Paul J. Shami,
MD
Languages Spoken: Arabic, English, French
Paul J. Shami, M.D. is a Professor of Medicine in the Division of Hematology and Hematologic Malignancies, Department of Internal Medicine at the University of Utah. He is an Investigator at Huntsman Cancer Institute, a member of the Experimental Therapeutics program, and holds an adjunct appointment of Professor in the Department of Pharmaceutics and Pharmaceutical Chemistry.
Dr. Shami oversees leukemia studies at Hunstman Cancer Institute, where he has established the most comprehensive leukemia clinical trials program in the Intermountain West. Because of his expertise and national recognition in the treatment of blood cancers, he serves or has served on the Acute Myeloid Leukemia, Chronic Myelogenous Leukemia and Myelodysplastic Syndrome panels of the National Cancer Center Network (NCCN). These NCCN panels develop guidelines that are followed nationally and internationally for the treatment of cancer.
He initially established his research lab at the George E. Wahlen Veterans Affairs Medical Center, where he was Chief of Hematology/Oncology between 2002 and 2005. In 2004 his lab was moved to the University of Utah. The Shami laboratory focuses on the development of new therapies for cancer. In collaboration with a team of chemists (led by Dr. Larry Keefer) at the National Cancer Institute, he has developed a new class of drugs that deliver nitric oxide to cancer cells in a targeted fashion. To lead this effort, he founded JSK Therapeutics Inc. (JSKT), a Utah-based biotech start-up company. Dr. Shami has received multiple grants and significant support from the Leukemia and Lymphoma Society, and the National Cancer Institute.
Dr, Shami obtained his B.S. in Chemistry at the American University of Beirut in Lebanon, followed by his degree in medicine at the same institution. He completed both his internship and residency in Internal Medicine at Duke University in Durham, North Carolina. He remained at Duke for a fellowship in Hematology/Oncology. During that time he trained under and conducted research in the laboratory of Dr. J. Brice Weinberg, a leader in hematology research.
Dr. Paul Shami is a Professor of Medicine in the Division of Hematology and Hematologic Malignancies at the University of Utah and is a Member and Clinical Investigator at the University’s Huntsman Cancer Institute (HCI). Dr. Shami also holds an Adjunct appointment as a Professor of Pharaceutics and Pharmaceutical Chemistry at the University of Utah. He is Board Certified in Hematology and Medical Oncology. Dr. Shami oversees leukemia clinical trials at Hunstman Cancer Institute, where he has established the most comprehensive leukemia clinical trials program in the Intermountain West. Because of his expertise and national recognition in the treatment of blood cancers, he serves or has served on the Acute Myeloid Leukemia, Chronic Myelogenous Leukemia and Myelodysplastic Syndrome panels of the National Cancer Center Network (NCCN). These NCCN panels develop guidelines that are followed nationally and internationally for the treatment of cancer.
For questions regarding Dr. Shami's practice, our clinical programs or for help identifying the right Hematology specialist for you or for your family member, please feel free to contact our Clinical Care Specialist/New Patient Coordinator at www.huntsmancancer.org or (801) 585-6906.
Clinical Locations
Hematology Clinic
801-585-2626
Specialties
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Professor Pharmaceutics and Pharmaceutical Chemistry - Adjunct Professor |
| Academic Divisions | Hematology/BMT |
| Board Certification | American Board of Internal Medicine (Internal Medicine) American Board of Internal Medicine (Sub: Medical Oncology) American Board of Internal Medicine (Sub: Hematology) |
| Cancer Center Programs | Experimental Therapeutics |
Patient Rating
The Patient Rating score is an average of all responses to care provider related questions on our nationally-recognized Press Ganey Patient Satisfaction Survey.
Responses are measured on a scale of 1 to 5 with 5 being the best score.
Likelihood of recommending care provider
4.8/ 5
Care provider spoke using clear language
4.8/ 5
Care provider's explanation of condition/problem
4.8/ 5
My confidence in care provider
4.8/ 5
Care provider's effort to include me in decisions
4.8/ 5
Wait time at clinic
3.0/ 5
Time care provider spent with me
4.7/ 5
Care provider's concern for questions & worries
4.8/ 5
Care provider's friendliness and courtesy
4.8/ 5
Patient Comments
Patient comments are gathered from our Press Ganey Patient Satisfaction Survery and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
UofU Patient
April 19, 2019
Dr. Shami is the best hands down. I was prepared for a wait and happy to do it because he is so worth it, but there was only a brief wait. He is so good, kind, and knowledgeable. Best. Oncologist. Ever.
UofU Patient
April 15, 2019
He was listening to me, but laughed at me about something that I said. I'm a sensitive person and it hurt my feelings.
UofU Patient
March 22, 2019
Good experience. I felt comfortable and positive about what was going on.
UofU Patient
March 15, 2019
Dr Shami was through and was willing to work with our out of state Dr. He was positive in the treatment available.
UofU Patient
March 14, 2019
This is the first time I had seen Dr. Shami. My experience with him was outstanding and 'off-the-charts' so to speak. He was thoughtful, very competent, conscientious, communicative and very helpful. He was very liberal with his time in explaining things and gave me a more thorough physical exam that I believe I have every had in my life. He had reviewed all of my previous test results as well as the blood work that was done in the lab before seeing him that day. He as very helpful and informative. I would with confidence recommend him to else I know. I felt privileged to be able to see him and have him review my case and provide useful information based on his expertise and experience. Our visit with him was a very positive experience for both me (as the patient) and my wife who accompanied me.
