Christian Con Yost,
MD
Languages Spoken: English, German
Christian Con Yost, MD is a tenured Associate Professor in the Department of Pediatrics within the University of Utah School of Medicine. He serves as the Director of the Neonatal-Perinatal Medicine Fellowship Training Program at the University of Utah. He provides clinical care as an attending physician to critically ill patients admitted to the newborn intensive care units at the University of Utah Medical Center, Primary Children’s Hospital, and Intermountain Medical Center. His clinical areas of expertise include all aspects of neonatal care with a particular interest in improving clinical outcomes for patients with necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and all neonatal patients requiring extracorporeal membrane oxygenation (ECMO) as treatment for cardio-respiratory failure.
Clinical Locations
Intermountain Medical Center
801-507-7000
Primary Children's Hospital
Newborn Intensive Care Unit801-662-4100
Newborn Intensive Care Unit
801-581-2745
Specialties
Board Certification and Academic Information
| Academic Departments | Pediatrics
-
Professor |
| Academic Divisions | Neonatology |
| Board Certification | American Board of Pediatrics (Pediatrics) American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine) |
Christian Con Yost, MD is a tenured Associate Professor in the Department of Pediatrics within the University of Utah School of Medicine. He serves as the Director of the Neonatal-Perinatal Medicine Fellowship Training Program at the University of Utah. He provides clinical care as an attending physician to critically ill patients admitted to the newborn intensive care units at the University of Utah Medical Center, Primary Children’s Hospital, and Intermountain Medical Center. His clinical areas of expertise include all aspects of neonatal care with a particular interest in improving clinical outcomes for patients with necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and all neonatal patients requiring extracorporeal membrane oxygenation (ECMO) as treatment for cardio-respiratory failure.
Academic Locations
Research Statement
Dr. Yost's research interests include the study of regulatory mechanisms governing the acute inflammatory response in newborn infants, both term and preterm, as it relates to syndromes of dysregulated inflammation such as necrotizing enterocolitis, neonatal chronic lung disease, and early onset sepsis. He has received extramural funding to examine translational regulation of protein expression via the mammalian target of rapamycin (mTOR) signaling cascade in neonatal PMNs. As part of this effort, his research team recently described for the first time a novel deficiency of innate immunity in newborn infants leading to an increased risk of infection in term and preterm infants - failure of neutrophil extracellular trap (NET) formation with decreased extracellular killing of bacteria. Dr. Yost’s research efforts currently focus on elucidating the regulatory mechanisms governing NET formation by human PMNs and the role of dysregulated NET formation in the inflammatory syndromes associated with prematurity.
Board Certification and Academic Information
| Academic Departments | Pediatrics
-
Professor |
| Academic Divisions | Neonatology |
| Board Certification | American Board of Pediatrics (Pediatrics) American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine) |
Education History
| Fellowship | University of Utah School of Medicine Neonatology Fellow, 2003 |
| Residency | University of Vermont College of Medicine Pediatrics Resident, 2000 |
| Internship | University of Vermont College of Medicine Pediatrics Intern, 1998 |
| Professional Medical | University of Utah School of Medicine M.D., 1997 |
| Undergraduate | University of Utah Biology B.S., 1993 |
Selected Publications - Journal Articles
Journal Article
- Campbell RA, Campbell HD, Bircher JS, de Araujo CV, Denorme F, Crandell JL, Rustad JL, Monts J, Cody MJ, Kosaka Y, Yost CC (2021). Placental HTRA1 cleaves alpha-1-antitrypsin to generate a NET-Inhibitory Peptide. (Epub ahead of print) Blood.
- Trivedi S, Grossmann AH, Jensen O, Cody MJ, Wahlig TA, Hayakawa Serpa P, Langelier C, Warren KJ, Yost CC, Leung DT (2021). Intestinal Infection Is Associated With Impaired Lung Innate Immunity to Secondary Respiratory Infection. Open Forum Infect Dis, 8(6), ofab237.
