Patricia R. Slev
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Patricia R. Slev, PhD

Languages spoken: English

Dr. Slev is the medical director of the Serological Hepatitis/Retrovirus Laboratory and Co-Director Immunogenetics at ARUP and an Associate Professor of Pathology at the University of Utah, School of Medicine. Dr. Slev's research interests are in immunogenetics and pathogen interactions, particularly HIV and viral hepatitis.

Specialties

  • Pathology, Clinical

Board Certification

American Board of Clinical Chemistry (Sub: Clinical Chemistry)

Dr. Slev is the medical director of the Serological Hepatitis/Retrovirus Laboratory and Co-Director Immunogenetics at ARUP and an Associate Professor of Pathology at the University of Utah, School of Medicine. Dr. Slev's research interests are in immunogenetics and pathogen interactions, particularly HIV and viral hepatitis.

Board Certification and Academic Information

Academic Departments Pathology -Professor (Clinical)
Board Certification
American Board of Clinical Chemistry (Sub: Clinical Chemistry)

Education history

Undergraduate Biology - Florida Atlantic University B.A.
Doctoral Training Immunology, Laboratory Medicine - University of Florida Ph.D.
Postdoctoral Fellowship Biology - University of Utah Postdoctoral Fellow
Fellowship Clinical Chemistry - University of Utah School of Medicine Fellow

