Archana M. Agarwal
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Archana M. Agarwal, MBBS, MD

Languages spoken: English, Hindi

  • My clinical service responsibilities are in hematopathology, where I sign out molecular hematopathology, lymph node/bone marrow cases and flow cytometric evaluation for blood related disorders. My other clinical service responsibilities are in the Red Blood Cell Laboratory/Special Genetics Laboratory at ARUP, where I am the Co Medical Director. In this capacity, I am involved in review of patient test results, case sign out, review of quality control and quality assurance data, proficiency testing, and other clinical and administrative laboratory-related activities. I also provide consultation with clinical colleagues both locally and nationally in the area of hemoglobinopathies. My goal is to provide physicians with high quality test results and to give them my consultative expertise. In the area of teaching, I act as the director for the hemoglobinopathy/ thalassemia and benign red blood cell disorders rotation for hematopathology fellows.

    Specialties

    Board Certification

    American Board of Pathology (Clinical Path)
    American Board of Pathology (Sub: Anatomic Path)
    American Board of Pathology (Sub: Hematology)
    American Board of Pathology (Sub: Molecular Genetic Pathology)
    National Board of Medical Examiners

  • My clinical service responsibilities are in hematopathology, where I sign out molecular hematopathology, lymph node/bone marrow cases and flow cytometric evaluation for blood related disorders. My other clinical service responsibilities are in the Red Blood Cell Laboratory/Special Genetics Laboratory at ARUP, where I am the Co Medical Director. In this capacity, I am involved in review of patient test results, case sign out, review of quality control and quality assurance data, proficiency testing, and other clinical and administrative laboratory-related activities. I also provide consultation with clinical colleagues both locally and nationally in the area of hemoglobinopathies. My goal is to provide physicians with high quality test results and to give them my consultative expertise. In the area of teaching, I act as the director for the hemoglobinopathy/ thalassemia and benign red blood cell disorders rotation for hematopathology fellows.

    Board Certification and Academic Information

    Academic Departments Pathology -Primary
    Board Certification
    American Board of Pathology (Clinical Path)
    American Board of Pathology (Sub: Anatomic Path)
    American Board of Pathology (Sub: Hematology)
    American Board of Pathology (Sub: Molecular Genetic Pathology)
    National Board of Medical Examiners

    Education history

    Fellowship Molecular Genetic Pathology - University of Utah School of Medicine, Department of Pathology Fellow
    Anatomic and Clinical - University of Utah School of Medicine, Department of Pathology Resident
    Fellowship Hematopathology - University of Utah School of Medicine Fellow
    Anatomic and Clinical - University of Utah School of Medicine, Department of Pathology Resident
    Postdoctoral Fellowship Research Scholar - University of Iowa Postdoctoral Fellow
    Pathology - Delhi University M.D.
    Professional Medical Medicine - Assam Medical College M.B.B.S.

