), 2974-2978.
  13. Lichtman MA, Prchal J (2024). Measurement of red cell, plasma and blood volume: Essential components of diagnostic and research studies of oxygen transport. Blood cells, molecules & diseases, 105, 102819.
  14. Sergeev I, Prchal JT, Nouraie SM, Shah BN, Zhang X, Sergueeva A, Miasnikova G, Ganz T, Gordeuk V (2025). VHL, transferrin, and erythropoietin in the regulation of hepcidin. HemaSphere, 9(12), e70271.

Other

  1. Zhang X, Song J, Shah BN, Han J, Hassan T, Miasniakova G, Sergueeva A, Nekhai S, Machado RF, Gladwin MT, Saraf SL, Prchal JT, Gordeuk V (2023). Publisher Correction: Gene expression changes in sickle cell reticulocytes and their clinical associations. Scientific reports, 13(1), 15225.

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