Benjamin L. Witt
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Benjamin L. Witt, MD

Languages spoken: English

  • Dr. Witt's research interests include studies related to fine-needle aspiration and Head and Neck pathology.

    Specialties

    Board Certification

    American Board of Pathology (Anatomic & Clinical)

  • Dr. Witt's research interests include studies related to fine-needle aspiration and Head and Neck pathology.

    Board Certification and Academic Information

    Academic Departments Pathology -Associate Professor (Clinical)
    Board Certification
    American Board of Pathology (Anatomic & Clinical)

    Education history

    Fellowship Cytopathology - University of Utah/ARUP Laboratories Fellow
    Residency Anatomic and Clinical Pathology - University of Chicago - NorthShore Resident
    Professional Medical University of Colorado Denver School of Medicine M.D.
    Undergraduate Molecular, Cellular, and Developmental Biology - University of Colorado at Boulder B.A.

    Selected Publications

    Journal Article

    1. Ireland AS, Hawgood SB, Xie DA, Barbier MW, Lucas-Randolph S, Tyson DR, Zuo LY, Witt BL, Govindan R, Dowlati A, Moser JC, Puri S, Rudin CM, Chan JM, Elliott A, Oliver TG (2024). Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer. bioRxiv. (Read full article)
    2. Mahomva CR, Smith KA, Minkah PAB, Witt BL, Oakley GM, Orlandi RR, Alt JA, Pulsipher A (2024). Chemokine CCL19 and Its Receptors CCR7 and CCRL1 in Chronic Rhinosinusitis. J Inflamm Res, 17, 2991-3002. (Read full article)
    3. Smith KA, Gill AS, Pollard CE, Sumsion JS, Saffari H, Ashby S, Witt BL, Shipman PA, Gabrielsen DA, Yim MT, Levy JM, Oakley GM, Orlandi RR, Gleich GJ, Alt JA, Pulsipher A (2023). An eosinophil peroxidase activity assay accurately predicts eosinophilic chronic rhinosinusitis. J Allergy Clin Immunol, 152(2), 400-407. (Read full article)
    4. Bansal S, Bechara RI, Patel JD, Mehta HJ, Ferguson JS, Witt BL, Murgu SD, Yasufuku K, Casal RF (2023). Safety and Feasibility of Photodynamic Therapy for Ablation of Peripheral Lung Tumors. J Bronchology Interv Pulmonol, 30(2), 135-143. (Read full article)
    5. Witt BL, Zhou W, Ambaye AB, Bellizzi A, Booth CN, Sundling K, Nguyen L, Russell DK, Schinstine M, Staats PN, Thomsen J, Troxell M, Souers RJ, Dvorak J, Lin X, Kurtycz DFI (2022). Using American Type Culture Collection Cell Lines to Evaluate Interlaboratory Variables for Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 Immunostaining. Arch Pathol Lab Med, 147(2), 143-148. (Read full article)
    6. Dong Z, Barraza G, Affolter KE, Witt BL, Jedrzkiewicz J (2022). Distinguishing Gastrointestinal Leiomyomas From Muscularis Propria in Biopsy Specimens by Differential Expression of S100 Immunohistochemical Stain. Am J Clin Pathol, 159(1), 53-59. (Read full article)
    7. Gibson BA, McKinnon E, Bentley RC, Mohlman J, Witt BL, Yang EJ, Geisler D, DeFrances M (2021). Communicating Certainty in Pathology Reports. Arch Pathol Lab Med, 146(7), 886-893. (Read full article)
    8. Staats PN, Davey DD, Witt BL, Ghofrani M, Zhao C, Dodd LG, Goodrich K, Husain M, Kurtycz DFI, Russell DK, Shen RZ, Souers RJ, Tabatabai ZL, Crothers BA (2021). Performance of specific morphologic features in distinguishing low-grade squamous intraepithelial lesions from high-grade squamous intraepithelial lesions in borderline cases: a College of American Pathologists Cytopathology Committee multiobserver study. J Am Soc Cytopathol, 11(2), 102-113. (Read full article)
    9. Witt BL (2021). Rapid On Site Evaluation (ROSE): A Pathologists' Perspective. Tech Vasc Interv Radiol, 24(3), 100767. (Read full article)
    10. Olsen RR, Ireland AS, Kastner DW, Groves SM, Spainhower KB, Pozo K, Kelenis DP, Whitney CP, Guthrie MR, Wait SJ, Soltero D, Witt BL, Quaranta V, Johnson JE, Oliver TG (2021). ASCL1 represses a SOX9(+) neural crest stem-like state in small cell lung cancer. Genes Dev, 35(11-12), 847-869. (Read full article)
    11. Zhu GG, Witt BL, Winter Iii TC, Rogers DM (2021). Multiple enlarging hepatic and retroperitoneal myelolipomas in the setting of Cushing disease. BMJ Case Rep, 14(2). (Read full article)
