Aylin R. Rodan,
MD, PhD, FASN
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Languages Spoken: English
Dr. Rodan received her undergraduate degree in Biology from Yale University. She then completed M.D./Ph.D. training in the Medical Scientist Training Program at the University of California San Francisco, followed by Internal Medicine residency at UCSF. She completed a postdoctoral fellowship and nephrology subspecialty training at the University of Texas Southwestern Medical Center, where she remained on faculty for five years prior to coming to the University of Utah. Dr. Rodan is a general nephrologist specializing in disorders of the kidney, electrolytes and high blood pressure. She oversees Nephrology Fellows in training in the outpatient and inpatient settings.
Clinical Locations
Kidney and Liver Clinic
801-585-6320
Fax: (801) 581-7627
Specialties
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Associate Professor Human Genetics - Adjunct Assistant Professor |
| Academic Divisions | Nephrology |
| Board Certification | American Board of Internal Medicine American Board of Internal Medicine (Sub: Nephrology) |
Dr. Rodan received her undergraduate degree in Biology from Yale University. She then completed M.D./Ph.D. training in the Medical Scientist Training Program at the University of California San Francisco, followed by Internal Medicine residency at UCSF. She completed a postdoctoral fellowship and nephrology subspecialty training at the University of Texas Southwestern Medical Center, where she remained on faculty for five years prior to coming to the University of Utah. Dr. Rodan is a general nephrologist specializing in disorders of the kidney, electrolytes and high blood pressure. She oversees Nephrology Fellows in training in the outpatient and inpatient settings.
Academic Locations
Research Statement
Ion transport, the vectorial movement of ions across cell membranes, is a fundamental process that is essential to normal physiology and is perturbed in a variety of disease processes. Epithelial ion transport in the kidney regulates the blood concentration of ions, such as sodium and potassium, and determines extracellular volume and blood pressure. Kidney dysfunction can lead to perturbations in these regulatory processes, resulting in electrolyte disturbances, hypotension, or hypertension.
My laboratory uses the fruit fly Drosophila melanogaster as a model to study ion transport processes relevant to human physiology. One area of focus is the SLC12 family of cation-chloride transporters, such as the potassium-chloride cotransporter and the sodium-potassium-2 chloride cotransporter, and their regulation by WNK and SPAK/OSR1 kinases, which have been implicated in hypertensive disorders in humans. We study these pathways in the fly renal tubule, stroke and circadian rhythm, as well as the role of this and other pathways in salt sensitivity. Our goal is to understand these transporters and their regulation in greater mechanistic detail, identify new regulatory factors, and translate these insights into improved understanding of ion transport processes in health and disease.
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Associate Professor Human Genetics - Adjunct Assistant Professor |
| Academic Divisions | Nephrology |
| Board Certification | American Board of Internal Medicine American Board of Internal Medicine (Sub: Nephrology) |
Research Interests
- Ion Transport
- Renal Physiology
- Hypertension
- Protein-Serine-Threonine Kinases
- Drosophila melanogaster
- Malpighian Tubules
- Sodium-Potassium-Chloride Symporters
- Potassium Channels
- Potassium Homeostasis
- Osmoregulation
- Water-Electrolyte Balance
- Stroke
- Circadian Rhythm
- Alcohol & Drug Abuse
Education History
| Research Fellow | University of Texas Southwestern Medical Center NIH/NIDDK Nephrology T32 Training Program Postdoctoral Research Fellow, 2011 |
| Fellowship | University of Texas Southwestern Medical Center Nephrology Fellow, 2011 |
| Postdoctoral Fellowship | University of Texas Southwestern Medical Center Genetics Postdoctoral Fellow, 2008 |
| Residency | University of California, San Francisco Internal Medicine Resident, 2007 |
| Professional Medical | University of California, San Francisco Medicine/Medical Scientist Training Program M.D., 2004 |
| Doctoral Training | University of California, San Francisco Genetics/Medical Scientist Training Program Ph.D., 2002 |
| Undergraduate | Yale University Biology B.S., 1995 |
Selected Publications - Journal Articles
Journal Article
- Jonusaite S, Rodan AR (2021). Molecular basis for epithelial morphogenesis and ion transport in the Malpighian tubule. Curr Opin Insect Sci, 47, 7-11.
- Hyndman KA, Isaeva E, Palygin O, Mendoza LD, Rodan AR, Staruschenko A, Pollock JS (2021). Role of collecting duct principal cell NOS1β in sodium and potassium homeostasis. Physiol Rep, 9(20), e15080.
- Al-Rabadi LF, Caza T, Trivin-Avillach C, Rodan AR, Andeen N, Hayashi N, Williams B, Revelo MP, Clayton F, Abraham J, Lin E, Liou W, Zou CJ, Ramkumar N, Cummins T, Wilkey DW, Kawalit I, Herzog C, Storey A, Edmondson R, Sjoberg R, Yang T, Chien J, Merchant M, Arthur J, Klein J, Larsen C, Beck LH Jr (2021). Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy. (Epub ahead of print) J Am Soc Nephrol.
