Kevin M. Watt
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Kevin M. Watt, MD, PhD

Dr. Kevin Watt received his medical degree and PhD from the University of North Carolina at Chapel Hill. He completed his pediatric residency, pediatric critical care fellowship, and a research fellowship at Duke University. He was a faculty member at Duke for 7 years before accepting a position in 2019 at the University of Utah. He is currently the Robert M. Ward Endowed Chair in Clinical Pharmacology and an Associate Professor of Pediatrics. He serves as the Chief of the Division of Clinical Pharmacology in the Department of Pediatrics and treats patients in the pediatric intensive care unit at Primary Children’s Hospital.

Dr. Watt’s research career spans over twenty-four years at institutions such as the Thomas J Watson Foundation, The JW Jones Ecological Research Center and the Duke Clinical Research Institute at Duke University. This research coincided with his work in the US Food and Drug Administration where his focus was appropriate dosage and labeling for prescription drugs for children.

Dr. Watt’s overarching career goals are to advance public health by optimizing drug therapy in critically ill children and to train the future generation of health care scientists. To accomplish these goals, I lead a multidisciplinary team of cross-trained scientists and staff who have expertise in critical illness physiology, advanced pharmacokinetic (PK)/ pharmacodynamic (PD) modeling, biostatistics, and clinical trial design and conduct. His NIH-funded research program uses modeling and simulation to determine optimal drug dosing in vulnerable populations (e.g., critically ill children, breastfeeding women and their infants). In addition, he has led and continues to lead, single and multi-center trials for pediatric labeling including several first-in-human and first-in-children trials. He serves in a leadership role in the NICHD-funded Collaborative Pediatric Critical Research Network and the NCATS-funded Utah Trial Innovation Center and HEAL-initiative.

Specialties

Board Certification

American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Pediatric Critical Care Medicine)
American Board of Clinical Pharmacology

Dr. Kevin Watt received his medical degree and PhD from the University of North Carolina at Chapel Hill. He completed his pediatric residency, pediatric critical care fellowship, and a research fellowship at Duke University. He was a faculty member at Duke for 7 years before accepting a position in 2019 at the University of Utah. He is currently the Robert M. Ward Endowed Chair in Clinical Pharmacology and an Associate Professor of Pediatrics. He serves as the Chief of the Division of Clinical Pharmacology in the Department of Pediatrics and treats patients in the pediatric intensive care unit at Primary Children’s Hospital.

Dr. Watt’s research career spans over twenty-four years at institutions such as the Thomas J Watson Foundation, The JW Jones Ecological Research Center and the Duke Clinical Research Institute at Duke University. This research coincided with his work in the US Food and Drug Administration where his focus was appropriate dosage and labeling for prescription drugs for children.

Dr. Watt’s overarching career goals are to advance public health by optimizing drug therapy in critically ill children and to train the future generation of health care scientists. To accomplish these goals, I lead a multidisciplinary team of cross-trained scientists and staff who have expertise in critical illness physiology, advanced pharmacokinetic (PK)/ pharmacodynamic (PD) modeling, biostatistics, and clinical trial design and conduct. His NIH-funded research program uses modeling and simulation to determine optimal drug dosing in vulnerable populations (e.g., critically ill children, breastfeeding women and their infants). In addition, he has led and continues to lead, single and multi-center trials for pediatric labeling including several first-in-human and first-in-children trials. He serves in a leadership role in the NICHD-funded Collaborative Pediatric Critical Research Network and the NCATS-funded Utah Trial Innovation Center and HEAL-initiative.

Board Certification and Academic Information

Academic Departments Pediatrics -Professor
Academic Divisions Critical Care
Board Certification
American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Pediatric Critical Care Medicine)
American Board of Clinical Pharmacology

Education history

Undergraduate Natural Resources - University of the South B.S.
Professional Medical Medicine - University of North Carolina School of Medicine M.D.
Internship/Residency Pediatrics - Duke University School of Medicine Intern/Resident
Fellowship Pediatric Critical Care - Duke University School of Medicine Fellow
Fellowship Pediatric Clinical Research - Duke Clinical Research Institute Clinical Research Fellow
Graduate Training Pharmaceutical Sciences - University of North Carolina Eshelman School of Pharmacy Ph.D.