Selected Publications

Journal Article

  1. Balogun K, Slev P (2023). Towards achieving the end of the HIV epidemic: Advances, challenges and scaling-up strategies. Clinical biochemistry, 117, 53-59.
  2. Nandakumar V, Profaizer T, Lozier BK, Elgort MG, Rychert J, Slev PR, Delgado J (2022). Evaluation of a Novel Multiplex Platform for Simultaneous Detection of IgG Antibodies Against the 4 Main SARS-CoV-2 Antigens. The journal of applied laboratory medicine, 7(3), 698-710.
  3. Rodriguez RM, Montroy JCC, Hoth KF, Talan DA, Harland KK, Eyck PT, Mower W, Krishnadasan A, SAntibanez S, Mohr N (2021). Project COVERED Emergency Network (Slev P, member & author COVERED Emergency Network). Ann Emerg Med.
  4. Victoria Zhang, Joesph Wiencek, Qing H. Meng, Elitza S. Theel, Nikolina Babic, Lusia Sepiashvili, Nicole D. Pecora, Patricia Slev, Andrew Cameron, Danijela Konforte on behalf of the AACC COVID 19 Serologic Testing Task Forc (2021). AACC Practical Recommendations for Implementing and Interpreting SARS-CoV-2 EUA and LDT Serologic Testing in Clinical Laboratories. Clinical chemistry,
  5. Walter A Schrading , Stacy A Trent , James H Paxton , Robert M Rodriguez 5, Morgan B Swanson , Nicholas M Mohr , David A Tala (2021). Project COVERED Emergency Department Network (Slev P, author in COVERED Emerg Dept Network). Vaccination rates and acceptance of SARS-CoV-2 vaccination among U.S. emergency department health care personnel. Academic emergency medicine, 28(4), 455-458.
  6. Rychert J, Couturier MR, Elgort M, Lozier BK, La'ulu S, Genzen JR, Straseski JA, Delgado JC, Slev P (2021). Evaluation of 3 SARS-CoV-2 IgG Antibody Assays and Correlation with Neutralizing Antibodies. The journal of applied laboratory medicine, 6(3), 614-624.
  7. Mohr N, Harland K, Krishnadasan A, Eyck PT, Mower Wr, Wiley J, Chisolm-Straker M, Lim SC, McDonald CL, Kutty PK, Hesse E, Santibanez S, Talan DA (2020). PROJECT COVERED Emergency Department Network (Slev P author in COVERED Emergency Department Network). Diagnosed and Undiagnosed COVID-19 in US Emergency Department Healthcare Personnell– Cross-sectional Analysis. Ann Emerg Med, 20, 31455-4.
  8. Theel ES, Slev P, Wheeler S, Couturier MR, Wong SJ, Kadkhoda K, et a (2020). The Role of Antibody Testing for SARS-CoV-2: is There One?. Journal of clinical microbiology, in press,
  9. Wesolowski LG, Chavez PR, Cardenas AM, Katayev A, Slev P, Valsamakis A, Wang YF, Yao JD, Dougherty C, Gillim-Ross L, Harmon C, Delaney KP et a (2020). Routine HIV Test Results in 6 US Clinical Laboratories Using the Recommended Laboratory HIV Testing Algorithm With Geenius HIV 1/2 Supplemental Assay. Sexually transmitted diseases, (Suppl 1:S13-S17),
  10. Luetkens T, Metcalf R, Planelles V, Zheng Y, Larragoite ET, Spivak ES, Spivak AM, Steinbach M, Blaylock RC, Avila SV, Hankey KG, Martins TB, Slev PR, Mannuel HD, Sajadi M, Rapoport AP, Atanackovic (2020). Successful transfer of anti-SARS-CoV-2 immunity using convalescent plasma in an MM patient with hypogammaglobulinemia and COVID-19. Blood advances, 4(19), 4864-4868.
  11. Profaizer T, Slev P (2020). Multiplex Droplet Digital PCR Assay for the Detection of T-Cell Receptor Excision Circles and Kappa-Deleting Recombination Excision Circles. 1(66), 229-238.
  12. Ravkov EV, Charlton CM, Barker AP, Hill H, Peterson LK, Slev P, Tebo A, Voelkerding KV, Wittwer CT, Heikal N, Delgado JC, Lázár-Molnár E, Kumánovics (2019). Evaluation of Mass Cytometry in the Clinical Laboratory. Cytometry. Part B, Clinical cytometry, 96(4), 266-274.
  13. Apanius V, Penn D, Slev PR, Ruff LR, Potts W (2017). The Nature of Selection on the Major Histocompatibility Complex. Critical reviews in immunology, 37(2-6), 75-120.
  14. Kuo CY, Garcia-Lioret MI, Slev P, Bohnsack JF, Chen (2017). Profound T-cell lymphopenia associated with prenatal exposure to purine antagonists detected by TREC newborn screening. The Journal of allergy and clinical immunology, 5(1), 198-200.
  15. Martins TB, Bandhauer ME, Wilcock DM, Hill HR, Slev P (2016). Specific Immunoglobulin (Ig) G Reference Intervals for Common Food, Insect, and Mold Allergens. Annals of clinical and laboratory science, 46(6), 635-638.
  16. Slev, P (2016). The status of laboratory testing for the diagnosis of HIV infection. MLO, 48(9), 32.
  17. Chow SK, Atienza EE, Cook L, Prince H, Slev P, Lapé-Nixon M, Jerome K (2016). Comparison of Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum. Clinical and vaccine immunology, 23(8), 732-4.
  18. Slev, P (2016). Laboratory Testing for HIV.
  19. Ravkov E, Slev P, Heikal N (2015). Thymic output: Assessment of CD4+ Recent Thymic Emigrants and T-Cell Receptor Excision Circles in Infants. Cytometry. Part B, Clinical cytometry, Epub ahead(print),
  20. Slev P (2013). US preventive services task force HIV screening guidelines:a laboratory perspective. Clinical chemistry, 59(8), 1281-2.
  21. Slev P (2013). HIV Universal Screening & Laboratory Diagnosis. Clinical leadership & management review, 27(2),
  22. Slev (2012). Host genomics and HCV personalized medicine. Annals of clinical and laboratory science, 42(4), 363-9.
  23. Slev (2012). The changing landscape of HIV diagnostics. MLO, 44(11), 8-10, 12, 14; quiz 16.
  24. Kubinak JL, Ruff JS, Hyzer CW, Slev PR, Potts W (2012). Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types. Proceedings of the National Academy of Sciences of the United States of America, 109(9), 3422-7.
  25. Melis R, Lewis T, Millson A, Lyon E, McMillin GA, Slev PR, Swensen (2012). Copy Number Variation and Incomplete Linkage Disequilibrium Interfere with the HCP5 Genotyping Assay for Abacavir Hypersensitivity. Genetic testing and molecular biomarkers, 16(9), 1111-4.
  26. Pranzatelli MR, Slev PR, Tate ED, Travelstead AL, Colliver JA, Joseph S (2011). Cerebrospinal fluid oligoclonal bands in childhood opsoclonus-myoclonus. Pediatric neurology, 45(1), 27-33.
  27. Melis R, Faun C, McMillin G, Lyon E, Shirts B, Hubley LM, Slev P (2011). Simulaneous genotyping of rs1297860 and rs8099917 variants near the IL28B locus associated with HCV clearance and treatment response. The Journal of molecular diagnostics, 13(4), 446-51.
  28. Slev PR, Bunker AM, Owen WE, Roberts W (2010). Pediatric reference intervals for random urine calcium, phosphorus and total protein. Pediatric nephrology (Berlin, Germany), 25(9), 1707-10.
  29. Slev P (2009). A look at CDC 2006 HIV testing guidelines and rapid tests. Clinical Laboratory News. 35, 14-16.
  30. Slev PR, La'ulu SL, Roberts WL (2008). Intermethod differences in results for total PSA, free PSA, and percentage of free PSA. Am J Clin Pathol, 129(6), 952-8.
  31. Slev PR, Williams BG, Harville TO, Ashwood ER, Bornhorst JA (2008). Efficacy of the detection of the alpha1-antitrypsin "Z" deficiency variant by routine serum protein electrophoresis. Am J Clin Pathol, 130(4), 568-72.
  32. La'ulu SL, Slev PR, Roberts W (2007). Performance characteristics of 5 automated thyroglobulin autoantibody and thyroid peroxidase autoantibody assays. Clinica chimica acta; international journal of clinical chemistry, 376(1-2), 88-95.
  33. Slev PR, Rawlins ML, Roberts WL (2006). Performance characteristics of seven automated CA 15-3 assays. Am J Clin Pathol, 125(5), 752-7.
  34. Slev PR, Nelson AC, Potts W (2006). Sensory neurons with MHC-like peptide binding properties: disease consequences. Current opinion in immunology, 18(5), 608-16.
  35. Slev PR, Potts W (2002). Disease consequences of pathogen adaptation. Current opinion in immunology, 14(5), 609-14.
  36. Penn D, Schneider G, White K, Slev PR, Potts W (2002). Female mice (Mus musculus domesticus) prefer the odor of uninfected males over males infected with influenza viruses. Ethology, 104, 685-694.

