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Stephen L. Guthery, M.D., M.S.

Clinical Details

Locations

Schedule An Appointment Clinical Office Address
(801) 662-2900 Primary Children's Hospital
Pediatric Gastroenterology
100 N Mario Capecchi Drive
Salt Lake City, UT 84113

Bio

Dr. Guthery received his medical degree from the Oregon Health Sciences University and completed his pediatric residency at Cincinnati Children’s Hospital Medical Center. He subsequently completed his fellowship in pediatric gastroenterology at Cincinnati Children’s Hospital Medical Center.

Dr. Guthery is currently Professor of Pediatrics and Adjunct Professor of Human Genetics. Dr. Guthery’s clinical interests include Crohn disease, ulcerative colitis, and primary sclerosing cholangitis in children and adolescents. His research interests include the genetics of Crohn disease in children. He is also interested in the genetics of Crohn disease and ulcerative colitis in families.

Dr. Guthery is board certified in General Pediatrics, Pediatric Gastroenterology, and Pediatric Transplant Hepatology. He has served as a member of the Pediatric Affairs Committee of the Crohn’s and Colitis Foundation of America, and is listed among Best Doctors in America. He is the Program Director of the Training Program in Pediatric Gastroenterology at the University of Utah and Primary Children’s Medical Center.

Board Certification and Academic Information

Academic Departments Pediatrics - Professor
Human Genetics - Adjunct Professor
Academic Divisions Pediatric Gastroenterology
Board Certification American Board of Pediatrics (Pediatric Transplant Hepatology)
American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Ped Gastroenterology)

Academic Profile

Research Interests

  • Sequence Analysis, DNA
  • Epidemiology of Childhood Crohn Disease and Ulcerative Colitis
  • Rare and Undiagnosed Diseases in Children
  • Human Population Genetics
  • Genetics of Childhood Crohn Disease and Ulcerative Colitis

Board Certification and Academic Information

Academic Departments Pediatrics - Professor
Human Genetics - Adjunct Professor
Academic Divisions Pediatric Gastroenterology
Board Certification American Board of Pediatrics (Pediatric Transplant Hepatology)
American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Ped Gastroenterology)

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 662-2900 Primary Children's Hospital
Pediatric Gastroenterology
100 N Mario Capecchi Drive
Salt Lake City, UT 84113

Academic Bio

Dr. Guthery completed a Clinical Research Fellowship at Cincinnati Children’s Hospital Medical Center in 2002. He obtained a Master’s of Science degree in Epidemiology from the University of Cincinnati, with a focus on biostatistics. In 2002, he came to the University of Utah, and received a Career Development Award from the National Institutes of Health. Dr. Guthery received further research training in human genetics under the mentorship of Drs. Michael Bamshad and subsequently Lynn Jorde. Dr. Guthery is currently a Professor of Pediatrics and Adjunct Professor of Human Genetics.

Dr. Guthery’s research focuses on genome sequencing using novel analytical tools such as VAAST to better understand how genomic variation contributes to liver and GI diseases affecting infants and children. Diseases currently under study include childhood-onset Crohn disease and ulcerative colitis, undiagnosed immune-mediated disease of the GI tract, and undiagnosed liver disease. Additionally, Dr. Guthery is the local principal investigator for several multicenter clinical studies in Crohn disease and ulcerative colitis.

Dr. Guthery is the director of the Fellowship Training Program in Pediatric Gastroenterology at the University of Utah and Primary Children’s Medical Center. He is also the Associate Director of the Clinical Services Core, a component of the University of Utah’s Center for Clinical and Translational Sciences, a funded CTSA.

Education

Education History

Type School Degree
Graduate Training University of Cincinnati
Epidemiology
Master's
Fellowship Cincinnati Children's Hospital Medical Center
Pediatric Gastroenterology, Hepatology, and Nutrition
Fellow
Residency Cincinnati Children's Hospital Medical Center
Pediatrics
Resident
Professional Medical Oregon Health Sciences University
Medicine
M.D.
Undergraduate Lewis and Clark College
Biology
B.A.

