Archana M. Agarwal
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Archana M. Agarwal, MBBS, MD

Languages spoken: English, Hindi

My clinical service responsibilities are in hematopathology, where I sign out molecular hematopathology, lymph node/bone marrow cases and flow cytometric evaluation for blood related disorders. My other clinical service responsibilities are in the Red Blood Cell Laboratory/Special Genetics Laboratory at ARUP, where I am the Co Medical Director. In this capacity, I am involved in review of patient test results, case sign out, review of quality control and quality assurance data, proficiency testing, and other clinical and administrative laboratory-related activities. I also provide consultation with clinical colleagues both locally and nationally in the area of hemoglobinopathies. My goal is to provide physicians with high quality test results and to give them my consultative expertise. In the area of teaching, I act as the director for the hemoglobinopathy/ thalassemia and benign red blood cell disorders rotation for hematopathology fellows.

Specialties

  • Hematopathology
  • Flow Cytometry
  • Pathology, Anatomical

Board Certification

American Board of Pathology (Sub: Anatomic Path)
American Board of Pathology (Clinical Path)
American Board of Pathology (Sub: Hematology)
American Board of Pathology (Sub: Molecular Genetic Pathology)
National Board of Medical Examiners

My clinical service responsibilities are in hematopathology, where I sign out molecular hematopathology, lymph node/bone marrow cases and flow cytometric evaluation for blood related disorders. My other clinical service responsibilities are in the Red Blood Cell Laboratory/Special Genetics Laboratory at ARUP, where I am the Co Medical Director. In this capacity, I am involved in review of patient test results, case sign out, review of quality control and quality assurance data, proficiency testing, and other clinical and administrative laboratory-related activities. I also provide consultation with clinical colleagues both locally and nationally in the area of hemoglobinopathies. My goal is to provide physicians with high quality test results and to give them my consultative expertise. In the area of teaching, I act as the director for the hemoglobinopathy/ thalassemia and benign red blood cell disorders rotation for hematopathology fellows.

Board Certification and Academic Information

Academic Departments Pathology -Professor (Clinical)
Board Certification
American Board of Pathology (Sub: Anatomic Path)
American Board of Pathology (Clinical Path)
American Board of Pathology (Sub: Hematology)
American Board of Pathology (Sub: Molecular Genetic Pathology)
National Board of Medical Examiners

Education history

Professional Medical Medicine - Assam Medical College M.B.B.S.
Professional Medical Pathology - Delhi University M.D.
Postdoctoral Fellowship Research Scholar - University of Iowa Postdoctoral Fellow
Residency Anatomic and Clinical - University of Utah School of Medicine, Department of Pathology Resident
Fellowship Hematopathology - University of Utah School of Medicine Fellow
Residency Anatomic and Clinical - University of Utah School of Medicine, Department of Pathology Resident
Fellowship Molecular Genetic Pathology - University of Utah School of Medicine, Department of Pathology Fellow

