Kevin B. Jones,
MD
Languages Spoken: English, Spanish
Labs: Website
Kevin B. Jones, MD
Leader, Huntsman Cancer Institute Sarcoma Disease Center
Division Chief, Sarcoma, Department of Orthopaedics
Professor, Department of Orthopaedics and
Adjunct Professor of Oncological Sciences
As an orthopaedic surgeon specialized in the care of pediatric and adult patients with sarcoma, I see first-hand the limitations and frank failures of the currently available treatment options. Not only do we fail to cure far too many young patients with sarcomas, but the long-term effects of our treatments create other major challenges to the health of the survivors in the long term.
With protected time for basic investigation, I dedicate my entire laboratory to the study of pediatric and young adult fusion oncogene-associated sarcomas. In efforts always angling toward improved targeted therapies, we use mouse genetic models of sarcomagenesis to dissect pathways of importance to initiation and progression of tumors. This work utilizes conditional activation of translocation-associated fusion oncogenes as well as manipulation of additional modifying genes directed toward improved understanding of the conditions that promote or inhibit sarcomagenesis. This work has led to generous experience with comparative genomics and epigenomics.
The simple genetic changes that drive translocation-associated sarcomas make a strong argument for cancer being defined as a transcriptional state for cells, rather than a state of accumulated mutations or genetic losses and gains. The study of the epigenetic determinants of this transcriptional state in cells that harbor very few genetic code alterations has already revealed important knowledge that pertains to more complex genome cancer types as well as to transcriptional biology more generally.
I also believe firmly in the synergy possible in collaborative team science. Such efforts are required for progress toward improved treatments for rare malignancies that can never be studied with optimal efficacy in a silo. With such collaborative work as direct goal, I have participated in and assembled teams to work on pediatric sarcomas both within my institution and internationally.
Clinical Locations
Clinic 3A, Sarcoma
801-585-7180
Primary Children's Hospital
Pediatric Orthopaedics801-662-5600
Board Certification and Academic Information
| Academic Departments | Orthopaedics
-
Professor Oncological Sciences - Adjunct Associate Professor |
| Board Certification | American Board of Orthopaedic Surgery |
| Cancer Center Programs | Nuclear Control of Cell Growth & Differentiation |
Patient Rating
The Patient Rating score is an average of all responses to care provider related questions on our nationally-recognized Press Ganey Patient Satisfaction Survey.
Responses are measured on a scale of 1 to 5 with 5 being the best score.
Likelihood of recommending care provider
4.8/ 5
Care provider's explanation of condition/problem
4.7/ 5
Care provider's effort to include me in decisions
4.8/ 5
Wait time at clinic
4.1/ 5
Care provider's concern for questions & worries
4.8/ 5
Patient Comments
Patient comments are gathered from our Press Ganey Patient Satisfaction Survery and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
UofU Patient
January 14, 2021
HUNTSMAN CANCER CENTER
I felt all questions were answered and next steps provided in an atmosphere of true caring and competency
UofU Patient
January 14, 2021
HUNTSMAN CANCER CENTER
Dr Jones was thorough, he showed us the xrays where [NAME REMOVED]'s hip was shattered and explained it so we knew what he was up against. he did not push [NAME REMOVED] to have surgery. the risk is too great.
UofU Patient
January 06, 2021
PRIMARY CHILDREN'S MEDICAL CENTER
Dr Jones listened to my son when my son said the cast that was just placed wasn't fitting correctly. He knows my son and involves my son in the medical plan.
UofU Patient
December 10, 2020
PRIMARY CHILDREN'S MEDICAL CENTER
Dr Jones is incredible! He has a great relationship with my son and our family. My son has had some challenging orthopedic issues and my son knows Dr Jones has his (my son's) best outcome in mind.
UofU Patient
December 04, 2020
HUNTSMAN CANCER CENTER
Excellent doctor! Professional and compassionate.
UofU Patient
December 02, 2020
PRIMARY CHILDREN'S MEDICAL CENTER
Very caring and thorough.
UofU Patient
October 25, 2020
HUNTSMAN CANCER CENTER
Great people
UofU Patient
October 24, 2020
HUNTSMAN CANCER CENTER
the doctors and nurse were very good we just have to wait for more tests to decided on treatment
UofU Patient
October 09, 2020
HUNTSMAN CANCER CENTER
Dr. Jones has been phenomenal during my medical situation. He is very thorough & takes whatever time is needed to answer all questions & concerns.
