Benjamin L. Witt
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Benjamin L. Witt, MD

Languages spoken: English

Dr. Witt's research interests include studies related to fine-needle aspiration and Head and Neck pathology.

Specialties

  • Cytopathology
  • Surgical Pathology
  • Pathology, Anatomical

Board Certification

American Board of Pathology (Anatomic & Clinical)

Dr. Witt's research interests include studies related to fine-needle aspiration and Head and Neck pathology.

Board Certification and Academic Information

Academic Departments Pathology -Professor (Clinical)
Board Certification
American Board of Pathology (Anatomic & Clinical)

Education history

Undergraduate Molecular, Cellular, and Developmental Biology - University of Colorado at Boulder B.A.
Professional Medical University of Colorado Denver School of Medicine M.D.
Residency Anatomic and Clinical Pathology - University of Chicago - NorthShore Resident
Fellowship Cytopathology - University of Utah/ARUP Laboratories Fellow

Selected Publications

Journal Article

  1. Schmidt RL, Witt BL, Narra K, Factor R (2014). Diagnostic Accuracy Studies of Fine-Needle Aspiration Show Wide Variation in Reporting of Study Population Characteristics: Implications for External Validity. Archives of pathology & laboratory medicine, 138(1), 88-97.
  2. Chengquan Zhao, Zaibo Li, Ritu Nayar, Angelique Levi, Barbara Winkler, Ann T Moriarty, Güliz A Barkan, Jianyu Rao, Fern Miller, Fang Fan, Zhongren Zhou, Qiusheng Si, Andrew H Fischer, Charles D Sturgis, Xin Jing, Carrie B Marshall, Benjamin L. Witt, George Birdsong, Barbara A. Crothers (2015). Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Carcinomas Diagnosed in 2012: Results of a Retrosepctive Multicenter Study. Archives of pathology & laboratory medicine, 139(2), 184-188.
  3. Chadwick BE, Layfield LJ, Witt BL, Schmidt RL, Cox K, Adler D (2014). Significance of atypia in pancreatic and bile duct brushings: Follow-up analysis of the categories atypical and suspicious for malignancy. Diagnostic cytopathology, 42(4), 285-291.
  4. Layfield LJ, Esebua M, Witt B (2014). Cytotechnologist Screening of Fine Needle Aspiration Specimens: Impact on Turnaround Time and Diagnostic Accuracy. Diagnostic cytopathology, 42(7), 606-608.
  5. Witt BL, Albertson DJ, Coppin MG, Horrocks CF, Gulbahce H (2015). Use of In Situ Hybridization for HPV in Head and Neck Tumors: Experience from a National Reference Laboratory. Head and neck pathology, 9(1), 60-64.
  6. Ireland AS, Hawgood SB, Xie DA, Barbier MW, Lucas-Randolph S, Tyson DR, Zuo LY, Witt BL, Govindan R, Dowlati A, Moser JC, Puri S, Rudin CM, Chan JM, Elliott A, Oliver T (2024). Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer. bioRxiv,
  7. Mahomva CR, Smith KA, Minkah PAB, Witt BL, Oakley GM, Orlandi RR, Alt JA, Pulsipher (2024). Chemokine CCL19 and Its Receptors CCR7 and CCRL1 in Chronic Rhinosinusitis. Journal of inflammation research, 17, 2991-3002.
  8. Smith KA, Gill AS, Pollard CE, Sumsion JS, Saffari H, Ashby S, Witt BL, Shipman PA, Gabrielsen DA, Yim MT, Levy JM, Oakley GM, Orlandi RR, Gleich GJ, Alt JA, Pulsipher (2023). An eosinophil peroxidase activity assay accurately predicts eosinophilic chronic rhinosinusitis. The Journal of allergy and clinical immunology, 152(2), 400-407.
  9. Bansal S, Bechara RI, Patel JD, Mehta HJ, Ferguson JS, Witt BL, Murgu SD, Yasufuku K, Casal R (2023). Safety and Feasibility of Photodynamic Therapy for Ablation of Peripheral Lung Tumors. Journal of bronchology & interventional pulmonology, 30(2), 135-143.
  10. Witt BL, Zhou W, Ambaye AB, Bellizzi A, Booth CN, Sundling K, Nguyen L, Russell DK, Schinstine M, Staats PN, Thomsen J, Troxell M, Souers RJ, Dvorak J, Lin X, Kurtycz DF (2023). Using American Type Culture Collection Cell Lines to Evaluate Interlaboratory Variables for Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 Immunostaining. Archives of pathology & laboratory medicine, 147(2), 143-148.
  11. Dong Z, Barraza G, Affolter KE, Witt BL, Jedrzkiewicz (2023). Distinguishing Gastrointestinal Leiomyomas From Muscularis Propria in Biopsy Specimens by Differential Expression of S100 Immunohistochemical Stain. American journal of clinical pathology, 159(1), 53-59.
  12. Gibson BA, McKinnon E, Bentley RC, Mohlman J, Witt BL, Yang EJ, Geisler D, DeFrances (2022). Communicating Certainty in Pathology Reports. Archives of pathology & laboratory medicine, 146(7), 886-893.