Selected Publications

Journal Article

  1. Bianchi P, Fermo E, Glader B, Kanno H, Agarwal A, Barcellini W, Eber S, Hoyer JD, Kuter DJ, Maia TM, Mañu-Pereira MDM, Kalfa TA, Pissard S, Segovia JC, van Beers E, Gallagher PG, Rees DC, van Wijk R, with the endorsement of EuroBloodNet, the European Reference Network in Rare Hematological., Disease (2019). Addressing the diagnostic gaps in pyruvate kinase deficiency: Consensus recommendations on the diagnosis of pyruvate kinase deficiency. American journal of hematology, 94(1), 149-161.
  2. Kim SJ, Song J, Reading NS, Lautersztain J, Kutlar A, Agarwal AM, Coetzer TL, Prchal J (2021). Novel Mechanism of Hereditary Pyropoikilocytosis Phenotype due to Co-inheritance of β Globin and α Spectrin Mutations. American journal of hematology, 96(5), Epub 2021 Feb 25.
  3. Patel AB, Franzini A, Leroy E, Kim SJ, Pomicter AD, Genet L, Xiao M, Yan D, Ahmann JM, Agarwal AM, Clair P, Addada J, Lambert J, Salmon M, Gleich GJ, Cross NCP, Constantinescu SN, O'Hare T, Prchal JT, Deininger M (2019). JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera. Blood, 134(26), 2388-2398.
  4. Davis KL, Agarwal AM, Verma A (2017). Checkpoint inhibition in pediatric hematologic malignancies. Pediatric hematology and oncology, 34(6-7), 379-394.
  5. Nussenzveig RH, Burjanivova T, Salama ME, Ogilvie NW, Marcinek J, Plank L, Agarwal AM, Perkins SL, Prchal J (2012). Detection of JAK2 mutations in paraffin marrow biopsies by high resolution melting analysis: identification of L611S alone and in cis with V617F in polycythemia vera. Leukemia & lymphoma, 53(12), 2479-86.
  6. Luedeke M, Rinckleb AE, FitzGerald LM, Geybels MS, Schleutker J, Eeles RA, Teixeira MR, Cannon-Albright L, Ostrander EA, Weikert S, Herkommer K, Wahlfors T, Visakorpi T, Leinonen KA, Tammela TLJ, Cooper CS, Kote-Jarai Z, Edwards S, Goh CL, McCarthy F, Parker C, Flohr P, Paulo P, Jerónimo C, Henrique R, Krause H, Wach S, Lieb V, Rau TT, Vogel W, Kuefer R, Hofer MD, Perner S, Rubin MA, Agarwal AM, Easton DF, Al Olama AA, Benlloch S, PRACTICAL consortium., Hoegel J, Stanford JL, Maier (2016). Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status. Human molecular genetics, 25(24), 5490-5499.
  7. Reading NS, Shooter C, Song J, Miller R, Agarwal A, Lanikova L, Clark B, Thein SL, Divoky V, Prchal J (2016). Loss of Major DNase I Hypersensitive Sites in Duplicated ß-globin Gene Cluster Incompletely Silences HBB Gene Expression. Human mutation, 37(11), 1153-1156.
  8. He L, Rockwood AL, Agarwal AM, Anderson LC, Weisbrod CR, Hendrickson CL, Marshall A (2019). Diagnosis of Hemoglobinopathy and ß-Thalassemia by 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry of Hemoglobin from Blood. Clinical chemistry, 65(8), 986-994.
  9. Agarwal AM, Bentz JS, Hungerford R, Abraham (2009). Parathyroid fine-needle aspiration cytology in the evaluation of parathyroid adenoma: cytologic findings from 53 patients. Diagnostic cytopathology, 37(6), 407-10.
  10. Bruchova H, Yoon D, Agarwal AM, Mendell J, Prchal J (2007). Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis. Experimental hematology, 35(11), 1657-67.
  11. Swierczek S, Agarwal AM, Naidoo K, Lorenzo FR, Whisenant J, Nussenzveig RH, Agarwal N, Coetzer TL, Prchal J (2013). Novel exon 2 ¿ spectrin mutation and intragenic crossover: three morphological phenotypes associated with four distinct ¿ spectrin defects. Haematologica, 98(12), 1972-9.
  12. Samha L, Sirdah MM, Reading NS, Karmi B, Agarwal A (2020). Molecular Understanding of Severe Cases of ß-Thalassemia in the Nablus Region, West Bank, Palestine. Hemoglobin, 44(2), 128-130.
  13. Rets AV, Reading NS, Agarwal A (2020). ¿-Globin Chain Variants Associated with Decreased Hb A2 Levels: A National Reference Laboratory Experience. Hemoglobin, 44(6), 438-441.
  14. Agarwal AM, Agarwal N, Glenn MJ, Lim M (2007). Blastic transformation of low-grade follicular lymphoma. Journal of clinical oncology, 25(16), 2326-8.
  15. Yaish HM, Christensen RD, Agarwal (2013). A neonate with Coombs-negative hemolytic jaundice with spherocytes but normal erythrocyte indices: a rare case of autosomal-recessive hereditary spherocytosis due to alpha-spectrin deficiency. Journal of perinatology, 33(5), 404-6.
  16. Bahr TM, Agarwal AM, Christensen R (2021). Does heterozygosity for UGT1A1 *28 convey increased risk for severe neonatal jaundice?. Journal of perinatology, 41(4), 658-660.
  17. Lim HY, Agarwal AM, Agarwal N, Ward J (2009). Recurrent epistaxis as a presenting sign of androgen-sensitive metastatic prostate cancer. Singapore medical journal, 50(5), e178-80.
