Kevin B. Jones, M.D.

Locations

Schedule An Appointment	Clinical Office Address
(801) 585-0262	Huntsman Cancer Institute Clinic 2E, Sarcoma 2000 Circle of Hope Salt Lake City, UT 84112 Map
(801) 285-1440	PCH Outpatient Services at Riverton 3773 West 12600 South Riverton, UT 84065
(801) 662-5600	Primary Children's Hospital Pediatric Orthopaedics 100 N Mario Capecchi Drive , Suite 4550 Salt Lake City, UT 84113

Bio

Specializing in the evaluation, diagnosis, and surgical management of sarcomas, tumors arising in bone and soft-tissue, Dr. Jones sees both pediatric and adult patients. His practice also includes surgery for benign bone tumors such as giant cell tumor of bone, chondromyxoid fibroma, osteochondromas, and others as well as stabilization of the bones with metastatic disease from other cancers causing pathologic fractures or impending fractures. Children and adults in need of resection and reconstruction for osteosarcoma, Ewing's sarcoma, chondrosarcoma, synovial sarcoma, liposarcoma, and leiomyosarcoma of the extremities and pelvis come from all across the mountain west to see Dr. Jones and the multidisciplinary team approach used by Sarcoma Services at the Huntsman Cancer Institute. Weekly meetings bring together surgeons, chemotherapy specialists, radiation oncologists, pathologists, radiologists, and other providers to discuss every new case of sarcoma. Dr. Jones emphasizes clear communication and educates and empowers patients to make wise choices with regard to their cancer care. He studied English literature at Harvard and received his medical degree from Johns Hopkins University. After orthopaedic residency training at the University of Iowa, he specialized in musculoskeletal oncology through fellowship training at the University of Toronto, Mount Sinai and Princess Margaret Hospitals.

Board Certification and Academic Information

Academic Departments	Orthopaedics - Assistant Professor
Board Certification	American Board of Orthopedic Surgery
Cancer Center Programs	Nuclear Control of Cell Growth & Differentiation

Board Certification and Academic Information

Academic Departments	Orthopaedics - Assistant Professor
Board Certification	American Board of Orthopedic Surgery
Cancer Center Programs	Nuclear Control of Cell Growth & Differentiation

Academic Office Locations

Academic Office Phone Number	Academic Office Address
(801) 585-0300	Huntsman Cancer Institute Sarcoma Services 2000 Circle of Hope Salt Lake City, UT 84112

Academic Bio

Supported by a K08 award, I have been a surgeon-scientist under the mentorship of Mario R. Capecchi, PhD. My laboratory's move to independent space in the Huntsman Cancer Institute took place in July 2013. As a junior faculty member embedded with the Capecchi Genetics Laboratory for a training period of 5 years, I directed the sarcoma-related efforts underway with a variety of mouse genetic models. Investigation for each of these continues under my now independent research program. This work focuses on conditional activation of translocation-associated fusion oncogenes as well as conditional inactivation of a variety of tumor suppressors. We utilize transposon-mediated insertional mutagenesis to identify critical pathways with somatic forward genetic screens. Specifically in my growing independent program, we focus on the epigenetics of sarcomagenesis, impacted by fusion oncogenes. Current models under investigation in the laboratory include synovial sarcoma, Ewing’s sarcoma, osteosarcoma, chondrosarcoma, clear cell sarcoma, and alveolar soft-part sarcoma. Identification of therapeutic targets is a central goal in each project.

Education History

Type	School	Degree
Fellowship	Mount Sinai Hospital Musculoskeletal Oncology	Fellow
Residency	University of Iowa Hospitals and Clinics Orthopaedic Surgery	Resident
Professional Medical	Johns Hopkins University Medicine	M.D.
Undergraduate	Harvard University English and American Literature and Language	A.B.