  13. Staats PN, Davey DD, Witt BL, Ghofrani M, Zhao C, Dodd LG, Goodrich K, Husain M, Kurtycz DFI, Russell DK, Shen RZ, Souers RJ, Tabatabai ZL, Crothers B (2022). Performance of specific morphologic features in distinguishing low-grade squamous intraepithelial lesions from high-grade squamous intraepithelial lesions in borderline cases: a College of American Pathologists Cytopathology Committee multiobserver study. Journal of the American Society of Cytopathology, 11(2), 102-113.
  14. Witt B (2021). Rapid On Site Evaluation (ROSE): A Pathologists' Perspective. Techniques in vascular and interventional radiology, 24(3), 100767.
  15. Olsen RR, Ireland AS, Kastner DW, Groves SM, Spainhower KB, Pozo K, Kelenis DP, Whitney CP, Guthrie MR, Wait SJ, Soltero D, Witt BL, Quaranta V, Johnson JE, Oliver T (2021). ASCL1 represses a SOX9(+) neural crest stem-like state in small cell lung cancer. Genes & development, 35(11-12), 847-869.
  16. Zhu GG, Witt BL, Winter Iii TC, Rogers D (2021). Multiple enlarging hepatic and retroperitoneal myelolipomas in the setting of Cushing disease. BMJ case reports, 14(2),
  17. Chandan S, Mohan BP, Khan SR, Ofosu A, Dhaliwal AS, Shah AR, Bhogal N, Mashiana HS, Mashiana SS, Kassab LL, Ponnada S, Facciorusso A, Bhat I, Singh S, Witt BL, Adler D (2020). Comparison of EUS-guided conventional smear and liquid-based cytology in pancreatic lesions: A systematic review and meta-analysis. Endoscopy international open, 8(11), E1611-E1622.
  18. Ireland AS, Micinski AM, Kastner DW, Guo B, Wait SJ, Spainhower KB, Conley CC, Chen OS, Guthrie MR, Soltero D, Qiao Y, Huang X, Tarapcsák S, Devarakonda S, Chalishazar MD, Gertz J, Moser JC, Marth G, Puri S, Witt BL, Spike BT, Oliver T (2020). MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate. Cancer cell, 38(1), 60-78.e12.
  19. Balwan A, Bixby B, Grotepas C, Witt BL, Iravani A, Ansari S, Reddy C (2020). Core needle biopsy with endobronchial ultrasonography: single center experience with 100 cases. Journal of the American Society of Cytopathology, 9(4), 249-253.
  20. Chen C, Lohavanichbutr P, Zhang Y, Houck JR, Upton MP, Abedi-Ardekani B, Agudo A, Ahrens W, Alemany L, Anantharaman D, Conway DI, Futran ND, Holcatova I, Günther K, Hansen BT, Healy CM, Itani D, Kjaerheim K, Monroe MM, Thomson PJ, Witt BL, Nakoneshny S, Peterson LA, Schwartz SM, Zarins KR, Hashibe M, Brennan P, Rozek LS, Wolf G, Dort JC, Wang (2020). Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature: A multicenter study using FFPE samples. Oral oncology, 100, 104487.
  21. Witt B (2019). Communicating communication to pathology residents and fellows. Cancer cytopathology, 127(4), 211-212.
  22. Lloyd IE, Zhou W, Witt BL, Chadwick B (2019). Characterization of PD-L1 Immunohistochemical Expression in Cell Blocks With Different Specimen Fixation and Processing Methods. Applied immunohistochemistry & molecular morphology, 27(2), 107-113.
  23. Crothers BA, Ghofrani M, Zhao C, Dodd LG, Goodrich K, Husain M, Kurtycz DFI, Russell DK, Shen RZ, Souers RJ, Staats PN, Tabatabai ZL, Witt BL, Davey D (2019). Low-Grade Squamous Intraepithelial Lesion or High-Grade Squamous Intraepithelial Lesion? Concordance Between the Interpretation of Low-Grade Squamous Intraepithelial Lesion and High-Grade Squamous Intraepithelial Lesion in Papanicolaou Tests: Results From the College of American Pathologists PAP Education Program. Archives of pathology & laboratory medicine, 143(1), 81-85.
  24. Mollaoglu G, Jones A, Wait SJ, Mukhopadhyay A, Jeong S, Arya R, Camolotto SA, Mosbruger TL, Stubben CJ, Conley CJ, Bhutkar A, Vahrenkamp JM, Berrett KC, Cessna MH, Lane TE, Witt BL, Salama ME, Gertz J, Jones KB, Snyder EL, Oliver T (2018). The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Immunity, 49(4), 764-779.e9.
  25. Witt BL, Factor RE, Chadwick BE, Caron J, Siddiqui AA, Adler D (2018). Evaluation of the SharkCore(®) needle for EUS-guided core biopsy of pancreatic neuroendocrine tumors. Endoscopic ultrasound, 7(5), 323-328.
  26. Bank JS, Witt BL, Taylor LJ, Adler D (2018). Diagnostic yield and accuracy of a new cytology brush design compared to standard brush cytology for evaluation of biliary strictures. Diagnostic cytopathology, 46(3), 234-238.
  27. Sowder AM, Witt BL, Hunt J (2018). An Update on the Risk of Lymph Node Metastasis for the Follicular Variant of Papillary Thyroid Carcinoma with the New Diagnostic Paradigm. Head and neck pathology, 12(1), 105-109.
  28. Cannon RB, Dundar Y, Thomas A, Monroe MM, Buchmann LO, Witt BL, Sowder AM, Hunt J (2017). Elective Neck Dissection for Head and Neck Cutaneous Squamous Cell Carcinoma with Skull Base Invasion. Otolaryngology--head and neck surgery, 156(4), 671-676.
