Timothy M. Hanley

Timothy M. Hanley, MD, PhD

Languages spoken: English

  • Dr. Hanley is an Assistant Professor of Pathology at the University of Utah Spencer Fox Eccles School of Medicine. He received his MD and a PhD in Microbiology from Boston University School of Medicine and is certified by the American Board of Pathology in anatomic pathology, clinical pathology, and hematopathology. His research interests include the establishment and maintenance of HIV-1 latency in myeloid cells, the role of chronic viral infection in promoting cellular senescence, the contribution of cellular signaling pathways to the control of retroviral replication, and the role of oncogenic viruses in the development of hematologic malignancies. Dr. Hanley is a member of the American Medical Association, the American Society for Clinical Pathology, the American Society of Microbiology, the College of American Pathologists, and the United States and Canadian Academy of Pathology.

    Specialties

    Board Certification

    American Board of Pathology (Anatomic)
    American Board of Pathology (Clinical Path)
    American Board of Pathology (Sub: Hematology)

  • Dr. Hanley is an Assistant Professor of Pathology at the University of Utah Spencer Fox Eccles School of Medicine. He received his MD and a PhD in Microbiology from Boston University School of Medicine and is certified by the American Board of Pathology in anatomic pathology, clinical pathology, and hematopathology. His research interests include the establishment and maintenance of HIV-1 latency in myeloid cells, the role of chronic viral infection in promoting cellular senescence, the contribution of cellular signaling pathways to the control of retroviral replication, and the role of oncogenic viruses in the development of hematologic malignancies. Dr. Hanley is a member of the American Medical Association, the American Society for Clinical Pathology, the American Society of Microbiology, the College of American Pathologists, and the United States and Canadian Academy of Pathology.

    Board Certification and Academic Information

    Academic Departments Pathology -Primary
    Board Certification
    American Board of Pathology (Anatomic)
    American Board of Pathology (Clinical Path)
    American Board of Pathology (Sub: Hematology)

    Education history

    Postdoctoral Fellowship Hematopathology - University of Utah School of Medicine Postdoctoral Fellow
    Clinical Pathology - University of Utah School of Medicine Chief Resident
    Residency Anatomic and Clinical Pathology - University of Utah School of Medicine Resident
    Medicine, Microbiology - Boston University School of Medicine M.D., Ph.D.
    Undergraduate Government - Harvard University B.A.

