Qinwen Mao,
MD, PhD

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Languages Spoken: English
Specialties
Board Certification and Academic Information
Academic Departments | Pathology
-
Professor (Clinical) |
Academic Divisions | Anatomic Pathology |
Board Certification | American Board of Pathology (Sub: Anatomic Path) American Board of Pathology (Sub: Neuropathology) |
Academic Locations
Huntsman Cancer Hospital
801-587-7000
Board Certification and Academic Information
Academic Departments | Pathology
-
Professor (Clinical) |
Academic Divisions | Anatomic Pathology |
Board Certification | American Board of Pathology (Sub: Anatomic Path) American Board of Pathology (Sub: Neuropathology) |
Education History
Fellowship | University of Texas Southwestern Medical School Neuropathology Clinical Fellow |
Residency | University of Texas Southwestern Medical School Anatomic Pathology Resident |
Postdoctoral Fellowship | University of Iowa Carver College of Medicine Gene Therapy for Neurodegenerative Diseases Postdoctoral Fellow |
Professional Medical | Fourth Military Medical University Physiology Ph.D. |
Graduate Training | Fourth Military Medical University Histology M.S. |
Professional Medical | Fourth Military Medical University Medicine M.D. |
Selected Publications - Journal Articles
Journal Article
- Kam KL, Appin CL, Mao Q, Ikegami S, Lukas RV, Nikiforova MN, Roy S, Brat DJ, Horbinski C (2020). Is Next-Generation Sequencing Alone Sufficient to Reliably Diagnose Gliomas? J Neuropathol Exp Neurol, 79(7), 763-766.
- McCord MR, Bigio EH, Kam KL, Fischer V, Obeidin F, White CL, Brat DJ, Muller WA, Mao Q (2019). Spinocerebellar Ataxia Type 3: A Case Report and Literature Review. J Neuropathol Exp Neurol, 79(6), 641-646.
- Li Y, Li S, Li Y, Xia H, Mao Q (2019). Generation of a novel HEK293 luciferase reporter cell line by CRISPR/Cas9-mediated site-specific integration in the genome to explore the transcriptional regulation of the PGRN gene. Bioengineered, 10(1), 98-107.
- Zhu J, Wang N, Li X, Zheng X, Zhao J, Xia H, Mao Q (2019). Suppression of Progranulin Expression Leads to Formation of Intranuclear TDP-43 Inclusions In Vitro: A Cell Model of Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol, 78(12), 1124-1129.
- Zhang J, Zhao J, Mao Q, Xia H (2019). A simple, efficient and economical method for isolating and culturing human umbilical cord blood‑derived mesenchymal stromal cells. Mol Med Rep, 20(6), 5257-5264.
- Jara JH, Gautam M, Kocak N, Xie EF, Mao Q, Bigio EH, zdinler PH (2019). MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology. J Neuroinflammation, 16(1), 196.
- Maniar KP, Arva N, Blanco LZ Jr, Mao Q, Morency EG, Rodriguez R, Wolniak K, Yaseen NR, Nayar R (2019). Accreditation Council for Graduate Medical Education Self-Study for Pathology: One Institution's Experience and Lessons Learned. Arch Pathol Lab Med, 143(10), 1271-1277.
- Mao Q, Zheng X, Gefen T, Rogalski E, Spencer CL, Rademakers R, Fought AJ, Kohler M, Weintraub S, Xia H, Mesulam MM, Bigio EH (2019). FTLD-TDP With and Without GRN Mutations Cause Different Patterns of CA1 Pathology. J Neuropathol Exp Neurol, 78(9), 844-853.
- Zhang D, Kim SSR, Kelly DF, Asa SL, Movassaghi M, Mareninov S, Yong WH, Cloughesy TF, Rodriguez FJ, McKeever P, Qian J, Li JY, Mao Q, Newell KL, Green RM, Welsh CT, Xiong Z, Heaney AP (2018). Somatostatin Receptor Ligand Therapy-A Potential Therapy for Neurocytoma. J Clin Endocrinol Metab, 104(6), 2395-2402.
- Apple AC, Mao Q, Bigio E, Bonakdarpour B (2019). Sleep talking and primary progressive aphasia: case study and autopsy findings in a patient with logopenic primary progressive aphasia and dementia with Lewy bodies. BMJ Case Rep, 12(5).