Selected Publications

Journal Article

  1. Zimmerman KO, Wu H, Laughon M, Greenberg RG, Walczak R, Schulman SR, Smith PB, Hornik CP, Cohen-Wolkowiez M, Watt KM (2018). Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass.(Epub ahead of print). Anesth Analg.
  2. Zimmerman KO, Wu H, Laughon M, Greenberg RG, Walczak R, Schulman SR, Smith PB, Hornik CP, Cohen-Wolkowiez M, Watt KM (2019). Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass. Anesth Analg, 129(6), 1519-1528.
  3. Cohen-Wolkowiez M, Watt KM, Zhou C, Bloom BT, Poindexter B, Castro L, Gao J, Capparelli EV, Benjamin DK Jr, Smith PB (2014). Developmental pharmacokinetics of piperacillin and tazobactam using plasma and dried blood spots from infants. Antimicrob Agents Chemother, 58(5), 2856-65.
  4. Watt KM, Gonzalez D, Benjamin DK Jr, Brouwer KL, Wade KC, Capparelli E, Barrett J, Cohen-Wolkowiez M (2015). Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation. Antimicrob Agents Chemother, 59(7), 3935-43.
  5. Smith MJ, Gonzalez D, Goldman JL, Yogev R, Sullivan JE, Reed MD, Anand R, Martz K, Berezny K, Benjamin DK Jr, Smith PB, Cohen-Wolkowiez M, Watt K, Best Pharmaceuticals for Children Act'Pediatric Trials Network Steering Committee. (2017). Pharmacokinetics of Clindamycin in Obese and Nonobese Children. Antimicrob Agents Chemother, 61(4).
  6. Cohen-Wolkowiez M, Poindexter B, Bidegain M, Weitkamp JH, Schelonka RL, Randolph DA, Ward RM, Wade K, Valencia G, Burchfield D, Arrieta A, Mehta V, Walsh M, Kantak A, Rasmussen M, Sullivan JE, Finer N, Rich W, Brozanski BS, van den Anker J, Blumer J, Laughon M, Watt KM, Kearns GL, Capparelli EV, Martz K, Berezny K, Benjamin DK Jr, Smith PB, Meropenem Study Team. (2012). Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections. Clin Infect Dis, 55(11), 1495-502.
  7. Watt KM, Hornik CP, Balevic SJ, Mundakel G, Cotten CM, Harper B, Benjamin DK Jr, Anand R, Laughon M, Smith PB, Cohen-Wolkowiez M, Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee. (2019). Pharmacokinetics of ticarcillin-clavulanate in premature infants. Br J Clin Pharmacol, 85(5), 1021-1027.
  8. Maharaj AR, Wu H, Zimmerman KO, Autmizguine J, Kalra R, Al-Uzri A, Sherwin CMT, Goldstein SL, Watt K, Erinjeri J, Payne EH, Cohen-Wolkowiez M, Hornik CP (2021). Population pharmacokinetics of olanzapine in children. Br J Clin Pharmacol, 87(2), 542-554.
  9. Watt KM, Avant D, Sherwin J, Benjamin DK, Hornik C, Benjamin DK Jr, Li JS, Smith PB (2018). Effect of renal function on antihypertensive drug safety and efficacy in children. Pediatr Nephrol, 33(1), 139-146.
  10. Williams DC, Turi JL, Hornik CP, Bonadonna DK, Williford WL, Walczak RJ, Watt KM, Cheifetz IM (2015). Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis. ASAIO J, 61(2), 190-5.
  11. Imburgia CE, Rower JE, Green DJ, Mcknite AM, Kelley WE, Reilly CA, Watt KM (2021). Remdesivir and GS-441524 Extraction by Ex Vivo Extracorporeal Life Support Circuits. ASAIO J, 68(9), 1204-1210.
  12. Watt KM, Cohen-Wolkowiez M, Williams DC, Bonadonna DK, Cheifetz IM, Thakker D, Benjamin DK Jr, Brouwer KLR (2017). Antifungal Extraction by the Extracorporeal Membrane Oxygenation Circuit. J Extra Corpor Technol, 49(3), 150-159.
  13. McDaniel CG, Honeycutt CC, Watt KM (2021). Amiodarone Extraction by the Extracorporeal Membrane Oxygenation Circuit. J Extra Corpor Technol, 53(1), 68-74.
  14. Dallefeld SH, Sherwin J, Zimmerman KO, Watt KM (2020). Dexmedetomidine extraction by the extracorporeal membrane oxygenation circuit: results from an in vitro study. Perfusion, 35(3), 209-216.
  15. Sherwin J, Heath T, Watt K (2016). Pharmacokinetics and Dosing of Anti-infective Drugs in Patients on Extracorporeal Membrane Oxygenation: A Review of the Current Literature. Clin Ther, 38(9), 1976-94.
  16. Zhao W, Le Guellec C, Benjamin DK Jr, Hope WW, Bourgeois T, Watt KM, van den Anker JN, Matrot B, Saxen H, Hoppu K, Manzoni P, Jacqz-Aigrain E (2014). First dose in neonates: are juvenile mice, adults and in vitro-in silico data predictive of neonatal pharmacokinetics of fluconazole. Clin Pharmacokinet, 53(11), 1005-18.