UofU Patient
February 17, 2019
app't for Dr. was 3 think I saw him at 4
UofU Patient
October 28, 2018
dr.shami and dr.lee are amazing doctors and I trust them with my life
UofU Patient
October 15, 2018
Truly cares about each patient
UofU Patient
October 14, 2018
Dr Shami is the best
UofU Patient
September 30, 2018
There is no better facility than Huntsman Cancer Institute. Dr. Shami and ALL of his staff always treat us with the most respect, keep us informed on every test result as well as next steps forward, and honor requests, if at all possible.
UofU Patient
June 21, 2018
Dr. Shami may be late sometimes but he never makes me feel rushed. He is excellent at listening to my concerns.
UofU Patient
April 09, 2018
I'm very grateful for the kind and compassionate care I received. I also appreciate the explanations they gave and the willingness to answer my questions. I have great confidence that they have the knowledge and experience to help me.
UofU Patient
March 09, 2018
I trust the team for the care. It just takes too long to meet the medical provider(s) and it made the visit quite exhausting and tiring.
UofU Patient
February 22, 2018
I really appreciated the time the care providers spent to help me. They were thorough and also explained and helped me to understand. I would much rather wait a bit for a doctor who carefully takes his time. I felt very confident in the care I received.
UofU Patient
February 12, 2018
Dr Shami and his staff are the best
UofU Patient
February 03, 2018
Dr Shami has been excellent in every appointment and phone communication by being clear, thoughtful, kind, and knowledgeable.
UofU Patient
January 22, 2018
All of the care providers were wonderful. I would like to commend the infusion center nurse on the 2nd floor named Rob, and his MA Nicky. I would also like to commend Dr. Shami, his NP, as well as the infusion team who got my Dad in quickly for platelets and blood.
UofU Patient
December 19, 2017
Very good experience.
UofU Patient
December 03, 2017
Dr Shami did an excellent job of explaining the exam, the possible diagnoses and treatments, and what the next steps would be and why. He answered our questions patiently and thoroughly.
UofU Patient
November 06, 2017
Dr. Shami is the BEST provider anyone could ever have the good fortune to work with.
UofU Patient
October 29, 2017
Dr. Shami is the best, I am very comfortable and assured in his competence and professional judgement.
UofU Patient
October 09, 2017
The epitome of excellence. Dr. Shami even takes time for personal topics. When asked a question about past tests, knows the answer or looks it up.
UofU Patient
September 08, 2017
Dr. Shami is knowledgeable, caring and worth waiting for.
UofU Patient
August 27, 2017
very thorough
UofU Patient
August 04, 2017
The only reason I would hesitate to recommend this care provider is the extremely long wait times just to see him.
UofU Patient
July 30, 2017
good
UofU Patient
July 24, 2017
4 your wait time in exam room is unacceptable.
UofU Patient
July 17, 2017
very late rushed. eager to end apt.
UofU Patient
July 04, 2017
Dr. Sham's the best. There was a marked change in my labs and he was concerned. He spent a lot of time explaining my options, his thoughts and listening to my thoughts and concerns.
UofU Patient
June 20, 2017
I am grateful for the above and beyond care Dr. Shamii and his staff afford me. His PA and numerous occasions had researched medications and file to make recommendations that would work best for me. I want Dr. Shamii to know how much I appreciate his patience with me. I know I am not an easy patients to deal with. Thank you Dr. SHamii and Andrea. Daniel along with other staff make sure I am comfortable when there.
UofU Patient
May 10, 2017
For question 10 - I will only recommend Dr Shami if someone requires his special type of care. But of all the BMT/Hematology doctors, he is the one I would most recommend.
UofU Patient
April 30, 2017
I arrived at 12:15 for my labs and left the hospital at 4:30. However, I completely understand that Dr. Shami was essentially on call. It would have been nice, however, to have been given the option of rescheduling my appointment.
UofU Patient
April 10, 2017
Always receive excellent care from Dr. Shami, even with concerns or health issues unrelated to my diagnosis.
UofU Patient
April 08, 2017
The Dr was amazing and went over all details and answered all questions. Very polite and professional. He went over results of my tests and explained them in great detail in terms someone with a degree in medicine would understand which was greatly appreciated.
UofU Patient
March 07, 2017
These comments were about the PA not the doctor.
UofU Patient
February 28, 2017
I always have to wait to see the doctor. Anywhere between 1 hour and 2 hours. That's not acceptable.
UofU Patient
February 17, 2017
Dr. Shami is fantastic! He is great at what he does, and seems to have a genuine interest in it. My mom joined me at my appointment, and loved how non-arrogant he was. I completely agree! Dr. Shami is a breath of fresh air!
UofU Patient
February 02, 2017
Very good experience
UofU Patient
January 29, 2017
We really appreciate Dr. Shami's professionalism and knowledge. Also, he's a very pleasant personality.
UofU Patient
January 12, 2017
I really like Dr. Shami! He is very thorough, and seems detail-oriented. He definitely listens, and I never felt rushed. I've only had one appointment, so far, but, based on it, I recommend him!
UofU Patient
January 05, 2017
Dr. shami is one of the few doctors who will give the time to ask questions and helps the patient understand exactly what is going on. I would recommend that new doctors learn from him because really there are not many as genuine as he is.
