Xiaomei Feng
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Xiaomei Feng, MD, PhD

Languages spoken: English

Clinical Locations

Primary Location

University of Utah Hospital

Anesthesiology
50 N Medical Dr
Salt Lake City , UT 84132
801-581-2121
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  • Specialties

    • Anesthesiology

    Board Certification

    American Board of Anesthesiology

  • Board Certification and Academic Information

    Academic Departments Anesthesiology -Assistant Professor (Clinical)
    Board Certification
    American Board of Anesthesiology

    Education history

    Professional Medical Medicine - Medical College of Nanjing University M.D.
    Doctoral Training Medical College of Nanjing University Ph.D.
    Doctoral Training Short Program - Utrecht University Ph.D.
    Fellowship Neuroscience - University of California, San Francisco School of Medicine Research Fellow
    Residency Anesthesiology - University of Utah Spencer Fox Eccles School of Medicine Resident
    Fellowship Neuroanesthesia - University of Utah Spencer Fox Eccles School of Medicine Fellow

    Selected Publications

    Journal Article

    1. Zhang Y, Hu J, Zuo W, He P, Xue Q, Feng X, Zhang Y, Maze (2023). Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study. Anesthesia and analgesia, 136(1), 34-42. (Read full publication)
    2. Hu J, Zhang Y, Huang C, Feng X, He S, Zhang Y, Maze (2022). Interleukin-6 trans-signalling in hippocampal CA1 neurones mediates perioperative neurocognitive disorders in mice. British journal of anaesthesia, 129(6), 923-936. (Read full publication)
    3. Lu Y, Fang PP, Yu YQ, Cheng XQ, Feng XM, Wong GTC, Maze M, Liu XS, POGF Study Collaborator (2021). Effect of Intraoperative Dexmedetomidine on Recovery of Gastrointestinal Function After Abdominal Surgery in Older Adults: A Randomized Clinical Trial. JAMA network open, 4(10), e2128886. (Read full publication)
    4. Hu J, Zhu M, Gao Z, Zhao S, Feng X, Chen J, Zhang Y, Maze (2021). Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia: A double-blind, randomised clinical trial. European journal of anaesthesiology, 38(Suppl 1), S9-S17. (Read full publication)
    5. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze (2020). Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. British journal of anaesthesia, 125(3), 298-307. (Read full publication)
    6. Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze (2018). Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice. British journal of anaesthesia, 120(3), 537-545. (Read full publication)
    7. Hu J, Vacas S, Feng X, Lutrin D, Uchida Y, Lai IK, Maze (2018). Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice. Anesthesiology, 128(5), 921-931. (Read full publication)
    8. Feng X, Uchida Y, Koch L, Britton S, Hu J, Lutrin D, Maze (2017). Exercise Prevents Enhanced Postoperative Neuroinflammation and Cognitive Decline and Rectifies the Gut Microbiome in a Rat Model of Metabolic Syndrome. Frontiers in immunology, 8, 1768. (Read full publication)
    9. Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad S (2017). Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. JCI insight, 2(7), e91229. (Read full publication)
    10. Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze (2015). Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome. Brain, behavior, and immunity, 50, 203-208. (Read full publication)
    11. Feng X, Maze M, Koch LG, Britton SL, Hellman (2015). Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. PloS one, 10(5), e0126906. (Read full publication)
    12. Wei H, Cao X, Zeng Q, Zhang F, Xue Q, Luo Y, Lee JW, Yu B, Feng (2015). Ghrelin inhibits proinflammatory responses and prevents cognitive impairment in septic rats. Critical care medicine, 43(5), e143-50. (Read full publication)
    13. Zhang F, Feng X, Zeng Q, Wang B, Wilhelmsen K, Li Q, Cao X, Yu (2014). Sevoflurane induced amnesia inhibits hippocampal Arc expression partially through 5-hydroxytryptamine-7 receptors in the bilateral basolateral amygdala in rats. Neuroscience letters, 562, 13-8. (Read full publication)
    14. Zhu YG, Feng XM, Abbott J, Fang XH, Hao Q, Monsel A, Qu JM, Matthay MA, Lee J (2014). Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem cells (Dayton, Ohio), 32(1), 116-25. (Read full publication)
    15. Zhu YG, Hao Q, Monsel A, Feng XM, Lee J (2013). Adult stem cells for acute lung injury: remaining questions and concerns. Respirology (Carlton, Vic.), 18(5), 744-56. (Read full publication)
    16. Feng X, Degos V, Koch LG, Britton SL, Zhu Y, Vacas S, Terrando N, Nelson J, Su X, Maze (2013). Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology, 118(5), 1098-105. (Read full publication)
