Matthew T. Rondina
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Matthew T. Rondina, MD, MS

Languages spoken: English

Dr. Matthew Rondina is a Professor in the Departments of Internal Medicine and Pathology at the University of Utah. He is also the Director of Molecular Medicine at the University of Utah and is the Medical Director of the Thrombosis Service at the Salt Lake City Veteran’s Administration Health Center. Dr. Rondina's laboratory focuses on discovering how inflammation alters gene expression in platelets and their progenitor cells, megakaryocytes. Major ongoing efforts are:

  • using innovative sequencing technologies to comprehensively map changes in cell gene expression;
  • determining how changes in gene expression regulate function in stem cell and peripheral blood compartments;
  • establishing the functional impact of these changes on host outcomes;
  • applying AI/ML computational approaches to enable the use of gene expression changes to improve early cancer diagnostics.

Specialties

Board Certification

American Board of Internal Medicine (Internal Medicine)

Dr. Matthew Rondina is a Professor in the Departments of Internal Medicine and Pathology at the University of Utah. He is also the Director of Molecular Medicine at the University of Utah and is the Medical Director of the Thrombosis Service at the Salt Lake City Veteran’s Administration Health Center. Dr. Rondina's laboratory focuses on discovering how inflammation alters gene expression in platelets and their progenitor cells, megakaryocytes. Major ongoing efforts are:

  • using innovative sequencing technologies to comprehensively map changes in cell gene expression;
  • determining how changes in gene expression regulate function in stem cell and peripheral blood compartments;
  • establishing the functional impact of these changes on host outcomes;
  • applying AI/ML computational approaches to enable the use of gene expression changes to improve early cancer diagnostics.

Board Certification and Academic Information

Academic Departments Internal Medicine -Professor
Pathology -Adjunct Professor
Academic Divisions Hematology & Hematologic Malignancies
Board Certification
American Board of Internal Medicine (Internal Medicine)

Education history

Undergraduate Brigham Young University
Undergraduate Psychology - University of Utah B.S.
Professional Medical Medicine - University of Utah Medical School M.D.
Internship Internal Medicine - University of Utah Health Sciences Center Intern
Residency Internal Medicine - University of Utah Health Sciences Center Resident
Chief Resident Internal Medicine - University of Utah Chief Medical Resident
Graduate Training Clinical Investigation - University of Utah M.S.

