Aylin R. Rodan,
MD, PhD, FASN
Languages Spoken: English
Dr. Rodan received her undergraduate degree in Biology from Yale University. She then completed M.D./Ph.D. training in the Medical Scientist Training Program at the University of California San Francisco, followed by Internal Medicine residency at UCSF. She completed a postdoctoral fellowship and nephrology subspecialty training at the University of Texas Southwestern Medical Center, where she remained on faculty for five years prior to coming to the University of Utah. Dr. Rodan is a general nephrologist specializing in disorders of the kidney, electrolytes and high blood pressure. She oversees Nephrology Fellows in training in the outpatient and inpatient settings.
Specialties
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Assistant Professor Human Genetics - Adjunct Assistant Professor |
| Academic Divisions | Nephrology |
| Board Certification | American Board of Internal Medicine American Board of Internal Medicine (Sub: Nephrology) |
Academic biography
Dr. Rodan received her undergraduate degree in Biology from Yale University, where she studied mechanisms of unfolded protein recognition in the endoplasmic reticulum. She then completed M.D./Ph.D. training in the Medical Scientist Training Program at the University of California San Francisco. Her Ph.D. research focused on use of the fly, Drosophila melanogaster, to understand the molecular and cellular mechanisms mediating behavioral changes to alcohol. She then completed Internal Medicine residency at UCSF, followed by clinical nephrology subspecialty training and postdoctoral fellowships in renal physiology and Drosophila genetics at the University of Texas Southwestern Medical Center, where she remained on faculty for five years prior to coming to the University of Utah. The primary focus of Dr. Rodan’s research is understanding signaling cascades regulating ion transport processes, particularly in the kidney, but also in other settings such as stroke. Dr. Rodan uses genetic techniques in Drosophila melanogaster to understand the molecular basis of ion transport physiology relevant to human physiology and pathophysiology, including electrolyte disorders and high blood pressure. She teaches high school, undergraduate, medical and graduate students, and medical residents and nephrology fellows, with a focus on renal physiology.
Academic Locations
Ezekiel R & Edna Dumke Building
801-585-5215
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Assistant Professor Human Genetics - Adjunct Assistant Professor |
| Academic Divisions | Nephrology |
| Board Certification | American Board of Internal Medicine American Board of Internal Medicine (Sub: Nephrology) |
Research Interests
- Ion Transport
- Renal Physiology
- Hypertension
- Protein-Serine-Threonine Kinases
- Drosophila melanogaster
- Malpighian Tubules
- Sodium-Potassium-Chloride Symporters
- Potassium Homeostasis
- Osmoregulation
- Water-Electrolyte Balance
- Stroke
- Circadian Rhythm
Education History
| Research Fellow | University of Texas Southwestern Medical Center NIH/NIDDK Nephrology T32 Training Program Postdoctoral Research Fellow |
| Fellowship | University of Texas Southwestern Medical Center Nephrology Fellow |
| Postdoctoral Fellowship | University of Texas Southwestern Medical Center Genetics Postdoctoral Fellow |
| Residency | University of California, San Francisco Internal Medicine Resident |
| Professional Medical | University of California, San Francisco Medicine/Medical Scientist Training Program M.D. |
| Doctoral Training | University of California, San Francisco Genetics/Medical Scientist Training Program Ph.D. |
| Undergraduate | Yale University Biology B.S. |
Publications - Journal Articles
Journal Article
- Mahajan A, Rodan AR, Le TH, Gaulton KJ, Haessler J, Stilp AM, Kamatani Y, Zhu G, Sofer T, Puri S, Schellinger JN, Chu PL, Cechova S, van Zuydam N, Arnlov J, Flessner MF, Giedraitis V, Heath AC, Kubo M, Larsson A, Lindgren CM, Madden PA, Montgomery GW, Papanicolaou GJ, Reiner AP, Sundstrom J, Thornton TA, Lind L, Ingelsson E, Cai J, Martin NG, Kooperberg C, Matsuda K, Whitfield JB, Okada Y, Laurie CC, Morris AP, Franceschini N (2016). Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity. Am J Hum Genet, 99(3), 636-46.
- Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A, Ruggeri B, Charoen P, Lemaitre H, Banaschewski T, Buchel C, Bokde AL, Carvalho F, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lubbe S, Martinot JL, Paus T, Smolka MN, Spanagel R, OReilly PF, Laitinen J, Veijola JM, Feng J, Desrivieres S, Jarvelin MR, Schumann G, Rothenfluh A (2015). Rsu1 regulates ethanol consumption in Drosophila and humans. Proc Natl Acad Sci U S A, 112(30), E4085-93.