- Sumanth MS, Jacob SP, Abhilasha KV, Manne BK, Basrur V, Lehoux S, Campbell RA, Yost CC, McIntyre TM, Cummings RD, Weyrich AS, Rondina MT, Marathe GK (2020). Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils. J Leukoc Biol, 109(5), 915-930.
- Yost CC (2021). Neutrophils clear sterile inflammatory debris. Blood, 137(3), 293-294.
- Bouck EG, Denorme F, Holle LA, Middelton EA, Blair AM, de Laat B, Schiffman JD, Yost CC, Rondina MT, Wolberg AS, Campbell RA (2020). COVID-19 and Sepsis Are Associated With Different Abnormalities in Plasma Procoagulant and Fibrinolytic Activity. Arterioscler Thromb Vasc Biol, 41(1), 401-414.
- Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA (2020). Platelet gene expression and function in patients with COVID-19. Blood, 136(11), 1317-1329.
- Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC (2020). Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 136(10), 1169-1179.
- Yang MJ, Fenton S, Russell K, Yost CC, Yoder BA (2020). Left-sided congenital diaphragmatic hernia: can we improve survival while decreasing ECMO? J Perinatol, 40(6), 935-942.
- Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, Salvatore S, Schwartz RE, Spicer JD, Yost CC, Weber A, Zuo Y, Egeblad M (2020). Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J Exp Med, 217(6).
- Yost CC (2019). Pediatric immunothrombosis-Understudied… but what potential! Pediatr Res, 86(1), 17-18.
- Campbell RA, Cody MJ, Manne BK, Zimmerman GA, Yost CC (2019). Interleukin 6 receptor alpha expression in PMNs isolated from prematurely born neonates: decreased expression is associated with differential mTOR signaling. Pediatr Res, 86(1), 55-62.
- Brunelli L, Jenkins SM, Gudgeon JM, Bleyl SB, Miller CE, Tvrdik T, Dames SA, Ostrander B, Daboub JAF, Zielinski BA, Zinkhan EK, Underhill HR, Wilson T, Bonkowsky JL, Yost CC, Botto LD, Jenkins J, Pysher TJ, Bayrak-Toydemir P, Mao R (2019). Targeted gene panel sequencing for the rapid diagnosis of acutely ill infants. Mol Genet Genomic Med, 7(7), e00796.
- Morales-Ortz J, Deal V, Reyes F, Maldonado-Martnez G, Ledesma N, Staback F, Croft C, Pacheco A, Ortiz-Zuazaga H, Yost CC, Rowley JW, Madera B, John AS, Chen J, Lopez J, Rondina MT, Hunter R, Gibson A, Washington AV (2018). Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model. Blood, 132(23), 2495-2505.
- MacQueen BC, Christensen RD, Yost CC, Gordon PV, Baer VL, Schlaberg R, Lowe J (2018). Reference intervals for stool calprotectin in preterm neonates and their utility for the diagnosis of necrotizing enterocolitis. J Perinatol, 38(10), 1379-1385.
- Murphy J, Yost CC, Short S, Alashari M, Chan B (Sep 2018). Black eschar on a 4 day old preterm infant. Neoreviews, 19(9), e564-e568.
- Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman GA (2016). Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. J Clin Invest, 126(10), 3783-3798.
- MacQueen BC, Christensen RD, Yost CC, Lambert DK, Baer VL, Sheffield MJ, Gordon PV, Cody MJ, Gerday E, Schlaberg R, Lowe J, Shepherd JG (2016). Elevated fecal calprotectin levels during necrotizing enterocolitis are associated with activated neutrophils extruding neutrophil extracellular traps. J Perinatol, 36(10), 862-9.
- McKnight RA, Yost CC, Zinkhan EK, Fu Q, Callaway CW, Fung CM (2016). Intrauterine growth restriction inhibits expression of eukaryotic elongation factor 2 kinase, a regulator of protein translation. Physiol Genomics, 48(8), 616-25.
