Kevin B. Jones, M.D.

Schedule An Appointment	Clinical Office Address
(801) 585-0262	Huntsman Cancer Institute Clinic 2E, Sarcoma 2000 Circle of Hope Salt Lake City, UT 84112 Map
(801) 285-1440	PCH Outpatient Services at Riverton 3773 West 12600 South Riverton, UT 84065
(801) 662-5600	Primary Children's Hospital Pediatric Orthopaedics 100 N Mario Capecchi Drive , Suite 4550 Salt Lake City, UT 84113

Bio

Specializing in the evaluation, diagnosis, and surgical management of sarcomas, tumors arising in bone and soft-tissue, Dr. Jones sees both pediatric and adult patients. His practice also includes surgery for benign bone tumors such as giant cell tumor of bone, chondromyxoid fibroma, osteochondromas, and others as well as stabilization of the bones with metastatic disease from other cancers causing pathologic fractures or impending fractures. Children and adults in need of resection and reconstruction for osteosarcoma, Ewing's sarcoma, chondrosarcoma, synovial sarcoma, liposarcoma, and leiomyosarcoma of the extremities and pelvis come from all across the mountain west to see Dr. Jones and the multidisciplinary team approach used by Sarcoma Services at the Huntsman Cancer Institute. Weekly meetings bring together surgeons, chemotherapy specialists, radiation oncologists, pathologists, radiologists, and other providers to discuss every new case of sarcoma. Dr. Jones emphasizes clear communication and educates and empowers patients to make wise choices with regard to their cancer care. He studied English literature at Harvard and received his medical degree from Johns Hopkins University. After orthopaedic residency training at the University of Iowa, he specialized in musculoskeletal oncology through fellowship training at the University of Toronto, Mount Sinai and Princess Margaret Hospitals.

Board Certification and Academic Information

Academic Departments	Orthopaedics - Assistant Professor
Board Certification	American Board of Orthopedic Surgery
Cancer Center Programs	Nuclear Control of Cell Growth & Differentiation

Board Certification and Academic Information

Academic Departments	Orthopaedics - Assistant Professor
Board Certification	American Board of Orthopedic Surgery
Cancer Center Programs	Nuclear Control of Cell Growth & Differentiation

Academic Office Locations

Academic Office Phone Number	Academic Office Address
(801) 585-0300	Huntsman Cancer Institute Sarcoma Services 2000 Circle of Hope Salt Lake City, UT 84112

Academic Bio

Supported by a K08 award, I have been a surgeon-scientist under the mentorship of Mario R. Capecchi, PhD. My laboratory's move to independent space in the Huntsman Cancer Institute took place in July 2013. As a junior faculty member embedded with the Capecchi Genetics Laboratory for a training period of 5 years, I directed the sarcoma-related efforts underway with a variety of mouse genetic models. Investigation for each of these continues under my now independent research program. This work focuses on conditional activation of translocation-associated fusion oncogenes as well as conditional inactivation of a variety of tumor suppressors. We utilize transposon-mediated insertional mutagenesis to identify critical pathways with somatic forward genetic screens. Specifically in my growing independent program, we focus on the epigenetics of sarcomagenesis, impacted by fusion oncogenes. Current models under investigation in the laboratory include synovial sarcoma, Ewing’s sarcoma, osteosarcoma, chondrosarcoma, clear cell sarcoma, and alveolar soft-part sarcoma. Identification of therapeutic targets is a central goal in each project.

Education History

Type	School	Degree
Fellowship	Mount Sinai Hospital Musculoskeletal Oncology	Fellow
Residency	University of Iowa Hospitals and Clinics Orthopaedic Surgery	Resident
Professional Medical	Johns Hopkins University Medicine	M.D.
Undergraduate	Harvard University English and American Literature and Language	A.B.

Selected Provider Publications

Journal Article

1. Goodwin ML, Jin H, Straessler K, Smith-Fry K, Zhu JF, Monument MJ, Grossmann A, Randall RL, Capecchi MR, Jones KB (2014). Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment. Cancer Cell, 26(6), 851-62.
2. Quist T, Jin H, Zhu JF, Smith-Fry K, Capecchi MR, Jones KB (2014). The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse.LID - 10.1038/onc.2014.354 [doi]. Oncogene.
3. Monument MJ, Bernthal NM, Bowles AJ, Jones KB, Randall RL (2014). What Are the 5-year Survivorship Outcomes of Compressive Endoprosthetic Osseointegration Fixation of the Femur? Clin Orthop Relat Res.
4. Monument MJ, Jones KB (2014). Molecular characterization of bone tumors and implications for treatment and prognosis. J Natl Compr Canc Netw, 12(2), 214-20.
5. Kafchinski LA, Jones KB (2014). MicroRNAs in Osteosarcomagenesis. Adv Exp Med Biol, 804, 119-27.
6. Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi MR (2013). SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene, 32(18), 2365-71, 2375.e1-5.
7. Jones KB, Datar M, Ravichandran S, Jin H, Jurrus E, Whitaker R, Capecchi MR (2013). Toward an understanding of the short bone phenotype associated with multiple osteochondromas. J Orthop Res, 31(4), 651-7.
8. Straessler KM, Jones KB, Hu H, Jin H, van de Rijn M, Capecchi MR (2013). Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell, 23(2), 215-27.
9. Jones KB, Ferguson PC, Lam B, Biau DJ, Hopyan S, Deheshi B, Griffin AM, White LM, Wunder JS (2012). Effects of neoadjuvant chemotherapy on image-directed planning of surgical resection for distal femoral osteosarcoma. J Bone Joint Surg Am, 94(15), 1399-405.
10. Jones KB, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo GJ, Lovat F, LeBlanc K, Palatini J, Randall RL, Volinia S, Stein GS, Croce CM, Lian JB, Ageilan RI (04/01/2012). miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res, 72(7), 1865-77.
11. Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin S, Poulin N, Yi L, Rossi FM, Kast J, Capecchi MR, Underhill TM, Nielsen TO (2012). Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell, 21(3), 333-47.
12. Jones KB, Schiffman JD, Kohlmann W, Randall RL, Lessnick SL, Cannon-Albright LA (2011). Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes. Cancer Epidemiol Biomarkers Prev, 20(5), 751-7.
13. Israelsen RB, Ilium BE, Crabtree S, Randall RL, Jones KB (2011). Extremity sarcoma surgery in younger children: ten years of patients ten years and under. Iowa Orthop J, 31, 145-53.
14. Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield VC (2010). A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A, 107(5), 2054-9.

Review

1. Jones KB, Pacifici M, Hilton MJ (2014). Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research. [Review]. Connect Tissue Res, 55(2), 80-8.
2. Jones KB (2011). Osteosarcomagenesis: modeling cancer initiation in the mouse. [Review]. Sarcoma, 2011, 694136.

In The News

• Research on a rare cancer exposes possible route to new treatments
• Utah physician wins research funding for childhood cancers

Video