    12. Chandan S, Mohan BP, Khan SR, Ofosu A, Dhaliwal AS, Shah AR, Bhogal N, Mashiana HS, Mashiana SS, Kassab LL, Ponnada S, Facciorusso A, Bhat I, Singh S, Witt BL, Adler DG (2020). Comparison of EUS-guided conventional smear and liquid-based cytology in pancreatic lesions: A systematic review and meta-analysis. Endosc Int Open, 8(11), E1611-E1622. (Read full article)
    13. Ireland AS, Micinski AM, Kastner DW, Guo B, Wait SJ, Spainhower KB, Conley CC, Chen OS, Guthrie MR, Soltero D, Qiao Y, Huang X, Tarapcsk S, Devarakonda S, Chalishazar MD, Gertz J, Moser JC, Marth G, Puri S, Witt BL, Spike BT, Oliver TG (2020). MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate. Cancer Cell, 38(1), 60-78.e12. (Read full article)
    14. Balwan A, Bixby B, Grotepas C, Witt BL, Iravani A, Ansari S, Reddy CB (2020). Core needle biopsy with endobronchial ultrasonography: single center experience with 100 cases. J Am Soc Cytopathol, 9(4), 249-253. (Read full article)
    15. Chen C, Lohavanichbutr P, Zhang Y, Houck JR, Upton MP, Abedi-Ardekani B, Agudo A, Ahrens W, Alemany L, Anantharaman D, Conway DI, Futran ND, Holcatova I, Gnther K, Hansen BT, Healy CM, Itani D, Kjaerheim K, Monroe MM, Thomson PJ, Witt BL, Nakoneshny S, Peterson LA, Schwartz SM, Zarins KR, Hashibe M, Brennan P, Rozek LS, Wolf G, Dort JC, Wang P (2019). Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature: A multicenter study using FFPE samples. Oral Oncol, 100, 104487. (Read full article)
    16. Witt BL (2018). Communicating communication to pathology residents and fellows. Cancer Cytopathol, 127(4), 211-212. (Read full article)
    17. Lloyd IE, Zhou W, Witt BL, Chadwick BE (2017). Characterization of PD-L1 Immunohistochemical Expression in Cell Blocks With Different Specimen Fixation and Processing Methods. Appl Immunohistochem Mol Morphol, 27(2), 107-113. (Read full article)
    18. Crothers BA, Ghofrani M, Zhao C, Dodd LG, Goodrich K, Husain M, Kurtycz DFI, Russell DK, Shen RZ, Souers RJ, Staats PN, Tabatabai ZL, Witt BL, Davey DD (2018). Low-Grade Squamous Intraepithelial Lesion or High-Grade Squamous Intraepithelial Lesion? Concordance Between the Interpretation of Low-Grade Squamous Intraepithelial Lesion and High-Grade Squamous Intraepithelial Lesion in Papanicolaou Tests: Results From the College of American Pathologists PAP Education Program. Arch Pathol Lab Med, 143(1), 81-85. (Read full article)
    19. Mollaoglu G, Jones A, Wait SJ, Mukhopadhyay A, Jeong S, Arya R, Camolotto SA, Mosbruger TL, Stubben CJ, Conley CJ, Bhutkar A, Vahrenkamp JM, Berrett KC, Cessna MH, Lane TE, Witt BL, Salama ME, Gertz J, Jones KB, Snyder EL, Oliver TG (2018). The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Immunity, 49(4), 764-779.e9. (Read full article)
    20. Witt BL, Factor RE, Chadwick BE, Caron J, Siddiqui AA, Adler DG (2018). Evaluation of the SharkCore(®) needle for EUS-guided core biopsy of pancreatic neuroendocrine tumors. Endosc Ultrasound, 7(5), 323-328. (Read full article)
    21. Sowder AM, Witt BL, Hunt JP (2017). An Update on the Risk of Lymph Node Metastasis for the Follicular Variant of Papillary Thyroid Carcinoma with the New Diagnostic Paradigm. Head Neck Pathol, 12(1), 105-109. (Read full article)
    22. Bank JS, Witt BL, Taylor LJ, Adler DG (2017). Diagnostic yield and accuracy of a new cytology brush design compared to standard brush cytology for evaluation of biliary strictures. Diagn Cytopathol, 46(3), 234-238. (Read full article)
    23. Cannon RB, Dundar Y, Thomas A, Monroe MM, Buchmann LO, Witt BL, Sowder AM, Hunt JP (2017). Elective Neck Dissection for Head and Neck Cutaneous Squamous Cell Carcinoma with Skull Base Invasion. Otolaryngol Head Neck Surg, 156(4), 671-676. (Read full article)
    24. Mollaoglu G, Guthrie MR, Bhm S, Brgelmann J, Can I, Ballieu PM, Marx A, George J, Heinen C, Chalishazar MD, Cheng H, Ireland AS, Denning KE, Mukhopadhyay A, Vahrenkamp JM, Berrett KC, Mosbruger TL, Wang J, Kohan JL, Salama ME, Witt BL, Peifer M, Thomas RK, Gertz J, Johnson JE, Gazdar AF, Wechsler-Reya RJ, Sos ML, Oliver TG (2017). MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Cancer Cell, 31(2), 270-285. (Read full article)
    25. Witt BL, Cohen MB, Chadwick BE, Stephenson PD, Abasolo P, Schmidt RL (2015). Cytomorphology is often insufficient to categorize non-small-cell lung carcinoma on FNA specimens. Diagn Cytopathol, 44(2), 73-9. (Read full article)