Selected Publications

Journal Article

  1. Freeman A, Horner T, Pendleton RC, Rondina M (2012). Prospective comparison of three enoxaparin dosing regimens to achieve target anti-factor Xa levels in hospitalized, medically ill patients with extreme obesity. American journal of hematology, 87(7), 740-3.
  2. Vazquez S, Rondina M (2010). ACP Journal Club. Review: Graduated compression stockings reduce deep venous thrombosis in hospitalized patients. Annals of internal medicine, 153(12), JC6-6.
  3. Vazquez S, Rondina M (2013). ACP Journal Club. Apixaban reduced stroke or systemic embolism in AF more than warfarin regardless of type or duration of AF. Annals of internal medicine, 159(2), JC8.
  4. Johnson SA, Rondina M (2014). Edoxaban was noninferior to warfarin for preventing stroke or systemic embolism in atrial fibrillation. Annals of internal medicine, 160(6), JC7.
  5. Watkins RD, Rondina M (2015). ACP Journal Club. Review: DOACs do not differ from standard anticoagulants for recurrent VTE; factor Xa inhibitors reduce bleeding. Annals of internal medicine, 163(8), JC3.
  6. Franks ZG, Campbell RA, Weyrich AS, Rondina M (2010). Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke. Annals of the New York Academy of Sciences, 1207, 11-7.
  7. Zhao YX, Tang F, Ga Q, Wuren T, Wang YP, Rondina MT, Ge R (2015). High fat diet exacerbates vascular endothelial dysfunction in rats exposed to continuous hypobaric hypoxia. Biochemical and biophysical research communications, 457(3), 485-91.
  8. McInturff AM, Cody MJ, Elliott EA, Glenn JW, Rowley JW, Rondina MT, Yost C (2012). Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 alpha. Blood, 120(15), 3118-25.
  9. Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich A (2012). Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood, 120(25), 5014-20.
  10. Rondina MT, Weyrich A (2015). Dengue virus pirates human platelets. Blood, 126(3), 286-7.
  11. Simeoni I, Stephens JC, Hu F, Deevi SV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJ, Westbury SK, Greene D, Papadia S, Alessi MC, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve AC, Guerrero JA, Hampshire DJ, Hart DP, Heemskerk JW, Henskens YM, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, Lopez JA, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina MT, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet C, Whitehorn D, Wilcox DA, Zhang B, Revel-Vilk S, Gresele P, Bellissimo DB, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro (2016). A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood, 127(23), 2791-803.
  12. Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz HOR, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris E, Zimmerman GA, Weyrich AS, Rondina M (2019). Sepsis Alters the Transcriptional and Translational Landscape of Human and Murine Platelets. Blood, 134(12), 911-923.
  13. Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, D'Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras E, DeGregori J, Rondina MT, Di Paola (2019). TNF-alpha driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood, 134(9), 727-740.
  14. Campbell RA, Schwertz H, Hottz ED, Rowley JW, Manne BK, Washington AV, Hunter-Mellado R, Tolley ND, Christensen M, Eustes AS, Montenont E, Bhatlekar S, Ventrone CH, Kirkpatrick BD, Pierce KK, Whitehead SS, Diehl SA, Bray PF, Zimmerman GA, Kosaka Y, Bozza PT, Bozza FA, Weyrich AS, Rondina M (2019). Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3. Blood, 133(19), 2013-2026.
  15. Madden JL, Drakos SG, Stehlik J, McKellar SH, Rondina MT, Weyrich AS, Selzman C (2014). Baseline red blood cell osmotic fragility does not predict the degree of post-LVAD hemolysis. ASAIO journal (American Society for Artificial Internal Organs, 60(5), 524-8.
  16. Cook RM, Rondina MT, Horton D (2014). Rivaroxaban for the Long-term Treatment of Spontaneous Ovarian Vein Thrombosis Caused by Factor V Leiden Homozygosity. The Annals of pharmacotherapy, 48(8), 1055-1060.
  17. Brown SM, Tate MQ, Jones JP, Kuttler KG, Lanspa MJ, Rondina MT, Grissom CK, Mathews V (2015). Coefficient of Variation of Coarsely Sampled Heart Rate is Associated With Early Vasopressor Independence in Severe Sepsis and Septic Shock. Journal of intensive care medicine, 30(7), 420-5.
  18. Brown SM, Tate Q, Jones JP, Knox DB, Kuttler KG, Lanspa M, Rondina MT, Grissom CK, Behera S, Mathews VJ, Morris (2013). Initial fractal exponent of heart rate variability is associated with success of early resuscitation in patients with severe sepsis or septic shock: a prospective cohort study. Journal of critical care, 28(6), 959-63.
  19. Rondina MT, Brewster B, Grissom CK, Zimmerman GA, Kastendieck DH, Harris ES, Weyrich A (2012). In vivo platelet activation in critically ill patients with primary 2009 influenza A(H1N1). Chest, 141(6), 1490-1495.
  20. Rondina MT, Weyrich AS, Zimmerman G (2013). Platelets as cellular effectors of inflammation in vascular diseases. Circulation research, 112(11), 1506-19.