UofU Patient
November 28, 2016
AndREA Schlindler reviews my case thoroughly. Excellent job in looking at all things and making recommendations to reduce eliminate oxycodine. Dr Shami continues to take xpecial attemps to quite my concers about remission. Anything I bring up with him gets priority discussion with me. Thank you both.
UofU Patient
September 24, 2016
We were treated with respect and all of our questions were answered.
UofU Patient
September 17, 2016
one of the most caring Dr. I have ever had or known.
UofU Patient
June 27, 2016
Dr. Shami, the best.
UofU Patient
June 02, 2016
TWO HOUR WAIT TO SEE THE DOCTOR
UofU Patient
April 17, 2016
Dr. Shami, his staff, and all of the people at Huntsman are the absolute BEST for so many reasons. I accompany my husband to his appointments at other offices and HCI by far, exceeds in professional, personable, encouraging personnel who convey an encouraging attitude to all patients.
UofU Patient
April 05, 2016
Dr. Shami was very caring and extremely knowledgeable
UofU Patient
March 14, 2016
These responses all apply to Dr. Shami
UofU Patient
February 18, 2016
Dr Shami is the best!!!!!!!!!
UofU Patient
December 08, 2015
She is one of the best!
UofU Patient
November 23, 2015
These comment refer to the Nurse Practitioner, Renee. I also saw Dr. Shami. I would rate Dr. Shami as very good - even better as excellent for each of these questions
UofU Patient
November 14, 2015
Waited in exam room for 2 hours and never saw the doctor. Left due to the amount of time needed to return home. Love Dr. Shami, I think he was over scheduled the day of my appointment.
UofU Patient
October 27, 2015
Dr. Shami is terrific, and I have the utmost confidence in his care and treatment decisions for me.
UofU Patient
October 04, 2015
Aimee and Dr. Shami certainly took their time with me and my questions at my appointment. So very appreciated. Dr. Shami knows me as a person; even asked about a concern I expressed six months ago regarding the health of a family member. Couldn't believe he'd remembered! Dr. Shami's humor when answering one of my many questions, is so refreshing. My family always asks how my appointment and labs went and I can relay the answers to them in a way that relieves their minds about my well being. Thank you, Dr. Shami.
UofU Patient
September 05, 2015
VERY FRIENDLY AND KNOWLEDGEABLE
UofU Patient
July 30, 2015
Dr Shami is the best
UofU Patient
July 13, 2015
The doctor and PA's always answer all of our questions, they are honest and frank, yet talk to you like a friend.
UofU Patient
June 15, 2015
Dr. Shami, is the best. He is not an alarmist, he picks up on abnormal testing when my primary care did not. He is very thorough, and I know I am in good hands. He is supportive and listens to my questions. I am very confident in his medical advice. I feel lucky to have him as my physician.
UofU Patient
June 13, 2015
I was extremely impressed with Renee and Dr. Shami. They both demonstrated interest and concern for my health as well as my understanding of the procedures.
UofU Patient
March 04, 2015
During my appointment, I had a concern about a loved one's future treatments. Dr. Shami took his valuable time explaining to me about this issue to alleviate my worries. It is an understatement to say that Dr. Shami and his staff have truly changed my life because of the health care they have given to me.
UofU Patient
January 26, 2015
Dr Shami is the best!!!!
UofU Patient
January 25, 2015
Thank you for taking the time to try to help. I am glad it wasnt anything bad but if it ever was I would definatly want Dr Shami as my doctor.
UofU Patient
December 26, 2014
I dont think it will be anything bad, But he was very thourough and kind. If I or any family member ever need an oncologist this is where I will recommend.
UofU Patient
October 30, 2014
I adore the nurses, and doctors I see. Every one makes me feel cared about and like my concerns matter
UofU Patient
September 08, 2014
Did not see a care provider. I have been seeing Dr. Shami for years and have ultimate trust in him. I am frustrated no one let me know of delays or even checked on me.
UofU Patient
August 30, 2014
Dr Shami and Renee are the best!!!
UofU Patient
August 24, 2014
My husband and I always feel well informed as well as part of any decisions that are made on my behalf.
UofU Patient
July 18, 2014
Because of the circumstances, this was a difficult visit. Dr Shami is very good at explaining a difficult situation. I have much confidence in him. It takes so much out of the trauma of serious illness to have an excellent physician.
UofU Patient
July 17, 2014
This doctor is so busy and usually an hour and a half to two hours behind.
UofU Patient
July 07, 2014
Dr. Shami is so wonderful. He never rushes me and lets me ask as many questions as I want. He also seems to genuinely care about my health.
UofU Patient
June 04, 2014
One thing we appreciate about Dr. Shami is his honesty and he uses words we understand. He doesn't talk down to us.
UofU Patient
May 11, 2014
Dr. Shami is a very gentle Dr. He spends time with you and he uses words that we can understand and he doesn't talk down to us. He is a wonderful Dr. I am lucky to have him in my corner!
UofU Patient
April 28, 2014
EVERYONE in my circle of friends and family knows about Dr. Shami! As an example of #2 and#7, Dr. Shami explained about my stem cells and how they are like the "Special Forces" where there may not be as many of them, but they sure do their job. This analogy helped my family understand how my counts can be so low, and I still do so well. As an example of #4, I asked to continue my magnesium supplements until my blood test convinced me I had enough. Dr. Shami listened to me and my concerns. He is the best, without a doubt, and I feel so fortunate to have him as my physician. I hope Mr. Huntsman knows this.