    26. Layfield LJ, Schmidt RL, Chadwick BE, Esebua M, Witt BL (2015). Interobserver reproducibility and agreement with original diagnosis in the categories "atypical" and "suspicious for malignancy" for bile and pancreatic duct brushings. Diagn Cytopathol, 43(10), 797-801. (Read full article)
    27. Layfield LJ, Esebua M, Schmidt RL, Witt BL (2015). Malignancy risk associated with the EBUS-FNA diagnostic categories nondiagnostic, benign, atypical, suspicious for malignancy, and malignant for mediastinal lymph node aspirate specimens. J Am Soc Cytopathol, 4(5), 276-281. (Read full article)
    28. Witt BL, Albertson DJ, Coppin MG, Horrocks CF, Post M, Gulbahce HE (2014). Use of in situ hybridization for HPV in head and neck tumors: experience from a national reference laboratory. Head Neck Pathol, 9(1), 60-4. (Read full article)
    29. Witt BL, Albertson DJ, Coppin MG, Horrocks CF, Gulbahce HE (March 2015). Use of In Situ Hybridization for HPV in Head and Neck Tumors: Experience from a National Reference Laboratory. Head Neck Pathol, 9(1), 60-64.
    30. Chengquan Zhao, Zaibo Li, Ritu Nayar, Angelique Levi, Barbara Winkler, Ann T Moriarty, Gliz A Barkan, Jianyu Rao, Fern Miller, Fang Fan, Zhongren Zhou, Qiusheng Si, Andrew H Fischer, Charles D Sturgis, Xin Jing, Carrie B Marshall, Benjamin L Witt, George Birdsong, Barbara A Crothers (Feb 2015). Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Carcinomas Diagnosed in 2012: Results of a Retrosepctive Multicenter Study. Arch Pathol Lab Med, 139(2), 184-188.
    31. Zhao C, Li Z, Nayar R, Levi AW, Winkler BA, Moriarty AT, Barkan GA, Rao J, Miller F, Fan F, Zhou Z, Si Q, Fischer AH, Sturgis CD, Jing X, Marshall CB, Witt BL, Birdsong GG, Crothers BA (2014). Prior high-risk human papillomavirus testing and Papanicolaou test results of 70 invasive cervical carcinomas diagnosed in 2012: results of a retrospective multicenter study. Arch Pathol Lab Med, 139(2), 184-8. (Read full article)
    32. Jedrzkiewicz J, Witt BL (2013). FNA diagnosis of a metastatic papillary thyroid carcinoma arising from a previously unknown follicular variant of papillary thyroid microcarcinoma. Diagn Cytopathol, 42(8), 711-5. (Read full article)
    33. Layfield LJ, Esebua M, Witt BL (July 2014). Cytotechnologist Screening of Fine Needle Aspiration Specimens: Impact on Turnaround Time and Diagnostic Accuracy. Diagn Cytopathol, 42(7), 606-608.
    34. Mukhopadhyay A, Berrett KC, Kc U, Clair PM, Pop SM, Carr SR, Witt BL, Oliver TG (2014). Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer. Cell Rep, 8(1), 40-9. (Read full article)
    35. Witt BL, Garcia CA, Cohen MB (2013). Giant cell tumor of bone presenting in the lumbar spine of a 35-year-old female: cytodiagnosis and other diagnostic considerations. Diagn Cytopathol, 42(7), 624-7. (Read full article)
    36. Chadwick BE, Layfield LJ, Witt BL, Schmidt RL, Cox K, Adler DG (April 2014). Significance of atypia in pancreatic and bile duct brushings: Follow-up analysis of the categories atypical and suspicious for malignancy. Diagn Cytopathol, 42(4), 285-291.
    37. Chadwick BE, Layfield LJ, Witt BL, Schmidt RL, Cox RN, Adler DG (2013). Significance of atypia in pancreatic and bile duct brushings: follow-up analysis of the categories atypical and suspicious for malignancy. Diagn Cytopathol, 42(4), 285-91. (Read full article)
    38. Schmidt RL, Witt BL, Narra K, Factor RE (January 2014). Diagnostic Accuracy Studies of Fine-Needle Aspiration Show Wide Variation in Reporting of Study Population Characteristics: Implications for External Validity. Arch Pathol Lab Med, 138(1), 88-97.
    39. Schmidt RL, Narra KK, Witt BL, Factor RE (2014). Diagnostic accuracy studies of fine-needle aspiration show wide variation in reporting of study population characteristics: implications for external validity. Arch Pathol Lab Med, 138(1), 88-97. (Read full article)
    40. Witt BL, Kristen Hilden RN, Scaife C, Chadwick B, Layfield L, Cory Johnston W, Safaee M, Siddiqui A, Adler DG (2012). Identification of factors predictive of malignancy in patients with atypical biliary brushing results obtained via ERCP. Diagn Cytopathol, 41(8), 682-8. (Read full article)