UofU Patient
September 28, 2020
PRIMARY CHILDREN'S MEDICAL CENTER
Seemed a little bit rushed; would have liked more details on professional assessment of x-rays
UofU Patient
September 19, 2020
HUNTSMAN CANCER CENTER
all the doctors I have worked with there are great at explaining everything and helping you.
UofU Patient
August 31, 2020
PRIMARY CHILDREN'S MEDICAL CENTER
dr Jones was very helpful and if we ever need to return, we will call his office first.
UofU Patient
August 23, 2020
HUNTSMAN CANCER CENTER
Dr. Jones was very pleasant and informative. He didn't seem rushed and took the time to reassure me and answer all of my questions.
UofU Patient
August 14, 2020
HUNTSMAN CANCER CENTER
I have recommended others and I have a lot of confidence in all those who have taken care of me.
UofU Patient
August 14, 2020
HUNTSMAN CANCER CENTER
Very good !
UofU Patient
August 14, 2020
HUNTSMAN CANCER CENTER
All good
UofU Patient
August 01, 2020
HUNTSMAN CANCER CENTER
I have been under Dr Kevin B. Jones care since 2015. always professional. caring clearly explains results and in a manner of communication that is understandable the actions associated with questions have always been exceptional.
UofU Patient
July 27, 2020
HUNTSMAN CANCER CENTER
well pleased with the care and how well you listened to me
UofU Patient
July 24, 2020
HUNTSMAN CANCER CENTER
Dr Jones said take medication and then we'll see how u feel, but then someone called me later to schedule an MRI that I didn't think we were doing unless the medicine didn't work. tried to tell them that, but they didn't bother to figure out what the Dr really wanted.
UofU Patient
July 16, 2020
HUNTSMAN CANCER CENTER
The doctor is great; he listens to me. There is just not enough information from testing yet.
UofU Patient
June 29, 2020
HUNTSMAN CANCER CENTER
He was very thoughtful and insightful. He was concerned about my wellbeing and wanted to give me the best advice he could give.
UofU Patient
June 19, 2020
HUNTSMAN CANCER CENTER
I had a very thorough visit with the fellow who explained everything I detail. I was satisfied and then had to wait again for the doctor. as my visit was just a follow up with no concerns or findings, I think I could have just concluded my visit with the fellow and not waited for the doc.
UofU Patient
May 10, 2020
HUNTSMAN CANCER CENTER
Very careing
UofU Patient
March 06, 2020
HUNTSMAN CANCER CENTER
everyone has been so amazing during a very stressful time!
UofU Patient
February 07, 2020
HUNTSMAN CANCER CENTER
I want informed that they were going to increase the area that is currently being treated with radiation. it was only afterwards that I had to ask why. The explanation was very complete and made sense.
UofU Patient
February 06, 2020
PRIMARY CHILDREN'S MEDICAL CENTER
I wish he would have taken more time to address lower back pain cause. showed us xrays or recommended help for back spasms and how it could relate to his past surgery on his hips.
UofU Patient
January 31, 2020
HUNTSMAN CANCER CENTER
Huntsman is most professional health care organization I have ever dealt with
UofU Patient
January 10, 2020
HUNTSMAN CANCER CENTER
Love Dr Jones!
UofU Patient
December 27, 2019
HUNTSMAN CANCER CENTER
doctor Kevin Jones not only is he a great doctor, but goes out of his way to become your friend. as I was going thru my cancer treatments knowing my doctor was my friend showed me he was willing to do anything he could to heal me and to listen to me when there was a problem and find a solution. Thank you Dr Kevin Jones
UofU Patient
December 14, 2019
PRIMARY CHILDREN'S MEDICAL CENTER
Dr Jones is our favorite. He shows so much care and concern for our son and explains things very well. He takes time to listen and answer question and goes the extra mile. Sometimes we have to wait a little longer but it is worth it to see him. I think it's because he takes time and doesn't seem rushed when he visits with us.
UofU Patient
November 22, 2019
HUNTSMAN CANCER CENTER
Dr. Jones and his staff have always had my back at every appointment I've had at Huntsman. Caring, informative, genuine people that I've been lucky to have on "my team".
UofU Patient
November 05, 2019
PRIMARY CHILDREN'S MEDICAL CENTER
We felt very confident with the information discussed and the plan of action. The doctor was very patient and answered every single question we had with patience.
