Afaf E. Osman
Rating: 4.9 of 5
( out of 55 reviews )

Afaf E. Osman, MD

Languages spoken: Arabic, English

Clinical Locations

Primary Location

Huntsman Cancer Institute - Cancer Research North

Clinic 2D/E, BMT/Hematology
2000 Circle of Hope
Salt Lake City , UT 84112
801-585-2626
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  • Dr. Afaf E. Osman is an Assistant Professor specializing in Hematology and Hematologic Malignancies within the Division of Hematology at the University of Utah. Board certified in Hematology and Medical Oncology, Dr. Osman focuses on the diagnosis, management, and underlying mechanisms of clonal hematopoiesis, myeloid malignancies, and bone marrow failure syndromes.

    After completing her Internal Medicine residency at Johns Hopkins University and Hematology and Oncology fellowship at the University of Chicago, Dr. Osman joined the faculty at the University of Utah in 2020. She is actively involved in multi-institutional studies and clinical trials aimed at improving the understanding and treatment of conditions such as acute myeloid leukemia (AML) and clonal cytopenias of undetermined significance (CCUS).

    Dr. Osman's research centers on uncovering the genetic and inflammatory drivers of myeloid malignancies, with a focus on how these factors contribute to disease progression and therapeutic resistance. Her work emphasizes the translation of laboratory findings into clinical strategies to enhance patient outcomes. Dr. Osman is a member of American Society of Hematology, Society of Hematologic Oncology, and American Society of Clinical Oncology.

    To schedule an appointment: New Patients: 801-585-4630 Returning Patients: 801-585-2626 or schedule through MyChart.

    For questions regarding our clinical programs or for help identifying the right Hematology specialist for you or for your family member, please feel free to contact our Clinical Care Specialist (801) 587-4630.

    Specialties

    Board Certification

    American Board of Internal Medicine (Internal Medicine)
    American Board of Internal Medicine (Sub: Hematology)
    American Board of Internal Medicine (Sub: Medical Oncology)

    Patient Rating

    Rating: 4.9 out of 5
    4.9 /5
    ( out of 55 reviews )

    The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers.

    The scale on which responses are measured is 1 to 5 with 5 being the best score.

    Patient Comments

    Patient comments are gathered from our patient experience survey and displayed in their entirety. For the convenience of our visitors, some patient comments have been translated from their original language into English while preserving their original meaning as accurately as possible. Patients are de-identified for confidentiality and patient privacy.

    September 08, 2025
    HUNTSMAN CANCER CENTER
    Rating: 5 out of 5

    Dr Osman is amazing. Professional, smart, kind and caring. She asks questions and gives me positive answers

    June 10, 2025
    HUNTSMAN CANCER CENTER
    Rating: 5 out of 5

    I like doctor Osman but hate sitting around for 3 hours

    February 17, 2025
    HUNTSMAN CANCER CENTER
    Rating: 5 out of 5

    Very nice. Extremely helpful.

    February 13, 2025
    HUNTSMAN CANCER CENTER
    Rating: 5 out of 5

    Dr Osman is amazing, caring and empathetic. I hate my cancer, but Dr Osman always has suggestions and options for me

    February 09, 2025
    HUNTSMAN CANCER CENTER
    Rating: 5 out of 5

    SheÕs best!

    February 03, 2025
    HUNTSMAN CANCER CENTER
    Rating: 5 out of 5

    It was wonderful to finally find someone with the experience and caring in the same office. Dr. Osman and entire staff are wonderful.

    February 02, 2025
    HUNTSMAN CANCER CENTER
    Rating: 4 out of 5

    My experience with Dr Osman was good. The wait time to see her was not.

    November 05, 2024
    HUNTSMAN CANCER CENTER
    Rating: 5 out of 5

    She is professional, smart and kind.

    November 03, 2024
    HUNTSMAN CANCER CENTER
    Rating: 5 out of 5

    Dr Osman has been a tremendous advocate for my health care and that of my brother. She pays attention to detail and explains he processes in a way that is understandable.

