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Kristi J. Smock, MD

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Languages Spoken: English

Dr. Smock is currently an Associate Professor in the Department of Pathology at the University of Utah. She completed her residency and fellowship training at the University of Utah and is board certified in Anatomic and Clinical Pathology and Hematopathology. She has a particular interest in Coagulation Medicine and is a Medical Director of the Hemostasis/Thrombosis Laboratory at ARUP Laboratories where she enjoys being involved in all aspects of the laboratory, including new test development and validation. She particularly enjoys making contributions to patient care by consulting on difficult coagulation cases. She has additional clinical service responsibilities in Hematopathology, where she signs out bone marrow cases. Dr. Smock enjoys teaching and serves as the Residency Program Director for the Department of Pathology and Chair of the Hematopathology Fellowship Clinical Competency Committee. As Rotation Director for the resident and fellow rotations in Coagulation Medicine, she is actively involved in resident and fellow training, and she received the Department's Outstanding Teaching Award in Clinical Pathology in 2010, 2013, and 2017. She serves on the University of Utah Alpha Omega Alpha Faculty Board of Directors. She is an active member of several professional organizations and currently serves as President of the North American Specialized Coagulation Laboratory Association (NASCOLA). She is also actively involved with the College of American Pathologists, where she serves on the Hemostasis/Thrombosis Committee and the National Comprehensive Cancer Network (NCCN), where she represents the Huntsman Cancer Institute on the Clinical Practice Guidelines Panel for Cancer-Associated Venous Thromboembolic Disease. Dr. Smock serves on the Editorial Boards for Research and Practice in Thrombosis and Haemostasis and International Journal of Laboratory Hematology. In 2016, Dr. Smock was named as an American Society for Clinical Pathology 40 Under Forty honoree, recognizing her as a leader in Pathology and Laboratory Medicine. In 2018, she received the Bill Roberts Award for Clinical Excellence in Laboratory Medicine from the University of Utah Department of Pathology. She has many research interests in Coagulation Medicine.

Specialties

  • Pathology, Clinical
  • Hematopathology
  • Pathology, Anatomical

Board Certification and Academic Information

Academic Departments Pathology - Associate Professor (Clinical)
Academic Divisions Clinical Pathology
Board Certification American Board of Pathology (Anatomic & Clinical)
American Board of Pathology (Sub: Hematology)

Dr. Smock is currently an Associate Professor in the Department of Pathology at the University of Utah. She completed her residency and fellowship training at the University of Utah and is board certified in Anatomic and Clinical Pathology and Hematopathology. She has a particular interest in Coagulation Medicine and is a Medical Director of the Hemostasis/Thrombosis Laboratory at ARUP Laboratories where she enjoys being involved in all aspects of the laboratory, including new test development and validation. She particularly enjoys making contributions to patient care by consulting on difficult coagulation cases. She has additional clinical service responsibilities in Hematopathology, where she signs out bone marrow cases. Dr. Smock enjoys teaching and serves as the Residency Program Director for the Department of Pathology and Chair of the Hematopathology Fellowship Clinical Competency Committee. As Rotation Director for the resident and fellow rotations in Coagulation Medicine, she is actively involved in resident and fellow training, and she received the Department's Outstanding Teaching Award in Clinical Pathology in 2010, 2013, and 2017. She serves on the University of Utah Alpha Omega Alpha Faculty Board of Directors. She is an active member of several professional organizations and currently serves as President of the North American Specialized Coagulation Laboratory Association (NASCOLA). She is also actively involved with the College of American Pathologists, where she serves on the Hemostasis/Thrombosis Committee and the National Comprehensive Cancer Network (NCCN), where she represents the Huntsman Cancer Institute on the Clinical Practice Guidelines Panel for Cancer-Associated Venous Thromboembolic Disease. Dr. Smock serves on the Editorial Boards for Research and Practice in Thrombosis and Haemostasis and International Journal of Laboratory Hematology. In 2016, Dr. Smock was named as an American Society for Clinical Pathology 40 Under Forty honoree, recognizing her as a leader in Pathology and Laboratory Medicine. In 2018, she received the Bill Roberts Award for Clinical Excellence in Laboratory Medicine from the University of Utah Department of Pathology. She has many research interests in Coagulation Medicine.