    Selected Publications

    Journal Article

    1. Arabi S, Vardell V, Hanley TM, Florell S, Halwani A, Lim M (). Primary Cutaneous Gamma-Delta T-cell Lymphoma Presenting with Hemophagocytic Lymphohistiocytosis: A Case Report. (Epub ahead of print) Case Rep Hematol.
    2. Galarza Fortuna GM, Alnoor FNU, Parkinson B, Hanley TM, Li P, Osman A (). Chronic Myeloid Leukemia Presenting in T-Cell Blast Crisis and Responding to Asciminib and Ponatinib Combination: A Case Report. (Epub ahead of print) Blood Adv.
    3. Williamson AJH, Pruitt LCC, Williams M, Hanley TM, Grudziak J (2024). Littoral Cell Angioma Presenting as an Atraumatic Splenic Rupture in a Patient with Multiple Sclerosis. ACS Case Rev Surg, 4(5), 92-95.
    4. Ravkov EV, Williams ESCP, Elgort M, Barker AP, Planelles V, Spivak AM, Delgado JC, Lin L, Hanley TM (2024). Reduced monocyte proportions and responsiveness in convalescent COVID-19 patients. Front Immunol, 14, 1329026. (Read full article)
    5. Dickey LL, Martins LJ, Planelles V, Hanley TM (2022). HIV-1-induced type I IFNs promote viral latency in macrophages. J Leukoc Biol, 112(5), 1343-1356. (Read full article)
    6. Martins LJ, Szaniawski MA, Williams ESCP, Coiras M, Hanley TM, Planelles V (2022). HIV-1 Accessory Proteins Impart a Modest Interferon Response and Upregulate Cell Cycle-Related Genes in Macrophages. Pathogens, 11(2). (Read full article)
    7. Williams ESCP, Szaniawski MA, Martins LJ, Innis EA, Alcam J, Hanley TM, Spivak AM, Coiras M, Planelles V (2022). Dasatinib: effects on the macrophage phospho proteome with a focus on SAMHD1 and HIV-1 infection. Clin Res HIV AIDS, 8(1). (Read full article)
    8. Viglianti GA, Planelles V, Hanley TM (2021). Interactions with Commensal and Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the LTR. J Virol. (Read full article)
    9. Agarwal AM, Hanley TM (2020). Osteopetrosis in a six-month-old infant. J Hematop, 13, 193-196.
    10. Szaniawski MA, Spivak AM, Cox JE, Catrow JL, Hanley T, Williams ESCP, Tremblay MJ, Bosque A, Planelles V (2018). SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition. mBio, 9(3), e00819-18.
    11. Hanley T, Sowder AM, Palmer CA, Weiss RL (2016). Teaching Laboratory Management Principles and Practices Through Mentorship and Graduated Responsibility: The Assistant Medical Directorship. Acad Pathol, 3, 2374289516678972. (Read full article)
    12. Dickey LL, Duncan JK, Hanley TM, Fearns R (2015). Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection. Virology, 481, 199-209. (Read full article)
    13. Hanley TM, Viglianti GA (2011). Nuclear receptor signaling inhibits HIV-1 replication in macrophages through multiple trans-repression mechanisms. J Virol, 85(20), 10834-50. (Read full article)
    14. Hanley TM, Blay Puryear W, Gummuluru S, Viglianti GA (2010). PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection. PLoS Pathog, 6, e1000981. (Read full article)
    15. Kiefer HL, Hanley TM, Marcello JE, Karthik AG, Viglianti GA (2004). Retinoic acid inhibition of chromatin remodeling at the human immunodeficiency virus type 1 promoter. Uncoupling of histone acetylation and chromatin remodeling. J Biol Chem, 279(42), 43604-13. (Read full article)
    16. Hanley TM, Kiefer HL, Schnitzler AC, Marcello JE, Viglianti GA (2004). Retinoid-dependent restriction of human immunodeficiency virus type 1 replication in monocytes/macrophages. J Virol, 78(6), 2819-30. (Read full article)
    17. Viglianti GA, Lau CM, Hanley TM, Miko BA, Shlomchik MJ, Marshak-Rothstein A (2003). Activation of autoreactive B cells by CpG dsDNA. Immunity, 19(6), 837-47. (Read full article)
    18. Gallina A, Hanley TM, Mandel R, Trahey M, Broder CC, Viglianti GA, Ryser HJ (2002). Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry. J Biol Chem, 277(52), 50579-88. (Read full article)
    19. Brown XQ, Hanley TM, Viglianti GA (2002). Interleukin 1 beta and interleukin 6 potentiate retinoic acid-mediated repression of human immunodeficiency virus type 1 replication in macrophages. AIDS Res Hum Retroviruses, 18(9), 649-56. (Read full article)

    Review

    1. Dickey LL, Hanley TM, Huffaker TB, Ramstead AG, OConnell RM, Lane TE (2017). MicroRNA 155 and viral-induced neuroinflammation. [Review]. J Neuroimmunol, 308, 17-24. (Read full article)

    Abstract

    1. Hanley TM (2022). cGAS/STING Signaling Drives HIV-1 Replication in Acutely Infected Macrophages [Abstract]. J Virus Erad, 8(S).
    2. Hanley TM, Dickey L, Planelles V (2019). Low-level Persistent/Latent HIV-1 Infection of Macrophages Corresponds to Decreased NF-kB Activity [Abstract]. J Virus Erad, 5, 1-58.
    3. Hanley TM, Planelles V, Viglianti G (2019). Interactions with Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the LTR [Abstract]. J Virus Erad.

    Other

    1. Signorelli H, Hanley TM (2015). Considerations in Choosing Hemoglobin A1c Methods. Clinical Laboratory News: Bench Matters.