UofU Patient
September 13, 2019
HUNTSMAN CANCER CENTER
I felt my problems were dismissed, however the dr explained it well, I was just optimistic there was something he could do to help but didn't.
UofU Patient
September 13, 2019
HUNTSMAN CANCER CENTER
As I said, dr Jones is the best doctor I have ever dealt with.
UofU Patient
September 10, 2019
HUNTSMAN CANCER CENTER
Doctor was good to explain to patient and wife so she understood what needed to be done at home
UofU Patient
August 16, 2019
HUNTSMAN CANCER CENTER
very impressed
UofU Patient
July 25, 2019
HUNTSMAN CANCER CENTER
Great experience with Dr Jones because he likes to cover things and talk about my condition and treatments.
UofU Patient
June 25, 2019
HUNTSMAN CANCER CENTER
Both Dr. Jones and his PA (Robert) were both pleasant to be cared for by.
UofU Patient
June 14, 2019
HUNTSMAN CANCER CENTER
I was very impressed with all the workers & Dr. Kevin Jones. The social worker Jamie Schipaanbocrd was very good!
UofU Patient
May 26, 2019
HUNTSMAN CANCER CENTER
dr Kevin Jones is very thorough and understanding of my situation and listened to my concerns
UofU Patient
May 10, 2019
HUNTSMAN CANCER CENTER
Dr Jones was amazing, I couldn't ask for a better doctor.
UofU Patient
April 26, 2019
HUNTSMAN CANCER CENTER
I feel so fortunate that I am under the care of Dr. Kevin B. Jones. I have never doubted or questioned ANYTHING he has told me. I remain so grateful that his team (Dr. Groundland, Nurse Nancy Boyd, PA Robert Serpico, and of course Shannon Lorimer) have been part of my care over the past 9 months.
UofU Patient
March 01, 2019
PRIMARY CHILDREN'S MEDICAL CENTER
worst dr ever. honestly he should not be dealing with children his bedside manners were awful. the way he treated and talked to my daughter was just not right. he had my daughter crying to the point she shut down and quit talking to everyone in the room. I do not feel we got the care we needed by this dr.
UofU Patient
February 16, 2019
PRIMARY CHILDREN'S MEDICAL CENTER
Our doctor was absolutely amazing. Answered every question we had with words we could understand. We never felt rushed. And he was very kind.
UofU Patient
February 03, 2019
HUNTSMAN CANCER CENTER
Dr Jones was very kind and professional
UofU Patient
January 25, 2019
PRIMARY CHILDREN'S MEDICAL CENTER
Although we had to wait awhile for our appointment, Dr. Jones ALWAYS spends time with every patient and answers all our questions and concerns. We are happy to wait for his expertise and knowledge as we know he will give us the same attention he has given his previous patients.
UofU Patient
January 21, 2019
HUNTSMAN CANCER CENTER
I have the best; Dr. Jones
UofU Patient
January 07, 2019
PRIMARY CHILDREN'S MEDICAL CENTER
Although Dr Jones was fitting us in at the last minute he didn't make us feel rushed.
UofU Patient
January 05, 2019
HUNTSMAN CANCER CENTER
DR. Jones is very thorough, knowledgeable, and compassionate. He took the time necessary to explain my situation and options in a way I could understand. He answered all of my questions.
UofU Patient
January 03, 2019
HUNTSMAN CANCER CENTER
Very professional and personable. Very good.
UofU Patient
December 19, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
Dr. Jones gave me my life back. I am forever grateful for him.
UofU Patient
December 14, 2018
HUNTSMAN CANCER CENTER
we were so impressed with the level of concern and thoroughness of the provider and his assistant
UofU Patient
December 11, 2018
HUNTSMAN CANCER CENTER
This was a very positive and helpful visit. The doctor was well-informed regarding my situation (had studied the MRI) and provided clear, understandable information.
UofU Patient
November 12, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
Dr. Jones is knowledgeable, helpful, and concise.
UofU Patient
November 11, 2018
HUNTSMAN CANCER CENTER
very good
UofU Patient
November 03, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
the Dr was quick and thorough. frustrated with how long we waited with how long the dr took
UofU Patient
November 02, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
we came in for 2 "problems " and everything was explained very clearly. all the doctors made Kenna feel very involved and didn't leave her out of the conversation. they ALL were very kind and understanding. We weren't sure what we would be dealing with and they reassured us during the entire visit and we were lucky that it was nothing serious. But if it was, I would not hesitate for a second in returning here. wonderful care.
