Srinivasan Beddhu

Srinivasan Beddhu, MD

Languages spoken: English, Tamil

Clinical Locations

University of Utah Hospital

Kidney and Liver Clinic
Salt Lake City
801-581-2772

Veterans Administration Medical Center

Salt Lake City

  • Dr. Beddhu is a Professor and Dialysis Research Foundation Presidential Endowed Chair in the Department of Internal Medicine. He also serves as the Clinical Research Medical Director in the Department of Internal Medicine. His research focus is on cardiovascular disease, nutritional status and lifestyle factors in CKD and dialysis patients. He leads a strong research team that is conducting studies of large national databases using cutting-edge statistical techniques and investigator initiated randomized controlled trials.

    His research is funded by NIH, VA and industry with his current total federal funding exceeding $10 million. He was actively involved for 9 years in the NHLBI-funded Systolic Blood Pressure Intervention Trial (SPRINT) as the Co-Director of the Utah Clinical Center Network (CCN) and the Utah site- PI. He has authored more than 150 publications with many papers in high impact journals. He has mentored junior faculty, post-docs, fellows, residents, graduate students and medical students, some of whom have become independent, funded investigators.

    Specialties

    Board Certification

    American Board of Internal Medicine
    American Board of Internal Medicine

  • Dr. Beddhu is a Professor and Dialysis Research Foundation Presidential Endowed Chair in the Department of Internal Medicine. He also serves as the Clinical Research Medical Director in the Department of Internal Medicine. His research focus is on cardiovascular disease, nutritional status and lifestyle factors in CKD and dialysis patients. He leads a strong research team that is conducting studies of large national databases using cutting-edge statistical techniques and investigator initiated randomized controlled trials.

    His research is funded by NIH, VA and industry with his current total federal funding exceeding $10 million. He was actively involved for 9 years in the NHLBI-funded Systolic Blood Pressure Intervention Trial (SPRINT) as the Co-Director of the Utah Clinical Center Network (CCN) and the Utah site- PI. He has authored more than 150 publications with many papers in high impact journals. He has mentored junior faculty, post-docs, fellows, residents, graduate students and medical students, some of whom have become independent, funded investigators.

    Board Certification and Academic Information

    Academic Departments Internal Medicine -Primary
    Population Health Sciences -Adjunct
    Academic Divisions Nephrology
    Board Certification
    American Board of Internal Medicine
    American Board of Internal Medicine

    Education history

    Research Fellow Renal Division - University of Pittsburg Research Fellow
    Nephrology - University Health Center of Pittsburgh Fellow
    Residency Internal Medicine - St. Mary's Hospital of Rochester Resident
    Internal Medicine - Bangalore Medical College Resident
    Residency Internal Medicine - Stanley Medical College Resident
    Medicine - Stanley Medical College M.B.B.S.
    Undergraduate D. B. Higher SEC - School