  • Dr. Afaf E. Osman is an Assistant Professor specializing in Hematology and Hematologic Malignancies within the Division of Hematology at the University of Utah. Board certified in Hematology and Medical Oncology, Dr. Osman focuses on the diagnosis, management, and underlying mechanisms of clonal hematopoiesis, myeloid malignancies, and bone marrow failure syndromes.

    After completing her Internal Medicine residency at Johns Hopkins University and Hematology and Oncology fellowship at the University of Chicago, Dr. Osman joined the faculty at the University of Utah in 2020. She is actively involved in multi-institutional studies and clinical trials aimed at improving the understanding and treatment of conditions such as acute myeloid leukemia (AML) and clonal cytopenias of undetermined significance (CCUS).

    Dr. Osman's research centers on uncovering the genetic and inflammatory drivers of myeloid malignancies, with a focus on how these factors contribute to disease progression and therapeutic resistance. Her work emphasizes the translation of laboratory findings into clinical strategies to enhance patient outcomes. Dr. Osman is a member of American Society of Hematology, Society of Hematologic Oncology, and American Society of Clinical Oncology.

    To schedule an appointment: New Patients: 801-585-4630 Returning Patients: 801-585-2626 or schedule through MyChart.

    For questions regarding our clinical programs or for help identifying the right Hematology specialist for you or for your family member, please feel free to contact our Clinical Care Specialist (801) 587-4630.

    Board Certification and Academic Information

    Academic Departments Internal Medicine -Assistant Professor (Clinical)
    Academic Divisions Hematology & Hematologic Malignancies
    Board Certification
    American Board of Internal Medicine (Internal Medicine)
    American Board of Internal Medicine (Sub: Hematology)
    American Board of Internal Medicine (Sub: Medical Oncology)

    Education history

    Fellowship Leukemia - University of Chicago Research Fellow
    Fellowship Hematology & Oncology - University of Chicago Clinical Fellow
    Residency Internal Medicine - Johns Hopkins Hospital Resident
    Doctoral Training Medicine - Weill Cornell Medical College in Qatar M.D.
    Certification Premedical Program - Weill Cornell Medical College in Qatar Pre Med