UofU Patient
October 30, 2018
HUNTSMAN CANCER CENTER
Both Robert and Dr. Jones were so helpful in explaining my condition and answering our questions. Their care and professionalism is excellent and we felt total confidence in our care from them. Nancy was also most helpful and efficient.
UofU Patient
September 22, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
Like I said, we love Dr. Jones.
UofU Patient
September 19, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
Dr Jones was amazing. I was nervous to start seeing a new provider after Dr Randall left, but Dr Jones was just as caring and patient with my son.
UofU Patient
September 10, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
We had a great experience with Dr. Jones. He had to talk with us about sensitive matters, and showed concern for us.
UofU Patient
September 09, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
We were very impressed by the doctor's knowledge, his ability to share it with us in a way we understood, and the amount of time he spent with us. He was the 6th doctor we took our daughter to, and the first one who gave us solid answers.
UofU Patient
August 25, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
received no follow up as promised
UofU Patient
August 25, 2018
HUNTSMAN CANCER CENTER
Although Dr. Jones explained and told me things I may have not been prepared to hear, he was very honest and thorough and considerate of my getting emotional!!
UofU Patient
August 17, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
excellent bedside manner!
UofU Patient
August 11, 2018
PRIMARY CHILDREN'S MEDICAL CENTER
all good
UofU Patient
July 13, 2018
HUNTSMAN CANCER CENTER
dr. Jones was upfront and honest
UofU Patient
June 26, 2018
Dr. Jones is outstanding.
UofU Patient
June 26, 2018
Dr. Jones was amazing as usual! We love him and the clinic
UofU Patient
May 23, 2018
This was a brief, yet informative meeting just to start me off, with another one planned soon after for more details on the plan of action. This just set up the beginning labs/tests/etc/
UofU Patient
May 21, 2018
Dr. Jones is a very kind person and truly cares about his patients.
UofU Patient
May 19, 2018
Dr Jones was excellent
UofU Patient
May 01, 2018
Much gratitude to Dr. Jones for diagnosing the problem and taking care of it after so many months of pain, seeing other specialists, taking various tests, and several months of physical therapy!
UofU Patient
April 13, 2018
He did a good job with the surgery, but he always seems rushed.
UofU Patient
March 20, 2018
we love Dr Jones! he's amazing!
UofU Patient
March 12, 2018
dr Jones is flipping awesome! (_____ comment)
UofU Patient
March 05, 2018
dr Jones was awesome
UofU Patient
February 05, 2018
I am very happy with Dr. Jones and his staff. He never rushes me and patiently answers all my questions. His bedside manner is an A++!
UofU Patient
January 17, 2018
I got worried and scared after he told me for the 3rd or 4th time that he had never seen my daughter's injury before and the first surgery failed and the screws pulled through her bone. This was a scary situation and it failed once. So I guess I could have used some reassurance that everything would be ok.
UofU Patient
January 02, 2018
Dr Jones is probably the best surgeon and physician I have ever come across. He speaks in plain English but you can see that he is extremely knowledgeable about sarcoma and the human anatomy. This is the doctor everyone wants to have but there is only one of him.
UofU Patient
December 31, 2017
We really loved Dr. Jones, but I would definitely express my concerns to others about waiting so long for results. I'm not sure where the breakdown occurred, but it should be unacceptable to you!
UofU Patient
October 21, 2017
was great
UofU Patient
October 16, 2017
I am very happy with the care and concern i have received from Dr Jones and his fellow. I have never felt rushed through my appt or felt like I was just another patient.
UofU Patient
September 06, 2017
I love Dr. Jones and his staff :-)
UofU Patient
August 07, 2017
Dr Jones is a class A doctor. Very knowledgeable, considerate, sensitive to patients specific needs (my son has an anxiety issue and Aspergers). We absolutely love Dr Jones. He listens very intently to us, looks to be processing and evaluating while we speak and then responds and explains things with great effort to be both thorough and clear. Working with Dr Jones was a wonderful experience. (Plus he smiles, has a natural soft laugh, and shows great respect and actually affection for my son). If every doctor were like Dr Jones- the world would be a much happier place. _____ (______ mom)
UofU Patient
June 12, 2017
Dr. Jones always goes over results very thoroughly and explains things in common language.
UofU Patient
May 08, 2017
we didn't feel hurried and all of our questions were answered. he was very good with my son
UofU Patient
February 28, 2017
Loved his bow tie. Loved how he explained things and why we should look at another option.