  17. Hornik CP, Wu H, Edginton AN, Watt K, Cohen-Wolkowiez M, Gonzalez D (2017). Development of a Pediatric Physiologically-Based Pharmacokinetic Model of Clindamycin Using Opportunistic Pharmacokinetic Data. Clin Pharmacokinet, 56(11), 1343-1353.
  18. Pineda LC, Watt K (2015). New antibiotic dosing in infants. Clinics in perinatology, 42(1), 167-76, ix-x.
  19. Gonzalez D, Melloni C, Yogev R, Poindexter BB, Mendley SR, Delmore P, Sullivan JE, Autmizguine J, Lewandowski A, Harper B, Watt KM, Lewis KC, Capparelli EV, Benjamin DK Jr, Cohen-Wolkowiez M, Best Pharmaceuticals for Children Act ¿ Pediatric Trials Network Administrative Core Committee (2014). Use of opportunistic clinical data and a population pharmacokinetic model to support dosing of clindamycin for premature infants to adolescents. Clinical pharmacology and therapeutics, 96(4), 429-37.
  20. Watt K, Benjamin DK Jr, Cohen-Wolkowiez (2011). Pharmacokinetics of antifungal agents in children. Early human development, 87 Suppl 1, S61-5.
  21. Ascher SB, Smith PB, Clark RH, Cohen-Wolkowiez M, Li JS, Watt K, Jacqz-Aigrain E, Kaguelidou F, Manzoni P, Benjamin DK J (2012). Sepsis in young infants with congenital heart disease. Early human development, 88 Suppl 2, S92-7.
  22. Hornik CP, Fort P, Clark RH, Watt K, Benjamin DK Jr, Smith PB, Manzoni P, Jacqz-Aigrain E, Kaguelidou F, Cohen-Wolkowiez (2012). Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Early human development, 88 Suppl 2, S69-74.
  23. Hornik CP, Yogev R, Mourani PM, Watt KM, Sullivan JE, Atz AM, Speicher D, Al-Uzri A, Adu-Darko M, Payne EH, Gelber CE, Lin S, Harper B, Melloni C, Cohen-Wolkowiez M, Gonzalez D, Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee (2019). Population Pharmacokinetics of Milrinone in Infants, Children, and Adolescents. Journal of clinical pharmacology, 59(12), 1606-1619.
  24. Maharaj AR, Wu H, Zimmerman KO, Speicher DG, Sullivan JE, Watt K, Al-Uzri A, Payne EH, Erinjeri J, Lin S, Harper B, Melloni C, Hornik CP, Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee (2019). Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis. Journal of clinical pharmacology,
  25. Tan WW, Watt KM, Boakye-Agyeman F, Cohen-Wolkowiez M, Mok YH, Yung CF, Chan Y (2021). Optimal Dosing of Meropenem in a Small Cohort of Critically Ill Children Receiving Continuous Renal Replacement Therapy. Journal of clinical pharmacology, 61(6), 744-754.
  26. Downey LC, Benjamin DK Jr, Clark RH, Watt KM, Hornik CP, Laughon MM, Cohen-Wolkowiez M, Smith P (2013). Urinary tract infection concordance with positive blood and cerebrospinal fluid cultures in the neonatal intensive care unit. Journal of perinatology, 33(4), 302-6.
  27. Gonski S, Hupp SR, Cotten CM, Clark RH, Laughon M, Watt K, Hornik CP, Kumar K, Smith PB, Greenberg R (2019). Risk of development of treated retinopathy of prematurity in very low birth weight infants. Journal of perinatology, 39(11), 1562-1568.
  28. Zimmerman KO, Hornik CP, Ku L, Watt K, Laughon MM, Bidegain M, Clark RH, Smith P (2015). Sedatives and Analgesics Given to Infants in Neonatal Intensive Care Units at the End of Life. The Journal of pediatrics, 167(2), 299-304.e3.
  29. Watt K, Li JS, Benjamin DK Jr, Cohen-Wolkowiez (2011). Pediatric cardiovascular drug dosing in critically ill children and extracorporeal membrane oxygenation. Journal of cardiovascular pharmacology, 58(2), 126-32.
  30. Watt KM, Massaro MM, Smith B, Cohen-Wolkowiez M, Benjamin DK Jr, Laughon M (2012). Pharmacokinetics of moxifloxacin in an infant with Mycoplasma hominis meningitis. The Pediatric infectious disease journal, 31(2), 197-9.
  31. Ascher SB, Smith PB, Watt K, Benjamin DK, Cohen-Wolkowiez M, Clark RH, Benjamin DK Jr, Moran (2012). Antifungal therapy and outcomes in infants with invasive Candida infections. The Pediatric infectious disease journal, 31(5), 439-43.
  32. Cohen-Wolkowiez M, Watt KM, Hornik CP, Benjamin DK Jr, Smith P (2012). Pharmacokinetics and tolerability of single-dose daptomycin in young infants. The Pediatric infectious disease journal, 31(9), 935-7.
  33. Watt KM, Benjamin DK Jr, Cheifetz IM, Moorthy G, Wade KC, Smith PB, Brouwer KL, Capparelli EV, Cohen-Wolkowiez (2012). Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation. The Pediatric infectious disease journal, 31(10), 1042-7.