    Selected Publications

    Journal Article

    1. SPRINT Research Group, Lewis CE, Fine LJ, Beddhu S, Cheung AK, Cushman WC, Cutler JA, Evans GW, Johnson KC, Kitzman DW, Oparil S, Rahman M, Reboussin DM, Rocco MV, Sink KM, Snyder JK, Whelton PK, Williamson JD, Wright JT Jr, Ambrosius WT (2021). Final Report of a Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med, 384(20), 1921-1930. (Read full article)
    2. Lyden K, Boucher R, Wei G, Zhou N, Christensen J, Chertow GM, Greene T, Beddhu S (2021). Targeting Sedentary Behavior in CKD: A Pilot and Feasibility Randomized Controlled Trial. Clin J Am Soc Nephrol, 16(5), 717-726. (Read full article)
    3. Chang AR, Kramer H, Wei G, Boucher R, Grams ME, Berlowitz D, Bhatt U, Cohen DL, Drawz P, Punzi H, Freedman BI, Haley W, Hawfield A, Horwitz E, McLouth C, Morisky D, Papademetriou V, Rocco MV, Wall B, Weiner DE, Zias A, Beddhu S, SPRINT Research Group (2020). Effects of Intensive Blood Pressure Control in Patients with and without Albuminuria: Post Hoc Analyses from SPRINT. Clin J Am Soc Nephrol, 15(8), 1121-1128. (Read full article)
    4. Ilkun OL, Greene T, Cheung AK, Whelton PK, Wei G, Boucher RE, Ambrosius W, Chertow GM, Beddhu S (2020). The Influence of Baseline Diastolic Blood Pressure on the Effects of Intensive Blood Pressure Lowering on Cardiovascular Outcomes and All-Cause Mortality in Type 2 Diabetes. Diabetes Care, 43(8), 1878-1884. (Read full article)
    5. Beddhu S, Shen J, Cheung AK, Kimmel PL, Chertow GM, Wei G, Boucher RE, Chonchol M, Arman F, Campbell RC, Contreras G, Dwyer JP, Freedman BI, Ix JH, Kirchner K, Papademetriou V, Pisoni R, Rocco MV, Whelton PK, Greene T (2019). Implications of Early Decline in eGFR due to Intensive BP Control for Cardiovascular Outcomes in SPRINT. J Am Soc Nephrol, 30(8), 1523-1533. (Read full article)
    6. Beddhu S, Chertow GM, Greene T, Whelton PK, Ambrosius WT, Cheung AK, Cutler J, Fine L, Boucher R, Wei G, Zhang C, Kramer H, Bress AP, Kimmel PL, Oparil S, Lewis CE, Rahman M, Cushman WC (2018). Effects of Intensive Systolic Blood Pressure Lowering on Cardiovascular Events and Mortality in Patients With Type 2 Diabetes Mellitus on Standard Glycemic Control and in Those Without Diabetes Mellitus: Reconciling Results From ACCORD BP and SPRINT. J Am Heart Assoc, 7(18), e009326. (Read full article)
    7. Beddhu S, Greene T, Boucher R, Cushman WC, Wei G, Stoddard G, Ix JH, Chonchol M, Kramer H, Cheung AK, Kimmel PL, Whelton PK, Chertow GM (2018). Intensive systolic blood pressure control and incident chronic kidney disease in people with and without diabetes mellitus: secondary analyses of two randomised controlled trials. Lancet Diabetes Endocrinol, 6(7), 555-563. (Read full article)
    8. Kramer H, Boucher RE, Leehey D, Fried L, Wei G, Greene T, Rosas SE, Cooper R, Cao G, Beddhu S (02/07/2018). Increasing Mortality in Adults With Diabetes and Low Estimated Glomerular Filtration Rate in the Absence of Albuminuria. Diabetes Care, 41(4), 775-781.
    9. Beddhu S, Chertow GM, Cheung AK, Cushman WC, Rahman M, Greene T, Wei G, Campbell RC, Conroy M, Freedman BI, Haley W, Horwitz E, Kitzman D, Lash J, Papademetriou V, Pisoni R, Riessen E, Rosendorff C, Watnick SG, Whittle J, Whelton PK, SPRINT Research Group (01/09/2018). Influence of Baseline Diastolic Blood Pressure on Effects of Intensive Compared With Standard Blood Pressure Control. Circulation, 137(2), 134.
    10. Beddhu S, Rocco M, Toto R, Craven TE, Greene T, Bhatt U, Cheung AK, Cohen D, Freedman BI, Hawfield AT, Kileen AA, Kimmell PL, LashJ, Papademtriou V, Rahman M, Rastogi A, Servilla K, Townsend RR, Wall B, Whelton PK, SPRINT Rsearch Group (09/19/2017). Effects of Intensive Systolic Blood Pressure Control on Kidney and Cardiovascular Outcomes in Persons Withour Kidney Disease: A Secondary Analysis of Randomized Trial. Ann Intern Med, 167(6), 375-383.
    11. Bress AP, Bellows BK, King JB, Hess R, Beddhu S, Zhang Z, Berlowitz DR, Conroy MB, Fine L, Oparil S, Morisky DE, Kazis LE, Ruiz-Negrn N, Powell J, Tamariz L, Whittle J, Wright JT Jr, Supiano MA, Cheung AK, Weintraub WS, Moran AE, SPRINT Research Group (08/24/2017). Cost-Effectiveness of Intensive versus Standard Blood-Pressure Control. N Engl J Med, 377(8), 745-755.