    Selected Publications

    Journal Article

    1. Verma A, Chi YY, Malvar J, Lamble A, Chaudhury S, Agarwal A, Li HT, Liang G, Leong R, Brown PA, Kaplan J, Schafer ES, Slone T, Pauly M, Chang BH, Stieglitz E, Wayne AS, Hijiya N, Bhojwani D (2024). Nivolumab Plus 5-Azacitidine in Pediatric Relapsed/Refractory Acute Myeloid Leukemia (AML): Phase I/II Trial Results from the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium. Cancers (Basel), 16(3). (Read full article)
    2. Agarwal AM, McMurty V, Clayton AL, Bolia A, Reading NS, Mani C, Patel JL, Rets A (2023). Clinical utility of targeted next-generation sequencing panel in routine diagnosis of hereditary hemolytic anemia: A national reference laboratory experience. Eur J Haematol, 110(6), 688-695. (Read full article)
    3. Lin Y, Agarwal AM, Anderson LC, Marshall AG (2023). Discovery of a biomarker for β-Thalassemia by HPLC-MS and improvement from Proton Transfer Reaction - Parallel Ion Parking. J Mass Spectrom Adv Clin Lab, 28, 20-26. (Read full article)
    4. Gorfinkel L, Wachter F, Luo HY, Hansbury E, Williams DA, Agarwal A, Chui DHK, Cantor AB (2022). Transient neonatal hemolytic anemia due to the novel gamma globin gene mutation HBG2:C.290T>C, p.Leu97Pro (hemoglobin Wareham). Pediatr Blood Cancer, 70(1), e30067. (Read full article)
    5. Montgomery HD, Agarwal AM, Lim MY (2022). A case of azathioprine-induced aplastic anemia. Int J Lab Hematol, 44(6), 1015-1016. (Read full article)
    6. Lin Y, Agarwal AM, Marshall AG, Anderson LC (2021). Characterization of Structural Hemoglobin Variants by Top-Down Mass Spectrometry and R Programming Tools for Rapid Identification. J Am Soc Mass Spectrom, 33(1), 123-130. (Read full article)
    7. Meznarich JA, Rets A, Agarwal AM, Christensen RD, Reading NS, Kuypers FA, Prchal JT (2021). Novel, de novo, beta-globin variant with decreased oxygen affinity (HBB:c.317T>A, "Hemoglobin St. George") in a healthy child with low oxygen saturations and anemia. Am J Hematol, 96(12), E448-E450. (Read full article)
    8. Bahr TM, Agarwal AM, Meznarich JA, Prince WL, Wait TWP, Prchal JT, Christensen RD (2021). Thirty-five males with severe (Class 1) G6PD deficiency (c.637G>T) in a North American family of European ancestry. Blood Cells Mol Dis, 92, 102625. (Read full article)
    9. Agarwal AM, Rets A (2021). Laboratory approach to investigation of anemia in pregnancy. Int J Lab Hematol, 43 Suppl 1, 65-70. (Read full article)
    10. Bahr TM, Agarwal AM, Christensen RD (2020). Does heterozygosity for UGT1A1 *28 convey increased risk for severe neonatal jaundice? J Perinatol, 41(4), 658-660. (Read full article)
    11. Lozano-Chinga M, Draper L, George TI, Agarwal AM, Dansie DM, Maese L (2020). Bone marrow necrosis in pediatric malignancies: 10-Year retrospective review and review of literature. Pediatr Blood Cancer, 68(3), e28806. (Read full article)
    12. Kim SJ, Song J, Reading NS, Lautersztain J, Kutlar A, Agarwal AM, Coetzer TL, Prchal JT (2021). Novel Mechanism of Hereditary Pyropoikilocytosis Phenotype due to Co-inheritance of β Globin and α Spectrin Mutations. Am J Hematol, 96(5), Epub 2021 Feb 25.
    13. Iglesias Cardenas F, Agarwal AM, Vagher J, Maese L, Fluchel M, Afify Z (2021). Two Clonally Distinct B-Cell Lymphomas Reveal the Diagnosis of XLP1 in a Male Child and His Asymptomatic Male Relatives: Case Report and Review of the Literature. J Pediatr Hematol Oncol, 43(8), e1210-e1213. (Read full article)
    14. Bahr TM, Knudsen MC, Lozano-Chinga M, Agarwal AM, Meznarich JA, Ohls RK, Christensen RD (2020). Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin. Biomed Hub, 5(3), 227-234. (Read full article)
    15. Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Gerday E, Smoot JL, Taylor A, Christensen RD (2020). Dizygotic twins with prolonged jaundice and microcytic, hypochromic, hemolytic anemia with pyropoikilocytosis. Blood Cells Mol Dis, 85, 102462. (Read full article)
    16. Rets AV, Reading NS, Agarwal AM (2020). δ-Globin Chain Variants Associated with Decreased Hb A2 Levels: A National Reference Laboratory Experience. Hemoglobin, 44(6), 438-441. (Read full article)
    17. Cowman SJ, Fuja DG, Liu XD, Tidwell RSS, Kandula N, Sirohi D, Agarwal AM, Emerson LL, Tripp SR, Mohlman JS, Stonhill M, Garcia G, Conley CJ, Olalde AA, Sargis T, Ramirez-Torres A, Karam JA, Wood CG, Sircar K, Tamboli P, Boucher K, Maughan B, Spike BT, Ho TH, Agarwal N, Jonasch E, Koh MY (2020). Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer. Clin Cancer Res, 26(18), 4970-4982. (Read full article)