UofU Patient
February 20, 2017
Dr. Jones is great--very much appreciate his expertise, his caring, his professionalism.
UofU Patient
February 06, 2017
Dr came in with entourage- had already met resident who introduced himself- 2 others came in who did not introduce themselves. WOuld be nice to know who people are and why they are there.
UofU Patient
February 04, 2017
I would recommend Dr. Jones to anyone that has an issue I feel he can give the best care for. I highly approve of every aspect of Dr. Jones's care.
UofU Patient
October 25, 2016
Great physician- I would go back. I appreciated the time that he spent- also what he told me- I was a bit overwhelmed by the info and really did not formulate my questions till after I had left. Had x-rays which were done quickly.
UofU Patient
October 25, 2016
If all the doctors had the same compassion and respect for their patient's as these doctors the world would be a better place. If I ever were in a fight for my life with cancer these would be the doctor's that I would want on my team to beat this disease.
UofU Patient
August 22, 2016
Dr. Jones is the best. Very pleased with him and his work!
UofU Patient
August 18, 2016
see previous comment - I would recommend him to someone whose child had a bone tumor but not to someone with a sports related injury/fracture
UofU Patient
July 26, 2016
Dr. Jones and his group were very thorough and thoughtful, taking time to explain to me in detail about my condition and to ensure that I understood everything and had an opportunity to ask questions. They greatly relieved my anxieties and concerns.
UofU Patient
May 31, 2016
I only wish that we had come to Dr Jones sooner. My son's suffering would have been greatly lessened in both intensity and duration. God bless Dr Jones.
UofU Patient
May 14, 2016
Kevin jones is awesome
UofU Patient
May 09, 2016
Dr Jones and everyone on staff has been amazing!
UofU Patient
March 20, 2016
I was extremely impressed with Dr. Jones and the team that saw me. He made me feel at ease even though I was extremely nervous and frightened by this whole tumor thing.
UofU Patient
March 16, 2016
Doctor Jones was an excellent choice. He is caring, knowledgeable, and explained my condition and his recommendation to correct my bone fracture clearly. I could not expect better care from anyone else.
UofU Patient
January 10, 2016
I hope no one I know ever needs this kind of a doctor, but if they do I would recommend Dr. Jones.
UofU Patient
December 04, 2015
because he didn't know what he was seeing and called it curious. it's hard when the Dr doesn't know what it is. And we can't do anything until she stops growing. even after that I got the impression that their wasn't a good option to getting the problem taken care of. they didn't know what surgery they could do and I left feeling like their was nothing we could do. basically if it hurts bad enough stop doing what you are doing. my daughter likes to run and is in track and x country. running hurts her and not running isn't an option for her.
UofU Patient
September 18, 2015
We've never met a Dr. like Dr. Jones. We've never felt like anyone cared so much for our child. This was the hardest experience of our lives and he went way beyond normal measures to take care of us.
UofU Patient
September 14, 2015
Dr. Jones takes time to listen to the patient's and family's concerns. He has excellent bedside manner. It is obvious that he truly cares about his patients. We have complete confidence in him and would recommend him to anyone looking for a sarcoma or pediatric orthopedic expert.
UofU Patient
May 27, 2015
Dr. Jones is always very caring and personable. He explained everything to my satisfaction.
UofU Patient
May 23, 2015
I was completely satisfied
UofU Patient
May 05, 2015
Felt very good with both physicians I met during my appointment, they confirmed what I had expected all along.
UofU Patient
April 15, 2015
the staff and doctor were the best
UofU Patient
March 28, 2015
I cannot imagine that any other facility could provide me with care of a higher quality.
UofU Patient
March 24, 2015
I liked the doctor's very much
UofU Patient
December 15, 2014
I am so fortunate to have a doctor such as Dr. Jones who took excellent care of the tumor in my leg/hip and gives me hope that the leg will serve me well as I proceed through cancer treatments and beyond. I trust him and his team to continue to take care of me - wanting the best despite unfortunate circumstances.
UofU Patient
June 07, 2014
Dr Jones is a very gifted doctor.
UofU Patient
March 29, 2014
Dr. Kevin Jones did an exceptional job of examining my condition, explaining my situation, and providing his analysis in an understandable way. His demeanor was calming and extremely professional.
UofU Patient
February 05, 2014
FUll confidence in Dr. Kevin B Jones.
UofU Patient
September 30, 2013
Always excellent.