  34. Autmizguine J, Watt KM, Théorêt Y, Kassir N, Laferrière C, Parent S, Tapiéro B, Ovetchkine (2013). Pharmacokinetics and pharmacodynamics of oral cephalexin in children with osteoarticular infections. The Pediatric infectious disease journal, 32(12), 1340-4.
  35. Autmizguine J, Moran C, Gonzalez D, Capparelli EV, Smith PB, Grant GA, Benjamin DK Jr, Cohen-Wolkowiez M, Watt K (2014). Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections. The Pediatric infectious disease journal, 33(10), e270-2.
  36. Autmizguine J, Hornik CP, Benjamin DK Jr, Brouwer KL, Hupp SR, Cohen-Wolkowiez M, Watt K (2016). Pharmacokinetics and Safety of Micafungin in Infants Supported With Extracorporeal Membrane Oxygenation. The Pediatric infectious disease journal, 35(11), 1204-1210.
  37. Gonzalez D, Bradley JS, Blumer J, Yogev R, Watt KM, James LP, Palazzi DL, Bhatt-Mehta V, Sullivan JE, Zhang L, Murphy J, Ussery XT, Puttagunta S, Dunne MW, Cohen-Wolkowiez (2017). Dalbavancin Pharmacokinetics and Safety in Children 3 Months to 11 Years of Age. The Pediatric infectious disease journal, 36(7), 645-653.
  38. Watt KM, Cohen-Wolkowiez M, Ward RM, Benjamin DK J (2012). Commentary: pediatric antifungal drug development: lessons learned and recommendations for the future. The Pediatric infectious disease journal, 31(6), 635-7.
  39. Watt KM, Walgos J, Cheifetz IM, Turner D (2012). Dexmedetomidine for transport of a spontaneously breathing combative child. Pediatrics, 130(3), e690-4.
  40. Tripathi N, Watt K, Benjamin DK J (2012). Treatment and prophylaxis of invasive candidiasis. Seminars in perinatology, 36(6), 416-23.
  41. Sherwin J, Thompson E, Hill KD, Watt K, Lodge AJ, Gonzalez D, Hornik C (2018). Clinical pharmacology considerations for children supported with ventricular assist devices. Cardiology in the young, 28(9), 1082-1090.
  42. Kyler KE, Wagner J, Hosey-Cojocari C, Watt K, Shakhnovich (2019). Drug Dose Selection in Pediatric Obesity: Available Information for the Most Commonly Prescribed Drugs to Children. Paediatric drugs, 21(5), 357-369.
  43. Manzoni P, Benjamin DK Jr, Franco C, Rizzollo S, Stronati M, Watt K, Cohen-Wolkowiez M, Jacqz-Aigrain (2013). Echinocandins for the nursery: an update. Current drug metabolism, 14(2), 203-7.
  44. Watt K, Manzoni P, Cohen-Wolkowiez M, Rizzollo S, Boano E, Jacqz-Aigrain E, Benjamin D (2013). Triazole use in the nursery: fluconazole, voriconazole, posaconazole, and ravuconazole. Current drug metabolism, 14(2), 193-202.
  45. Kanesvaran R, Watt K, Turnbull JD, Armstrong AJ, Wolkowiez MC, George D (2015). A Single-Arm Phase 1b Study of Everolimus and Sunitinib in Patients With Advanced Renal Cell Carcinoma. Clinical genitourinary cancer, 13(4), 319-327.
  46. Watt K, Waddle E, Jhaveri (2010). Changing epidemiology of serious bacterial infections in febrile infants without localizing signs. PloS one, 5(8), e12448.
  47. Yellepeddi V, Sayre C, Burrows A, Watt K, Davies S, Strauss J, Battaglia (2020). Stability of extemporaneously compounded amiloride nasal spray. PloS one, 15(7), e0232435.
  48. Autmizguine J, Benjamin DK Jr, Smith PB, Sampson M, Ovetchkine P, Cohen-Wolkowiez M, Watt K (2014). Pharmacokinetic studies in infants using minimal-risk study designs. Current clinical pharmacology, 9(4), 350-8.
  49. Yellepeddi VK, Parashar K, Dean SM, Watt KM, Constance JE, Baker O (2021). Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically-Based Pharmacokinetic Modeling. Clinical and translational science, 14(2), 683-691.
  50. Zimmerman KO, Dallefeld SH, Hornik CP, Watt K (2020). Sedative and Analgesic Pharmacokinetics During Pediatric ECMO. The journal of pediatric pharmacology and therapeutics, 25(8), 675-688.
  51. Harskamp-van Ginkel MW, Hill KD, Becker KC, Testoni D, Cohen-Wolkowiez M, Gonzalez D, Barrett JS, Benjamin DK Jr, Siegel DA, Banks P, Watt KM, Best Pharmaceuticals for Children Act'Pediatric Trials Network Administrative Core Committee (2015). Drug Dosing and Pharmacokinetics in Children With Obesity: A Systematic Review. JAMA pediatrics, 169(7), 678-85.