  29. Mollaoglu G, Guthrie MR, Böhm S, Brägelmann J, Can I, Ballieu PM, Marx A, George J, Heinen C, Chalishazar MD, Cheng H, Ireland AS, Denning KE, Mukhopadhyay A, Vahrenkamp JM, Berrett KC, Mosbruger TL, Wang J, Kohan JL, Salama ME, Witt BL, Peifer M, Thomas RK, Gertz J, Johnson JE, Gazdar AF, Wechsler-Reya RJ, Sos ML, Oliver T (2017). MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition. Cancer cell, 31(2), 270-285.
  30. Witt BL, Cohen MB, Chadwick BE, Stephenson PD, Abasolo P, Schmidt R (2016). Cytomorphology is often insufficient to categorize non-small-cell lung carcinoma on FNA specimens. Diagnostic cytopathology, 44(2), 73-9.
  31. Layfield LJ, Schmidt RL, Chadwick BE, Esebua M, Witt B (2015). Interobserver reproducibility and agreement with original diagnosis in the categories "atypical" and "suspicious for malignancy" for bile and pancreatic duct brushings. Diagnostic cytopathology, 43(10), 797-801.
  32. Layfield LJ, Esebua M, Schmidt RL, Witt B (2015). Malignancy risk associated with the EBUS-FNA diagnostic categories nondiagnostic, benign, atypical, suspicious for malignancy, and malignant for mediastinal lymph node aspirate specimens. Journal of the American Society of Cytopathology, 4(5), 276-281.
  33. Witt BL, Albertson DJ, Coppin MG, Horrocks CF, Post M, Gulbahce H (2015). Use of in situ hybridization for HPV in head and neck tumors: experience from a national reference laboratory. Head and neck pathology, 9(1), 60-4.
  34. Zhao C, Li Z, Nayar R, Levi AW, Winkler BA, Moriarty AT, Barkan GA, Rao J, Miller F, Fan F, Zhou Z, Si Q, Fischer AH, Sturgis CD, Jing X, Marshall CB, Witt BL, Birdsong GG, Crothers B (2015). Prior high-risk human papillomavirus testing and Papanicolaou test results of 70 invasive cervical carcinomas diagnosed in 2012: results of a retrospective multicenter study. Archives of pathology & laboratory medicine, 139(2), 184-8.
  35. Jedrzkiewicz J, Witt B (2014). FNA diagnosis of a metastatic papillary thyroid carcinoma arising from a previously unknown follicular variant of papillary thyroid microcarcinoma. Diagnostic cytopathology, 42(8), 711-5.
  36. Mukhopadhyay A, Berrett KC, Kc U, Clair PM, Pop SM, Carr SR, Witt BL, Oliver T (2014). Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer. Cell reports, 8(1), 40-9.
  37. Witt BL, Garcia CA, Cohen M (2014). Giant cell tumor of bone presenting in the lumbar spine of a 35-year-old female: cytodiagnosis and other diagnostic considerations. Diagnostic cytopathology, 42(7), 624-7.
  38. Chadwick BE, Layfield LJ, Witt BL, Schmidt RL, Cox RN, Adler D (2014). Significance of atypia in pancreatic and bile duct brushings: follow-up analysis of the categories atypical and suspicious for malignancy. Diagnostic cytopathology, 42(4), 285-91.
  39. Schmidt RL, Narra KK, Witt BL, Factor R (2014). Diagnostic accuracy studies of fine-needle aspiration show wide variation in reporting of study population characteristics: implications for external validity. Archives of pathology & laboratory medicine, 138(1), 88-97.
  40. Witt BL, Kristen Hilden RN, Scaife C, Chadwick B, Layfield L, Cory Johnston W, Safaee M, Siddiqui A, Adler D (2013). Identification of factors predictive of malignancy in patients with atypical biliary brushing results obtained via ERCP. Diagnostic cytopathology, 41(8), 682-8.
  41. Ireland AS, Xie DA, Hawgood SB, Barbier MW, Zuo LY, Hanna BE, Lucas-Randolph S, Tyson DR, Witt BL, Govindan R, Dowlati A, Moser JC, Thomas A, Puri S, Rudin CM, Chan JM, Elliott A, Oliver T (2025). Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer. Nature, 647(8088), 257-267.
  42. Beiriger J, McCrary HC, Carpenter P, Witt BL, Abraham D, Monroe M (2025). Medullary thyroid cancer arising from a thyroid rest: a case report. Journal of surgical case reports, 2025(8), rjaf613.
  43. Bhatti I, Rogers RE, Witt BL, Nevala-Plagemann C, Patterson-Fortin (2025). A rare case report on esophageal squamous cell carcinoma metastatic to the pancreas. Frontiers in oncology, 15, 1602987.
  44. Cannon RB, Wiggins RH 3rd, Witt BL, Dundar Y, Johnston TM, Hunt J (2017). Imaging and Outcomes for a New Entity: Low-Grade Sinonasal Sarcoma with Neural and Myogenic Features. Journal of neurological surgery reports, 78(1), e15-e19.
  45. Koontz NA, Quigley EP, Witt BL, Sanders RK, Shah L (2015). Pigmented villonodular synovitis of the cervical spine: case report and review of the literature. BJR case reports, 2(1), 20150264.