UofU Patient
July 20, 2013
Dr Jones was awesome. He took care in explaining the diagnosis spending extra time to answer our questions. He is very compassionate.
UofU Patient
July 03, 2013
I came to this appointment with and for our 21 year old young looking daughter. I greatly appreciate that the conversation was consistently directed at her. This is critical as she is the life long patient. Obviously, we are here for support but this was a good transition from the prepubescent care to adult care. Thank you.
UofU Patient
April 24, 2013
My husband and I are so impressed with Dr. Jones and his staff. He is totally amazing!
UofU Patient
April 23, 2013
Intern gave initial exam. Dr only asked questions.
UofU Patient
March 04, 2013
To Dr. Kevin Jones & Staff: Thank you for your expertise, kindness, support and care. You made what could have been a bad traumatic cancer treatment into one that was comfortable and informative. You are the best!
UofU Patient
December 28, 2012
I feel I have a good relationship with Dr Kevin Jones and Nurse Nancy. They are always so caring and helpful. I and my wife appreciate them.
UofU Patient
December 10, 2012
even though we still don't know what i have, the waiting is not enjoyable, I stress only because I don't know
UofU Patient
November 16, 2012
Dr Jones is very caring and shows a great interest in your well being he doesn't rush you and listenes to your concerns
UofU Patient
September 17, 2012
We felt we received outstanding attention at the clinic.
UofU Patient
March 01, 2012
Dr Jones and his team are excellent. Compassionate
UofU Patient
January 19, 2012
I felt very validated for my concerns and pain and I felt understood and listened to. It was a very impressive experience.
Kevin B. Jones, MD
Leader, Huntsman Cancer Institute Sarcoma Disease Center
Division Chief, Sarcoma, Department of Orthopaedics
Professor, Department of Orthopaedics and
Adjunct Professor of Oncological Sciences
As an orthopaedic surgeon specialized in the care of pediatric and adult patients with sarcoma, I see first-hand the limitations and frank failures of the currently available treatment options. Not only do we fail to cure far too many young patients with sarcomas, but the long-term effects of our treatments create other major challenges to the health of the survivors in the long term.
With protected time for basic investigation, I dedicate my entire laboratory to the study of pediatric and young adult fusion oncogene-associated sarcomas. In efforts always angling toward improved targeted therapies, we use mouse genetic models of sarcomagenesis to dissect pathways of importance to initiation and progression of tumors. This work utilizes conditional activation of translocation-associated fusion oncogenes as well as manipulation of additional modifying genes directed toward improved understanding of the conditions that promote or inhibit sarcomagenesis. This work has led to generous experience with comparative genomics and epigenomics.
The simple genetic changes that drive translocation-associated sarcomas make a strong argument for cancer being defined as a transcriptional state for cells, rather than a state of accumulated mutations or genetic losses and gains. The study of the epigenetic determinants of this transcriptional state in cells that harbor very few genetic code alterations has already revealed important knowledge that pertains to more complex genome cancer types as well as to transcriptional biology more generally.
I also believe firmly in the synergy possible in collaborative team science. Such efforts are required for progress toward improved treatments for rare malignancies that can never be studied with optimal efficacy in a silo. With such collaborative work as direct goal, I have participated in and assembled teams to work on pediatric sarcomas both within my institution and internationally.
Academic Locations
Huntsman Cancer Institute
801-585-0300
Research Statement
With 80 percent protected time for academic pursuits, and an independent laboratory at the Huntsman Cancer Institute, I focus most of my research on dissecting the genetic and epigenetic underpinnings of sarcoma initiation. Although sarcomas are rare cancers, the tissues which give rise to sarcomas when they become cancerous are the predominant tissues in the human body, the muscles, tendons, bones, vessels, fat, etc. These tissues derive from mesenchyme or mesoderm. While many organ-based cancer cells gain some characteristics of mesenchyme or mesoderm as they become malignant, turning mesenchyme itself into cancer is much more difficult. The intrinsic resistance to transformation (the process of becoming cancerous) in mesenchyme has brought particular focus to any factor capable of overcoming that resistance and forming cancers from connective tissues.Thus, sarcomas--not only in spite of, but actually because of their low frequency in the general population--have played a central role in the fundamental discoveries of cancer biology. For example, radium dial painters developing osteosarcomas led to the discovery that radiation causes cancer. Oncogenes, the tumor causing genes, were discovered by study of a virus that caused sarcomas in birds. Tumor suppressor genes, the genes that when turned off lead to cancer, were discovered because families had too many sarcomas (Even two is way too common in any one family!) We therefore pursue sarcoma biology vigorously not only because we need to generate better treatment strategies for this horrible group of cancers that impacts young people disproportionately, but also because sarcoma will likely yet teach us much more about cancer biology in general, especially its beginnings.