    17. Vacas S, Degos V, Feng X, Maze (2013). The neuroinflammatory response of postoperative cognitive decline. British medical bulletin, 106(1), 161-78. (Read full publication)
    18. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze (2013). Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Molecular medicine (Cambridge, Mass.), 18(1), 1481-90. (Read full publication)
    19. Peng Z, Zhu Y, Zhang Y, Wilhelmsen K, Jia C, Jin J, Xue Q, Feng X, Zhang F, Yu (2012). Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-¿B activation when protects against acute lung injury in rats challenged with cecal ligation and puncture. International immunopharmacology, 13(4), 440-5. (Read full publication)
    20. Zhang F, Feng X, Dong R, Wang H, Liu J, Li W, Xu J, Yu (2011). Effects of clonidine on bilateral pain behaviors and inflammatory response in rats under the state of neuropathic pain. Neuroscience letters, 505(3), 254-9. (Read full publication)
    21. Liu J, Zhao X, Cao J, Xue Q, Feng X, Liu X, Zhang F, Yu (2011). Differential roles of PKA and Epac on the production of cytokines in the endotoxin-stimulated primary cultured microglia. Journal of molecular neuroscience, 45(2), 186-93. (Read full publication)
    22. Liu XS, Xue QS, Zeng QW, Li Q, Liu J, Feng XM, Yu B (2010). Sevoflurane impairs memory consolidation in rats, possibly through inhibiting phosphorylation of glycogen synthase kinase-3ß in the hippocampus. Neurobiology of learning and memory, 94(4), 461-7. (Read full publication)
    23. Feng X, Zhang F, Dong R, Wang H, Liu J, Liu X, Li W, Yao J, Xu J, Yu (2010). Effects of hydroxyethyl starch (130 kD) on brain inflammatory response and outcome during normotensive sepsis. International immunopharmacology, 10(8), 859-64. (Read full publication)
    24. Feng X, Zhang F, Dong R, Li W, Liu J, Zhao X, Xue Q, Yu B, Xu (2009). Intrathecal administration of clonidine attenuates spinal neuroimmune activation in a rat model of neuropathic pain with existing hyperalgesia. European journal of pharmacology, 614(1-3), 38-43. (Read full publication)
    25. Feng X, Yan W, Wang Z, Liu J, Yu M, Zhu S, Xu (2007). Hydroxyethyl starch, but not modified fluid gelatin, affects inflammatory response in a rat model of polymicrobial sepsis with capillary leakage. Anesthesia and analgesia, 104(3), 624-30. (Read full publication)
    26. Yan W, Wang HD, Feng XM, Ding YS, Jin W, Tang (2009). The expression of NF-E2-related factor 2 in the rat brain after traumatic brain injury. The Journal of trauma, 66(5), 1431-5. (Read full publication)
    27. Jia H, Feng X, Li W, Hu Y, Zeng Q, Liu J, Xu (2009). Recombinant human erythropoietin attenuates spinal neuroimmune activation of neuropathic pain in rats. Annals of clinical and laboratory science, 39(1), 84-91. (Read full publication)
    28. Zhu J, Wei X, Feng X, Song J, Hu Y, Xu (2008). Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-kappaB in a rat model of neuropathic pain. Neuroscience letters, 433(1), 33-7. (Read full publication)
    29. Yan W, Wang HD, Zhu L, Feng XM, Qiao L, Jin W, Tang (2008). Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats. Brain injury, 22(10), 802-10. (Read full publication)
    30. Huang H, Yin R, Zhu J, Feng X, Wang C, Sheng Y, Dong G, Li D, Jing (2008). Exogenous melatonin ameliorates hepatic injury in a rat cardiopulmonary bypass model. European journal of pharmacology, 580(3), 416-24. (Read full publication)
    31. Liu J, Li W, Zhu J, Zhang J, Feng X, Guan R, Xu (2008). The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy. Anesthesia and analgesia, 106(2), 650-3, table of contents. (Read full publication)
    32. Yin R, Zhu J, Shao H, Cheng X, Feng X, Li Z, Jing (2007). Inhibition of chemokine receptor CCR2 and CCR5 expression contributes to simvastatin-induced attenuation of cardiac allograft vasculopathy. The Journal of heart and lung transplantation, 26(5), 485-93. (Read full publication)
    33. Yu M, Shao D, Feng X, Duan M, Xu (2007). Effects of ketamine on pulmonary TLR4 expression and NF-kappa-B activation during endotoxemia in rats. Methods and findings in experimental and clinical pharmacology, 29(6), 395-9. (Read full publication)
    34. Shi HJ, Zhuang MY, Hu JH, Long YQ, Gao YP, Zheng Z, Feng XM, Ji FH, Peng K (2024). Use of dexmedetomidine during light versus deep anaesthesia on postoperative delirium among elderly patients undergoing major non-cardiac surgery: protocol for a multicentre randomised factorial trial. BMJ open, 14(10), e083312.
    35. Chan KM, Peng K, Ji F, Yeranossian A, Fowler J, Feng (2025). Mechanisms Underlying the Renal Protective Effects of Dexmedetomidine. Current anesthesiology reports, 15,

    Book Chapter

    1. Feng X, Yu B, Yu X, Huang Y, Wang G, Liu (2014). A History of Anesthesia in China. 345-54.
    2. Feng X, Maze (2019). Comorbidities and Postoperative Neurocognitive Disorder. 115-22.