    18. Agarwal AM, Hanley TM (2020). Osteopetrosis in a six-month-old infant. J Hematop, 13(3), 193-196. (Read full article)
    19. Agarwal AM, Rets A (2020). Laboratory approach to investigation of anemia with a focus on pyruvate kinase deficiency. Int J Lab Hematol, 42 Suppl 1, 107-112. (Read full article)
    20. Samha L, Sirdah MM, Reading NS, Karmi B, Agarwal AM (2020). Molecular Understanding of Severe Cases of β-Thalassemia in the Nablus Region, West Bank, Palestine. Hemoglobin, 44(2), 128-130. (Read full article)
    21. He L, Rockwood AL, Agarwal AM, Anderson LC, Weisbrod CR, Hendrickson CL, Marshall AG (2020). Top-down proteomics-a near-future technique for clinical diagnosis? Ann Transl Med, 8(4), 136. (Read full article)
    22. Patel AB, Franzini A, Leroy E, Kim SJ, Pomicter AD, Genet L, Xiao M, Yan D, Ahmann JM, Agarwal AM, Clair P, Addada J, Lambert J, Salmon M, Gleich GJ, Cross NCP, Constantinescu SN, OHare T, Prchal JT, Deininger MW (2019). JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera. Blood, 134(26), 2388-2398. (Read full article)
    23. Bianchi P, Fermo E, Glader B, Kanno H, Agarwal A, Barcellini W, Eber S, Hoyer JD, Kuter DJ, Maia TM, Mau-Pereira MDM, Kalfa TA, Pissard S, Segovia JC, van Beers E, Gallagher PG, Rees DC, van Wijk R, with the endorsement of EuroBloodNet, the European Reference Network in Rare Hematological, Diseases (2019). Addressing the diagnostic gaps in pyruvate kinase deficiency: Consensus recommendations on the diagnosis of pyruvate kinase deficiency. Am J Hematol, 94(1), 149-161.
    24. He L, Rockwood AL, Agarwal AM, Anderson LC, Weisbrod CR, Hendrickson CL, Marshall AG (2019). Diagnosis of Hemoglobinopathy and β-Thalassemia by 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry of Hemoglobin from Blood. Clin Chem, 65(8), 986-994. (Read full article)
    25. Rets A, Clayton AL, Christensen RD, Agarwal AM (2019). Molecular diagnostic update in hereditary hemolytic anemia and neonatal hyperbilirubinemia. Int J Lab Hematol, 41 Suppl 1, 95-101. (Read full article)
    26. Stenehjem DD, Hahn AW, Gill DM, Albertson D, Gowrishankar B, Merriman J, Agarwal AM, Thodima V, Harrington EB, Au TH, Maughan BL, Houldsworth J, Pal SK, Agarwal N (2019). Predictive genomic markers of response to VEGF targeted therapy in metastatic renal cell carcinoma. PLoS One, 14(1), e0210415. (Read full article)
    27. Bahr TM, Christensen RD, Agarwal AM, George TI, Bhutani VK (2019). The Neonatal Acute Bilirubin Encephalopathy Registry (NABER): Background, Aims, and Protocol. Neonatology, 115(3), 242-246. (Read full article)
    28. Christensen RD, Agarwal AM, George TI, Bhutani VK, Yaish HM (2018). Acute neonatal bilirubin encephalopathy in the State of Utah 2009-2018. Blood Cells Mol Dis, 72, 10-13. (Read full article)
    29. Hahn AW, Gill DM, Maughan B, Agarwal A, Arjyal L, Gupta S, Streeter J, Bailey E, Pal SK, Agarwal N (2017). Correlation of genomic alterations assessed by next-generation sequencing (NGS) of tumor tissue DNA and circulating tumor DNA (ctDNA) in metastatic renal cell carcinoma (mRCC): potential clinical implications. Oncotarget, 8(20), 33614-33620. (Read full article)
    30. Kuzman JA, Stenehjem DD, Merriman J, Agarwal AM, Patel SB, Hahn AW, Alex A, Albertson D, Gill DM, Agarwal N (2017). Neutrophil-lymphocyte ratio as a predictive biomarker for response to high dose interleukin-2 in patients with renal cell carcinoma. BMC Urol, 17(1), 1. (Read full article)
    31. Davis KL, Agarwal AM, Verma AR (2017). Checkpoint inhibition in pediatric hematologic malignancies. Pediatr Hematol Oncol, 34(6-7), 379-394. (Read full article)
    32. Luedeke M, Rinckleb AE, FitzGerald LM, Geybels MS, Schleutker J, Eeles RA, Teixeira MR, Cannon-Albright L, Ostrander EA, Weikert S, Herkommer K, Wahlfors T, Visakorpi T, Leinonen KA, Tammela TLJ, Cooper CS, Kote-Jarai Z, Edwards S, Goh CL, McCarthy F, Parker C, Flohr P, Paulo P, Jernimo C, Henrique R, Krause H, Wach S, Lieb V, Rau TT, Vogel W, Kuefer R, Hofer MD, Perner S, Rubin MA, Agarwal AM, Easton DF, Al Olama AA, Benlloch S, PRACTICAL consortium, Hoegel J, Stanford JL, Maier C (2016). Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status. Hum Mol Genet, 25(24), 5490-5499. (Read full article)