  52. Salerno SN, Edginton A, Cohen-Wolkowiez M, Hornik CP, Watt KM, Jamieson BD, Gonzalez (2017). Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid. CPT, 6(12), 814-822.
  53. Gerhart JG, Watt KM, Edginton A, Wade KC, Salerno SN, Benjamin DK Jr, Smith PB, Hornik CP, Cohen-Wolkowiez M, Duara S, Ross A, Shattuck K, Stewart DL, Neu N, Gonzalez D, Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee (2019). Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants. CPT, 8(7), 500-510.
  54. Watt KM, Cohen-Wolkowiez M, Barrett JS, Sevestre M, Zhao P, Brouwer KLR, Edginton A (2018). Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO. CPT, 7(10), 629-637.
  55. Sampson M, Cohen-Wolkowiez M, Benjamin D Jr, Capparelli E, Watt (2013). Pharmacokinetics of Antimicrobials in Obese Children. GaBI journal, 2(2), 76-81.
  56. McMahon AW, Watt K, Wang J, Green D, Tiwari R, Burckart G (2016). Stratification, Hypothesis Testing, and Clinical Trial Simulation in Pediatric Drug Development. Therapeutic innovation & regulatory science, 2016,
  57. Van Eldik LJ, Sawaki L, Bowen K, Laskowitz DT, Noveck RJ, Hauser B, Jordan L, Spears TG, Wu H, Watt K, Raja S, Roy SM, Watterson DM, Guptill J (2021). First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers. Clinical pharmacology in drug development, 10(2), 131-143.
  58. Dubinsky S, Watt K, Saleeb S, Ahmed B, Carter C, Yeung CHT, Edginton (2021). Pharmacokinetics of Commonly Used Medications in Children Receiving Continuous Renal Replacement Therapy: A Systematic Review of Current Literature.
  59. Job KM, Dallmann A, Parry S, Saade G, Haas DM, Hughes B, Berens P, Chen JY, Fu C, Humphrey K, Hornik C, Balevic S, Zimmerman K, Watt (2022). Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk. Clinical pharmacology and therapeutics, 111(5), 1111-1120.
  60. Jason Roberts, Rinaldo Bellomo, Menino Cotta, Birgit Koch, Haifa Lyster, Marlies Ostermann, Claire Roger, Kiran Shekar, Kevin Watt, Mohd-Hafiz Abdul-Azi (2022). Machines that help machines to help patients: optimising drug dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy. European journal of intensive care medicine, 48(10), 1338-1351.
  61. Stitt G, Dubinsky S, Edginton A, Huang YV, Zuppa AF, Watt K, Downes (2022). Antimicrobial Dosing Recommendations in Pediatric Continuous Renal Replacement Therapy: A Critical Appraisal of Current Evidence. Frontiers in pediatrics, 10, 889958.
  62. Baserga M, DuPont TL, Ostrander B, Minton S, Sheffield M, Balch AH, Bahr TM, Watt K (2021). Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial): A Randomized Controlled Trial: Background, Aims and Study Protocol. Frontiers in pain research (Lausanne, Switzerland), 2, 770511.
  63. Gerhart JG, Carreño FO, Ford JL, Edginton AN, Perrin EM, Watt KM, Muller WJ, Atz AM, Al-Uzri A, Delmore P, Gonzalez D, Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee (2022). Use of physiologically-based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity. CPT, 11(6), 778-791.
  64. Chambers CD, Krishnan JA, Alba L, Albano JD, Bryant AS, Carver M, Cohen LS, Gorodetsky E, Hernandez-Diaz S, Honein MA, Jones BL, Murray RK, Namazy JA, Sahin L, Spong CY, Vasisht KP, Watt K, Wurst KE, Yao L, Schatz (2021). The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities. The Journal of allergy and clinical immunology, 147(6), 2009-2020.
  65. Danielle J Green, Kevin M Watt, Douglas N Fish, Autumn McKnite, Walter Kelley, Adam R Bensimho (2022). Cefepime Extraction by Extracorporeal Life Support Circuits. J Extra Corpor Technol, 54(3), 212-222.
  66. Zimmerman KO, Spears TG, Cobbaert M, Boakye-Agyeman F, Wu H, Cohen-Wolkowiez M, Watt KM, Benjamin DK Jr, Becker ML, Traube C, Smith PB (2021). Use of Electronic Health Records to Identify Exposure-Response Relationships in Critically Ill Children: An Example of Midazolam and Delirium. J Pediatr Intensive Care, 11(4), 300-307.
  67. Zimmerman KO, Spears TG, Cobbaert M, Boakye-Agyeman F, Wu H, Cohen-Wolkowiez M, Watt KM, Benjamin DK Jr, Becker ML, Traube C, Smith PB (2022). Use of Electronic Health Records to Identify Exposure-Response Relationships in Critically Ill Children: An Example of Midazolam and Delirium. J Pediatr Intensive Care, 11(4), 300-307.