Academic Locations

ARUP

801-583-2787-Ext.2154

500 Chipeta Way
Medical Directors, MS115-G04
Salt Lake City, UT  84108

Research Statement

Dr. Smock is currently an Associate Professor in the Department of Pathology at the University of Utah. She completed her residency and fellowship training at the University of Utah and is board certified in Anatomic and Clinical Pathology and Hematopathology. She has a particular interest in Coagulation Medicine and is Medical Director of the Hemostasis/Thrombosis Laboratory at ARUP where she enjoys being involved in all aspects of the laboratory, including new test development and validation. She particularly enjoys making contributions to patient care by consulting on difficult coagulation cases. She has additional clinical service responsibilities in Hematopathology, where she signs out bone marrow cases. Dr. Smock enjoys teaching and serves as the Residency Program Director for the Department of Pathology and Chair of the Hematopathology Fellowship Clinical Competency Committee. As Rotation Director for the resident and fellow rotations in Coagulation Medicine, she is actively involved in resident and fellow training, and she received the Department's Outstanding Teaching Award in Clinical Pathology in 2010, 2013, and 2017. She is an active member of several professional organizations, including the College of American Pathologists, where she serves on the Coagulation Resource Committee, the National Comprehensive Cancer Network (NCCN), where she represents the Huntsman Cancer Institute at the University of Utah as a Committee Member on the Clinical Practice Guidelines Panel for Cancer-Associated Venous Thromboembolic Disease, and the North American Specialized Coagulation Laboratory Association (NASCOLA), where she is currently Vice President of the organization and also serves as a member of the Proficiency Testing/External Quality Assessment Working Group and Chair of the Membership Committee. Dr. Smock serves on the Editorial Boards for Research and Practice in Thrombosis and Haemostasis and International Journal of Laboratory Hematology. In 2016, Dr. Smock was named as an American Society for Clinical Pathology 40 Under Forty honoree, recognizing her as a leader in Pathology and Laboratory Medicine. In 2018, she received the Bill Roberts Award for Clinical Excellence in Laboratory Medicine from the University of Utah Department of Pathology. She has many research interests in Coagulation Medicine.

Board Certification and Academic Information

Academic Departments Pathology - Associate Professor (Clinical)
Academic Divisions Clinical Pathology
Board Certification American Board of Pathology (Anatomic & Clinical)
American Board of Pathology (Sub: Hematology)

Research Interests

  • Bleeding Disorders
  • Thrombotic Disorders
  • Laboratory Coagulation Medicine

Education History

Fellowship University of Utah School of Medicine
Hematopathology
Fellow
Residency University of Utah School of Medicine
Pathology
Resident
Professional Medical University of Utah
Medicine
M.D.
Undergraduate Utah State University
Biology
B.S.