  21. Chen K, Rondina MT, Weyrich A (2013). A sticky story for signal transducer and activator of transcription 3 in platelets. Circulation, 127(4), 421-3.
  22. Rondina MT, Lam UT, Pendleton RC, Kraiss LW, Wanner N, Zimmerman GA, Hoffman JM, Hanrahan C, Boucher K, Christian PE, Butterfield RI, Morton K (2012). (18)F-FDG PET in the evaluation of acuity of deep vein thrombosis. Clinical nuclear medicine, 37(12), 1139-45.
  23. Rondina MT, Tatsumi K, Bastarache JA, Mackman (2016). Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection. Critical care medicine, 44(7), e574-8.
  24. Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel E (2019). Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes. Diabetes, 68(5), 932-938.
  25. Brown SM, Grissom CK, Rondina MT, Hoidal JR, Scholand MB, Wolff RK, Morris AH, Paine R 3r (2015). Polymorphisms in key pulmonary inflammatory pathways and the development of acute respiratory distress syndrome. Experimental lung research, 41(3), 155-62.
  26. Xu J, Yang YZ, Tang F, Ga Q, Wuren T, Wang Z, Ma L, Rondina MT, Ge R (2015). CYP17A1 and CYP2E1 variants associated with high altitude polycythemia in Tibetans at the Qinghai-Tibetan Plateau. Gene, 566(2), 257-63.
  27. Bhatlekar S, Basak I, Edelstein LC, Campbell RA, Lindsey CR, Italiano JE Jr, Weyrich AS, Rowley JW, Rondina MT, Sola-Visner M, Bray P (2019). Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood. Haematologica, 104(10), 2075-2083.
  28. Mohebali D, Kaplan D, Carlisle M, Supiano MA, Rondina M (2014). Alterations in platelet function during aging: clinical correlations with thromboinflammatory disease in older adults. Journal of the American Geriatrics Society, 62(3), 529-35.
  29. Edholm K, Ragle N, Rondina M (2015). Antithrombotic management of atrial fibrillation in the elderly. The Medical clinics of North America, 99(2), 417-30.
  30. Vazquez SR, Johnson SA, Rondina M (2010). Peri-procedural anticoagulation in patients undergoing ablation for atrial fibrillation. Thrombosis research, 126(2), e69-77.
  31. Rondina MT, Grissom CK, Men S, Harris ES, Schwertz H, Zimmerman GA, Weyrich A (2012). Whole blood flow cytometry measurements of in vivo platelet activation in critically-Ill patients are influenced by variability in blood sampling techniques. Thrombosis research, 129(6), 729-35.
  32. Rondina MT, Wheeler M, Rodgers GM, Draper L, Pendleton R (2010). Weight-based dosing of enoxaparin for VTE prophylaxis in morbidly obese, medically-Ill patients. Thrombosis research, 125(3), 220-3.
  33. Rondina MT, Wanner N, Pendleton RC, Kraiss LW, Vinik R, Zimmerman GA, Heilbrun M, Hoffman JM, Morton K (2012). A pilot study utilizing whole body 18 F-FDG-PET/CT as a comprehensive screening strategy for occult malignancy in patients with unprovoked venous thromboembolism. Thrombosis research, 129(1), 22-7.
  34. Johnson S, Rondina M (2011). Local INR control had some effect on the benefits of dabigatran over warfarin for major bleeding in atrial fibrillation. ACP journal club, 154(2), JC1-6.
  35. Rondina MT, Carlisle M, Fraughton T, Brown SM, Miller RR 3rd, Harris ES, Weyrich AS, Zimmerman GA, Supiano MA, Grissom CK (2014). Platelet-Monocyte Aggregate Formation and Mortality Risk in Older Patients With Severe Sepsis and Septic Shock. The journals of gerontology. Series A, Biological sciences and medical sciences, 70(2), 225-231.
  36. Rondina MT, Carlisle M, Fraughton T, Brown SM, Miller RR 3rd, Harris ES, Weyrich AS, Zimmerman GA, Supiano MA, Grissom C (2015). Platelet-monocyte aggregate formation and mortality risk in older patients with severe sepsis and septic shock. The journals of gerontology. Series A, Biological sciences and medical sciences, 70(2), 225-31.
  37. Montenont E, Rondina MT, Campbell R (2019). Altered functions of platelets during aging. Current opinion in hematology, 26(5), 336-342.
  38. Vazquez S, Rondina M (2015). Direct oral anticoagulants (DOACs). Vascular medicine (London, England), 20(6), 575-7.
  39. Stewart LK, Peitz GW, Nordenholz KE, Courtney DM, Kabrhel C, Jones AE, Rondina MT, Diercks DB, Klinger JR, Kline J (2015). Contribution of fibrinolysis to the physical component summary of the SF-36 after acute submassive pulmonary embolism. Journal of thrombosis and thrombolysis, 40(2), 161-6.
  40. Woller SC, Stevens SM, Kaplan DA, Branch DW, Aston VT, Wilson EL, Gallo HM, Johnson EG, Rondina MT, Lloyd JF, Evans RS, Elliott C (2016). Apixaban for the Secondary Prevention of Thrombosis Among Patients With Antiphospholipid Syndrome: Study Rationale and Design (ASTRO-APS). Clinical and applied thrombosis/hemostasis, 22(3), 239-47.
  41. Shang C, Wuren T, Ga Q, Bai Z, Guo L, Eustes AS, McComas KN, Rondina MT, Ge (2019). The human platelet transcriptome and proteome is altered and pro-thrombotic functional responses are increased during prolonged hypoxia exposure at high altitude. Platelets, 1-10.
  42. Franks Z, Carlisle M, Rondina M (2015). Current challenges in understanding immune cell functions during septic syndromes. BMC immunology, 16, 11.