  18. Iglesias Cardenas F, Agarwal AM, Vagher J, Maese L, Fluchel M, Afify (2021). Two Clonally Distinct B-Cell Lymphomas Reveal the Diagnosis of XLP1 in a Male Child and His Asymptomatic Male Relatives: Case Report and Review of the Literature. Journal of pediatric hematology/oncology, 43(8), e1210-e1213.
  19. Bruchova H, Yoon D, Agarwal AM, Swierczek S, Prchal J (2009). Erythropoiesis in polycythemia vera is hyper-proliferative and has accelerated maturation. Blood cells, molecules & diseases, 43(1), 81-7.
  20. Christensen RD, Agarwal AM, George TI, Bhutani VK, Yaish H (2018). Acute neonatal bilirubin encephalopathy in the State of Utah 2009-2018. Blood cells, molecules & diseases, 72, 10-13.
  21. Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Gerday E, Smoot JL, Taylor A, Christensen R (2020). Dizygotic twins with prolonged jaundice and microcytic, hypochromic, hemolytic anemia with pyropoikilocytosis. Blood cells, molecules & diseases, 85, 102462.
  22. Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zúñiga-Pflücker JC, Dominguez M, Ferrando A (2007). Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nature medicine, 13(10), 1203-10.
  23. Cowman SJ, Fuja DG, Liu XD, Tidwell RSS, Kandula N, Sirohi D, Agarwal AM, Emerson LL, Tripp SR, Mohlman JS, Stonhill M, Garcia G, Conley CJ, Olalde AA, Sargis T, Ramirez-Torres A, Karam JA, Wood CG, Sircar K, Tamboli P, Boucher K, Maughan B, Spike BT, Ho TH, Agarwal N, Jonasch E, Koh M (2020). Macrophage HIF-1¿ Is an Independent Prognostic Indicator in Kidney Cancer. Clinical cancer research, 26(18), 4970-4982.
  24. Sangle NA, Agarwal AM, Smock KJ, Leavitt MO, Warnke R, Bahler D, Perkins S (2011). Diffuse large B-cell lymphoma with aberrant expression of the T-cell antigens CD2 and CD7. Applied immunohistochemistry & molecular morphology, 19(6), 579-83.
  25. Kuzman JA, Stenehjem DD, Merriman J, Agarwal AM, Patel SB, Hahn AW, Alex A, Albertson D, Gill DM, Agarwal (2017). Neutrophil-lymphocyte ratio as a predictive biomarker for response to high dose interleukin-2 in patients with renal cell carcinoma. BMC urology, 17(1), 1.
  26. Vanhille DL, Nussenzveig RH, Glezos C, Perkins S, Agarwal A (2012). Best practices for use of the HEMOX analyzer in the clinical laboratory: quality control determination and choice of anticoagulant. Laboratory hematology, 18(3), 17-9.
  27. Lozano-Chinga M, Draper L, George TI, Agarwal AM, Dansie DM, Maese (2021). Bone marrow necrosis in pediatric malignancies: 10-Year retrospective review and review of literature. Pediatric blood & cancer, 68(3), e28806.
  28. Agarwal AM, Liew MA, Nussenzveig RH, Sangle N, Heikal N, Yaish H, Christensen (2016). Improved harmonization of eosin-5-maleimide binding test across different instruments and age groups. Cytometry. Part B, Clinical cytometry, 90(6), 512-516.
  29. Stenehjem DD, Hahn AW, Gill DM, Albertson D, Gowrishankar B, Merriman J, Agarwal AM, Thodima V, Harrington EB, Au TH, Maughan BL, Houldsworth J, Pal SK, Agarwal (2019). Predictive genomic markers of response to VEGF targeted therapy in metastatic renal cell carcinoma. PloS one, 14(1), e0210415.
  30. Bahr TM, Christensen RD, Agarwal AM, George TI, Bhutani V (2019). The Neonatal Acute Bilirubin Encephalopathy Registry (NABER): Background, Aims, and Protocol. Neonatology, 115(3), 242-246.
  31. Rets A, Clayton AL, Christensen RD, Agarwal A (2019). Molecular diagnostic update in hereditary hemolytic anemia and neonatal hyperbilirubinemia. International journal of laboratory hematology, 41 Suppl 1, 95-101.
  32. Agarwal AM, Rets (2020). Laboratory approach to investigation of anemia with a focus on pyruvate kinase deficiency. International journal of laboratory hematology, 42 Suppl 1, 107-112.
  33. Hahn AW, Gill DM, Maughan B, Agarwal A, Arjyal L, Gupta S, Streeter J, Bailey E, Pal SK, Agarwal (2017). Correlation of genomic alterations assessed by next-generation sequencing (NGS) of tumor tissue DNA and circulating tumor DNA (ctDNA) in metastatic renal cell carcinoma (mRCC): potential clinical implications. Oncotarget, 8(20), 33614-33620.
  34. Patel JC, Maughan BL, Agarwal AM, Batten JA, Zhang TY, Agarwal (2013). Emerging molecularly targeted therapies in castration refractory prostate cancer. Prostate cancer, 2013, 981684.
  35. He L, Rockwood AL, Agarwal AM, Anderson LC, Weisbrod CR, Hendrickson CL, Marshall A (2020). Top-down proteomics-a near-future technique for clinical diagnosis?. Annals of translational medicine, 8(4), 136.