- Rogalski E, Gefen T, Mao Q, Connelly M, Weintraub S, Geula C, Bigio EH, Mesulam MM (2018). Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first 10 cases. Hippocampus, 29(5), 458-467.
- Li Y, Wang D, Li Y, Zhu J, Zhao J, Deng Y, Rogalski EJ, Bigio EH, Rademaker AW, Xia H, Mao Q (2019). A Highly Sensitive Sandwich ELISA to Detect CSF Progranulin: A Potential Biomarker for CNS Disorders. J Neuropathol Exp Neurol, 78(5), 406-415.
- Shan L, Wang D, Mao Q, Xia H (2018). Establishment of a DGKθ Endogenous Promoter Luciferase Reporter HepG2 Cell Line for Studying the Transcriptional Regulation of DGKθ Gene. Appl Biochem Biotechnol, 187(4), 1344-1355.
- Hojat A, Wei B, Olson MG, Mao Q, Yong WH (2018). Procurement and Storage of Surgical Biospecimens. Methods Mol Biol, 1897, 65-76.
- Chen H, Li Y, Du C, Li Y, Zhao J, Zheng X, Mao Q, Xia H (2018). Aptazyme-mediated direct modulation of post-transcriptional sgRNA level for conditional genome editing and gene expression. J Biotechnol, 288, 23-29.
- Li Y, Zhang W, Zhao J, Li S, Shan L, Zhu J, Li Y, Zhu H, Mao Q, Xia H (2018). Establishing a dual knock-out cell line by lentivirus based combined CRISPR/Cas9 and Loxp/Cre system. Cytotechnology, 70(6), 1595-1605.
- Li Z, Zhao J, Muhammad N, Wang D, Mao Q, Xia H (2018). Establishment of a HEK293 cell line by CRISPR/Cas9-mediated luciferase knock-in to study transcriptional regulation of the human SREBP1 gene. Biotechnol Lett, 40(11-12), 1495-1506.
- Gefen T, Ahmadian SS, Mao Q, Kim G, Seckin M, Bonakdarpour B, Ramos EM, Coppola G, Rademakers R, Rogalski E, Rademaker A, Weintraub S, Mesulam MM, Geula C, Bigio EH (2018). Combined Pathologies in FTLD-TDP Types A and C. J Neuropathol Exp Neurol, 77(5), 405-412.
- Zhang J, Zhao J, Zheng X, Cai K, Mao Q, Xia H (2017). Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout. Mol Med Rep, 17(2), 2169-2176.
- Huang QQ, Birkett R, Doyle R, Shi B, Roberts EL, Mao Q, Pope RM (2017). The Role of Macrophages in the Response to TNF Inhibition in Experimental Arthritis. J Immunol, 200(1), 130-138.
- Zhang W, Xiao D, Shan L, Zhao J, Mao Q, Xia H (2017). Generation of apoptosis-resistant HEK293 cells with CRISPR/Cas mediated quadruple gene knockout for improved protein and virus production. Biotechnol Bioeng, 114(11), 2539-2549.
- Mao Q, Wang D, Li Y, Kohler M, Wilson J, Parton Z, Shmaltsuyeva B, Gursel D, Rademakers R, Weintraub S, Mesulam MM, Xia H, Bigio EH (2017). Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol, 76(11), 957-968.
- Muhammad N, Mao Q, Xia H (2018). CAR T-cells for cancer therapy. Biotechnol Genet Eng Rev, 33(2), 190-226.
- Chen F, Li Y, Zhao J, Mao Q, Xia H (2016). Domain-Specific Monoclonal Antibodies Against Human Rev-erbβ. Appl Biochem Biotechnol, 182(3), 978-989.
- Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobgyi T, Ironside JW, King A, Kofler J, Kvari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ (2017). Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). J Neuropathol Exp Neurol, 76(7), 605-619.
- Li Y, Li Y, Ye M, Wang D, Zhao J, Sun X, Mao Q, Xia H (2016). Biological function analysis of monoclonal antibodies against human granulins in vitro using U251 cells as a model. Protein Expr Purif, 130, 55-62.
- Hakar M, Chandler JP, Bigio EH, Mao Q (2016). Neuroendocrine carcinoma of the pineal parenchyma. The first reported case. J Clin Neurosci, 35, 68-70.