  43. Su J, Li Z, Cui S, Ji L, Geng H, Chai K, Ma X, Bai Z, Yang Y, Wuren T, Ge RL, Rondina M (2015). The Local HIF-2alpha/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness. High altitude medicine & biology, 16(4), 318-30.
  44. Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, Grissom CK, Weyrich AS, Zimmerman G (2011). The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. Journal of thrombosis and haemostasis, 9(4), 748-58.
  45. Kline JA, Nordenholz KE, Courtney DM, Kabrhel C, Jones AE, Rondina MT, Diercks DB, Klinger JR, Hernandez (2014). Treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial. Journal of thrombosis and haemostasis, 12(4), 459-68.
  46. Rondina MT, Weyrich A (2015). Regulation of the genetic code in megakaryocytes and platelets. Journal of thrombosis and haemostasis, 13 Suppl 1, S26-32.
  47. Rondina MT, Freitag M, Pluthero FG, Kahr WH, Rowley JW, Kraiss LW, Franks Z, Zimmerman GA, Weyrich AS, Schwertz (2016). Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets. Journal of thrombosis and haemostasis, 14(5), 1082-94.
  48. Freeman AL, Pendleton RC, Rondina M (2010). Prevention of venous thromboembolism in obesity. Expert review of cardiovascular therapy, 8(12), 1711-21.
  49. Rondina MT, Graves K (2016). The addition of abdomen and pelvis CT to limited cancer screening does not increase diagnosis of cancer in patients with unprovoked venous thromboembolism. Evidence-based medicine, 21(1), 19.
  50. Rondina MT, Weyrich A (2012). Targeting phosphodiesterases in anti-platelet therapy. Handbook of experimental pharmacology, (210), 225-38.
  51. Rondina MT, Walker A, Pendleton R (2010). Drug-induced thrombocytopenia for the hospitalist physician with a focus on heparin-induced thrombocytopenia. Hospital practice (1995), 38(2), 19-28.
  52. Stubblefield WB, Alves NJ, Rondina MT, Kline J (2016). Variable Resistance to Plasminogen Activator Initiated Fibrinolysis for Intermediate-Risk Pulmonary Embolism. PloS one, 11(2), e0148747.
  53. Shih L, Kaplan D, Kraiss LW, Casper TC, Pendleton RC, Peters CL, Supiano MA, Zimmerman GA, Weyrich AS, Rondina M (2016). Platelet-Monocyte Aggregates and C-Reactive Protein are Associated with VTE in Older Surgical Patients. Scientific reports, 6, 27478.
  54. Jessica MO, Fiorella R, Ocatavio S, Linnette R, Nahomy L, Kanth MB, Bismarck M, Rondina MT, Valance W (2018). TLT-1-CONTROLS EARLY THROMBUS FORMATION AND STABILITY BY FACILITATING AIIBB3 OUTSIDE-IN SIGNALING IN MICE. International journal of advanced research, 6(3), 1143-1149.
  55. Petrocelli JJ, McKenzie AI, de Hart NMMP, Reidy PT, Mahmassani ZS, Keeble AR, Kaput KL, Wahl MP, Rondina MT, Marcus RL, Welt CK, Holland WL, Funai K, Fry CS, Drummond M (2023). Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment. Aging cell, 22(11), e13936.
  56. Guo L, Jacob S, Manne BK, Kolawole EM, Guo S, Wang X, Murray D, Tugolukova EA, Portier I, Kosaka Y, Barba C, Rondina MT, Evavold B, Morley C, Bhatlekar S, Bray P (2023). Actin-bundling protein L-plastin promotes megakaryocyte rigidity and dampens proplatelet formation. Haematologica, 109(1), 331-336.
  57. Siebert AE, Brake MA, Verbeek SC, Johnston AJ, Morgan AP, Cleuren AC, Jurek AM, Schneider CD, Germain DM, Battistuzzi FU, Zhu G, Miller DR, Johnsen JM, Pardo-Manuel de Villena F, Rondina MT, Westrick R (2023). Identification of genomic loci regulating platelet plasminogen activator inhibitor-1 in mice. Journal of thrombosis and haemostasis, 21(10), 2917-2928.
  58. Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins TP, Belshe RB, Chawla DG, Rondina MT, Gill TM, Montgomery RR, Allore HG, Kleinstein SH, Shaw A (2023). Platelet response to influenza vaccination reflects effects of aging. Aging cell, 22(2), e13749.
  59. Manne BK, Campbell RA, Bhatlekar S, Ajanel A, Denorme F, Portier I, Middleton EA, Tolley ND, Kosaka Y, Montenont E, Guo L, Rowley JW, Bray PF, Jacob S, Fukanaga R, Proud C, Weyrich AS, Rondina M (2022). MAPK-interacting kinase 1 regulates platelet production, activation, and thrombosis. Blood, 140(23), 2477-2489.
  60. Campbell RA, Manne BK, Banerjee M, Middleton EA, Ajanel A, Schwertz H, Denorme F, Stubben C, Montenont E, Saperstein S, Page L, Tolley ND, Lim DL, Brown SM, Grissom CK, Sborov DW, Krishnan A, Rondina M (2022). IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis. The Journal of clinical investigation, 132(23),
  61. Morrell CN, Mix D, Aggarwal A, Bhandari R, Godwin M, Owens P 3rd, Lyden SP, Doyle A, Krauel K, Rondina MT, Mohan A, Lowenstein CJ, Shim S, Stauffer S, Josyula VP, Ture SK, Yule DI, Wagner LE 3rd, Ashton JM, Elbadawi A, Cameron S (2022). Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. The Journal of clinical investigation, 132(9),
  62. McKenzie AI, Mahmassani ZS, Petrocelli JJ, de Hart NMMP, Fix DK, Ferrara PJ, LaStayo PC, Marcus RL, Rondina MT, Summers SA, Johnson JM, Trinity JD, Funai K, Drummond M (2022). Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H(2)O(2) emission and production in healthy, older adults: A randomized controlled trial. Experimental gerontology, 163, 111804.