  36. Meznarich JA, Rets A, Agarwal AM, Christensen RD, Reading NS, Kuypers FA, Prchal J (2021). Novel, de novo, beta-globin variant with decreased oxygen affinity (HBB:c.317T>A, "Hemoglobin St. George") in a healthy child with low oxygen saturations and anemia. American journal of hematology, 96(12), E448-E450.
  37. Agarwal AM, Rets (2021). Laboratory approach to investigation of anemia in pregnancy. International journal of laboratory hematology, 43 Suppl 1, 65-70.
  38. Bahr TM, Knudsen MC, Lozano-Chinga M, Agarwal AM, Meznarich JA, Ohls RK, Christensen R (2020). Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin. Biomedicine hub, 5(3), 227-234.
  39. Lin Y, Agarwal AM, Marshall AG, Anderson L (2022). Characterization of Structural Hemoglobin Variants by Top-Down Mass Spectrometry and R Programming Tools for Rapid Identification. Journal of the American Society for Mass Spectrometry, 33(1), 123-130.
  40. Bahr TM, Agarwal AM, Meznarich JA, Prince WL, Wait TWP, Prchal JT, Christensen R (2021). Thirty-five males with severe (Class 1) G6PD deficiency (c.637G>T) in a North American family of European ancestry. Blood cells, molecules & diseases, 92, 102625.
  41. Lin Y, Agarwal AM, Anderson LC, Marshall A (2023). Discovery of a biomarker for ß-Thalassemia by HPLC-MS and improvement from Proton Transfer Reaction - Parallel Ion Parking. Journal of mass spectrometry and advances in the clinical lab, 28, 20-26.
  42. Agarwal AM, McMurty V, Clayton AL, Bolia A, Reading NS, Mani C, Patel JL, Rets (2023). Clinical utility of targeted next-generation sequencing panel in routine diagnosis of hereditary hemolytic anemia: A national reference laboratory experience. European journal of haematology, 110(6), 688-695.
  43. Gorfinkel L, Wachter F, Luo HY, Hansbury E, Williams DA, Agarwal A, Chui DHK, Cantor A (2023). Transient neonatal hemolytic anemia due to the novel gamma globin gene mutation HBG2:C.290T>C, p.Leu97Pro (hemoglobin Wareham). Pediatric blood & cancer, 70(1), e30067.
  44. Verma A, Chi YY, Malvar J, Lamble A, Chaudhury S, Agarwal A, Li HT, Liang G, Leong R, Brown PA, Kaplan J, Schafer ES, Slone T, Pauly M, Chang BH, Stieglitz E, Wayne AS, Hijiya N, Bhojwani (2024). Nivolumab Plus 5-Azacitidine in Pediatric Relapsed/Refractory Acute Myeloid Leukemia (AML): Phase I/II Trial Results from the Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) Consortium. Cancers, 16(3),
  45. Montgomery HD, Agarwal AM, Lim M (2022). A case of azathioprine-induced aplastic anemia. International journal of laboratory hematology, 44(6), 1015-1016.
  46. Agarwal AM,Hanley T (2020). Osteopetrosis in a six-month-old infant. Journal of hematopathology, 13(3), 193-196.
  47. Gill DM,Stenehjem DD,Parikh K,Merriman J,Sendilnathan A,Agarwal AM,Hahn AW,Gupta S,Tantravahi SK,Samlowski WE,Agarwal (2016). Conditional survival of metastatic renal cell carcinoma patients treated with high-dose interleukin-2. Ecancermedicalscience, 10,
  48. Tantravahi SK,Albertson D,Agarwal AM,Ravulapati S,Poole A,Patel SB,Hawatmeh JS,Straubhar AM,Liu T,Stenehjem DD,Agarwal (2015). Survival outcomes and tumor IMP3 expression in patients with sarcomatoid metastatic renal cell carcinoma. Journal of oncology, 2015,
  49. Smock KJ,Agarwal AM,Lim MS,Tripp SR,Miles RR,Patel JL,Abromowitch M,Lones MA,Cairo MS,Perkins S (2014). Expression of Notch1 and mTOR pathway proteins in pediatric lymphoblastic lymphoma; a Children's Oncology Group report. Journal of hematopathology, 7(1), 9-14.
  50. Nussenzveig RH,Vanhille DL,Hussey D,Agarwal A (2013). Changes in the high-performance liquid chromatography pattern of hemoglobin lepore after treatment with hydroxyurea. Laboratory medicine, 44(3), 245-247.
  51. Obiorah I, McCall CM, Balmaceda A, Salansky S, Agarwal A, Pozdnyakova (2025). An 18-Year Review of Hemoglobinopathy Proficiency Testing: Recommendations From the College of American Pathologists Hematology and Clinical Microscopy Committee. Archives of pathology & laboratory medicine,
  52. Agarwal AM, Rets A, Mani (2025). Novel Mutations in SUPT5H Gene Associated With Beta-Thalassemia Phenotype. International journal of laboratory hematology, 47(3), 552-554.
  53. Balciuniene J, Yilmaz S, Chonat S, Grace RF, Soff GA, Ravindranath Y, Glader B, Bianchi P, McGee B, Agarwal AM, Puthenveetil (2025). Real-world insights from a cohort of approximately 2000 individuals who were analysed using a freely available next-generation sequencing anaemia screening programme. British journal of haematology, 206(6), 1853-1856.
  54. Shean R, Deshmukh N, Palmer M, Agarwal A, Rets (2025). Utility of Molecular Sequencing and Hematologic Parameters for Diagnosis of ¿-Thalassemia: A Perspective of the National Reference Laboratory. Hemoglobin, 1-7.