    Selected Publications

    Journal Article

    1. Jin N, Hoyd R, Yilmaz AS, Zhu J, Liu Y, Jagjit Singh MS, Grencewicz DJ, Mo X, Kalady MF, Rosenberg DW, Dravillas CE, Singer EA, Carpten JD, Chan CHF, Churchman ML, Denko N, Di Clemente F, Dodd RD, Eljilany I, Fei N, Hardikar S, Ikeguchi AP, Ma A, Ma Q, McCarter MD, Osman AEG, Riedlinger G, Robinson LA, Schneider BP, Tarhini AA, Tinoco G, Figueiredo JC, Zakharia Y, Ulrich CM, Tan AC, Spakowicz D (2025). Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer. Cancer Res Commun, 5(11), 1985-1997. (Read full publication)
    2. Liu X, Tang YH, Blachly J, Edge S, Jakubek YA, McCarter M, Naqash AR, Nepple KG, Osman A, Reilley MJ, Riedlinger G, Salhia B, Schneider BP, Shriver C, Churchman ML, Rounbehler RJ, Teer JK, Gillis N, Teng M (2025). qcCHIP: an R package to identify clonal hematopoiesis variants using cohort-specific data characteristics. Bioinformatics, 41(9). (Read full publication)
    3. Vagher J, Zakas A, Donovan L, Shoger K, Naumer A, Bly J, Smith-Simmer K, Maese L, Schiffman J, Kohlmann W, Garzon R, Churpek JE, Osman AEG (2025). Hematologic Malignancy Frequency, Phenotypes, and Outcomes in Li-Fraumeni Syndrome. JCO Precis Oncol, 9, e2400860. (Read full publication)
    4. Stubbins RJ, Arnovitz S, Vagher J, Asom A, Perpich M, Pies M, Akpan IJ, Chew E, Bridgers J, Karsan A, Rodgers C, Koppayi A, Basdag H, Drazer MW, Das S, Cheng J, Osman AEG, Godley LA (2025). Predisposition to hematopoietic malignancies by deleterious germline CHEK2 variants. Leukemia. (Read full publication)
    5. Greenberg PL, Stone RM, Abaza Y, Al-Kali A, Anand S, Ball B, Bennett JM, Borate U, Brunner AM, Chai-Ho W, Curtin P, DeZern AE, Gaensler K, Gahvari Z, Garcia-Manero G, Griffiths EA, Haque T, Jacoby M, Jonas BA, Keel S, Khanal R, Kishtagari A, Madanat Y, Maness LJ, McCurdy SR, McMahon C, Odenike O, Osman A, Reddy VV, Sallman DA, Sayar H, Shallis R, Singh A, Tanaka T, Thota S, Kovach E, Nguyen J, Hochstetler C (2025). NCCN Guidelines® Insights: Myelodysplastic Syndromes, Version 2.2025. J Natl Compr Canc Netw, 23(3), 66-75. (Read full publication)
    6. Li P, Alnoor FNU, Xie W, Williams M, Feusier J, Ding Y, Zhao X, Zheng G, Zhao C, Zieske AW, Zu Y, Raess PW, Tantravahi S, Osman A, Patel AB, Tashi T, Patel JL, Matynia AP, Menon MP, Miles RR, Jacobsen JR, George TI, Sborov DW, Szankasi P, Rindler P, Close D, Ohgami RS (2024). Rapid growth of acquired UBA1 mutations predisposes male patients to low-risk MDS. Leukemia, 39(1), 248-256. (Read full publication)
    7. Dravillas CE, Coleman SS 4th, Hoyd R, Caryotakis G, Denko L, Chan CHF, Churchman ML, Denko N, Dodd RD, Eljilany I, Hardikar S, Husain M, Ikeguchi AP, Jin N, Ma Q, McCarter MD, Osman AEG, Robinson LA, Singer EA, Tinoco G, Ulrich CM, Zakharia Y, Spakowicz D, Tarhini AA, Tan AC, exORIEN Consortium (2023). The Tumor Microbiome as a Predictor of Outcomes in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibitors. Cancer Res Commun, 4(8), 1978-1990. (Read full publication)
    8. Xie Z, Komrokji RS, Al-Ali N, Regelson A, Geyer S, Patel AA, Saygin C, Zeidan AM, Bewersdorf JP, Mendez LM, Kishtagari A, Zeidner JF, Coombs CC, Madanat YF, Chung SS, Badar T, Foran JM, Desai P, Tsai C, Griffiths EA, Al Malki MM, Amanam I, Lai C, Deeg HJ, Ades L, Arana-Yi C, Osman AE, Dinner SN, Abaza Y, Taylor J, Chandhok NS, Soong D, Brunner AM, Carraway HE, Singh A, Elena C, Ferrari J, Galli A, Pozzi S, Padron E, Patnaik MM, Malcovati L, Savona MR, Al-Kali A (2024). Risk Prediction for Clonal Cytopenia: Multicenter Real-World Evidence. Blood. (Read full publication)
    9. Benej M, Hoyd R, Kreamer M, Wheeler CE, Grencewicz DJ, Choueiry F, Chan CHF, Zakharia Y, Ma Q, Dodd RD, Ulrich CM, Hardikar S, Churchman ML, Tarhini AA, Robinson LA, Singer EA, Ikeguchi AP, McCarter MD, Tinoco G, Husain M, Jin N, Tan AC, Osman AEG, Eljilany I, Riedlinger G, Schneider BP, Benejova K, Kery M, Papandreou I, Zhu J, Denko N, Spakowicz D, exORIEN Consortium (2023). The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer. Cancer Res Commun, 4(7), 1690-1701. (Read full publication)