  63. Bhatlekar S, Jacob S, Tugolukova E, Manne BK, Kosaka Y, Loher P, O'Connell RM, Planelles V, Rondina MT, Rigoutsos I, Bray P (2022). Interferon ¿-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation. Haematologica, 107(2), 558-561.
  64. Sun S, Jin C, Si J, Lei Y, Chen K, Cui Y, Liu Z, Liu J, Zhao M, Zhang X, Tang F, Rondina MT, Li Y, Wang Q (2021). Single-cell analysis of ploidy and the transcriptome reveals functional and spatial divergency in murine megakaryopoiesis. Blood, 138(14), 1211-1224.
  65. Kempker JA, Martin GS, Rondina MT, Cannon-Albright L (2022). Evidence for an Inherited Contribution to Sepsis Susceptibility Among a Cohort of U.S. Veterans. Critical care explorations, 4(1), e0603.
  66. Queisser KA, Mellema RA, Middleton EA, Portier I, Manne BK, Denorme F, Beswick EJ, Rondina MT, Campbell RA, Petrey A (2021). COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction. JCI insight, 6(17),
  67. Othman M, Baker AT, Gupalo E, Elsebaie A, Bliss CM, Rondina MT, Lillicrap D, Parker A (2021). To clot or not to clot? Ad is the question-Insights on mechanisms related to vaccine-induced thrombotic thrombocytopenia. Journal of thrombosis and haemostasis, 19(11), 2845-2856.
  68. Supernat A, Pop'da M, Pastuszak K, Best MG, Gre'ner P, Veld SI', Siek B, Bednarz-Knoll N, Rondina MT, Stokowy T, Wurdinger T, Jassem J, ¿aczek A (2021). Transcriptomic landscape of blood platelets in healthy donors. Scientific reports, 11(1), 15679.
  69. Schwertz H, Rowley JW, Portier I, Middleton EA, Tolley ND, Campbell RA, Eustes AS, Chen K, Rondina M (2022). Human platelets display dysregulated sepsis-associated autophagy, induced by altered LC3 protein-protein interaction of the Vici-protein EPG5. Autophagy, 18(7), 1534-1550.
  70. Woller SC, Stevens SM, Kaplan D, Wang TF, Branch DW, Groat D, Wilson EL, Armbruster B, Aston VT, Lloyd JF, Rondina MT, Elliott C (2022). Apixaban compared with warfarin to prevent thrombosis in thrombotic antiphospholipid syndrome: a randomized trial. Blood advances, 6(6), 1661-1670.
  71. Campbell RA, Hisada Y, Denorme F, Grover SP, Bouck EG, Middleton EA, Wolberg AS, Rondina MT, Mackman (2021). Comparison of the coagulopathies associated with COVID-19 and sepsis. Research and practice in thrombosis and haemostasis, 5(4), e12525.
  72. Sumanth MS, Jacob SP, Abhilasha KV, Manne BK, Basrur V, Lehoux S, Campbell RA, Yost CC, McIntyre TM, Cummings RD, Weyrich AS, Rondina MT, Marathe G (2021). Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils. Journal of leukocyte biology, 109(5), 915-930.
  73. Guo L, Shen S, Rowley JW, Tolley ND, Jia W, Manne BK, McComas KN, Bolingbroke B, Kosaka Y, Krauel K, Denorme F, Jacob SP, Eustes AS, Campbell RA, Middleton EA, He X, Brown SM, Morrell CN, Weyrich AS, Rondina M (2021). Platelet MHC class I mediates CD8+ T-cell suppression during sepsis. Blood, 138(5), 401-416.
  74. Montenont E, Bhatlekar S, Jacob S, Kosaka Y, Manne BK, Lee O, Parra-Izquierdo I, Tugolukova E, Tolley ND, Rondina MT, Bray PF, Rowley J (2021). CRISPR-edited megakaryocytes for rapid screening of platelet gene functions. Blood advances, 5(9), 2362-2374.
  75. Eustes AS, Campbell RA, Middleton EA, Tolley ND, Manne BK, Montenont E, Rowley JW, Krauel K, Blair A, Guo L, Kosaka Y, Medeiros-de-Moraes IM, Lacerda M, Hottz ED, Neto HCF, Zimmerman GA, Weyrich AS, Petrey A, Rondina M (2021). Heparanase expression and activity are increased in platelets during clinical sepsis. Journal of thrombosis and haemostasis, 19(5), 1319-1330.
  76. Trinity JD, Craig JC, Fermoyle CC, McKenzie AI, Lewis MT, Park SH, Rondina MT, Richardson R (2021). Impact of presymptomatic COVID-19 on vascular and skeletal muscle function: a case study. Journal of applied physiology (Bethesda, Md., 130(6), 1961-1970.
  77. Granja MG, Alves LP, Leardini-Tristão M, Saul ME, Bortoni LC, de Moraes FM, Ferreira EC, de Moraes BPT, da Silva VZ, Dos Santos AFR, Silva AR, Gonçalves-de-Albuquerque CF, Bambini-Junior V, Weyrich AS, Rondina MT, Zimmerman GA, de Castro-Faria-Neto H (2021). Inflammatory, synaptic, motor, and behavioral alterations induced by gestational sepsis on the offspring at different stages of life. Journal of neuroinflammation, 18(1), 60.
  78. Griffiths TM, Page L, Weyrich AS, Rondina MT, Campbell R (2021). Platelet electrical resistance for measuring platelet activation and adhesion in human health and disease. Thrombosis research, 198, 204-209.
  79. Brown SM, Beesley SJ, Stubben C, Wilson EL, Presson AP, Grissom C, Maguire C, Rondina MT, Hopkins R (2021). Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study. Journal of intensive care medicine, 36(3), 262-270.
  80. Bouck EG, Denorme F, Holle LA, Middelton EA, Blair AM, de Laat B, Schiffman JD, Yost CC, Rondina MT, Wolberg AS, Campbell R (2021). COVID-19 and Sepsis Are Associated With Different Abnormalities in Plasma Procoagulant and Fibrinolytic Activity. Arteriosclerosis, thrombosis, and vascular biology, 41(1), 401-414.