UofU Patient
April 09, 2014
Dr. Shami is an awesome Dr. I would recommend him any day!
UofU Patient
February 28, 2014
Dr. Shami took the time to answer my questions and in a language I could understand. I felt like I was his only patient for the entire day!
UofU Patient
January 21, 2014
I even received a personal call within a couple of hours after my appointment regarding a question we asked. Dr. Shami consulted with another doctor on a report of two years ago and left me a message with the answer that very same day.
UofU Patient
December 18, 2013
Dr. Shami is wonderful. He takes care of all my needs and concerns. In my family - he is our hero!
UofU Patient
December 12, 2013
Dr Shami and Renee are the best
UofU Patient
December 12, 2013
Amanda PA, bone marrow biopsy, very good experience even though it hurt
UofU Patient
December 11, 2013
My visit was for lab work only
UofU Patient
October 23, 2013
Aimie, Renee, and Dr. Shami continue to provide such excellent care for me! As soon as Dr. Shami had the results of my bone marrow biopsy, he personally called to explain the numbers. As busy as he must be, he always communicates with my husband and myself as soon as he can. This is such a relief. I consider myself extremely fortunate to be under his care for so many reasons.
UofU Patient
October 07, 2013
Dr. Shami..Aimi and Renee have always treated me and my family with truth and respect!
UofU Patient
October 07, 2013
Dr. Shami is the best doctor I have ever seen. This last visit I was extremely ill and needed help for an issue other than my leukemia. He was on the phone and taking care of it within minutes of seeing me. He not only showed how much he cares about his patients but also just how far he is willing to go to see them get better. I will never be able to thank him for all he did and has done.
UofU Patient
September 23, 2013
Dr. Shami and Dr. Hildebrandt are just amazing to us, as are the teams behind each of them. I could not have two finer teams taking care of me. Both of them and their staffs have gone above and beyond to help me achieve my transplant under very difficult circumstances. Dr. Shami wrote a letter on my behalf to assist with the donor's concerns, to no avail, but it certainly meant so much to both myself and my husband and other family members. He did what he could. That letter was on target and explained my health status in such an understanding and caring manner. Dr. Shami stayed in contact with Dr. Hildebrandt while on vacation to assist with the donor process in a timely manner. They consulted on ways to address all the issues presented to them which took lots of time and dollars. They stood behind their ethics when presented with the bizarre, which was the right thing to do. It was tough for all of us when in the end the donor declined to help me; however, we knew all had been done that could have been done by the amazing Huntsman Teams to make my transplant happen.
UofU Patient
September 09, 2013
I really appreciated how the care provider made me feel like I was not rushed and that I could ask him and his assistant anything.
UofU Patient
September 04, 2013
Renae and Dr Shami are the best
UofU Patient
July 29, 2013
Dr. Shami told us what's happening and what caused it. He is very forth coming with what we can expect.
UofU Patient
July 08, 2013
love everyone there! felt cared for.
UofU Patient
June 12, 2013
Dr. Shami and his fellow gave me a lot of face time and explained everything in detail in a way myself and my family could understand.
UofU Patient
May 20, 2013
We continue to be grateful for everything we receive from Dr. Shami and ALL of his staff. Any documents we request are immediately printed off and discussed so we understand what they mean.
UofU Patient
May 14, 2013
I have so many health issues going on, I hope someone will eventually tie them altogether.
UofU Patient
May 07, 2013
Long time waitilng but doctor spent time with me and answered all our questions.
UofU Patient
April 30, 2013
I am so impressed with Dr. Shami's willingness to take the time to clearly explain the many possibilities of my illness and to answer all of my questions. He was compassionate while being thorough and professional. He made me feel like I was in the "BEST HANDS" possible.
UofU Patient
April 16, 2013
My husband and I always prepare questions for our appointment with Dr. Shami. These questions are always answered clearly and we leave with a sense of well being, knowing that Dr. Shami and all of his team know everything about me. All questions are dealt with in a friendly, non-hurried manner with clear explanations.
UofU Patient
March 13, 2013
We never, ever, feel rushed during our appointments. We ask many questions and always receive clear answers to them. Follow up on test results are conveyed on the spot with copies so we can examine the numbers. At this appointment, some results were not available until the next evening. I was sent an email at 9 p.m. with a personal note from my doctor explaining the bone marrow draw results. Now that is SERVICE!
UofU Patient
March 04, 2013
Dr. Shami rocks and I am lucky to have him as my physician
UofU Patient
February 25, 2013
Dr Shami is the best!!!!!!!!!!
UofU Patient
January 28, 2013
Outstanding - great listener.
UofU Patient
December 18, 2012
Dr. Shami has such a calming manner about him as he talks to us in a way we can understand. He ALWAYS takes his time to answer all of our questions and provide information for our many inquiries.
UofU Patient
November 19, 2012
My husband and I consider the experiences at Huntsman the absolute best anywhere. We drive 5 hours to and from our home to Huntsman because of the medical care I am receiving. So worth the trip! From the team at the front desk, lab technicians (Jolin today) nurses (Deirdre and Amy), and Dr. Shami... all make the total experience one in which my husband and I know we are receiving the very best care. Nick, who did my scheduling for my next appointment was very patient with me as I tried to make a decision about my December appointment. Very gracious and accommodating.