- Glenn JW, Cody MJ, McManus MP, Pulsipher MA, Schiffman JD, Yost CC (2016). Deficient Neutrophil Extracellular Trap Formation in Patients Undergoing Bone Marrow Transplantation. 7, 250.
- Arajo CV, Campbell C, Gonalves-de-Albuquerque CF, Molinaro R, Cody MJ, Yost CC, Bozza PT, Zimmerman GA, Weyrich AS, Castro-Faria-Neto HC, Silva AR (2016). A PPARγ AGONIST ENHANCES BACTERIAL CLEARANCE THROUGH NEUTROPHIL EXTRACELLULAR TRAP FORMATION AND IMPROVES SURVIVAL IN SEPSIS. Shock, 45(4), 393-403.
- McKnight RA, Yost CC, Yu X, Wiedmeier JE, Callaway CW, Brown AS, Lane RH, Fung CM (2015). Intrauterine growth restriction perturbs nucleosome depletion at a growth hormone-responsive element in the mouse IGF-1 gene. Physiol Genomics, 47(12), 634-43.
- Yost CC (2014). Toward the "ideal" inhibitor of NETs. Blood, 123(16), 2439-40.
- McInturff AM, Cody MJ, Elliott EA, Glenn JW, Rowley JW, Rondina MT, Yost CC (2012). Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α. Blood, 120(15), 3118-25.
- Thornton NL, Cody MJ, Yost CC (2011). Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants. Neonatology, 101(2), 140-6.
- Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS (2011). Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog, 7(11), e1002355.
- Rowley JW, Oler AJ, Tolley ND, Hunter BN, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich AS (2011). Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood, 118(14), e101-11.
- Yost CC, Weyrich AS, Zimmerman GA (2010). The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Biochimie, 92(6), 692-7.
- Yost CC, Cody MJ, Harris ES, Thornton NL, McInturff AM, Martinez ML, Chandler NB, Rodesch CK, Albertine KH, Petti CA, Weyrich AS, Zimmerman GA (2009). Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood, 113(25), 6419-27.
- Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, Yost CC, Rubner FJ, Albertine KH, Swoboda KJ, Fratto CM, Tolley E, Kraiss LW, McIntyre TM, Zimmerman GA, Weyrich AS (2005). Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell, 122(3), 379-91.
- Yost CC (2005). Neonatal necrotizing enterocolitis: diagnosis, management, and pathogenesis. J Infus Nurs, 28(2), 130-4.
- Yost CC, Denis MM, Lindemann S, Rubner FJ, Marathe GK, Buerke M, McIntyre TM, Weyrich AS, Zimmerman GA (2004). Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. J Exp Med, 200(5), 671-80.
- Bloom R, Yost CC (2004). A consideration of neonatal resuscitation. Pediatr Clin North Am, 51(3), 669-84, ix.
- Lindemann SW, Yost CC, Denis MM, McIntyre TM, Weyrich AS, Zimmerman GA (2004). Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proc Natl Acad Sci U S A, 101(18), 7076-81.
- Yost CC, Soll RF (2000). Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. Cochrane Database Syst Rev, (2), CD001456.
Book Chapter
- Yost CC, Bloom RS (2004). Neonatal Resucitation. In Dildy GA, Belfort MA, Saade GR, et. al. (Eds.), Critical Care Obstetrics 4th Edition.
Case Report
Patent
- Yost CC, Zimmerman GA, Weyrich AS, Schiffman J. (2019). nNIF AND nNIF-RELATED PEPTIDES AND RELATED METHODS. U.S. Patent No. WO 2018/045371 A2. Washington, D.C.:U.S. Patent and Trademark Office.
- Yost CC, Zimmerman GA, Weyrich AS. (2018). METHODS FOR TREATMENT OF AND PROPHYLAXIS AGAINST INFLAMMATORY DISORDERS. U.S. Patent No. 15/441,982. Washington, D.C.:U.S. Patent and Trademark Office.