  81. Ross JE, Zhang BM, Lee K, Mohan S, Branchford BR, Bray P, Dugan SN, Freson K, Heller PG, Kahr WHA, Lambert MP, Luchtman-Jones L, Luo M, Perez Botero J, Rondina MT, Ryan G, Westbury S, Bergmeier W, Di Paola (2021). Specifications of the variant curation guidelines for ITGA2B/ITGB3: ClinGen Platelet Disorder Variant Curation Panel. Blood advances, 5(2), 414-431.
  82. Trivedi S, Labuz D, Anderson CP, Araujo CV, Blair A, Middleton EA, Jensen O, Tran A, Mulvey MA, Campbell RA, Hale JS, Rondina MT, Leung D (2020). Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis. eLife, 9,
  83. Denorme F, Manne BK, Portier I, Petrey AC, Middleton EA, Kile BT, Rondina MT, Campbell R (2020). COVID-19 patients exhibit reduced procoagulant platelet responses. Journal of thrombosis and haemostasis, 18(11), 3067-3073.
  84. Melki I, Allaeys I, Tessandier N, Mailhot B, Cloutier N, Campbell RA, Rowley JW, Salem D, Zufferey A, Laroche A, Lévesque T, Patey N, Rauch J, Lood C, Droit A, McKenzie SE, Machlus KR, Rondina MT, Lacroix S, Fortin PR, Boilard (2020). Fc'RIIA expression accelerates nephritis and increases platelet activation in systemic lupus erythematosus. Blood, 136(25), 2933-2945.
  85. Sachetto ATA, Archibald SJ, Hisada Y, Rosell A, Havervall S, van Es N, Nieuwland R, Campbell RA, Middleton EA, Rondina MT, Thålin C, Mackman (2023). Tissue factor activity of small and large extracellular vesicles in different diseases. Research and practice in thrombosis and haemostasis, 7(3), 100124.
  86. Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell R (2020). Platelet gene expression and function in patients with COVID-19. Blood, 136(11), 1317-1329.
  87. Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost C (2020). Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 136(10), 1169-1179.
  88. Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O'Connell RM, Rondina MT, Campbell RA, Bray P (2020). miR-125a-5p regulates megakaryocyte proplatelet formation via the actin-bundling protein L-plastin. Blood, 136(15), 1760-1772.
  89. Frey C, Koliopoulou AG, Montenont E, Tolley ND, Javan H, McKellar SH, Drakos SG, Selzman CH, Rondina M (2020). Longitudinal assessment of the platelet transcriptome in advanced heart failure patients following mechanical unloading. Platelets, 31(7), 952-959.
  90. Manne BK, Bhatlekar S, Middleton EA, Weyrich AS, Borst O, Rondina M (2020). Phospho-inositide-dependent kinase 1 regulates signal dependent translation in megakaryocytes and platelets. Journal of thrombosis and haemostasis, 18(5), 1183-1196.
  91. Rondina MT, Voora D, Simon LM, Schwertz H, Harper JF, Lee O, Bhatlekar SC, Li Q, Eustes AS, Montenont E, Campbell RA, Tolley ND, Kosaka Y, Weyrich AS, Bray PF, Rowley J (2020). Longitudinal RNA-Seq Analysis of the Repeatability of Gene Expression and Splicing in Human Platelets Identifies a Platelet SELP Splice QTL. Circulation research, 126(4), 501-516.
  92. Marini I, Rigoni F, Zlamal J, Pelzl L, Althaus K, Nowak-Harnau S, Rondina MT, Bakchoul (2020). Blood donor-derived buffy coat to produce platelets in vitro. Vox sanguinis, 115(1), 94-102.
  93. Denorme F, Manne BK, Portier I, Eustes AS, Kosaka Y, Kile BT, Rondina MT, Campbell R (2020). Platelet necrosis mediates ischemic stroke outcome in mice. Blood, 135(6), 429-440.
  94. Cirulis MM, Beesley SJ, Wilson EL, Stubben C, Olsen TD, Hirshberg EL, Smith LM, Lanspa MJ, Abraham TP, Grissom CK, Rondina MT, Brown S (2019). The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study. Intensive care medicine experimental, 7(1), 57.
  95. Zheng Y, Larragoite ET, Williams ESCP, Lama J, Cisneros I, Delgado JC, Slev P, Rychert J, Innis EA, Coiras M, Rondina MT, Spivak AM, Planelles (2021). Neutralization assay with SARS-CoV-1 and SARS-CoV-2 spike pseudotyped murine leukemia virions. Virology journal, 18(1), 1.
  96. Rondina MT, Lappé JM, Carlquist JF, Muhlestein JB, Kolek MJ, Horne BD, Pearson RR, Anderson J (2008). Soluble CD40 ligand as a predictor of coronary artery disease and long-term clinical outcomes in stable patients undergoing coronary angiography. Cardiology, 109(3), 196-201.
  97. Nay I, Hutchinson D, ROndina M, Kim K, Kirkham A, Trujillo T, Tolley ND, Munger (2023). Prospective, randomized, controlled, trial to assess ASA DOSing by Body Mass Index in HEalthy Volunteers (DOSE Study) . Pharmacotherapy, 215-225.
  98. Jopek MA, Pastuszak K, Sieczczy'ski M, Cygert S, ¿aczek AJ, Rondina MT, Supernat (2024). Improving platelet-RNA-based diagnostics: a comparative analysis of machine learning models for cancer detection and multiclass classification. Molecular oncology, 18(11), 2743-2754.
  99. Petito E, Bury L, Antunes Heck L, Sadler B, De Candia E, Podda GM, Falanga A, Stefanini L, Boccatonda A, Sciancalepore P, Florio I, Imbalzano E, Marcucci R, Noris P, Panella M, Santoro RC, Turi MC, Vaudo G, Di Paola J, Rondina MT, Gresele (2024). Association of human leucocyte antigen loci with vaccine-induced immune thrombotic thrombocytopenia: Potential role of the interaction between platelet factor 4-derived peptides and MHC-II. British journal of haematology,