- Pleinis JM, Norrell L, Akella R, Humphreys JM, He H, Sun Q, Zhang F, Sosa-Pagan J, Morrison DE, Schellinger JN, Jackson LK, Goldsmith EJ, Rodan AR (2021). WNKs are potassium-sensitive kinases. Am J Physiol Cell Physiol, 320(5), C703-C721.
- Mishra P, Yang SE, Montgomery AB, Reed AR, Rodan AR, Rothenfluh A (2021). The fly liquid-food electroshock assay (FLEA) suggests opposite roles for neuropeptide F in avoidance of bitterness and shock. BMC Biol, 19(1), 31.
- Talsness DM, Owings KG, Coelho E, Mercenne G, Pleinis JM, Partha R, Hope KA, Zuberi AR, Clark NL, Lutz CM, Rodan AR, Chow CY (2020). A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency. eLife, 9.
- Beyenbach KW, Schne F, Breitsprecher LF, Tiburcy F, Furuse M, Izumi Y, Meyer H, Jonusaite S, Rodan AR, Paululat A (2020). The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster. Am J Physiol Cell Physiol, 318(6), C1107-C1122.
- Jonusaite S, Beyenbach KW, Meyer H, Paululat A, Izumi Y, Furuse M, Rodan AR (2020). The septate junction protein Mesh is required for epithelial morphogenesis, ion transport, and paracellular permeability in the Drosophila Malpighian tubule. Am J Physiol Cell Physiol, 318(3), C675-C694.
- Butts AR, Ojelade SA, Pronovost ED, Seguin A, Merrill CB, Rodan AR, Rothenfluh A (2019). Altered Actin Filament Dynamics in the Drosophila Mushroom Bodies Lead to Fast Acquisition of Alcohol Consumption Preference. J Neurosci, 39(45), 8877-8884.
- Rodan AR (2019). The Drosophila Malpighian tubule as a model for mammalian tubule function. Curr Opin Nephrol Hypertens, 28(5), 455-464.
- Rodan AR (2019). Intracellular chloride: a regulator of transepithelial transport in the distal nephron. Curr Opin Nephrol Hypertens, 28(4), 360-367.
- Lakshmipathi J, Wheatley W, Kumar A, Mercenne G, Rodan AR, Kohan DE (2019). Identification of NFAT5 as a transcriptional regulator of the EDN1 gene in collecting duct. Am J Physiol Renal Physiol, 316(3), F481-F487.
- Stenesen D, Moehlman AT, Schellinger JN, Rodan AR, Krmer H (2019). The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system. Sci Rep, 9(1), 2475.
- Rodan AR (2018). WNK-SPAK/OSR1 signaling: lessons learned from an insect renal epithelium. Am J Physiol Renal Physiol, 315(4), F903-F907.
- Sun Q, Wu Y, Jonusaite S, Pleinis JM, Humphreys JM, He H, Schellinger JN, Akella R, Stenesen D, Krmer H, Goldsmith EJ, Rodan AR (2018). Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule. J Am Soc Nephrol, 29(5), 1449-1461.
- Gonzalez DA, Jia T, Pinzon JH, Acevedo SF, Ojelade SA, Xu B, Tay N, Desrivieres S, Hernandez JL, Banaschewski T, Buchel C, Bokde ALW, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Martinot JL, Paus T, Smolka MN, Rodan AR, Schumann G, Rothenfluh A (2018). The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. Mol Psychiatry, 23(3), 621-628.
- Shalaby NA, Pinzon JH, Narayanan AS, Jin EJ, Ritz MP, Dove RJ, Wolfenberg H, Rodan AR, Buszczak M, Rothenfluh A (2018). JmjC domain proteins modulate circadian behaviors and sleep in Drosophila. Sci Rep, 8(1), 815.
- Pinzn JH, Reed AR, Shalaby NA, Buszczak M, Rodan AR, Rothenfluh A (2017). Alcohol-Induced Behaviors Require a Subset of Drosophila JmjC-Domain Histone Demethylases in the Nervous System. Alcohol Clin Exp Res, 41(12), 2015-2024.
- Cheng CJ, Rodan AR, Huang CL (2017). Emerging Targets of Diuretic Therapy. Clin Pharmacol Ther, 102(3), 420-435.
- Rodan AR (2017). Potassium: friend or foe? Pediatr Nephrol, 32(7), 1109-1121.