UofU Patient
November 19, 2012
Outstanding facility, outstanding professionals! I have the ultimate confidence in them all.
UofU Patient
October 29, 2012
What more can we say...coming to my appointments to Huntsman exceeds our expectations. Renee, who performed my bone marrow draw, made special accommodations, late in the day, to do the procedure. And it was a GOOD ONE! Deirdre was very gracious in listening to our request and ensured that this patient was comfortable and a "happy camper"! Dr. Shami truly listens to both me and my husband. How he maintains that calm, unhurried demeanor and concern for us as individuals when I'm sure he has so much going on, I just don't know. Recommend to others...YOU BET! All of my friends and family know I'm receiving the very best care!
UofU Patient
October 27, 2012
We have dealt with surgeons and doctors here in Idaho, and they did not inspire confidence on my part. On the other hand, our experience with HCI was a complete contrast to our experience here at home. All the doctors we dealt with at HCI did give us the confidence that I would be just fine.
UofU Patient
September 24, 2012
We love Dr Shami - he's the best
UofU Patient
August 28, 2012
I am very impressed with medical staff.
UofU Patient
August 27, 2012
We love Dr Shami !!!!!!!!
UofU Patient
August 22, 2012
My husband and I continue to boast about the personal care and concern I am receiving. Dr. Shami had just returned from vacation and am sure he had a huge list of patients and things to do. But never once did we feel rushed during this appointment. His humor, sincere concern, and patience with us is so greatly appreciated.
UofU Patient
August 14, 2012
Dr. Shami is excellent. He has a very kind and gentle manner about him. I appreciate how he explains things in terms I can understand. He uses helpful analogies in explaining things. I have full confidence in his abilities and his advice. I would highly recommend him.
UofU Patient
July 16, 2012
I have great faith in Dr. Shami and his assistants (Deidre, Sam and Renae)and feel rather insecure whenever they are not available and I have a medical issue that needs attention.
UofU Patient
June 25, 2012
Dr Shami is GREAT!!!!
UofU Patient
June 09, 2012
excellent
UofU Patient
May 03, 2012
Dr. Shami is the BEST!
UofU Patient
March 29, 2012
I absolutely adore Dr. Shami & Renee!!!
UofU Patient
March 22, 2012
Dr. Shami was very generous in time commitment to us. We did not feel rushed and felt that all of our numerous questions were answered in detail. Especially for me, the patient, I felt that both doctors explained the details in a way that I could understand what they were saying. Whenever we asked for a copy of reports or lab results, they were immediately printed off for our review. The bedside manner of both doctors was excellent.
UofU Patient
February 23, 2012
I feel confident about my care with your doctors, I know I am in good hands.
UofU Patient
February 13, 2012
The medical staff thinks you know everything they know. They ask for questions but don't give you anymore info than you ask for. What if I don't know right questions to ask?
UofU Patient
February 09, 2012
Dr. Shami is great.
UofU Patient
February 02, 2012
Spent some time at the Mayo Clinic. The level of service provided at Huntsman surpasses.
Paul J. Shami, M.D. is a Professor of Medicine in the Division of Hematology and Hematologic Malignancies, Department of Internal Medicine at the University of Utah. He is an Investigator at Huntsman Cancer Institute, a member of the Experimental Therapeutics program, and holds an adjunct appointment of Professor in the Department of Pharmaceutics and Pharmaceutical Chemistry.
Dr. Shami oversees leukemia studies at Hunstman Cancer Institute, where he has established the most comprehensive leukemia clinical trials program in the Intermountain West. Because of his expertise and national recognition in the treatment of blood cancers, he serves or has served on the Acute Myeloid Leukemia, Chronic Myelogenous Leukemia and Myelodysplastic Syndrome panels of the National Cancer Center Network (NCCN). These NCCN panels develop guidelines that are followed nationally and internationally for the treatment of cancer.
He initially established his research lab at the George E. Wahlen Veterans Affairs Medical Center, where he was Chief of Hematology/Oncology between 2002 and 2005. In 2004 his lab was moved to the University of Utah. The Shami laboratory focuses on the development of new therapies for cancer. In collaboration with a team of chemists (led by Dr. Larry Keefer) at the National Cancer Institute, he has developed a new class of drugs that deliver nitric oxide to cancer cells in a targeted fashion. To lead this effort, he founded JSK Therapeutics Inc. (JSKT), a Utah-based biotech start-up company. Dr. Shami has received multiple grants and significant support from the Leukemia and Lymphoma Society, and the National Cancer Institute.
Dr, Shami obtained his B.S. in Chemistry at the American University of Beirut in Lebanon, followed by his degree in medicine at the same institution. He completed both his internship and residency in Internal Medicine at Duke University in Durham, North Carolina. He remained at Duke for a fellowship in Hematology/Oncology. During that time he trained under and conducted research in the laboratory of Dr. J. Brice Weinberg, a leader in hematology research.