  100. Banerjee M, Rowley JW, Stubben CJ, Tolley ND, Freson K, Nelson B, Nagy B Jr, Fejes Z, Blair AM, Turro E, Gresele P, Taranta GC, Bury L, Falcinelli E, Lordkipanidzé M, Alessi MC, Johnson AD, Bakchoul T, Ramstrom S, Frontini M, Camera M, Brambilla M, Campbell RA, Rondina M (2024). Prospective, international, multisite comparison of platelet isolation techniques for genome-wide transcriptomics: communication from the SSC of the ISTH. Journal of thrombosis and haemostasis, 22(10), 2922-2934.
  101. Portier I, Manne BK, Kosaka Y, Tolley ND, Denorme F, Babur Ö, Reddy AP, Wilmarth PA, Aslan JE, Weyrich AS, Rondina MT, Campbell R (2024). Aging-related alterations in mechanistic target of rapamycin signaling promote platelet hyperreactivity and thrombosis. Journal of thrombosis and haemostasis, 22(9), 2576-2588.
  102. Blick-Nitko SK, Ture SK, Schafer XL, Munger JC, Livada AC, Li C, Maurya P, Rondina MT, Morrell C (2024). Platelet Ido1 expression is induced during Plasmodium yoelii infection, altering plasma tryptophan metabolites. Blood advances,
  103. Chen L, Liu J, Chen K, Su Y, Chen Y, Lei Y, Si J, Zhang J, Zhang Z, Zou W, Zhang X, Rondina MT, Wang QF, Li (2024). SET domain containing 2 promotes megakaryocyte polyploidization and platelet generation through methylation of ¿-tubulin. Journal of thrombosis and haemostasis, 22(6), 1727-1741.
  104. Jacob S, Kosaka Y, Bhatlekar S, Denorme F, Benzon H, Moody A, Moody V, Tugolukova EA, Hull G, Kishimoto N, Manne BK, Guo L, Souvenir R, Seliger BJ, Eustes AS, Hoerger K, Tolley ND, Fatahian AN, Boudina S, Christiani DC, Wei Y, Ju C, Campbell RA, Rondina MT, Abel ED, Bray PF, Weyrich AS, Rowley J (2024). Mitofusin-2 Regulates Platelet Mitochondria and Function. Circulation research, 134(2), 143-161.
  105. Portier I, Denorme F, Tolley ND, Kosaka Y, Andrianova I, Sigala PA, Lamb T, Zimmerman GA, Castro Faria Neto HC, Morrell CN, Rondina MT, Campbell R (2026). Heme-induced ITAM signaling exacerbates malaria-associated neuropathogenesis through activation of platelet mTOR. Blood,
  106. Hamouche R, Tatum SM, Dranow E, Maschek JA, Kyriakopoulos CP, Shankar TS, Visker JR, Ling J, Sideris K, Selzman CH, Kfoury AG, Stehlik J, Alharethi R, Fang JC, Hong T, Navankasattusas S, Rondina MT, Holland WL, Summers SA, Drakos SG, Tseliou (2026). The Role of Sphingolipids in Myocardial Recovery Mediated by Mechanical Unloading and Circulatory Support. JACC. Basic to translational science, 11(1), 101435.
  107. Mellema RA, Queisser KA, Ajanel A, Albtoush N, Smith-Sanchez L, Rondina MT, Will J, Valentine JF, Petrey A (2025). Layilin inhibits integrin activation, and its loss results in platelet hyperactivation via Rac1 in inflammatory bowel disease. Blood, 146(24), 2979-2992.
  108. Kosaka Y, Lopez B, Kishimoto N, Jacob S, Montenont E, Huallanca R, Coughenour G, Di Paola J, Ross J, Lee K, Rondina MT, Bray PF, Rowley J (2025). Functional classification of platelet gene variants using CRISPR HDR in CD34(+) cell-derived megakaryocytes. American journal of human genetics, 112(12), 2888-2901.
  109. Kong YX, Rehan R, Moreno CL, Madsen S, Zhang Y, Zhao H, Qi M, Houlahan CB, Cartland SP, Robertshaw D, Trang V, Ong FJL, Liu M, Cheng E, Alwis I, Dupuy A, Cielesh M, Cooke KC, Potter M, Stöckli J, Morahan G, Kalev-Zylinska ML, Rondina MT, Schulman S, Yang JYH, Neely GG, Schoenwaelder SM, Jackson SP, James DE, Kavurma MM, Hocking SL, Twigg SM, Weaver JC, Larance M, Passam F (2025). SEC61B regulates calcium flux and platelet hyperreactivity in diabetes. The Journal of clinical investigation, 135(16),
  110. Huang J, Marini F, Solari FA, Swieringa F, de Laat B, De Simone I, Grassi L, Gui X, Li K, Middleton EA, Morgan NV, Provenzale I, Santos C, Schols S, Westbury S, Sickmann A, Rondina MT, Ruf W, Frontini M, Heemskerk JW (2025). Human and mouse platelet transcriptomes and proteomes for phenotyping 3474 genes with hemostatic and platelet traits. Blood vessels, thrombosis & hemostasis, 2(3), 100068.
  111. Sinawang PD, Multani P, Ozen MO, Wong J, Akin D, Hanson C, Larsen M, Ampaw E, Rondina MT, Tolley ND, Wang L, Cunningham BT, Kohli M, Demirci (2025). Plasma Preparation Strategies for Extracellular Vesicle-Based Biomarkers in Metastatic Castration-Resistant Prostate Cancer. Journal of extracellular biology, 4(8), e70071.
  112. Jopek MA, Sieczczy'ski M, Pastuszak K, ¿api'ska-Szumczyk S, Jassem J, ¿aczek AJ, Rondina MT, Supernat (2025). Impact of clinical factors on accuracy of ovarian cancer detection via platelet RNA profiling. Blood advances, 9(5), 979-989.
  113. Zheng Y, Larragoite ET, Lama J, Cisneros I, Delgado JC, Slev P, Rychert J, Innis EA, Williams ESCP, Coiras M, Rondina MT, Spivak AM, Planelles (2020). Neutralization Assay with SARS-CoV-1 and SARS-CoV-2 Spike Pseudotyped Murine Leukemia Virions. bioRxiv,