    33. Agarwal AM, Liew MA, Nussenzveig RH, Sangle N, Heikal N, Yaish H, Christensen R (2015). Improved harmonization of eosin-5-maleimide binding test across different instruments and age groups. Cytometry B Clin Cytom, 90(6), 512-516. (Read full article)
    34. Reading NS, Shooter C, Song J, Miller R, Agarwal A, Lanikova L, Clark B, Thein SL, Divoky V, Prchal JT (2016). Loss of Major DNase I Hypersensitive Sites in Duplicated β-globin Gene Cluster Incompletely Silences HBB Gene Expression. Hum Mutat, 37(11), 1153-1156. (Read full article)
    35. Gill DM, Stenehjem DD, Parikh K, Merriman J, Sendilnathan A, Agarwal AM, Hahn AW, Gupta S, Tantravahi SK, Samlowski WE, Agarwal N (2016). Conditional survival of metastatic renal cell carcinoma patients treated with high-dose interleukin-2. Ecancermedicalscience, 10. (Read full article)
    36. Tantravahi SK, Albertson D, Agarwal AM, Ravulapati S, Poole A, Patel SB, Hawatmeh JS, Straubhar AM, Liu T, Stenehjem DD, Agarwal N (2015). Survival outcomes and tumor IMP3 expression in patients with sarcomatoid metastatic renal cell carcinoma. J Oncol, 2015. (Read full article)
    37. Smock KJ, Agarwal AM, Lim MS, Tripp SR, Miles RR, Patel JL, Abromowitch M, Lones MA, Cairo MS, Perkins SL (2014). Expression of Notch1 and mTOR pathway proteins in pediatric lymphoblastic lymphoma; a Children's Oncology Group report. J Hematop, 7(1), 9-14. (Read full article)
    38. Swierczek S, Agarwal AM, Naidoo K, Lorenzo FR, Whisenant J, Nussenzveig RH, Agarwal N, Coetzer TL, Prchal JT (2013). Novel exon 2 α spectrin mutation and intragenic crossover: three morphological phenotypes associated with four distinct α spectrin defects. Haematologica, 98(12), 1972-9. (Read full article)
    39. Nussenzveig RH, Vanhille DL, Hussey D, Agarwal AM (2013). Changes in the high-performance liquid chromatography pattern of hemoglobin lepore after treatment with hydroxyurea. Lab Med, 44(3), 245-247. (Read full article)
    40. Yaish HM, Christensen RD, Agarwal A (2013). A neonate with Coombs-negative hemolytic jaundice with spherocytes but normal erythrocyte indices: a rare case of autosomal-recessive hereditary spherocytosis due to alpha-spectrin deficiency. J Perinatol, 33(5), 404-6. (Read full article)
    41. Patel JC, Maughan BL, Agarwal AM, Batten JA, Zhang TY, Agarwal N (2013). Emerging molecularly targeted therapies in castration refractory prostate cancer. Prostate Cancer, 2013, 981684. (Read full article)
    42. Nussenzveig RH, Burjanivova T, Salama ME, Ogilvie NW, Marcinek J, Plank L, Agarwal AM, Perkins SL, Prchal JT (2012). Detection of JAK2 mutations in paraffin marrow biopsies by high resolution melting analysis: identification of L611S alone and in cis with V617F in polycythemia vera. Leuk Lymphoma, 53(12), 2479-86. (Read full article)
    43. Vanhille DL, Nussenzveig RH, Glezos C, Perkins S, Agarwal AM (2012). Best practices for use of the HEMOX analyzer in the clinical laboratory: quality control determination and choice of anticoagulant. Lab Hematol, 18(3), 17-9. (Read full article)
    44. Sangle NA, Agarwal AM, Smock KJ, Leavitt MO, Warnke R, Bahler D, Perkins SL (2011). Diffuse large B-cell lymphoma with aberrant expression of the T-cell antigens CD2 and CD7. Appl Immunohistochem Mol Morphol, 19(6), 579-83. (Read full article)
    45. Bruchova H, Yoon D, Agarwal AM, Swierczek S, Prchal JT (2009). Erythropoiesis in polycythemia vera is hyper-proliferative and has accelerated maturation. Blood Cells Mol Dis, 43(1), 81-7. (Read full article)
    46. Agarwal AM, Bentz JS, Hungerford R, Abraham D (2009). Parathyroid fine-needle aspiration cytology in the evaluation of parathyroid adenoma: cytologic findings from 53 patients. Diagn Cytopathol, 37(6), 407-10. (Read full article)
    47. Lim HY, Agarwal AM, Agarwal N, Ward JH (2009). Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore Med J, 50(5), e178-80. (Read full article)
    48. Bruchova H, Yoon D, Agarwal AM, Mendell J, Prchal JT (2007). Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis. Exp Hematol, 35(11), 1657-67. (Read full article)
    49. Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Ziga-Pflcker JC, Dominguez M, Ferrando AA (2007). Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med, 13(10), 1203-10. (Read full article)
    50. Agarwal AM, Agarwal N, Glenn MJ, Lim MS (2007). Blastic transformation of low-grade follicular lymphoma. J Clin Oncol, 25(16), 2326-8. (Read full article)