Dr. Paul Shami is a Professor of Medicine in the Division of Hematology and Hematologic Malignancies at the University of Utah and is a Member and Clinical Investigator at the University’s Huntsman Cancer Institute (HCI). Dr. Shami also holds an Adjunct appointment as a Professor of Pharaceutics and Pharmaceutical Chemistry at the University of Utah. He is Board Certified in Hematology and Medical Oncology. Dr. Shami oversees leukemia clinical trials at Hunstman Cancer Institute, where he has established the most comprehensive leukemia clinical trials program in the Intermountain West. Because of his expertise and national recognition in the treatment of blood cancers, he serves or has served on the Acute Myeloid Leukemia, Chronic Myelogenous Leukemia and Myelodysplastic Syndrome panels of the National Cancer Center Network (NCCN). These NCCN panels develop guidelines that are followed nationally and internationally for the treatment of cancer.
For questions regarding Dr. Shami's practice, our clinical programs or for help identifying the right Hematology specialist for you or for your family member, please feel free to contact our Clinical Care Specialist/New Patient Coordinator at http://www.huntsmancancer.org or (801) 585-6906.
Academic Locations
Huntsman Cancer Institute
801-585-2626
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Professor Pharmaceutics and Pharmaceutical Chemistry - Adjunct Professor |
| Academic Divisions | Hematology/BMT |
| Board Certification | American Board of Internal Medicine (Internal Medicine) American Board of Internal Medicine (Sub: Medical Oncology) American Board of Internal Medicine (Sub: Hematology) |
| Cancer Center Programs | Experimental Therapeutics |
Research Interests
- Leukemia, Myeloid
- Nitric Oxide
- Nitric Oxide Donors
- Glutathione Transferase
- Acute Myeloid Leukemia (AML)
- Drug Development
- Myelodysplastic Syndromes
Education History
| Fellowship | Duke University Medical Center Hematology/Oncology Fellow |
| Residency | Duke University Medical Center Internal Medicine Resident |
| Internship | Duke University Medical Center Internal Medicine Intern |
| Professional Medical | American University of Beirut Medicine M.D. |
| Undergraduate | American University of Beirut Chemistry B.S. |
Selected Publications - Journal Articles
Journal Article
- Zhang R, Yang J, Zhou Y, Shami PJ, Kopecek J (2016). N-(2-Hydroxypropyl)methacrylamide Copolymer-Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia. Macromol Biosci, 16(1), 121-128.
- Stuart RK, Cripe LD, Maris MB, Cooper MA, Stone RM, Dakhil SR, Turturro F, Stock W, Mason J, Shami PJ, Strickland SA, Costa LJ, Borthakur G, Michelson GC, Fox JA, Leavitt RD, Ravandi F (2015 Mar). REVEAL-1, a phase 2 dose regimen optimization study of vosaroxin in older poor-risk patients with previously untreated acute myeloid leukaemia. Br J Haematol, 168(6), 796-805.
- Greenberg PL, Stone RM, Bejar R, Bennett JM, Bloomfield CD, Borate U, De Castro CM, Deeg HJ, DeZern AE, Fathi AT, Frankfurt O, Gaensler K, Garcia-Manero G, Griffiths EA, Head D, Klimek V, Komrokji R, Kujawski LA, Maness LJ, ODonnell MR, Pollyea DA, Scott B, Shami PJ, Stein BL, Westervelt P, Wheeler B, Shead DA, Smith C (2015 Mar). Myelodysplastic syndromes, version 2.2015. J Natl Compr Canc Netw, 13(3), 261-72.
- Chu TW, Zhang R, Yang J, Chao MP, Shami PJ, Kopecek J (2015). A Two-Step Pretargeted Nanotherapy for CD20 Crosslinking May Achieve Superior Anti-Lymphoma Efficacy to Rituximab. Theranostics, 5(8), 834-46.
- Rudrapatna VK, Morley K, Boucher KM, Pierson AS, Shull CT, Kushner JP, Shami PJ (2015 Aug). Phase I trial of low-dose oral Clofarabine in myelodysplastic syndromes patients who have failed frontline therapy. Leuk Res, 39(8), 835-9.
- Kaur I, Kosak KM, Terrazas M, Herron JN, Kern SE, Boucher KM, Shami PJ (2015 Apr). Effect of a Pluronic((R)) P123 formulation on the nitric oxide-generating drug JS-K. Pharm Res, 32(4), 1395-406.
- Chu TW, Kosak KM, Shami PJ, Kopecek J (2014 Dec). Drug-free macromolecular therapeutics induce apoptosis of patient chronic lymphocytic leukemia cells. Drug Deliv Transl Res, 4(5-6), 389-94.
- Stenehjem DD, Albright F, Kuo KL, Raimundo K, Bauer H, Shami PJ, Deininger MW, Chen L, Brixner DI (2014 Aug). Response monitoring, tolerability, and effectiveness of imatinib treatment for chronic myeloid leukemia in a retrospective research database. J Natl Compr Canc Netw, 12(8), 1113-21.
- Zhuo R, Kosak KM, Sankar S, Wiles ET, Sun Y, Zhang J, Ayello J, Prestwich GD, Shami PJ, Cairo MS, Lessnick SL, Luo W (2014). Targeting Glutathione S-transferase M4 in Ewing sarcoma. Front Pediatr, 2, 83.
- Weidensteiner C, Reichardt W, Shami PJ, Saavedra JE, Keefer LK, Baumer B, Werres A, Jasinski R, Osterberg N, Weyerbrock A (2013 Apr 1). Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI. Nitric Oxide, 30, 17-25.