  68. McKnite AM, Job KM, Nelson R, Sherwin CMT, Watt KM, Brewer SC (2022). Medication based machine learning to identify subpopulations of pediatric hemodialysis patients in an electronic health record database. Inform Med Unlocked, 34(101104),
  69. Imburgia CE, Rower JE, Green DJ, Mcknite AM, Kelley WE, Reilly CA, Watt KM (2022). Remdesivir and GS-441524 Extraction by Ex Vivo Extracorporeal Life Support Circuits. ASAIO J, 68(9), 1204-1210.
  70. Hunt JP, McKnite AM, Green DJ, Whelan AJ, Imburgia CE, Watt KM (2023). Interaction of ceftazidime and clindamycin with extracorporeal life support. J Infect Chemother, 29(12), 1119-1125.
  71. Zantek ND, Steiner ME, Teruya J, Kreuziger LB, Raffini L, Muszynski JA, Alexander PMA, Gehred A, Lyman E, Watt K (2024). Recommendations on Monitoring and Replacement of Antithrombin, Fibrinogen, and Von Willebrand Factor in Pediatric Patients on Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. . Pediatric Critical Care Medicine, 25(7 Suppl 1), e35-e43.
  72. Alexander PMA, Bembea MM, Cashen K, Cheifetz IM, Dalton HJ, Himebauch AS, Karam O, Moynihan KM, Nellis ME, Ozment C, Raman L, Rintoul NE, Said AS, Saini A, Steiner ME, Thiagarajan RR, Watt K, Willems A, Zantek ND, Barbaro RP, Steffen K, Vogel AM, Almond C, Anders MM, Annich GM, Brandão LR, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli SK, Garcia AV, Haileselassie B, Hyslop R, Kneyber MCJ, Baumann Kreuziger L, Le J, Loftis L, McMichael ABV, McMullan DM, Monagle P, Nicol K, Paden ML, Patregnani J, Priest J, Raffini L, Ryerson LM, Sloan SR, Teruya J, Yates AR, Gehred A, Lyman E, Muszynski JA (2024). Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference. . Pediatric Critical Care Medicine, 25(7), 643-675.
  73. Dubinsky S, Hamadeh A, Imburgia C, McKnite A, Porter Hunt J, Wong K, Rice C, Rower J, Watt K, Edginton (2024). Physiologically Based Pharmacokinetic Modelling in Critically Ill Children Receiving Anakinra While on Extracorporeal Life Support. Clinical pharmacokinetics,
  74. Chevalier A, Porter Hunt J, Whelan A, McKnite A, Watt KM, Green D (2024). Extraction of ketamine and dexmedetomidine by extracorporeal life support circuits¿. The journal of extra-corporeal technology, 56(3), 101-107.
  75. Yellepeddi VK, Hunt JP, Green DJ, McKnite A, Whelan A, Watt (2024). A physiologically-based pharmacokinetic modeling approach for dosing amiodarone in children on ECMO. CPT, 13(9), 1542-1553.
  76. Muszynski JA, Bembea MM, Gehred A, Lyman E, Cashen K, Cheifetz IM, Dalton HJ, Himebauch AS, Karam O, Moynihan KM, Nellis ME, Ozment C, Raman L, Rintoul NE, Said A, Saini A, Steiner ME, Thiagarajan RR, Watt K, Willems A, Zantek ND, Barbaro RP, Steffen K, Vogel AM, Alexander PMA, Pediatric Extracorporeal Membrane Oxygenation (ECMO) Anticoagulation CollaborativE (PEACE), in collaboration with the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric ECMO subgroup of PALISI and the Extracorporeal Life Support Organization (PediECMO (2024). Priorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric critical care medicine, 25(7 Suppl 1), e78-e89.
  77. Moynihan KM, Ryerson LM, Le J, Nicol K, Watt K, Gadepalli SK, Alexander PMA, Muszynski JA, Gehred A, Lyman E, Steiner ME, Pediatric Extracorporeal Membrane Oxygenation (ECMO) Anticoagulation CollaborativE (PEACE), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, and the Pediatric ECMO subgroup of PALISI and the Extracorporeal Life Support Organization (PediECMO (2024). Antifibrinolytic and Adjunct Hemostatic Agents: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric critical care medicine, 25(7 Suppl 1), e44-e52.
  78. Zantek ND, Steiner ME, Teruya J, Kreuziger LB, Raffini L, Muszynski JA, Alexander PMA, Gehred A, Lyman E, Watt K, Pediatric ECMO Anticoagulation CollaborativE (PEACE), in collaboration with the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric ECMO subgroup of PALISI and the Extracorporeal Life Support Organization (PediECMO (2024). Recommendations on Monitoring and Replacement of Antithrombin, Fibrinogen, and Von Willebrand Factor in Pediatric Patients on Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric critical care medicine, 25(7 Suppl 1), e35-e43.