    Review

    1. Dadelahi A, Jackson T, Agarwal A, Lin L, Rets A, Ng DP (2024). Applications of Flow Cytometry in Diagnosis and Evaluation of Red Blood Cell Disorders. [Review]. Clin Lab Med. (Read full article)
    2. Agarwal AM, Rets A (2024). Advances in Hemoglobinopathies and Thalassemia Evaluation. [Review]. Clin Lab Med. (Read full article)
    3. Agarwal AM, Rets AV (2023). Molecular diagnosis of hereditary hemolytic anemias: Recent updates. [Review]. Int J Lab Hematol, 45 Suppl 2, 79-86. (Read full article)

    Book Chapter

    1. Sherrie L Perkins, Mohamed E Salama, Archana M Agarwal (In Press). Contributor: Case Studies in Hematology and Coagulation. In Gene L Gulati; Joanne Filicko-O'Hara; John R Krause (Ed.) (2nd). ASCP caseset.
    2. Agarwal AM, Rodgers GM (2018). Miscellaneous causes of thrombocytopenia. In Agarwal AM|Rodgers GM (Ed.), Wintrobe's Clinical Hematology: Fourteenth Edition (pp. 3391-3420). (Read full article)
    3. Bellissimo DB, Agarwal A (2016). Hematologic disorders: Hemochromatosis, hemoglobinopathies, and rh incompatibility. In Bellissimo DB|Agarwal A (Ed.), Molecular Pathology in Clinical Practice:Second Edition (pp. 225-238). (Read full article)
    4. Agarwal AM, Rodgers GM (2013). Miscellaneous causes of thrombocytopenia. In Agarwal AM|Rodgers GM (Ed.), Wintrobe's Clinical Hematology: Thirteenth Edition (pp. 1097-1105). (Read full article)
    5. Agarwal AM, Prchal JT (2011). Congenital Hemolytic Anemias. In Agarwal AM|Prchal JT (Ed.), Concise Guide to Hematology (pp. 62-74). (Read full article)

    Case Report

    1. Maglic D, Moss W, Pires G, Agarwal A, Matsen C, Kwok A (2021). A Case Report of Misdiagnosed Breast Implant-associated Anaplastic Large Cell Lymphoma with Lymphatic Extension. Plast Reconstr Surg Glob Open, 9(11), e3916. (Read full article)
    2. Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Yost CC, Li P, Reading NS, Prchal JT, Christensen RD (2020). A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity. Neonatology, 117(4), 532-535. (Read full article)

    Editorial

    1. Agarwal AM (2019). Ankyrin Mutations in Hereditary Spherocytosis. Acta Haematol, 141(2), 63-64. (Read full article)

    Abstract

    1. Yoon D, Bruchova H, Agarwal AM, Prchal JT, Prchal JF (2006). In Vitro Erythroid Cell Expansion Analysis in Polycythemia Vera. Publication only. American Society of Hematology, Annual Meeting. [Abstract]. [Abstract]. 108, 4916.