Selected Publications - Journal Articles

Journal Article

  1. Moyer AM, McMillin GA, Long TA, Gandhi MJ, Mao R, Smock KJ, Halley JG, Weck KE (2020). Genotype and Phenotype Concordance for Pharmacogenetic Tests Through Proficiency Survey Testing: An Update. (Epub ahead of print) Arch Path.
  2. Liederman Z, Van Cott EM, Smock K, Meijer P, Selby R (2019). Heparin-induced thrombocytopenia: An international assessment of the quality of laboratory testing. J Thromb Haemost, 17(12), 2123-2130.
  3. Smock KJ, Moser KA (2018). What have we learned from coagulation laboratory participation in external quality programs? Int J Lab Hematol, 41 Suppl 1, 49-55.
  4. Chandler WL, Brown AF, Chen D, Moser K, Olson JD, Pham HP, Smock KJ, Volod O, Higgins RA (2018). External Quality Assurance of Platelet Function Assays: Results of the College of American Pathologists Proficiency Testing Program. Arch Path, 143(4), 472-482.
  5. Khan J, Schmidt RL, Spittal MJ, Goldstein Z, Smock KJ, Greene DN (2019). Venous Thrombotic Risk in Transgender Women Undergoing Estrogen Therapy: A Systematic Review and Metaanalysis. Clin Chem, 65(1), 57-66.
  6. Streiff MB, Holmstrom B, Angelini D, Ashrani A, Bockenstedt PL, Chesney C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Gundabolu K, Hendrie P, Lee AI, Lee JT, Mann J, McMahon B, Millenson MM, Morton C, Ortel TL, Ozair S, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Williams E, Zakarija A, Hammond L, Dwyer MA, Engh AM (2018). NCCN Guidelines Insights: Cancer-Associated Venous Thromboembolic Disease, Version 2.2018. J Natl Compr Canc Netw, 16(11), 1289-1303.
  7. Crist RA, Heikal NM, Rodgers GM, Grenache DG, Smock KJ (2018). Evaluation of a new commercial method for von Willebrand factor multimeric analysis. Int J Lab Hematol, 40(5), 586-591.
  8. Gangaraju R, Rets A, Smock KJ, Heikal NM (2017). Rare complication of treated immune thrombocytopenia. Am J Hematol, 92(11), 1262-66.
  9. Rudolf J, Jackson BR, Wilson AR, Smock KJ, Schmidt RL (2017). Organizational Benchmarks for Test Utilization Performance: An Example Based on Positivity Rates for Genetic Tests. Am J Clin Pathol, 147(4), 382-389.
  10. Goodwin AJ, Higgins RA, Moser KA, Smock KJ, Chandler WL, Kottke-Marchant K, Hartman SK, Volod O, Brown AF, Johari VP, Burr S, Polyakov N, Chen D (2017). Issues Surrounding Age-Adjusted d-Dimer Cutoffs That Practicing Physicians Need to Know When Evaluating Patients With Suspected Pulmonary Embolism. Ann Intern Med, 165(5), 361-363.
  11. Schmidt RL, Chute DJ, Colbert-Getz JM, Firpo-Betancourt A, James DS, Karp KJ, Miller DC, Milner DA, Smock KJ, Sutton AT, Walker BS, White KL, Wilson AR, Wojcik EM, Yared MA, Factor RE (2017). Statistical Literacy Among Academic Pathologists: A Survey Study to Gauge Knowledge of Frequently Used Statistical Tests Among Trainees and Faculty. Arch Pathol Lab Med, 141(2), 279-287.
  12. Van Cott EM, Smock KJ, Chen D, Hsu P, Zantek ND, Meijer P (2016). Testing for dabigatran and rivaroxaban by clinical laboratories. Am J Hematol, 91(11), E464-E467.
  13. Zantek ND, Hayward CP, Simcox TG, Smock KJ, Hsu P, Van Cott EM (2016). An Assessment of the State of Current Practice in Coagulation Laboratories. Am J Clin Pathol, 146(3), 378-83.
  14. Smock KJ, Plumhoff EA, Meijer P, Hsu P, Zantek ND, Heikal NM, Van Cott EM (2016). Protein S testing in patients with protein S deficiency, factor V Leiden, and rivaroxaban by North American Specialized Coagulation Laboratories. Thromb Haemost, 116(1), 50-7.
  15. Smock KJ (2016). The role of ADAMTS13 testing in the work-up of patients with suspected thrombotic thrombocytopenic purpura. Clinical Laboratory News, 42(4), 10-14.
  16. Sono-Koree N, Crist RA, Heikal NM, Rodgers GM, Smock KJ (2016). A high-performance liquid chromatography method for the serotonin release assay is equivalent to the radioactive method. Int J Lab Hematol, 38(1), 72-80.
  17. Staddon JH, Smock KJ, Schiffman JD, Fluchel MN, Engel ME, Weyrich AS, Campbell RA (2015). Pegasparaginase treatment alters thrombin generation by modulating the protein C and S system in acute lymphoblastic leukaemia/lymphoma. Blood Coagul Fibrinolysis, 26(7), 840-3.
  18. Streiff MB, Holmstrom B, Ashrani A, Bockenstedt PL, Chesney C, Eby C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber SZ, Hendrie P, Kuderer N, Lee A, Lee JT, Lovrincevic M, Millenson MM, Neff AT, Ortel TL, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Yee GC, Zakarija A, McMillian N, Engh AM (2015). Cancer-Associated Venous Thromboembolic Disease, Version 1.2015. J Natl Compr Canc Netw, 13(9), 1079-95.
  19. Desai DS, Lyon E, Rodgers GM, Jama MA, Wallentine SL, Smock KJ (2015). Elderly female with a personal and family history of a bleeding disorder. Clin Chem, 61(7), 909-12.
  20. Zantek ND, Hsu P, Meijer P, Smock KJ, Plumhoff EA, Refaai MA, Van Cott EM (2015). Quality of factor XI activity testing in North American Specialized Coagulation Laboratories. Int J Lab Hematol, 37 Suppl 1, 99-107.