- Wu Y, Baum M, Huang CL, Rodan AR (2015). Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function. Am J Physiol Regul Integr Comp Physiol, 309(7), R747-56.
- Ojelade SA, Acevedo SF, Kalahasti G, Rodan AR, Rothenfluh A (2015). RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin. PLoS One, 10(9), e0137465.
- Acevedo SF, Peru y Colon de Portugal RL, Gonzalez DA, Rodan AR, Rothenfluh A (2015). S6 Kinase Reflects and Regulates Ethanol-Induced Sedation. J Neurosci, 35(46), 15396-402.
- Schellinger JN, Rodan AR (2015). Use of the Ramsay Assay to Measure Fluid Secretion and Ion Flux Rates in the Drosophila melanogaster Malpighian Tubule.LID - 10.3791/53144 [doi]. J Vis Exp, (105).
- Peru Y Colon de Portugal RL, Ojelade SA, Penninti PS, Dove RJ, Nye MJ, Acevedo SF, Lopez A, Rodan AR, Rothenfluh A (2014). Long-lasting, experience-dependent alcohol preference in Drosophila. Addict Biol, 19(3), 392-401.
- Wu Y, Schellinger JN, Huang CL, Rodan AR (2014). Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. J Biol Chem, 289(38), 26131-42.
- Rodan AR, Baum M, Huang CL (2012). The Drosophila NKCC Ncc69 is required for normal renal tubule function. Am J Physiol Cell Physiol, 303(8), C883-94.
- Peru Y Colon de Portugal RL, Acevedo SF, Rodan AR, Chang LY, Eaton BA, Rothenfluh A (2012). Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B. J Neurosci, 32(49), 17706-13.
- Corl AB, Rodan AR, Heberlein U (2005). Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci, 8(1), 18-9.
- Rodan AR, Kiger JA Jr, Heberlein U (2002). Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila. J Neurosci, 22(21), 9490-501.
- Wolf FW, Rodan AR, Tsai LT, Heberlein U (2002). High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila. J Neurosci, 22(24), 11035-44.
- Cheng Y, Endo K, Wu K, Rodan AR, Heberlein U, Davis RL (2001). Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol. Cell, 105(6), 757-68.
- Lin K, Dorman JB, Rodan A, Kenyon C (1997). daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science, 278(5341), 1319-22.
- Rodan AR, Simons JF, Trombetta ES, Helenius A (1996). N-linked oligosaccharides are necessary and sufficient for association of glycosylated forms of bovine RNase with calnexin and calreticulin. EMBO J, 15(24), 6921-30.
Review
- Cheng CJ, Rodan AR, Huang CL (2017). Emerging Targets of Diuretic Therapy.LID - 10.1002/cpt.754 [doi]. [Review]. Clinical Pharmacology and Therapeutics.
- Rodan AR (2017). Potassium: friend or foe? [Review]. Pediatr Nephrol, 32(7), 1109-1121.
- Rodan AR, Cheng CJ, Huang CL (2011). Recent advances in distal tubular potassium handling. [Review]. Am J Physiol Renal Physiol, 300(4), F821-7.
- Rodan AR, Rothenfluh A (2010). The genetics of behavioral alcohol responses in Drosophila. [Review]. Int Rev Neurobiol, 91, 25-51.
- Rodan AR, Huang CL (2009). Distal potassium handling based on flow modulation of maxi-K channel activity. [Review]. Curr Opin Nephrol Hypertens, 18(4), 350-5.
Book Chapter
- Rodan AR and Jenny A (2017). WNK kinases in development and disease. In Jenny A (Ed.), Protein Kinases in Development and Disease, Curr Topics Dev Biol (123, pp. 1-47). Burlington: Academic Press.
Commentary
- Rodan GA, Rodan AR (2005). The family of osteoblast transcription factors is growing. BoneKEy - Osteovision, 2, 12-15.
Case Report
- Neyra JA, Rocha NA, Bhargava R, Vaidya OU, Hendricks AR, Rodan AR (2015). Rhabdomyolysis-induced acute kidney injury in a cancer patient exposed to denosumab and abiraterone: a case report. BMC Nephrol, 16, 118.
- Chirinos JC, Neyra JA, Patel J, Rodan AR (2014). Hemodialysis catheter insertion: is increased PO2 a sign of arterial cannulation? A case report. BMC Nephrol, 15, 127.