    10. Osman AEG, Rets A, Patel AB (2024). KRAS mutations, autoimmunity and female sex in chronic myelomonocytic leukemia. Leuk Res, 138, 107466. (Read full publication)
    11. Wang C, Ma A, Li Y, McNutt ME, Zhang S, Zhu J, Hoyd R, Wheeler CE, Robinson LA, Chan CHF, Zakharia Y, Dodd RD, Ulrich CM, Hardikar S, Churchman ML, Tarhini AA, Singer EA, Ikeguchi AP, McCarter MD, Denko N, Tinoco G, Husain M, Jin N, Osman AEG, Eljilany I, Tan AC, Coleman SS, Denko L, Riedlinger G, Schneider BP, Spakowicz D, Ma Q, exORIEN Consortium (2023). A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset. Cancer Res Commun, 4(2), 293-302. (Read full publication)
    12. Wheeler CE, Coleman SS 4th, Hoyd R, Denko L, Chan CHF, Churchman ML, Denko N, Dodd RD, Eljilany I, Hardikar S, Husain M, Ikeguchi AP, Jin N, Ma Q, McCarter MD, Osman AEG, Robinson LA, Singer EA, Tinoco G, Ulrich CM, Zakharia Y, Spakowicz D, Tarhini AA, Tan AC (2023). The tumor microbiome as a predictor of outcomes in patients with metastatic melanoma treated with immune checkpoint inhibitors. (Read full publication)
    13. Wang C, Ma A, McNutt ME, Hoyd R, Wheeler CE, Robinson LA, Chan CHF, Zakharia Y, Dodd RD, Ulrich CM, Hardikar S, Churchman ML, Tarhini AA, Singer EA, Ikeguchi AP, McCarter MD, Denko N, Tinoco G, Husain M, Jin N, Osman AEG, Eljilany I, Tan AC, Coleman SS 4th, Denko L, Riedlinger G, Schneider BP, Spakowicz D, Ma Q (2023). A bioinformatics tool for identifying intratumoral microbes from the ORIEN dataset. (Read full publication)
    14. Osman AEG, Mencia-Trinchant N, Saygin C, Moma L, Kim A, Housman G, Pozsgai M, Sinha E, Chandra P, Hassane DC, Sboner A, Sangani K, DiNardi N, Johnson C, Wallace SS, Jabri B, Luu H, Guzman ML, Desai P, Godley LA (2022). Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones. Blood Adv, 7(9), 1910-1914. (Read full publication)
    15. Osman A, Mencia-Trinchant N, Saygin C, Moma L, Kim A, Housman G, Pozsgai MJ, Sinha E, Chandra P, Hassane DC, Sboner A, Sangani K, DiNardi N, Johnson C, Wallace SS, Jabri B, Luu H, Guzman ML, Desai P, Godley LA (2022). Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones. Blood Adv, 7(9), 1910-1914. (Read full publication)
    16. Yu B, Osman AEG, Sladojevic N, Prabhu N, Tai HC, Chen D, Perla G, Park L, Larson RA, Liao JK (2022). Involvement of Rho-Associated Coiled-Coil Containing Kinase (ROCK) in BCR-ABL1 Tyrosine Kinase Inhibitor Cardiovascular Toxicity. JACC CardioOncol, 4(3), 371-383. (Read full publication)
    17. Croci DM, Gamboa NT, Osman AEG, Maese L, Mazur M, Bisson EF, Dailey AT (2021). Solitary manifestations of primary B-lymphoblastic lymphoma of the spine: Systematic literature review with case illustration. Clin Neurol Neurosurg, 212, 107064. (Read full publication)
    18. Feusier JE, Madsen MJ, Avery BJ, Williams JA, Stephens DM, Hu B, Osman AEG, Glenn MJ, Camp NJ (2021). Shared genomic segment analysis in a large high-risk chronic lymphocytic leukemia pedigree implicates CXCR4 in inherited risk. J Transl Genet Genom, 5, 189-199. (Read full publication)
    19. Feurstein S, Adegunsoye A, Mojsilovic D, Vij R, DePersia AHW, Rajagopal PS, Osman A, Collins RH, Kim RH, Gore SD, Greenberg P, Godley LA, Li Z, Del Gaudio D, Subramanian HP, Das S, Walsh T, Gulsuner S, Segal JP, Husain AN, Gurbuxani S, King MC, Strek ME and Churpek JE (2020). Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations. Blood Adv, 4(19), 4873-4886.
    20. Osman A, Gocke CD, Gladstone DE (2016). Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones. Clin Lymphoma Myeloma Leuk, 17(2), 97-99. (Read full publication)
    21. Osman A, et al (2014). Sudden Worsening of DRESS Syndrome on Tapering Steroid Dose with Dramatic Improvement on N-acetylcysteine and Steroid Dose Escalation. 6(2), 101-10.