Selected Provider Publications

Journal Article

1. Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi M(2013)SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas.  Oncogene, 32(18),2365-71, 2375.e1-5
2. Jones KB, Datar M, Ravichandran S, Jin H, Jurrus E, Whitaker R, Capecchi M(2013)Toward an understanding of the short bone phenotype associated with multiple osteochondromas.  Journal of Orthopaedic Research, 31(4),651-7
3. Straessler KM, Jones KB, Hu H, Jin H, van de Rijn M, Capecchi M(2013)Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics.  Cancer Cell, 23(2),215-27
4. Price SL, Farukhi MA, Jones KB, Aoki SK, Randall R(2013)Complications of cemented long-stem hip arthroplasty in metastatic bone disease revisited.  Clinical Orthopaedics and Related Research, 471(10),3303-7
5. Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin S, Poulin N, Yi L, Rossi FM, Kast J, Capecchi MR, Underhill TM, Nielsen T(2012)Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics.  Cancer Cell, 21(3),333-47
6. de Andrea CE, Kroon HM, Wolterbeek R, Romeo S, Rosenberg AE, De Young BR, Liegl B, Inwards CY, Hauben E, McCarthy EF, Idoate M, Athanasou NA, Jones KB, Hogendoorn PC, Bovee J(2012)Interobserver reliability in the histopathological diagnosis of cartilaginous tumors in patients with multiple osteochondromas.  Modern Pathology, 25(9),1275-83
7. Jones KB, Ferguson PC, Lam B, Biau DJ, Hopyan S, Deheshi B, Griffin AM, White LM, Wunder J(2012)Effects of neoadjuvant chemotherapy on image-directed planning of surgical resection for distal femoral osteosarcoma.  Journal of Bone and Joint Surgery: American Volume, 94(15),1399-405
8. Jahromi MS, Putnam AR, Druzgal C, Wright J, Spraker-Perlman H, Kinsey M, Zhou H, Boucher KM, Randall RL, Jones KB, Lucas D, Rosenberg A, Thomas D, Lessnick SL, Schiffman J(2012)Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma.  Cancer Genetics, 205(7-8),391-404
9. Jones KB, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo GJ, Lovat F, LeBlanc K, Palatini J, Randall RL, Volinia S, Stein GS, Croce CM, Lian JB, Ageilan R(2012)miRNA signatures associate with pathogenesis and progression of osteosarcoma.  Cancer Research, 72(7),1865-77
10. Jones KB, Schiffman JD, Kohlmann W, Randall RL, Lessnick SL, Cannon-Albright L(2011)Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes.  Cancer Epidemiology, Biomarkers & Prevention, 20(5),751-7
11. Jones KB, Griffin AM, Chandrasekar CR, Biau D, Babinet A, Deheshi B, Bell RS, Grimer RJ, Wunder JS, Ferguson P(2011)Patient-oriented functional results of total femoral endoprosthetic reconstruction following oncologic resection.  Journal of Surgical Oncology, 104(6),561-5
12. Israelsen RB, Ilium BE, Crabtree S, Randall RL, Jones K(2011)Extremity sarcoma surgery in younger children: ten years of patients ten years and under.  Iowa Orthopaedic Journal, The, 31145-53
13. Joyner DE, Jones KB, Lessnick SL, Schiffman JD, Randall R(2011)Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas.  Sarcoma, 2011847409
14. Jones KB, Ferguson PC, Deheshi B, Riad S, Griffin A, Bell RS, Wunder J(2010)Complete femoral nerve resection with soft tissue sarcoma: functional outcomes.  Annals of Surgical Oncology, 17(2),401-6
15. Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield V(2010)A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes.  Proceedings of the National Academy of Sciences of the United States of America, 107(5),2054-9
16. Cummings J, Villanueva E, Cearley D, Jones KB, Randall R(2010)Stringent patient selection in bulk allograft reconstructions.  Orthopedics, 33(2),86-92
17. Kurek KC, Del Mare S, Salah Z, Abdeen S, Sadiq H, Lee SH, Gaudio E, Zanesi N, Jones KB, DeYoung B, Amir G, Gebhardt M, Warman M, Stein GS, Stein JL, Lian JB, Aqeilan R(2010)Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.  Cancer Research, 70(13),5577-86

Review

1. Jones KB, Pacifici M, Hilton M(2014)Multiple Hereditary Exostoses (MHE): Elucidating the Pathogenesis of a Rare Skeletal Disorder Through Interdisciplinary Research.  Connective Tissue Research,
2. Bernthal NM, Jones KB, Monument MJ, Liu T, Viskochil D, Randall R(2013)Lost in translation: ambiguity in nerve sheath tumor nomenclature and its resultant treatment effect.  Cancers, 5(2),519-28
3. Calvert GT, Randall RL, Jones KB, Cannon-Albright L, Lessnick S, Schiffman J(2012)At-risk populations for osteosarcoma: the syndromes and beyond.  Sarcoma, 2012152382
4. Spraker HL, Price SL, Chaturvedi A, Schiffman JD, Jones KB, Lessnick SL, Beckerle M, Randall R(2012)The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm.  Frontiers in Oncology, 22
5. Calvert GT, Monument MJ, Burt RW, Jones KB, Randall R(2012)Extra-abdominal desmoid tumors associated with familial adenomatous polyposis.  Sarcoma, 2012726537
6. Jones K(2011)Osteosarcomagenesis: modeling cancer initiation in the mouse.  Sarcoma, 2011694136
7. Jahromi MS, Jones KB, Schiffman J(2011)Copy Number Alterations and Methylation in Ewing's Sarcoma.  Sarcoma, 2011362173
8. Jones KB, Haldar M, Schiffman JD, Cannon-Albright L, Lessnick SL, Sharma S, Capecchi MR, Randall R(2011)Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation.  Cancer Control, 18(3),196-203
9. Gouw LG, Jones KB, Sharma S, Randall R(2011)Sarcoma immunotherapy.  Cancers, 3(4),4139-50
10. Randall RL, Lessnick SL, Jones KB, Gouw LG, Cummings JE, Cannon-Albright L, Schiffman J(2010)Is There a Predisposition Gene for Ewing's Sarcoma?  Journal of Oncology, 2010397632
11. Ferguson PC, Kulidjian AA, Jones KB, Deheshi BM, Wunder J(2009)Peripheral nerve considerations in the management of extremity soft tissue sarcomas.  Recent Results in Cancer Research, 179243-56
12. Jones KB, Ferguson PC, Kandel R, Wunder J(2009)Determination of Chromosomal Translocations in Soft Tissue Sarcomas: A Worthwhile Undertaking.  Pathology Case Reviews, 13(2),57-64

Clinical Trials

• Rotator Cuff Tissue Collection
  Keywords: Apoptosis, Tumor Suppressor, Genes, Rotator Cuff Tendon , Tears
  Status: Active, not recruiting Principal Investigator: Robert Tashjian

In The News

• Utah physician wins research funding for childhood cancers

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