    12. Raphael KL, Carroll DJ, Murray J, Greene T, Beddhu S (08/01/2017). Urine Ammonium Predicts Clinical Outcomes in Hypertensive Kidney Disease. J Am Soc Nephrol, 28(8), 2483-2490.
    13. Chen X, Wei G, Jalili T, Metos J, Giri A, Cho ME, Boucher R, Greene T, Beddhu S (2016). The Associations of Plant Protein Intake With All-Cause Mortality in CKD. Am J Kidney Dis, 67(3), 423-30.
    14. Beddhu S, Wei G, Marcus RL, Chonchol M, Greene T (2015). Light-intensity physical activities and mortality in the United States general population and CKD subpopulation. Clin J Am Soc Nephrol, 10(7), 1145-53.
    15. Krishnamurthy VM, Wei G, Baird BC, Murtaugh M, Chonchol MB, Raphael KL, Greene T, Beddhu S (2012). High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease. Kidney Int, 81(3), 300-6. (Read full article)
    16. Raphael KL, Wei G, Baird BC, Greene T, Beddhu S (2011). Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans. Kidney Int, 79(3), 356-62. (Read full article)
    17. Damera S, Raphael KL, Baird BC, Cheung AK, Greene T, Beddhu S (2011). Serum alkaline phosphatase levels associate with elevated serum C-reactive protein in chronic kidney disease. Kidney Int, 79(2), 228-33. (Read full article)
    18. Beddhu S, Baird BC, Zitterkoph J, Neilson J, Greene T (2009). Physical activity and mortality in chronic kidney disease (NHANES III). Clin J Am Soc Nephrol, 4(12), 1901-6. (Read full article)
    19. Navaneethan SD, Yehnert H, Moustarah F, Schreiber MJ, Schauer PR, Beddhu S (2009). Weight loss interventions in chronic kidney disease: a systematic review and meta-analysis. Clin J Am Soc Nephrol, 4(10), 1565-74. (Read full article)
    20. Kwan BC, Murtaugh MA, Beddhu S (2007). Associations of body size with metabolic syndrome and mortality in moderate chronic kidney disease. Clin J Am Soc Nephrol, 2(5), 992-8. (Read full article)
    21. Beddhu S, Kimmel PL, Ramkumar N, Cheung AK (2005). Associations of metabolic syndrome with inflammation in CKD: results From the Third National Health and Nutrition Examination Survey (NHANES III). Am J Kidney Dis, 46(4), 577-86. (Read full article)
    22. Morris D, Samore MH, Pappas LM, Ramkumar N, Beddhu S (2005). Nutrition and racial differences in cardiovascular events and survival in elderly dialysis patients. Am J Med, 118(6), 671-5. (Read full article)
    23. Beddhu S, Pappas LM, Ramkumar N, Samore MH (2004). Malnutrition and atherosclerosis in dialysis patients. J Am Soc Nephrol, 15(3), 733-42. (Read full article)
    24. Beddhu S, Pappas LM, Ramkumar N, Samore M (2003). Effects of body size and body composition on survival in hemodialysis patients. J Am Soc Nephrol, 14(9), 2366-72. (Read full article)
    25. Beddhu S, Samore MH, Roberts MS, Stoddard GJ, Ramkumar N, Pappas LM, Cheung AK (2003). Impact of timing of initiation of dialysis on mortality. J Am Soc Nephrol, 14(9), 2305-12. (Read full article)
    26. Beddhu S, Samore MH, Roberts MS, Stoddard GJ, Pappas LM, Cheung AK (2003). Creatinine production, nutrition, and glomerular filtration rate estimation. J Am Soc Nephrol, 14(4), 1000-5. (Read full article)
    27. Beddhu S, Allen-Brady K, Cheung AK, Horne BD, Bair T, Muhlestein JB, Anderson JL (2002). Impact of renal failure on the risk of myocardial infarction and death. Kidney Int, 62(5), 1776-83. (Read full article)
    28. Beddhu S, Bruns FJ, Saul M, Seddon P, Zeidel ML (2000). A simple comorbidity scale predicts clinical outcomes and costs in dialysis patients. Am J Med, 108(8), 609-13. (Read full article)

    Review

    1. Kramer HJ, Townsend RR, Griffin K, Flynn JT, Weiner DE, Rocco MV, Choi MJ, Weir MR, Chang TI, Agarwal R, Beddhu S (2018). KDOQI US Commentary on the 2017 ACC/AHA Hypertension Guideline. [Review]. Am J Kidney Dis, 73(4), 437-458. (Read full article)
    2. Kramer H, Tuttle KR, Leehey D, Luke A, Durazo-Arvizu R, Shoham D, Cooper R, Beddhu S (2009). Obesity management in adults with CKD. [Review]. Am J Kidney Dis, 53(1), 151-65. (Read full article)

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