- Greenberg PL, Attar E, Bennett JM, Bloomfield CD, Borate U, De Castro CM, Deeg HJ, Frankfurt O, Gaensler K, Garcia-Manero G, Gore SD, Head D, Komrokji R, Maness LJ, Millenson M, ODonnell MR, Shami PJ, Stein BL, Stone RM, Thompson JE, Westervelt P, Wheeler B, Shead DA, Naganuma M (2013 Jul). Myelodysplastic syndromes: clinical practice guidelines in oncology. J Natl Compr Canc Netw, 11(7), 838-74.
- Kaur I, Terrazas M, Kosak KM, Kern SE, Boucher KM, Shami PJ (2013 Sep). Cellular distribution studies of the nitric oxide-generating antineoplastic prodrug O(2) -(2,4-dinitrophenyl)1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate formulated in Pluronic P123 micelles. J Pharm Pharmacol, 65(9), 1329-36.
- ODonnell MR, Tallman MS, Abboud CN, Altman JK, Appelbaum FR, Arber DA, Attar E, Borate U, Coutre SE, Damon LE, Lancet J, Maness LJ, Marcucci G, Martin MG, Millenson MM, Moore JO, Ravandi F, Shami PJ, Smith BD, Stone RM, Strickland SA, Wang ES, Gregory KM, Naganuma M (2013 Sep 1). Acute myeloid leukemia, version 2.2013. J Natl Compr Canc Netw, 11(9), 1047-55.
- Maciag AE, Holland RJ, Saavedra JE, Chakrapani H, Shami PJ, Keefer LK (2012). Thiol Modification By Pharmacologically Active Agents of the Diazeniumdiolate Class. For Immunopathol Dis Therap, 3(2), 91-95.
- OBrien S, Abboud CN, Akhtari M, Altman J, Berman E, DeAngelo DJ, Devine S, Fathi AT, Gotlib J, Jagasia M, Moore JO, Pinilla-Ibarz J, Radich JP, Reddy VV, Shah NP, Shami PJ, Smith BD, Snyder DS, Wetzler M, Yunus F (2012 Jan). Chronic myelogenous leukemia. J Natl Compr Canc Netw, 10(1), 64-110.
- ODonnell MR, Abboud CN, Altman J, Appelbaum FR, Arber DA, Attar E, Borate U, Coutre SE, Damon LE, Goorha S, Lancet J, Maness LJ, Marcucci G, Millenson MM, Moore JO, Ravandi F, Shami PJ, Smith BD, Stone RM, Strickland SA, Tallman MS, Wang ES, Naganuma M, Gregory KM (2012 Aug). Acute myeloid leukemia. J Natl Compr Canc Netw, 10(8), 984-1021.
- Slomowitz SJ, Shami PJ (2012 Sep). Management of extramedullary leukemia as a presentation of acute myeloid leukemia. J Natl Compr Canc Netw, 10(9), 1165-9.
- Nandurdikar RS, Maciag AE, Holland RJ, Cao Z, Shami PJ, Anderson LM, Keefer LK, Saavedra JE (2012 May 1). Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs. Bioorg Med Chem, 20(9), 3094-9.
- Greenberg PL, Attar E, Bennett JM, Bloomfield CD, De Castro CM, Deeg HJ, Foran JM, Gaensler K, Garcia-Manero G, Gore SD, Head D, Komrokji R, Maness LJ, Millenson M, Nimer SD, ODonnell MR, Schroeder MA, Shami PJ, Stone RM, Thompson JE, Westervelt P (2011 Jan). NCCN Clinical Practice Guidelines in Oncology: myelodysplastic syndromes. J Natl Compr Canc Netw, 9(1), 30-56.
- ODonnell MR, Abboud CN, Altman J, Appelbaum FR, Coutre SE, Damon LE, Foran JM, Goorha S, Maness LJ, Marcucci G, Maslak P, Millenson MM, Moore JO, Ravandi F, Shami PJ, Smith BD, Stone RM, Strickland SA, Tallman MS, Wang ES (2011 Mar). Acute myeloid leukemia. J Natl Compr Canc Netw, 9(3), 280-317.
- OBrien S, Berman E, Moore JO, Pinilla-Ibarz J, Radich JP, Shami PJ, Smith BD, Snyder DS, Sundar HM, Talpaz M, Wetzler M (2011 Feb). NCCN Task Force report: tyrosine kinase inhibitor therapy selection in the management of patients with chronic myelogenous leukemia. J Natl Compr Canc Netw, 9 Suppl 2, S1-25.
- Maciag AE, Nandurdikar RS, Hong SY, Chakrapani H, Diwan B, Morris NL, Shami PJ, Shiao YH, Anderson LM, Keefer LK, Saavedra JE (2011 Nov 24). Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs. J Med Chem, 54(22), 7751-8.
- Maciag AE, Chakrapani H, Saavedra JE, Morris NL, Holland RJ, Kosak KM, Shami PJ, Anderson LM, Keefer LK (2011 Feb). The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species. J Pharmacol Exp Ther, 336(2), 313-20.
- Kantarjian HM, Erba HP, Claxton D, Arellano M, Craig M, Douer D, Gabrilove J, Lyons R, Kovascovics T, Maris M, Petersdorf S, Shami PJ, Yaeger A, Eckert S, Abichandani R, Faderl S, On behalf of the CLASSIC II Investigators (). Phase II Study of Clofarabine Induction and Consolidation Therapy In Previously Untreated Older Adults With Acute Myelogenous Leukemia for Whom Conventional Induction Chemotherapy is Unlikely to be of Benefit Due to Unfavorable Baseline Risk Factors. J Clin Oncol, 28, 549-555.