- Mahajan A, Rodan AR, Le TH, Gaulton KJ, Haessler J, Stilp AM, Kamatani Y, Zhu G, Sofer T, Puri S, Schellinger JN, Chu PL, Cechova S, van Zuydam N, SUMMIT Consortium, BioBank Japan Project, Arnlov J, Flessner MF, Giedraitis V, Heath AC, Kubo M, Larsson A, Lindgren CM, Madden PAF, Montgomery GW, Papanicolaou GJ, Reiner AP, Sundstrm J, Thornton TA, Lind L, Ingelsson E, Cai J, Martin NG, Kooperberg C, Matsuda K, Whitfield JB, Okada Y, Laurie CC, Morris AP, Franceschini N (2016). Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity. Am J Hum Genet, 99(3), 636-646.
- Schellinger JN, Rodan AR (2015). Use of the Ramsay Assay to Measure Fluid Secretion and Ion Flux Rates in the Drosophila melanogaster Malpighian Tubule. J Vis Exp, (105).
- Acevedo SF, Peru y Coln de Portugal RL, Gonzalez DA, Rodan AR, Rothenfluh A (2015). S6 Kinase Reflects and Regulates Ethanol-Induced Sedation. J Neurosci, 35(46), 15396-402.
- Wu Y, Baum M, Huang CL, Rodan AR (2015). Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function. Am J Physiol Regul Integr Comp Physiol, 309(7), R747-56.
- Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A, Ruggeri B, Charoen P, Lemaitre H, Banaschewski T, Bchel C, Bokde AL, Carvalho F, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lubbe S, Martinot JL, Paus T, Smolka MN, Spanagel R, OReilly PF, Laitinen J, Veijola JM, Feng J, Desrivires S, Jarvelin MR, IMAGEN Consortium, Schumann G, Rothenfluh A (2015). Rsu1 regulates ethanol consumption in Drosophila and humans. Proc Natl Acad Sci U S A, 112(30), E4085-93.
- Ojelade SA, Acevedo SF, Kalahasti G, Rodan AR, Rothenfluh A (2015). RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin. PLoS ONE, 10(9), e0137465.
- Wu Y, Schellinger JN, Huang CL, Rodan AR (2014). Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. J Biol Chem, 289(38), 26131-26142.
- Chirinos JC, Neyra JA, Patel J, Rodan AR (2014). Hemodialysis catheter insertion: is increased PO2 a sign of arterial cannulation? A case report. BMC Nephrol, 15, 127.
- Peru Y Coln de Portugal RL, Ojelade SA, Penninti PS, Dove RJ, Nye MJ, Acevedo SF, Lopez A, Rodan AR, Rothenfluh A (2014). Long-lasting, experience-dependent alcohol preference in Drosophila. Addict Biol, 19(3), 392-401.
- Peru Y Coln de Portugal RL, Acevedo SF, Rodan AR, Chang LY, Eaton BA, Rothenfluh A (2012). Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B. J Neurosci, 32(49), 17706-13.
- Rodan AR, Baum M, Huang CL (2012). The Drosophila NKCC Ncc69 is required for normal renal tubule function. Am J Physiol Cell Physiol, 303(8), C883-94.
- Rodan AR, Cheng CJ, Huang CL (2011). Recent advances in distal tubular potassium handling. Am J Physiol Renal Physiol, 300(4), F821-7.
- Rodan AR, Rothenfluh A (2010). The genetics of behavioral alcohol responses in Drosophila. Int Rev Neurobiol, 91, 25-51.
- Rodan AR, Huang CL (2009). Distal potassium handling based on flow modulation of maxi-K channel activity. Curr Opin Nephrol Hypertens, 18(4), 350-5.
- Corl AB, Rodan AR, Heberlein U (2005). Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci, 8(1), 18-9.
- Wolf FW, Rodan AR, Tsai LT, Heberlein U (2002). High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila. J Neurosci, 22(24), 11035-44.
- Rodan AR, Kiger JA Jr, Heberlein U (2002). Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila. J Neurosci, 22(21), 9490-501.
- Cheng Y, Endo K, Wu K, Rodan AR, Heberlein U, Davis RL (2001). Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol. Cell, 105(6), 757-68.
- Lin K, Dorman JB, Rodan A, Kenyon C (1997). daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science, 278(5341), 1319-22.
- Rodan AR, Simons JF, Trombetta ES, Helenius A (1996). N-linked oligosaccharides are necessary and sufficient for association of glycosylated forms of bovine RNase with calnexin and calreticulin. EMBO J, 15(24), 6921-30.
Book Chapter
- Rodan AR and Jenny A (2017). WNK kinases in development and disease. In Jenny A (Ed.), Protein Kinases in Development and Disease, Curr Topics Dev Biol (123, pp. 1-47). Burlington: Academic Press.
Commentary
- Rodan GA, Rodan AR (2005). The family of osteoblast transcription factors is growing. BoneKEy - Osteovision, 2, 12-15.