Review

  1. Agarwal AM, Rets A (2023). Molecular diagnosis of hereditary hemolytic anemias: Recent updates. International journal of laboratory hematology, 45 Suppl 2, 79-86.
  2. Dadelahi A, Jackson T, Agarwal AM, Lin L, Rets AV, Ng D (2024). Applications of Flow Cytometry in Diagnosis and Evaluation of Red Blood Cell Disorders. Clinics in laboratory medicine, 44(3), 495-509.
  3. Agarwal AM, Rets A (2024). Advances in Hemoglobinopathies and Thalassemia Evaluation. Clinics in laboratory medicine, 44(3), 441-453.

Book Chapter

  1. Sherrie L Perkins, Mohamed E Salama, Archana M Agarwa (2021). Contributor: Case Studies in Hematology and Coagulation.
  2. Agarwal AM,Rodgers G (2018). Miscellaneous causes of thrombocytopenia. Wintrobe's Clinical Hematology: Fourteenth Edition, 3391-3420.
  3. Bellissimo DB,Agarwal (2016). Hematologic disorders: Hemochromatosis, hemoglobinopathies, and rh incompatibility. Molecular Pathology in Clinical Practice:Second Edition, 225-238.
  4. Agarwal AM,Rodgers G (2013). Miscellaneous causes of thrombocytopenia. Wintrobe's Clinical Hematology: Thirteenth Edition, 1097-1105.
  5. Agarwal AM,Prchal J (2011). Congenital Hemolytic Anemias. Concise Guide to Hematology, 62-74.

Case Report

  1. Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Yost CC, Li P, Reading NS, Prchal JT, Christensen R (2020). A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity. Neonatology, 117(4), 532-535.
  2. Maglic D, Moss W, Pires G, Agarwal A, Matsen C, Kwok (2021). A Case Report of Misdiagnosed Breast Implant-associated Anaplastic Large Cell Lymphoma with Lymphatic Extension. Plastic and reconstructive surgery. Global open, 9(11), e3916.

Editorial

  1. Agarwal AM (2019). Ankyrin Mutations in Hereditary Spherocytosis. Acta Haematol, 141(2), 63-64.

Abstract

  1. Yoon D, Bruchova H, Agarwal AM, Prchal JT, Prchal J (2006). In Vitro Erythroid Cell Expansion Analysis in Polycythemia Vera. Publication only. American Society of Hematology, Annual Meeting. [Abstract]. 108, 4916.