Review

  1. Witt BL, Schmidt R (2014). Ultrasound guided core-needle biopsy of salivary gland lesions: A systematic review and meta-analysis. The Laryngoscope, 124(3), 695-700.
  2. Schmidt RL, Jedrzkiewicz JD, Allred RJ, Matsuoka S, Witt B (2014). Verification bias in diagnostic accuracy studies for fine- and core needle biopsy of salivary gland lesions in otolaryngology journals: a systematic review and analysis. Head & neck, 36(11), 1654-61.
  3. Witt BL, Schmidt R (2014). Ultrasound-guided core needle biopsy of salivary gland lesions: a systematic review and meta-analysis. The Laryngoscope, 124(3), 695-700.
  4. Schmidt RL, Factor RE, Witt BL, Layfield L (2013). Quality appraisal of diagnostic accuracy studies in fine-needle aspiration cytology: a survey of risk of bias and comparability. Archives of pathology & laboratory medicine, 137(4), 566-75.
  5. Witt BL, Schmidt R (2013). Rapid onsite evaluation improves the adequacy of fine-needle aspiration for thyroid lesions: a systematic review and meta-analysis. Thyroid, 23(4), 428-35.
  6. Schmidt RL, Witt BL, Lopez-Calderon LE, Layfield L (2013). The influence of rapid onsite evaluation on the adequacy rate of fine-needle aspiration cytology: a systematic review and meta-analysis. American journal of clinical pathology, 139(3), 300-8.
  7. Schmidt RL, Witt BL, Matynia AP, Barraza G, Layfield LJ, Adler D (2013). Rapid on-site evaluation increases endoscopic ultrasound-guided fine-needle aspiration adequacy for pancreatic lesions. Digestive diseases and sciences, 58(3), 872-82.