    Review

    1. Schmidt RL, Jedrzkiewicz JD, Allred RJ, Matsuoka S, Witt BL (2014). Verification bias in diagnostic accuracy studies for fine- and core needle biopsy of salivary gland lesions in otolaryngology journals: a systematic review and analysis. [Review]. Head Neck, 36(11), 1654-61. (Read full article)
    2. Witt BL, Schmidt RL (March 2014). Ultrasound guided core-needle biopsy of salivary gland lesions: A systematic review and meta-analysis. [Review]. Laryngoscope, 124(3), 695-700.
    3. Witt BL, Schmidt RL (2013). Ultrasound-guided core needle biopsy of salivary gland lesions: a systematic review and meta-analysis. [Review]. Laryngoscope, 124(3), 695-700. (Read full article)
    4. Witt BL, Schmidt RL (2013). Rapid onsite evaluation improves the adequacy of fine-needle aspiration for thyroid lesions: a systematic review and meta-analysis. [Review]. Thyroid, 23(4), 428-35. (Read full article)
    5. Schmidt RL, Factor RE, Witt BL, Layfield LJ (2013). Quality appraisal of diagnostic accuracy studies in fine-needle aspiration cytology: a survey of risk of bias and comparability. [Review]. Arch Pathol Lab Med, 137(4), 566-75. (Read full article)
    6. Schmidt RL, Witt BL, Matynia AP, Barraza G, Layfield LJ, Adler DG (2012). Rapid on-site evaluation increases endoscopic ultrasound-guided fine-needle aspiration adequacy for pancreatic lesions. [Review]. Dig Dis Sci, 58(3), 872-82. (Read full article)
    7. Schmidt RL, Witt BL, Lopez-Calderon LE, Layfield LJ (2013). The influence of rapid onsite evaluation on the adequacy rate of fine-needle aspiration cytology: a systematic review and meta-analysis. [Review]. Am J Clin Pathol, 139(3), 300-8. (Read full article)