Publications

Selected Provider Publications

Journal Article

  1. Deneau M, Book LS, Guthery SL, Jensen M(2014)Outcome after Discontinuation of Immunosuppression in Children with Autoimmune Hepatitis: A Population-Based Study.LID - S0022-3476(13)01533-3 [pii]LID - 10.1016/j.jpeds.2013.12.008 [doi]  Journal of Pediatrics, The,
  2. Deneau M, Jensen MK, Holmen J, Williams MS, Book LS, Guthery S(2013)Primary sclerosing cholangitis, autoimmune hepatitis, and overlap in utah children: Epidemiology and natural history.LID - 10.1002/hep.26454 [doi]  Hepatology,
  3. Walters TD, Kim M, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn M, Otley A, Heyman MB, Leleiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, Oliva-Hemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S, Liu C, Essers J, Kugathasan S, Hyams J(2013)Comparative Effectiveness of Early Therapy with Anti-Tumor Necrosis Factor-alpha vs an Immunomodulator in Children With Crohn's Disease.LID - S0016-5085(13)01501-1 [pii]LID - 10.1053/j.gastro.2013.10.027 [doi]  Gastroenterology,
  4. Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P, Comeau ME, Sajuthi S, Andrews R, Brown M, Chen WM, Concannon P, Deloukas P, Edkins S, Eyre S, Gaffney PM, Guthery SL, Guthridge JM, Hunt SE, James JA, Keddache M, Moser KL, Nigrovic PA, Onengut-Gumuscu S, Onslow ML, Rosé CD, Rich SS, Steel KJ, Wakeland EK, Wallace CA, Wedderburn LR, Woo P, Boston Children's JIA Registry, British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS), Childhood Arthritis Response to Medication Study (CHARMS), German Society for Pediatric Rheumatology (GKJR), JIA Gene Expression Study, NIAMS JIA Genetic Registry, TREAT Study, United Kingdom Juvenile Idiopathic Arthritis Genetics Consortium (UKJIAGC), Bohnsack JF, Haas JP, Glass DN, Langefeld CD, Thomson W, Thompson SD(2013)Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.  Nature Genetics, 45(6),664-669
  5. Willson TA, Kuhn BR, Jurickova I, Gerad S, Moon D, Bonkowski E, Carey R, Collins MH, Xu H, Jegga AG, Guthery SL, Denson LA(2012)

    STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease.