Review

  1. Slev P (2022). Severe Acute Respiratory Syndrome Coronavirus 2 Serology Testing - A Laboratory Primer. Clinics in laboratory medicine, 42(1), 1-13.
  2. Apanius V, Penn D, Slev PR, Ruff LR, Potts W (1997). The nature of selection on the major histocompatibility complex. Critical reviews in immunology, 17(2), 179-224.
  3. Potts WK, Slev P (1995). Pathogen-based models favoring MHC genetic diversity. Immunological reviews, 143, 181-97.

Book Chapter

  1. Hillyard DR, Slev P (2015). Infectious Disease and Pharmacogenomics.
  2. Slev (2009). HIV Methods.

Abstract

  1. Martins TB, Wilcock DM, First R, Slev PR, Hill HR (2017). Evaluation of A Basophil Activation Flow Cytometric Assay As An Alternative to Oral Food Challenge for Determining Peanut Allergy.
  2. Kish-Trier E, Ravkov , Barker A, Couturier M, Delgado J, Heikal N Hill H, Lazar-Molnar E, Peterson LK, Slev PR, Tebo A, Voelkerding K, Kumanovics A (2017). A Preliminary Evaluation of a Mass Cytometry Instrument at ARUP Laboratories. MSACL 2017.
  3. Nikolic D, Lesourd S, Slev P, Bornhorst J (2015). Comparison of the sensitivity of a type-specific and a combined Immunoassay against HSV-1 and HSV-2.
  4. Chow SK, Atienza E, Cook L, Prince H, Slev P, Jerome K (2015). Comparison of Commercial and In-House Enzyme Immunoassays for Detection of Antibodies to Hepatitis D Virus in Serum Specimens.
  5. Ravkov E, Slev P, Heikal N (2015). Correlation between Thymic Emigrants and T-cell Receptor Excision Circles in Newborn Screening for SCID.
  6. Ardon O, Blackley J, Griffiths S, Slev P (2013). Comparison of the AVIOQ HTLV I/II Microelisa System to MP Diagnostics (MPD) HTLV I/II Elisa 4.0 assay for detection of HTLV I/II.
  7. Ardon O, Blackley J, Griffiths S, Slev P (2013). Evaluation of multispot for detection of HIV-1 and HIV-2 infection.
  8. Fauron C, Slev (2012). Evaluation of the Bio-Rad GS HIV combo Ag/Ab EIA Assay.
  9. Melis R, Lewis T, McMillin G, Lyon E, Slev PR, Swensen J (2011). CNV and incomplete linkage diseqilibrium interference with the HCP5 genotyping assay for Abacavir hypsensitivity.
  10. Melis R, Lewis T, McMillin G, Lyon E, Slev PR, Swensen, J (2011). CNV and incomplete linkage disequillibrium interference with the HCP5 genotyping assay for Abacavir hypersensitivity.
  11. Melis R, Fauron C, McMillin G, Lyon E, Hubley LM, Slev P (2011). Genotype Frequency of Two Polymorphisms Associated with Clearance and Treatment Response in Different Ethnic Groups.
  12. Melis R, Millson A. McMillin G, Lyon E, Slev P (2010). A Rapid Screening Assay for Prediction of Hypersensitivity reaction to Abacavir. Clinical Virology Symposium, Daytona Florida.
  13. Pyne M, Roberts R, Griffiths S, Bradley R, Slev P (2010). Evaluation of the ADVIA Centaur® HIV 1/O/2 Enchanced (EHIV) Assay. 2010 HIV Diagnostics Conference, Orlando Florida.
  14. Melis R, Fauron C, McMillin G, Lyon E, Slev P (2010). Rapid detection of two variants near the IL28B locus associated with HCV clearance and treatment response. AACC National Meeting, Anaheim California.
  15. Slev P (2009). Estimating Hepatitis Delta Virus Prevalence Using Serologic Laboratory Results. Clinical Virology Symposium, Daytona, Florida.
  16. Erickson A, Slev PR, Ashwood E (2007). Reference Interval and Performance Characteristics of an Enzyme-Linked Immunosorbent Assay for Quantifying Soluable Mesothelin Related Peptides AACC National Meeting, San Diego, California.
  17. Slev PR, Williams B, Ashwood ER, Bornhorst J (2007). Evaluation of the Detection of a1-antitrypsin Deficiency Variants by Routine Serum Protein Electrophoresis. AACC National Meeting, San Diego, California.
  18. Slev P (2006). Performance characteristics of Five Automated Immunoassays for anti-Tg and anti-TPO.
  19. Slev P (2005). Performance characteristics of Seven Automated CA 15-3 Methods.