  79. Alexander PMA, Bembea MM, Cashen K, Cheifetz IM, Dalton HJ, Himebauch AS, Karam O, Moynihan KM, Nellis ME, Ozment C, Raman L, Rintoul NE, Said AS, Saini A, Steiner ME, Thiagarajan RR, Watt K, Willems A, Zantek ND, Barbaro RP, Steffen K, Vogel AM, Almond C, Anders MM, Annich GM, Brandão LR, Chandler W, Delaney M, DiGeronimo R, Emani S, Gadepalli SK, Garcia AV, Haileselassie B, Hyslop R, Kneyber MCJ, Baumann Kreuziger L, Le J, Loftis L, McMichael ABV, McMullan DM, Monagle P, Nicol K, Paden ML, Patregnani J, Priest J, Raffini L, Ryerson LM, Sloan SR, Teruya J, Yates AR, Gehred A, Lyman E, Muszynski JA, Pediatric ECMO Anticoagulation CollaborativE (PEACE), in collaboration with the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric ECMO subgroup of PALISI and the Extracorporeal Life Support Organization (PediECMO (2024). Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference. Pediatric critical care medicine, 25(7), 643-675.
  80. Khurana N, Watkins K, Ghatak D, Staples J, Hubbard O, Yellepeddi V, Watt K, Ghandehari (2024). Reducing hydrophobic drug adsorption in an in-vitro extracorporeal membrane oxygenation model. European journal of pharmaceutics and biopharmaceutics, 198, 114261.
  81. Hunt JP, Dubinsky S, McKnite AM, Cheung KWK, van Groen BD, Giacomini KM, de Wildt SN, Edginton AN, Watt K (2024). Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling. CPT, 13(4), 576-588.
  82. Dubinsky SDJ, Watt KM, Imburgia CE, Mcknite AM, Hunt JP, Rice C, Rower JE, Edginton A (2023). Anakinra Removal by Continuous Renal Replacement Therapy: An Ex Vivo Analysis. Critical care explorations, 5(12), e1010.
  83. Khurana N, Sünner T, Hubbard O, Imburgia CE, Yellepeddi V, Ghandehari H, Watt K (2023). Direct and continuous dosing of propofol can saturate Ex vivo ECMO circuit to improve propofol recovery. The journal of extra-corporeal technology, 55(4), 194-196.
  84. Honeycutt CC, McDaniel CG, McKnite A, Hunt JP, Whelan A, Green DJ, Watt K (2023). Meropenem extraction by ex vivo extracorporeal life support circuits. The journal of extra-corporeal technology, 55(4), 159-166.
  85. Hunt JP, McKnite AM, Green DJ, Whelan AJ, Imburgia CE, Watt K (2023). Interaction of ceftazidime and clindamycin with extracorporeal life support. Journal of infection and chemotherapy, 29(12), 1119-1125.
  86. VanBuren JM, Hall M, Zuppa AF, Mourani PM, Carcillo J, Dean JM, Watt K, Holubkov (2023). The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study. Pediatric critical care medicine, 24(12), e635-e646.
  87. Hunt JP, Free TJ, Galiardi J, Watt KM, Wood DW, Bundy B (2023). Streamlining the Detection of Human Thyroid Receptor Ligand Interactions with XL1-Blue Cell-Free Protein Synthesis and Beta-Galactosidase Fusion Protein Biosensors. Life (Basel, Switzerland), 13(10),
  88. Khurana N, Sünner T, Hubbard O, Imburgia C, Stoddard GJ, Yellepeddi V, Ghandehari H, Watt K (2023). Micellar Encapsulation of Propofol Reduces its Adsorption on Extracorporeal Membrane Oxygenator (ECMO) Circuit. The AAPS journal, 25(4), 52.
  89. Constance JE, McFarland MM, Casucci T, Deininger MW, Enioutina EY, Job K, Lemons RS, Lim CS, Ward RM, Yellepeddi V, Watt K (2023). Mapping the Evidence for Opioid-Mediated Changes in Malignancy and Chemotherapeutic Efficacy: Protocol for a Scoping Review. JMIR research protocols, 12, e38167.
  90. Green DJ, Watt KM, Fish DN, McKnite A, Kelley W, Bensimhon A (2022). Cefepime Extraction by Extracorporeal Life Support Circuits. The journal of extra-corporeal technology, 54(3), 212-222.
  91. McKnite AM, Job KM, Nelson R, Sherwin CMT, Watt KM, Brewer S (2022). Medication based machine learning to identify subpopulations of pediatric hemodialysis patients in an electronic health record database. Informatics in medicine unlocked, 34,
  92. Stitt G, Thibault C, Mueller BA, Cies JJ, Daniel JM, Arikan AA, Watt KM (2024). Pharmacokinetic Research in Pediatric Extracorporeal Therapies: Current State and Future Directions. Blood purification, 53(6), 520-526.