  21. Smock KJ, Perkins SL (2014). Thrombocytopenia: an update. Int J Lab Hematol, 36(3), 269-78.
  22. Smock KJ, Schmidt RL, Hadlock G, Stoddard G, Grainger D, Munger MA (2014). Assessment of orally-dosed commercial silver nanoparticles on human ex vivo platelet aggregation. Nanotoxicology, 8(3), 328-33.
  23. Smock KJ, Agarwal AM, Lim MS, Tripp SR, Miles RR, Patel JL, Abromowitch M, Lones MA, Cairo MS, Perkins SL (2014). Expression of Notch1 and mTOR Pathway Proteins in Pediatric Lymphoblastic Lymphoma; A Children’s Oncology Group Report. Journal of Hematopathology, 7(1), 9-14.
  24. Smock KJ, Ledford-Kraemer MR, Meijer P, Hsu P, Van Cott EM (2014). Proficiency testing results for heparin-induced thrombocytopenia in north america. Semin Thromb Hemost, 40(2), 254-60.
  25. Hsu P, Zantek ND, Meijer P, Hayward CP, Brody J, Zhang X, Smock KJ, Van Cott EM (2014). Factor XIII Assays and associated problems for laboratory diagnosis of factor XIII deficiency: an analysis of International Proficiency testing results. Semin Thromb Hemost, 40(2), 232-8.
  26. Heikal NM, Murphy KK, Crist RA, Wilson AR, Rodgers GM, Smock KJ (2013). Elevated factor IX activity is associated with an increased odds ratio for both arterial and venous thrombotic events. Am J Clin Pathol, 140(5), 680-5.
  27. Heikal NM, Smock KJ (2013). Laboratory testing for platelet antibodies. Am J Hematol, 88(9), 818-21.
  28. Pandey S, Post SR, Alapat DV, Smock KJ, Post GR (2013). Prolonged prothrombin time correlates with serum immunoglobulin levels in patients with plasma cell dyscrasia. Int J Lab Hematol, 35, 421-27.
  29. Shirts BH, Rodgers GM, Smock KJ (2012). Prothrombin time, activated partial thromboplastin time and dilute Russell's Viper Venom times are not shorter in patients with the prothrombin G20210A mutation, and dilute Russell's Viper Venom time may be longer. Thromb Res, 130(3), e134-8.
  30. Tantravahi SK, Williams LB, Digre KB, Creel DJ, Smock KJ, DeAngelis MM, Clayton FC, Vitale AT, Rodgers GM (2012). An inherited disorder with splenomegaly, cytopenias, and vision loss. Am J Med Genet A, 158A(3), 475-81.
  31. Sangle NA, Agarwal AM, Smock KJ, Leavitt MO, Warnke R, Bahler D, Perkins SL (2011). Diffuse large B-cell lymphoma with aberrant expression of the T-cell antigens CD2 and CD7. Appl Immunohistochem Mol Morphol, 19(6), 579-83.
  32. Smock KJ, Saunders PJ, Rodgers GM, Johari V (2011). Laboratory evaluation of clopidogrel responsiveness by platelet function and genetic methods. Am J Hematol, 86(12), 1032-34.
  33. Sangle NA, Smock KJ (2011). Antiphospholipid antibody syndrome. Arch Pathol Lab Med, 135(9), 1092-6.
  34. Wilcox R, Pendleton RC, Smock KJ, Rodgers GM (2011). Hospital-based clinical implications of the novel oral anticoagulant, dabigatran etexilate, in daily practice. Hosp Pract (Minneap), 39(3), 23-34.
  35. Sangle NA, Rodgers GM, Smock KJ (2011). Prevalence of heparin in samples submitted for lupus anticoagulant testing. Lab Hematol, 17(1), 6-11.
  36. Smock KJ, Rodgers GM (2010). Laboratory evaluation of aspirin responsiveness. Am J Hematol, 85(5), 358-60.
  37. Penmetsa GK, Rodgers GM, Smock KJ (2010). Avoiding errors in the laboratory evaluation of potent lupus anticoagulants. Am J Hematol, 85(4), 272-4.
  38. Smock KJ, Crist RA, Hansen SJ, Rodgers GM, Lehman CM (2010). Discard tubes are not necessary when drawing samples for specialized coagulation testing. Blood Coagul Fibrinolysis, 21(3), 279-82.
  39. Smock KJ, Rodgers GM (2009). Laboratory identification of lupus anticoagulants. Am J Hematol, 84(7), 440-2.
  40. Crist RA, Gibbs K, Rodgers GM, Smock KJ (2009). Effects of EDTA on routine and specialized coagulation testing and an easy method to distinguish EDTA-treated from citrated plasma samples. Lab Hematol, 15(4), 45-8.
  41. Smock KJ, Nelson M, Tripp SR, Sanger WG, Abromowitch M, Cairo MS, Perkins SL, Childrens Oncology Group (2008). Characterization of childhood precursor T-lymphoblastic lymphoma by immunophenotyping and fluorescent in situ hybridization: a report from the Children's Oncology Group. Pediatr Blood Cancer, 51(4), 489-94.
  42. Smock KJ, Yaish HM, Cairo MS, Lones MA, Willmore-Payne C, Perkins SL (2007). Mantle cell lymphoma presenting with unusual morphology in an adolescent female: a case report and review of the literature. Pediatr Dev Pathol, 10(5), 403-8.
  43. Smock KJ, Perkins SL, Bahler DW (2007). Quantitation of plasma cells in bone marrow aspirates by flow cytometric analysis compared with morphologic assessment. Arch Pathol Lab Med, 131(6), 951-5.
  44. Raetz EA, Perkins SL, Bhojwani D, Smock K, Philip M, Carroll WL, Min DJ (2006). Gene expression profiling reveals intrinsic differences between T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. Pediatr Blood Cancer, 47(2), 130-40.
  45. Herron MD, Vanderhooft SL, Smock K, Zhou H, Leachman SA, Coffin C (2004). Proliferative nodules in congenital melanocytic nevi: a clinicopathologic and immunohistochemical analysis. Am J Surg Pathol, 28(8), 1017-25.