    Review

    1. Liu J, Osman AEG, Bolton K, Godley LA (2023). Germline predisposition to clonal hematopoiesis. [Review]. Leuk Res, 132, 107344. (Read full publication)
    2. Croci DM, Gamboa NT, Osman AEG, Maese L, Mazur M, Bisson EF, Dailey AT (2021). Solitary manifestations of primary B-lymphoblastic lymphoma of the spine: Systematic literature review with case illustration. [Review]. Clin Neurol Neurosurg, 212, 107064. (Read full publication)
    3. Osman AEWG (2021). When are idiopathic and clonal cytopenias of unknown significance (ICUS or CCUS)? [Review]. Hematology Am Soc Hematol Educ Program, 2021(1), 399-404. (Read full publication)
    4. Osman AEG, Deininger MW (2021). Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions. [Review]. Blood Rev, 49, 100825. (Read full publication)
    5. Osman A, Patel JL (2021). Diagnostic Challenge and Clinical Dilemma: The Long Reach of Clonal Hematopoiesis. [Review]. Clin Chem, 67(8), 1062-1070. (Read full publication)
    6. Osman AEG, Luke JJ (2019). The Impact of the Fecal Microbiome on Cancer Immunotherapy. [Review]. BioDrugs, 33(1), 1-7. (Read full publication)
    7. Akpan IJ, Osman AEG, Drazer MW, Godley LA (2018). Hereditary Myelodysplastic Syndrome and Acute Myeloid Leukemia: Diagnosis, Questions, and Controversies. [Review]. Curr Hematol Malig Rep, 13(6), 426-434. (Read full publication)
    8. Osman AEG, Anderson J, Churpek JE, Christ TN, Curran E, Godley LA, Liu H, Thirman MJ, Odenike T, Stock W, Larson RA (2018). Treatment of Acute Promyelocytic Leukemia in Adults. [Review]. J Oncol Pract, 14(11), 649-657. (Read full publication)

    Case Report

    1. Osman A, Galiatsatos P, Bose S, Danoff S (2017). Rheumatoid arthritis causing diffuse alveolar haemorrhage: a novel therapeutic approach. BMJ Case Rep, 2017. (Read full publication)

    Abstract

    1. Osman AYu B, Glavin N, Polonsky T, Liao J, Larson RA (2018). ABL Tyrosine Kinase Inhibitors (TKIs) are Associated with Increased Rho-Associated Kinase (ROCK) Activity that May Contribute to Vascular Toxicity in Patients with Chronic Myeloid Leukemia (CML). Poster session: 632 Chronic Myeloid Leukemia: Therapy, American Society of Hematology 60th Annual Meeting, San Diego, CA [Abstract]. 132(Suppl 1), 1739.
    2. Osman AGaliatsatos PBose S (2017). Diffuse Alveolar Hemorrhage as a Rare Manifestation of Rheumatoid Arthritis. Poster session presented at the Autoimmune Lung Disease: Case Reports Thematic Poster Session. American Thoracic Society International Conference, Washington, DC [Abstract]. 195, A1460.

    Other

    1. Osman AEG, Luke JJ (2019). The Gut Microbiome and Cancer Immunotherapy. (4(8), pp. 14, 15).