- Zeng J, Yang N, Li XM, Shami PJ, Zhan J (). 4'-O-Methylglycosylation of Curcumin by Beauveria bassiana. Nat Prod Commun, 5, 77-80.
- Kiziltepe T, Anderson KC, Kutock JL, Jia L, Boucher KM, Saavedra JE, Keefer LK, Shami PJ (). JS-K has Potent Anti-Angiogenic Activity In Vitro and Inhibits Tumor Angiogenesis in a Multiple Myeloma Model In Vivo. J Pharm Pharmacol, 62, 145-151.
- Kantarjian HM, Erba HP, Claxton D, Arellano M, Lyons RM, Kovascovics T, Gabrilove J, Craig M, Douer D, Maris M, Petersdorf S, Shami PJ, Yeager AM, Eckert S, Abichandani R, Faderl S (2010 Feb 1). Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors. J Clin Oncol, 28(4), 549-55.
- Zeng J, Yang N, Li XM, Shami PJ, Zhan J (2010 Jan). 4'-O-methylglycosylation of curcumin by Beauveria bassiana. Utah Special Educator, 5(1), 77-80.
- Kiziltepe T, Anderson KC, Kutok JL, Jia L, Boucher KM, Saavedra JE, Keefer LK, Shami PJ (2010 Jan). JS-K has potent anti-angiogenic activity in vitro and inhibits tumour angiogenesis in a multiple myeloma model in vivo. Utah Special Educator, 62(1), 145-51.
- Edes K, Cassidy P, Shami PJ, Moos PJ (2010). JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. PLoS ONE, 5(1), e8786.
- OBrien S, Berman E, Borghaei H, Deangelo DJ, Devetten MP, Devine S, Erba HP, Gotlib J, Jagasia M, Moore JO, Mughal T, Pinilla-Ibarz J, Radich JP, Shah Md NP, Shami PJ, Smith BD, Snyder DS, Tallman MS, Talpaz M, Wetzler M (2009 Oct). NCCN clinical practice guidelines in oncology: chronic myelogenous leukemia. J Natl Compr Canc Netw, 7(9), 984-1023.
- Shami PJ, Maciag AE, Eddington JK, Udupi V, Kosak KM, Saavedra JE, Keefer LK (2009 Nov). JS-K, an arylating nitric oxide (NO) donor, has synergistic anti-leukemic activity with cytarabine (ARA-C). Leuk Res, 33(11), 1525-9.
- Liu J, Malavya S, Wang X, Saavedra JE, Keefer LK, Tokar E, Qu W, Waalkes MP, Shami PJ (2009 Jul). Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells. Genomics, 94(1), 32-8.
Review
- Narayanan S, Shami PJ (2012 Jan). Treatment of acute lymphoblastic leukemia in adults. [Review]. Crit Rev Oncol Hematol, 81(1), 94-102.
- Shami PJ, Deininger M (2012 Feb). Evolving treatment strategies for patients newly diagnosed with chronic myeloid leukemia: the role of second-generation BCR-ABL inhibitors as first-line therapy. [Review]. Leukemia, 26(2), 214-24.
- Shami PJ (2012 Jan). How to choose frontline therapy for chronic myelogenous leukemia: so many drugs, not so many patients. [Review]. J Natl Compr Canc Netw, 10(1), 112-8; quiz 119.
Abstract
- Rudrapatna RK, Morley K, Kushner JP, Pierson AS, Shull CT, Shami PJ (). Phase I Trial of Low-Dose Oral Clofarabine in Myelodysplastic Syndromes Patients Who Have Failed Frontline Therapy [Abstract]. Proceedings of the 2013 meeting of the American Association for Cancer Research.
- Maciag AE, Chakrapani H, Holland RJ, Morris JL, Shami PJ, Saavedra JE, Anderson LM, Keefer LK (). Diazeniumdiolate-based nitric oxide-releasing prodrugs kill lung adenocarcinoma in cells in culture and in vivo through alterations in cellular redox balance leading to mitochondrially-mediated apoptosis [Abstract]. Proceedings of the 2010 meeting of the American Association for Cancer Research, 4547.
- Kaur I, Kosak KM, Saavedra JE, Keefer LK, Kern Se, Shami PJ (). Cellular uptake and stability studies of the nitric oxide-generating pro-drug JS-K [Abstract]. Proceedings of the 2010 meeting of the American Association for Cancer Research, 2651.
- Rudrapatna R, Kosak KM, Terrazas M, Kennedy TP, Shami PJ (). Development of Dithiocarbamate/Metal Complexes in Pluronic® micelles for the Treatment of Malignancies [Abstract]. Proceedings of the 2010 meeting of the American Association for Cancer Research, 5526.
- Kosak KM, Saavedra JE, Keefer LK, Shami PJ (). A Pluronic® micelle formuation increases the stability of the novel anti-cancer nitric oxide prodrug JS-K [Abstract]. Proceedings of the 2009 meeting of the American Association for Cancer Research, 643.
Global Impact
Education History
| Professional Medical | American University of Beirut Medicine M.D. |
| Undergraduate | American University of Beirut Chemistry B.S. |