Board Certification and Academic Information
| Academic Departments | Orthopaedics
-
Professor Oncological Sciences - Adjunct Associate Professor |
| Board Certification | American Board of Orthopaedic Surgery |
| Cancer Center Programs | Nuclear Control of Cell Growth & Differentiation |
Research Interests
- Sarcoma, Synovial
- Osteosarcoma
- Mouse Models
- Ewing's Sarcoma
- Chondrosarcoma
- Sarcoma
- Soft Tissue Sarcomas
- Sarcoma, Clear Cell
Education History
| Other Training | Mario Capecchi Laboratory, University of Utah Mentored Scientific Training-Mouse Genetic Modeling of Sarcoma |
| Fellowship | Mount Sinai Hospital Musculoskeletal Oncology Fellow |
| Residency | University of Iowa Hospitals and Clinics Orthopaedic Surgery Resident |
| Professional Medical | Johns Hopkins University Medicine M.D. |
| Undergraduate | Harvard University English and American Literature and Language A.B. |
Selected Publications - Journal Articles
Journal Article
- Kim SK, Nguyen C, Jones KB, Tashjian RZ (2021). A Genome Wide Association Study For Shoulder Impingement and Rotator Cuff Disease. (Epub ahead of print) J Shoulder Elbow Surg.
- Kannan S, Lock I, Ozenberger BB, Jones KB (2021). Genetic drivers and cells of origin in sarcomagenesis. (Epub ahead of print) J Pathol.
- Nacev BA, Jones KB, Intlekofer AM, Yu JSE, Allis CD, Tap WD, Ladanyi M, Nielsen TO (2020). The epigenomics of sarcoma. Nat Rev Cancer, 20(10), 608-623.
- Tashjian RZ, Kim SK, Roche MD, Jones KB, Teerlink CC (2020). Genetic variants associated with rotator cuff tearing utilizing multiple population-based genetic resources. (Epub ahead of print) J Shoulder Elbow Surg.
- Tashjian RZ, Lock I, Granger EK, Wang Y, Lee Y, Chalmers PN, Jones KB (2020). Gene Expression in Torn Rotator Cuff Tendons Determined by RNA Sequencing. Orthop J Sports Med, 8(6), 2325967120927480.
- Blank AT, Larson BM, Shaw S, Wakefield CJ, King T, Jones KB, Randall RL (2020). National Comprehensive Cancer Network guidelines compliance of a sarcoma service: A retrospective review. World J Clin Oncol, 11(6), 389-396.
- Lambert SL, Jones KB (2020). SKP2 My Lou, My Darling. Cancer Res, 80(12), 2437-2438.
- Kirkham M, Kalivas A, Fatema K, Luelling S, Dubansky BH, Dubansky B, Jones KB, Barrott JJ (2020). Underlying Ossification Phenotype in a Murine Model of Metastatic Synovial Sarcoma. Int J Mol Sci, 21(7).
- Blank AT, Shaw S, Wakefield CJ, Zhang Y, Liu WJ, Jones KB, Randall RL (2019). What factors influence patient experience in orthopedic oncology office visits? World J Clin Oncol, 11(3), 136-142.
- Jones KB (2019). Dendritic Cells Drive Osteosarcomagenesis through Newly Identified Oncogene and Tumor Suppressor. Cancer Discov, 9(11), 1484-1486.
- Goodwin ML, Gundavda MK, Reddy R, Deogaonkar K, Lala M, Baliarsing A, Sciubba DM, Jones KB, Agarwal M (2019). Extracorporeal radiation and reimplantation: a safe and viable option for reconstruction after sacral tumor resection? Ann Transl Med, 7(10), 229.
- Barrott JJ, Illum BE, Jin H, Hedberg ML, Wang Y, Grossmann A, Haldar M, Capecchi MR, Jones KB (2018). Paracrine osteoprotegerin and beta-catenin stabilization support synovial sarcomagenesis in periosteal cells. J Clin Invest, 128(1), 207-218.
- Kwok AC, Tatro E, Jones KB, Agarwal JP (2017). Pedicled Retrograde Fibula Flap for Ankle Reconstruction after Oncologic Resection of the Distal Fibula. Plast Reconstr Surg Glob Open, 5(2), e1232.