     Journal of Pediatric Gastroenterology and Nutrition, 55(1),32-43
  6. Huff CD, Witherspoon DJ, Zhang Y, Gatenbee C, Denson LA, Kugathasan S, Hakonarson H, Whiting A, Davis CT, Wu W, Xing J, Watkins WS, Bamshad MJ, Bradfield JP, Bulayeva K, Simonson TS, Jorde LB, Guthery SL(2012)Crohn's disease and genetic hitchhiking at IBD5.  Molecular Biology and Evolution, 29(1),101-11
  7. Guthery SL, Mineau G, Pimentel R, Williams MS, Kerber R(2011)Inflammatory bowel disease aggregation in Utah kindreds.  Inflammatory Bowel Diseases, 17(3),823-30
  8. Moore JC, Thompson K, Lafleur B, Book LS, Jackson WD, O'Gorman MA, Black RE, Downey E Jr, Johnson DG, Matlak ME, Meyers RL, Scaife E, Guthery S(2011)Clinical variables as prognostic tools in pediatric-onset ulcerative colitis: a retrospective cohort study.  Inflammatory Bowel Diseases, 17(1),15-21
  9. Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagace C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panes J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux J(2011)Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.  Nature Genetics, 43(3),246-52
  10. Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde L(2011)Maximum-likelihood estimation of recent shared ancestry (ERSA).  Genome Research, 21(5),768-74
  11. Deneau M, Adler DG, Schwartz JJ, Hutson W, Sorensen J, Book L, Lowichik A, Guthery (2011)Cholangiocarcinoma in a 17-year-old boy with primary sclerosing cholangitis and inflammatory bowel disease.  Journal of Pediatric Gastroenterology and Nutrition, 52(5),617-20
  12. Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, Annese V, Dubinsky M, Rotter JI, Russell RK, Bradfield JP, Sleiman PM, Glessner JT, Walters T, Hou C, Kim C, Frackelton EC, Garris M, Doran J, Romano C, Catassi C, Van Limbergen J, Guthery SL, Denson L, Piccoli D, Silverberg MS, Stanley CA, Monos D, Wilson DC, Griffiths A, Grant SF, Satsangi J, Polychronakos C, Hakonarson (2010)Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.  Human Molecular Genetics, 19(10),2059-67
  13. Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panes J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes (2010)Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.  Nature Genetics, 42(12),1118-25
  14. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis G(2009)Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.  Nature Genetics, 41(2),199-204
  15. Pont-Kingdon G, Bohnsack J, Sumner K, Whiting A, Clifford B, Guthery SS, Jorde LB, Lyon E, Prahalad (2009)Lack of association between beta 2-adrenergic receptor polymorphisms and juvenile idiopathic arthritis.  Scandinavian Journal of Rheumatology, 38(2),91-5
  16. Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, Sleiman PM, Imielinski M, Glessner J, Hou C, Wilson DC, Walters T, Kim C, Frackelton EC, Lionetti P, Barabino A, Van Limbergen J, Guthery S, Denson L, Piccoli D, Li M, Dubinsky M, Silverberg M, Griffiths A, Grant SF, Satsangi J, Baldassano R, Hakonarson (2009)Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.  American Journal of Human Genetics, 84(3),399-405
  17. Xing J, Watkins WS, Witherspoon DJ, Zhang Y, Guthery SL, Thara R, Mowry BJ, Bulayeva K, Weiss RB, Jorde L(2009)Fine-scaled human genetic structure revealed by SNP microarrays.  Genome Research, 19(5),815-25
  18. Prahalad S, Hansen S, Whiting A, Guthery SL, Clifford B, McNally B, Zeft AS, Bohnsack JF, Jorde L(2009)Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis.  Arthritis & Rheumatism, 60(7),2124-30
  19. Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D, Silber G, Wrobel I, Quiros A, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Delukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson (2009)Common variants at five new loci associated with early-onset inflammatory bowel disease.  Nature Genetics, 41(12),1335-40
  20. Guthery SL, Dong L, Dean JM, Holubkov (2008)US estimates of hospitalized pediatric patients with ulcerative colitis: implications for multicenter clinical studies.  Inflammatory Bowel Diseases, 14(9),1253-8
  21. Prahalad S, Bohnsack JF, Whiting A, Clifford B, Jorde LB, Guthery SL, Thompson SD, Glass DN, Bamshad M(2008)Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis.  Arthritis & Rheumatism, 58(7),2147-52
  22. Kugathasan S, Baldassano RN, Bradfield JP, Sleiman PM, Imielinski M, Guthery SL, Cucchiara S, Kim CE, Frackelton EC, Annaiah K, Glessner JT, Santa E, Willson T, Eckert AW, Bonkowski E, Shaner JL, Smith RM, Otieno FG, Peterson N, Abrams DJ, Chiavacci RM, Grundmeier R, Mamula P, Tomer G, Piccoli DA, Monos DS, Annese V, Denson LA, Grant SF, Hakonarson (2008)Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.  Nature Genetics, 40(10),1211-5
  23. Guthery SL, Salisbury BA, Pungliya MS, Stephens JC, Bamshad (2007)The structure of common genetic variation in United States populations.  American Journal of Human Genetics, 81(6),1221-31
  24. Bamshad M, Guthery S(2007)Race, genetics and medicine: does the color of a leopard's spots matter?  Current Opinion in Pediatrics, 19(6),613-8
  25. Bucuvalas JC, Campbell KM, Cole CR, Guthery S(2006)Outcomes after liver transplantation: keep the end in mind.  Journal of Pediatric Gastroenterology and Nutrition, 43 Suppl 1S41-8
  26. Guthery SL, Heubi JE, Filipovich (2004)Enteral metronidazole for the prevention of graft versus host disease in pediatric marrow transplant recipients: results of a pilot study.  Bone Marrow Transplantation, 33(12),1235-9
  27. Guthery SL, Hutchings C, Dean JM, Hoff (2004)National estimates of hospital utilization by children with gastrointestinal disorders: analysis of the 1997 kids' inpatient database.  Journal of Pediatrics, The, 144(5),589-94
  28. Guthery SL, Pohl JF, Bucuvalas JC, Alonso MH, Ryckman FC, Balistreri WF, Heubi J(2003)Bone mineral density in long-term survivors following pediatric liver transplantation.  Liver Transplantation, 9(4),365-70
  29. Guthery SL, Heubi JE, Bucuvalas JC, Gross TG, Ryckman FC, Alonso MH, Balistreri WF, Hornung R(2003)Determination of risk factors for Epstein-Barr virus-associated posttransplant lymphoproliferative disorder in pediatric liver transplant recipients using objective case ascertainment.  Transplantation, 75(7),987-93
  30. Guthery SL, Heubi J(2001)Liver involvement in childhood histiocytic syndromes.  Current Opinion in Gastroenterology, 17(5),474-8

Letter

  1. Guthery SL, Gross T(2008)Assessing the risk of epstein-barr virus-related lymphoproliferative disorders before administration of visilizumab.  Gastroenterology, 134(3),895-6
  2. Peterson N, Guthery S, Denson L, Lee J, Saeed S, Prahalad S, Biank V, Ehlert R, Tomer G, Grand R, Rudolph C, Kugathasan (2008)Genetic variants in the autophagy pathway contribute to paediatric Crohn's disease.  Gut (electronic), 57(9),1336-7; author reply 1337

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