Book Chapter

  1. Smock KJ (2018). Examination of the Blood and Bone Marrow. In Greer, Appelbaum, Arber, Dispenzieri, Fehniger, Glader, List, Means, Rodgers (Eds.), Wintrobe's Clinical Hematology (14). Philadelphia: Wolters Kluwer.
  2. Smock KJ, Heikal NM (2015). Laboratory Assays for ADAMTS-13. In Rodgers GM (Ed.), ADAMTS-13 Biology and Disease (1). New York City: Springer.
  3. Smock KJ (2015). Pharmacogenetic Testing for Anticoagulant and Antiplatelet therapies. In Bennett ST, Lehman CM, Rodgers GM (Eds.), Laboratory Hemostasis (2). New York City: Springer.
  4. Smock KJ, Perkins SL (2013). Examination of the Blood and Bone Marrow. In Greer, Arber, Glader, List, Means, Paraskevas, Rodgers (Eds.), Wintrobe's Clinical Hematology (13). Philadelphia: Lippincott Williams & Wilkins.

Editorial

  1. Van Cott EM, Smock KJ, Lippi G (2019). Innovations in Thrombosis and Hemostasis: A Glimpse Toward the Future of Diagnostic Analyzers. Sem Thromb Haemost, 45(3), 225-227.
  2. Hayward CPM, George TI, Van Cott EM, Smock K (In press). Patient advocacy and its importance to laboratory medicine practice.