Review

  1. Mahamad S, Modi D, Al-Samkari H, Cuker A, Despotovic JM, Italiano JE, Lambert MP, Lee EJ, Rondina MT, Sholzberg M, Kruse C, Larché M, Nazy I, Miller MS, Arnold D (2023). Proceedings of the immune thrombocytopenia summit: new concepts in mechanisms, diagnosis, and management. Research and practice in thrombosis and haemostasis, 7(2), 100097.
  2. Conway EM, Mackman N, Warren RQ, Wolberg AS, Mosnier LO, Campbell RA, Gralinski LE, Rondina MT, van de Veerdonk FL, Hoffmeister KM, Griffin JH, Nugent D, Moon K, Morrissey J (2022). Understanding COVID-19-associated coagulopathy. Nature reviews. Immunology, 22(10), 639-649.
  3. Campbell RA, Boilard E, Rondina M (2021). Is there a role for the ACE2 receptor in SARS-CoV-2 interactions with platelets?. Journal of thrombosis and haemostasis, 19(1), 46-50.
  4. Guo L, Rondina M (2019). The Era of Thromboinflammation: Platelets Are Dynamic Sensors and Effector Cells During Infectious Diseases. Frontiers in immunology, 10, 2204.
  5. Davizon-Castillo P, Rowley JW, Rondina M (2020). Megakaryocyte and Platelet Transcriptomics for Discoveries in Human Health and Disease. Arteriosclerosis, thrombosis, and vascular biology, 40(6), 1432-1440.
  6. Trunk AD, Rondina MT, Kaplan D (2019). Venous Thromboembolism at High Altitude: Our Approach to Patients at Risk. High altitude medicine & biology, 20(4), 331-336.

Book Chapter

  1. Harris ES, Rondina MT, Schwertz H, Weyrich AS, Zimmerman G (2010). Pathogenesis of sepsis and sepsis-induced acute lung injury. 369-419.
  2. Rondina MT, Weyrich AS (2012). Targeting Phosphodiesterases in Anti-Platelet Therapy. 210, 225-38.

Editorial

  1. Denorme F, Rondina M (2019). Targeting Glycoprotein VI for Thromboembolic Disorders. Arteriosclerosis, thrombosis, and vascular biology, 39(5), 839-840.
  2. Schwertz H, Rondina M (2016). Cdkn2a Orchestrates Platelet Production and Reactivity in Atherosclerosis. Circulation. Cardiovascular genetics, 9(3), 203-5.
  3. Rondina M (2022). Editorial: special review series on viruses and platelets. Platelets, 33(2), 174-175.
  4. Portier I, Rondina M (2024). Platelets, plasma, and proteostasis: a translation tightrope. Blood advances, 8(6), 1567-1569.
  5. Banerjee M, Rondina M (2025). Of mice, men, and megakaryocytes: CK1¿ governs thrombopoiesis. Blood, 146(16), 1879-1880.

Abstract

  1. Rondina MT, Lam UT, Pendleton RC, Kraiss LW, Wanner N, Zimmerman GA, Hanrahan C. Boucher K, Hoffman M, Morton KA (2012). The role of 18-fluorine-fluorodeoxyglucose positron emission tomography in the evaluation of deep vein thrombosis. Thrombosis research, 129(S1), S165.

Other

  1. Othman M, Baker AT, Gupalo E, Elsebaie A, Bliss CM, Rondina MT, Lillicrap D, Parker A (2023). Corrigendum to To clot or not to clot? Ad is the question-Insights on mechanisms related to vaccine-induced thrombotic thrombocytopenia [J Thromb Haemost. 2021 Nov;19(11):2845-2856. doi: 10.1111/jth.15485]. Journal of thrombosis and haemostasis, 21(4), 1066.

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