Christian Con Yost,
MD
Languages Spoken: English, German
Christian Con Yost, MD is a tenured Associate Professor in the Department of Pediatrics within the University of Utah School of Medicine. He serves as the Director of the Neonatal-Perinatal Medicine Fellowship Training Program at the University of Utah. He provides clinical care as an attending physician to critically ill patients admitted to the newborn intensive care units at the University of Utah Medical Center, Primary Children’s Hospital, and Intermountain Medical Center. His clinical areas of expertise include all aspects of neonatal care with a particular interest in improving clinical outcomes for patients with necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and all neonatal patients requiring extracorporeal membrane oxygenation (ECMO) as treatment for cardio-respiratory failure.
Clinical Locations
Intermountain Medical Center
801-507-7000
Primary Children's Hospital
Newborn Intensive Care Unit801-662-4100
Newborn Intensive Care Unit
801-581-2745
Specialties
Board Certification and Academic Information
| Academic Departments | Pediatrics
-
Professor |
| Academic Divisions | Neonatology |
| Board Certification | American Board of Pediatrics (Pediatrics) American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine) |
Christian Con Yost, MD is a tenured Associate Professor in the Department of Pediatrics within the University of Utah School of Medicine. He serves as the Director of the Neonatal-Perinatal Medicine Fellowship Training Program at the University of Utah. He provides clinical care as an attending physician to critically ill patients admitted to the newborn intensive care units at the University of Utah Medical Center, Primary Children’s Hospital, and Intermountain Medical Center. His clinical areas of expertise include all aspects of neonatal care with a particular interest in improving clinical outcomes for patients with necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and all neonatal patients requiring extracorporeal membrane oxygenation (ECMO) as treatment for cardio-respiratory failure.
Academic Locations
Williams Building
801-581-7052
Research Statement
Dr. Yost's research interests include the study of regulatory mechanisms governing the acute inflammatory response in newborn infants, both term and preterm, as it relates to syndromes of dysregulated inflammation such as necrotizing enterocolitis, neonatal chronic lung disease, and early onset sepsis. He has received extramural funding to examine translational regulation of protein expression via the mammalian target of rapamycin (mTOR) signaling cascade in neonatal PMNs. As part of this effort, his research team recently described for the first time a novel deficiency of innate immunity in newborn infants leading to an increased risk of infection in term and preterm infants - failure of neutrophil extracellular trap (NET) formation with decreased extracellular killing of bacteria. Dr. Yost’s research efforts currently focus on elucidating the regulatory mechanisms governing NET formation by human PMNs and the role of dysregulated NET formation in the inflammatory syndromes associated with prematurity.
Board Certification and Academic Information
| Academic Departments | Pediatrics
-
Professor |
| Academic Divisions | Neonatology |
| Board Certification | American Board of Pediatrics (Pediatrics) American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine) |
Education History
| Fellowship | University of Utah School of Medicine Neonatology Fellow |
| Residency | University of Vermont College of Medicine Pediatrics Resident |
| Internship | University of Vermont College of Medicine Pediatrics Intern |
| Professional Medical | University of Utah School of Medicine M.D. |
| Undergraduate | University of Utah Biology B.S. |
Selected Publications - Journal Articles
Journal Article
- Sumanth MS, Jacob SP, Abhilasha KV, Manne BK, Basrur V, Lehoux S, Campbell RA, Yost CC, McIntyre TM, Cummings RD, Weyrich AS, Rondina MT, Marathe GK (2020). Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils. (Epub ahead of print) J Leukoc Biol.
- Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA (2020). Platelet gene expression and function in patients with COVID-19. Blood, 136(11), 1317-1329.
- Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC (2020). Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 136(10), 1169-1179.
- Yang MJ, Fenton S, Russell K, Yost CC, Yoder BA (2020). Left-sided congenital diaphragmatic hernia: can we improve survival while decreasing ECMO? J Perinatol, 40(6), 935-942.
- Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, Salvatore S, Schwartz RE, Spicer JD, Yost CC, Weber A, Zuo Y, Egeblad M (2020). Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J Exp Med, 217(6).
- Yost CC (2019). Pediatric immunothrombosis-Understudied… but what potential! Pediatr Res, 86(1), 17-18.
- Campbell RA, Cody MJ, Manne BK, Zimmerman GA, Yost CC (2019). Interleukin 6 receptor alpha expression in PMNs isolated from prematurely born neonates: decreased expression is associated with differential mTOR signaling. Pediatr Res, 86(1), 55-62.
- Brunelli L, Jenkins SM, Gudgeon JM, Bleyl SB, Miller CE, Tvrdik T, Dames SA, Ostrander B, Daboub JAF, Zielinski BA, Zinkhan EK, Underhill HR, Wilson T, Bonkowsky JL, Yost CC, Botto LD, Jenkins J, Pysher TJ, Bayrak-Toydemir P, Mao R (2019). Targeted gene panel sequencing for the rapid diagnosis of acutely ill infants. Mol Genet Genomic Med, 7(7), e00796.
- Yost CC, Soll RF (2000). Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. Cochrane Database Syst Rev, (2), CD001456.
Case Report
Patent
- Yost CC, Zimmerman GA, Weyrich AS, Schiffman J. (2019). nNIF AND nNIF-RELATED PEPTIDES AND RELATED METHODS. U.S. Patent No. WO 2018/045371 A2. Washington, D.C.:U.S. Patent and Trademark Office.
- Yost CC, Zimmerman GA, Weyrich AS. (2018). METHODS FOR TREATMENT OF AND PROPHYLAXIS AGAINST INFLAMMATORY DISORDERS. U.S. Patent No. 15/441,982. Washington, D.C.:U.S. Patent and Trademark Office.