Review

  1. McKnite AM, Green DJ, Nelson R, Brewer SC, Watt K (2024). Medication patterns and dosing guidance in pediatric patients supported with intermittent hemodialysis or continuous kidney replacement therapy. Pediatric nephrology (Berlin, Germany), 39(5), 1521-1532.
  2. Tarrell A, Giles L, Smith B, Traube C, Watt (2024). Delirium in the NICU. Journal of perinatology, 44(2), 157-163.
  3. Lyster H, Shekar K, Watt K, Reed A, Roberts JA, Abdul-Aziz M (2023). Antifungal Dosing in Critically Ill Patients on Extracorporeal Membrane Oxygenation. Clinical pharmacokinetics, 62(7), 931-942.
  4. Hudson RE, Metz TD, Ward RM, McKnite AM, Enioutina EY, Sherwin CM, Watt KM, Job K (2023). Drug exposure during pregnancy: Current understanding and approaches to measure maternal-fetal drug exposure. Frontiers in pharmacology, 14, 1111601.
  5. Roberts JA, Bellomo R, Cotta MO, Koch BCP, Lyster H, Ostermann M, Roger C, Shekar K, Watt K, Abdul-Aziz M (2022). Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software. Intensive care medicine, 48(10), 1338-1351.
  6. McCreary EK, Davis MR, Narayanan N, Andes DR, Cattaneo D, Christian R, Lewis RE, Watt KM, Wiederhold NP, Johnson M (2023). Utility of triazole antifungal therapeutic drug monitoring: Insights from the Society of Infectious Diseases Pharmacists: Endorsed by the Mycoses Study Group Education and Research Consortium. Pharmacotherapy, 43(10), 1043-1050.

Editorial

  1. Watt K (2020). How to Rapidly Determine First-in-Children Dosing for COVID-19 Therapeutics. JAMA pediatrics, 174(10), e202435.