- Li Y, Li Y, Zhao J, Zheng X, Mao Q, Xia H (2016). Development of a Sensitive Luciferase-Based Sandwich ELISA System for the Detection of Human Extracellular Matrix 1 Protein. Monoclon Antib Immunodiagn Immunother, 35(6), 273-279.
- Dai X, Li Y, Sun X, Cai K, Mao Q, Xia H (2016). Generation of Domain-Specific Monoclonal Antibodies Against Human Glutaredoxin3. Monoclon Antib Immunodiagn Immunother, 35(6), 285-292.
- Ampie L, Choy W, DiDomenico JD, Lamano JB, Williams CK, Kesavabhotla K, Mao Q, Bloch O (2016). Clinical attributes and surgical outcomes of angiocentric gliomas. J Clin Neurosci, 28, 117-22.
- Li Y, Li Y, Zhao J, Wang D, Mao Q, Xia H (2016). Production and characterization of domain-specific monoclonal antibodies against human ECM1. Protein Expr Purif, 121, 103-11.
- Zheng X, Li Y, Zhao J, Wang D, Xia H, Mao Q (2016). Production and Characterization of Monoclonal Antibodies against Human Nuclear Protein FAM76B. PLoS ONE, 11(3), e0152237.
- Xiao D, Zhang W, Li Y, Liu K, Zhao J, Sun X, Shan L, Mao Q, Xia H (2015). A novel luciferase knock-in reporter system for studying transcriptional regulation of the human Sox2 gene. J Biotechnol, 219, 110-6.
- Choy W, Ampie L, Lamano JB, Kesavabhotla K, Mao Q, Parsa AT, Bloch O (2015). Predictors of recurrence in the management of chordoid meningioma. J Neurooncol, 126(1), 107-116.
- Choy W, Ampie L, Lamano JB, Kesavabhotla K, Mao Q, Parsa AT, Bloch O (2015). Erratum to: Predictors of recurrence in the management of chordoid meningioma. J Neurooncol, 126(1), 117.
- Ampie L, Choy W, Lamano JB, Kesavabhotla K, Mao Q, Parsa AT, Bloch O (2015). Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature. Clin Neurol Neurosurg, 138, 129-36.
- Wang D, Guo Y, Li Y, Li W, Zheng X, Xia H, Mao Q (2015). Detection of CD133 expression in U87 glioblastoma cells using a novel anti-CD133 monoclonal antibody. Oncol Lett, 9(6), 2603-2608.
- Gu J, Yang T, Xing X, Kuang Y, Cheng G, Zhang J, Huang Y, Zhang B, Dong L, Mao Q (2015). A dorsally located giant posterior fossa neurenteric cyst in a Chinese woman. J Clin Neurosci, 22(5), 917-8.
- Chen H, Wang D, Xia R, Mao Q, Xia H (2015). A novel adenoviral vector carrying an all-in-one Tet-On system with an autoregulatory loop for tight, inducible transgene expression. BMC Biotechnol, 15, 4.
- Zhang W, Chen H, Zheng X, Wang D, Ji H, Xia H, Mao Q (2014). Targeted genome correction by a single adenoviral vector simultaneously carrying an inducible zinc finger nuclease and a donor template. J Biotechnol, 188, 1-6.
- Lall RR, Lall RR, Smith TR, Lee KH, Mao Q, Kalapurakal JA, Marymont MH, Chandler JP (2013). Delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery. J Clin Neurosci, 21(7), 1225-8.
- Wang D, Li W, Zhang H, Mao Q, Xia H (2014). A targeting peptide improves adenovirus-mediated transduction of a glioblastoma cell line. Oncol Rep, 31(5), 2093-8.
- Zhang W, Wang D, Liu S, Zheng X, Ji H, Xia H, Mao Q (2014). Multiple copies of a linear donor fragment released in situ from a vector improve the efficiency of zinc-finger nuclease-mediated genome editing. Gene Ther, 21(3), 282-8.
- Chen H, Zheng X, Di B, Wang D, Zhang Y, Xia H, Mao Q (2014). Aptamer modification improves the adenoviral transduction of malignant glioma cells. J Biotechnol, 168(4), 362-6.