Abstract

  1. Crist RA, Smock KJ, Rodgers GM, Heikal NM (2018). A correlation study of ADAMTS13 neutralizing and non-neutralizing antibodies [Abstract]. Am J Hematol, 93(9), E253-328.
  2. Liederman Z, Van Cott EM, Smock KJ, Meijer P, Selby R (2018). Heparin-induced thrombocytopenia: An international assessment of the quality of laboratory testing [Abstract]. Res Pract Thromb Haemost, 2(S1), 1-368, #PB570.
  3. Crist RA, Heikal NM, Rodgers GM, Grenache DG, Kunzler TM, Choi MA, Smock KJ (2017). Evaluation of a New Commercial Method for von Willebrand Factor Multimeric Analysis [Abstract]. Int J Lab Hematology, 39(S2), 31.
  4. Rudolf J, Smock K, Jackson B, Schmidt R (2016). Benchmarking utilization with population prevalence data: A novel use of national census data [Abstract]. J Pathol Inform, 7, 33.
  5. Crist RA, Heikal NM, Rodgers GM, Smock KJ (2016). Avoiding underestimation of protein S activity in APC resistant specimens [Abstract]. Am J Hematol, 91(9), E363-430, #T19.
  6. Nance D, Campbell RA, Rowley JW, Downie JM, Jorde LB, Kahr WH, Smock KJ, Mereby SA, Manne BK, Tolley ND, Zimmerman GA, Weyrich AS, Rondina MT (2016). Combined variants in factor VIII and PTGS-1 amplify hemorrhage severity across three generations of descendants [Abstract]. Am J Hematol, 91(9), E363-430, #4.
  7. Heikal NM, Crist RA, Rodgers GM, Smock KJ (2015). The serotonin release assay should be the first-line test for heparin-induced thrombocytopenia in patients with antiphospholipid antibodies [Abstract]. Int J Lab Hematol, 37(Supp 2), 1-130, #214.
  8. Crist RA, Sono-Koree N, Heikal NM, Rodgers GM, Smock KJ (2015). Automation of a factor XIII activity assay utilizing a plasma blank improves the quantitation of factor XIII activity [Abstract]. Int J Lab Hematol, 37(Supp 2), 1-130, #201.
  9. Sono-Koree N, Crist RA, Heikal NM, Rodgers GM, Smock KJ (2015). A high-performance liquid chromatography method for the serotonin release assay is equivalent to the radioactive method [Abstract]. Int J Lab Hematol, 2015(Supp 2), 1-130, #24.
  10. Staddon J, Smock K, Schiffman J, Engel M, Fluchel M, Weyrich A (2014). Pegasparaginase treatment in pediatric acute lymphoblastic malignancy alters thrombin generation through modulation of the protein C and S system [Abstract]. Pediatr Blood Cancer, 61(S1), S1-104.

Other

  1. National Comprehensive Cancer Network NCCN Guidelines Panel Members, Cancer-Associated Venous Thromboembolic Disease Streiff MB, Holmstrom B, Angelini D, Ashrani A, Bockenstedt PL, Chesney C, Fanikos J, Fenninger RB, Fogerty AE, Gao S, Goldhaber S, Gundabolu K, Hendrie P, Lee A, Lee JT, Mann J, McMahon B, Morton C, Ortel TL, Ozair S, Paschal R, Shattil S, Siddiqi T, Smock KJ, Soff G, Wang TF, Williams E, Zakarija A (2015-present). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines), Cancer-Associated Venous Thromboembolic Disease. NCCN.org (Contributed to Versions 1.2015, 1.2016, 1.2017, 1.2018, 1.2019 (2019 members shown above)).
  2. Tebo AE, Smock KJ, Branch WD (2011). Laboratory diagnostic assays for antiphospholipid syndrome. American Society for Clinical Pathology (ASCP) CheckSample Series- Clinical Chemistry (51(3)).

Video/Film/CD/Web/Podcast

  1. Smock KJ (2010-present). ARUP Technical Bulletins/Additional Technical Information (online test directory)Contributions: von Willebrand panel with reflex to von Willebrand multimeric analysis (2010); Diagnosis of common and uncommon bleeding disorders (2010); Factor XIII activity (2010); Heparin-induced thrombocytopenia (2014); Prolonged clotting time reflexive panel (2017) [Web].

Global Impact

Service

06/01/2019 Member Scientific Committee for Hemostasis and Platelets Australia

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