- Barrott JJ, Kafchinski LA, Jin H, Potter JW, Kannan SD, Kennedy R, Mosbruger T, Wang WL, Tsai JW, Araujo DM, Liu T, Capecchi MR, Lazar AJ, Jones KB (2016). Modeling synovial sarcoma metastasis in the mouse: PI3'-lipid signaling and inflammation. J Exp Med, 213(13), 2989-3005.
- Jones KB, Barrott JJ, Xie M, Haldar M, Jin H, Zhu JF, Monument MJ, Mosbruger TL, Langer EM, Randall RL, Wilson RK, Cairns BR, Ding L, Capecchi MR (2016). The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis. Oncogene, 35(38), 5021-32.
- Barrott JJ, Illum BE, Jin H, Zhu JF, Mosbruger T, Monument MJ, Smith-Fry K, Cable MG, Wang Y, Grossmann AH, Capecchi MR, Jones KB (2015). beta-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition. Oncotarget, 6(26), 22758-66.
- Quist T, Jin H, Zhu JF, Smith-Fry K, Capecchi MR, Jones KB (2015). The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse. Oncogene, 34(32), 4278-84.
- de Andrea CE, Zhu JF, Jin H, Bovee JV, Jones KB (2015). Cell cycle deregulation and mosaic loss of Ext1 drive peripheral chondrosarcomagenesis in the mouse and reveal an intrinsic cilia deficiency. J Pathol, 236(2), 210-8.
- Monument MJ, Bernthal NM, Bowles AJ, Jones KB, Randall RL (2015). What are the 5-year survivorship outcomes of compressive endoprosthetic osseointegration fixation of the femur? Clin Orthop Relat Res, 473(3), 883-90.
- Goodwin ML, Jin H, Straessler K, Smith-Fry K, Zhu JF, Monument MJ, Grossmann A, Randall RL, Capecchi MR, Jones KB (2014). Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment. Cancer Cell, 26(6), 851-862.
- Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi MR (2013). SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene, 32(18), 2365-71, 2375.e1-5.
- Jones KB, Datar M, Ravichandran S, Jin H, Jurrus E, Whitaker R, Capecchi MR (2013). Toward an understanding of the short bone phenotype associated with multiple osteochondromas. J Orthop Res, 31(4), 651-7.
- Straessler KM, Jones KB, Hu H, Jin H, van de Rijn M, Capecchi MR (2013). Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell, 23(2), 215-27.
- Jones KB, Ferguson PC, Lam B, Biau DJ, Hopyan S, Deheshi B, Griffin AM, White LM, Wunder JS (2012). Effects of neoadjuvant chemotherapy on image-directed planning of surgical resection for distal femoral osteosarcoma. J Bone Joint Surg Am, 94(15), 1399-405.
- Jones KB, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo GJ, Lovat F, LeBlanc K, Palatini J, Randall RL, Volinia S, Stein GS, Croce CM, Lian JB, Aqeilan RI (2012). miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res, 72(7), 1865-77.
- Jones KB, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo GJ, Lovat F, LeBlanc K, Palatini J, Randall RL, Volinia S, Stein GS, Croce CM, Lian JB, Ageilan RI (04/01/2012). miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res, 72(7), 1865-77.
- Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin S, Poulin N, Yi L, Rossi FM, Kast J, Capecchi MR, Underhill TM, Nielsen TO (2012). Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell, 21(3), 333-47.
- Jones KB, Schiffman JD, Kohlmann W, Randall RL, Lessnick SL, Cannon-Albright LA (2011). Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes. Cancer Epidemiol Biomarkers Prev, 20(5), 751-7.
- Israelsen RB, Illum BE, Crabtree S, Randall RL, Jones KB (2011). Extremity sarcoma surgery in younger children: ten years of patients ten years and under. Iowa Orthop J, 31, 145-53.
- Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield VC (2010). A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A, 107(5), 2054-9.
- Jones KB (2007). Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones [Skeletal Lesion Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group ]. J Bone Joint Surg Am, 89(10), 2113-2123.
- Jones KB, Buckwalter JA, Frassica FJ, McCarthy EF (2005). Intracortical chondroma: a report of two cases. Skeletal Radiol, 35(5), 298-301.
Case Report
Global Impact
Education History
| Fellowship | Mount Sinai Hospital Musculoskeletal Oncology Fellow |