- Li X, Xia R, Zhao J, Wang D, Mao Q, Xia H (2013). A one-step ligation system for rapid generation of armed, conditionally-replicating adenoviruses. Biotechnol Lett, 35(8), 1215-21.
- Bigio EH, Weintraub S, Rademakers R, Baker M, Ahmadian SS, Rademaker A, Weitner BB, Mao Q, Lee KH, Mishra M, Ganti RA, Mesulam MM (2012). Frontotemporal lobar degeneration with TDP-43 proteinopathy and chromosome 9p repeat expansion in C9ORF72: clinicopathologic correlation. Neuropathology, 33(2), 122-33.
- Lee KH, Lall RR, Chandler JP, Bigio EH, Mao Q (2012). Pineal chordoid meningioma complicated by repetitive hemorrhage during pregnancy: case report and literature review. Neuropathology, 33(2), 192-8.
- Zhang W, Zheng X, Wang Y, Mao Q, Xia H (2012). Establishment of a cell line carrying single copy of an exogenous mutant reporter gene for assaying the biological activity of ZFNs. J Biotechnol, 162(2-3), 191-6.
- Li X, Mao Q, Wang D, Xia H (2012). A novel Ad5/11 chimeric oncolytic adenovirus for improved glioma therapy. Int J Oncol, 41(6), 2159-65.
- Li X, Mao Q, Wang D, Zhang W, Xia H (2012). A fiber chimeric CRAd vector Ad5/11-D24 double-armed with TRAIL and arresten for enhanced glioblastoma therapy. Hum Gene Ther, 23(6), 589-96.
- Chai L, Liu S, Mao Q, Wang D, Li X, Zheng X, Xia H (2011). A novel conditionally replicating adenoviral vector with dual expression of IL-24 and arresten inserted in E1 and the region between E4 and fiber for improved melanoma therapy. Cancer Gene Ther, 19(4), 247-54.
- Di B, Mao Q, Zhao J, Li X, Wang D, Xia H (2011). A rapid generation of adenovirus vector with a genetic modification in hexon protein. J Biotechnol, 157(3), 373-8.
- Zhang W, Guo Y, Zhang C, Ji H, Meng W, Wang D, Li X, Mao Q, Xia H (2012). Rescue the failed half-ZFN by a sensitive mammalian cell-based luciferase reporter system. PLoS ONE, 7(9), e45169.
- Zheng X, Mao Q, Wang D, Zhao J, Xia H (2011). A novel system for rapid screening of effective siRNA target sites by one step transfection with a single vector. J Biotechnol, 155(2), 135-9.
- Chai L, Mao Q, Liu S, Xia H (2011). Domain-specific monoclonal antibodies produced against human PGRN. Hybridoma (Larchmt), 30(3), 271-8.
- Wang D, Liu S, Mao Q, Zhao J, Xia H (2011). A novel vector for a rapid generation of fiber-mutant adenovirus based on one step ligation and quick screening of positive clones. J Biotechnol, 152(3), 72-6.
- Liu S, Mao Q, Zhang W, Zheng X, Bian Y, Wang D, Li H, Chai L, Zhao J, Xia H (2008). Genetically modified adenoviral vector with the protein transduction domain of Tat improves gene transfer to CAR-deficient cells. Biosci Rep, 29(2), 103-9.
- Eliason SL, Stein CS, Mao Q, Tecedor L, Ding SL, Gaines DM, Davidson BL (2007). A knock-in reporter model of Batten disease. J Neurosci, 27(37), 9826-34.
- Passini MA, Dodge JC, Bu J, Yang W, Zhao Q, Sondhi D, Hackett NR, Kaminsky SM, Mao Q, Shihabuddin LS, Cheng SH, Sleat DE, Stewart GR, Davidson BL, Lobel P, Crystal RG (2006). Intracranial delivery of CLN2 reduces brain pathology in a mouse model of classical late infantile neuronal ceroid lipofuscinosis. J Neurosci, 26(5), 1334-42.
- Orii KO, Grubb JH, Vogler C, Levy B, Tan Y, Markova K, Davidson BL, Mao Q, Orii T, Kondo N, Sly WS (2004). Defining the pathway for Tat-mediated delivery of beta-glucuronidase in cultured cells and MPS VII mice. Mol Ther, 12(2), 345-52.
- Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL (2005). RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc Natl Acad Sci U S A, 102(16), 5820-5.
- Sleat DE, Wiseman JA, El-Banna M, Kim KH, Mao Q, Price S, Macauley SL, Sidman RL, Shen MM, Zhao Q, Passini MA, Davidson BL, Stewart GR, Lobel P (2004). A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration. J Neurosci, 24(41), 9117-26.
- Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, Paulson HL, Yang L, Kotin RM, Davidson BL (2004). RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med, 10(8), 816-20.
- Mao Q, Xia H, Davidson BL (2003). Intracellular trafficking of CLN3, the protein underlying the childhood neurodegenerative disease, Batten disease. FEBS Lett, 555(2), 351-7.
- Kim M, Mao Q, Davidson BL, Wiemer DF (2003). Tripeptide probes for tripeptidyl protease I production via gene transfer. J Med Chem, 46(9), 1603-8.
- Mao Q, Foster BJ, Xia H, Davidson BL (2003). Membrane topology of CLN3, the protein underlying Batten disease. FEBS Lett, 541(1-3), 40-6.
- Xia H, Mao Q, Paulson HL, Davidson BL (2002). siRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol, 20(10), 1006-10.
- Xia H, Mao Q, Davidson BL (2001). The HIV Tat protein transduction domain improves the biodistribution of beta-glucuronidase expressed from recombinant viral vectors. Nat Biotechnol, 19(7), 640-4.
- Zhang LF, Yu ZB, Ma J, Mao QW (2001). Peripheral effector mechanism hypothesis of postflight cardiovascular dysfunction. Aviat Space Environ Med, 72(6), 567-75.
- Zhang LF, Yu ZB, Ma J, Mao QW (2003). [Peripheral effector mechanism hypothesis on cardiovascular dysfunction after spaceflight]. Sheng Li Ke Xue Jin Zhan, 32(1), 13-7.
- Xia H, Anderson B, Mao Q, Davidson BL (2000). Recombinant human adenovirus: targeting to the human transferrin receptor improves gene transfer to brain microcapillary endothelium. J Virol, 74(23), 11359-66.
- Mao QW, Zhang LF, Zhang LN, Ma J (2001). [Ultrastructural changes of arterial wall from different body parts of rats during simulated weightlessness]. Space Med Med Eng (Beijing), 12(4), 249-53.
- Mao QW, Zhang LF, Ma J (2002). [Changes in lumen diameters of vessels in arteriolar network in rat soleus muscle after simulated weightlessness]. Space Med Med Eng (Beijing), 12(3), 177-80.
- Mao QW, Zhang LF, Ma J (2002). [Differentiated remodeling changes of medium-sized arteries from different body parts in tail-suspended rats and their reversibility]. Space Med Med Eng (Beijing), 12(2), 92-6.
- Mao QW, Zhang LF, Ma J (1997). Observations on arteriolar network structure in soleus of tail-suspended rats. J Gravit Physiol, 4(2), P129-30.
- Zhang LF, Mao QW, Ma J, Yu ZB (1996). Effects of simulated weightlessness on arterial vasculature (an experimental study on vascular deconditioning). J Gravit Physiol, 3(2), 5-8.
Case Report
Letter
- Nishihira Y, Gefen T, Mao Q, Appin C, Kohler M, Walker J, Rademakers R, Rademaker A, Rogalski E, Weintraub S, Geula C, Mesulam MM, Bigio EH (2019). Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes. [Letter to the editor]. Acta Neuropathol (Berl), 138(1), 167-169.
- Bit-Ivan EN, Lee KH, Gitelman D, Weintraub S, Mesulam M, Rademakers R, Isaacs AM, Hatanpaa KJ, White CL 3rd, Mao Q, Akman O, DiMauro S, Bigio EH (2014). Adult polyglucosan body disease with GBE1 haploinsufficiency and concomitant frontotemporal lobar degeneration. [Letter to the editor]. Neuropathol Appl Neurobiol, 40(6), 778-82.
- Bigio EH, Wu JY, Deng HX, Bit-Ivan EN, Mao Q, Ganti R, Peterson M, Siddique N, Geula C, Siddique T, Mesulam M (2013). Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid. [Letter to the editor]. Acta Neuropathol (Berl), 125(3), 463-5.