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Changhong Xing

Changhong Xing, MD, PhD

Languages spoken: English

Clinical Locations


Salt Lake City

University of Utah Hospital

Salt Lake City
  • Specialties

    • Pathology, Anatomical

    Board Certification

    American Board of Pathology (Sub: Anatomic Path)
  • Board Certification and Academic Information

    Academic Departments Pathology -Primary
    Board Certification
    American Board of Pathology (Sub: Anatomic Path)

    Education history

    Fellowship Neuropathology - University of Texas Southwestern Medical Center Fellow
    Pathology - University of Texas Southwestern Medical Center Resident
    Research Fellow Massachusetts General Hospital Harvard Medical School Research Fellow
    Neurobiology - Tsinghua University Ph.D.
    Professional Medical Pathology - Peking University Health Science Center MMed
    Medicine - Hebei Medical University BMed

    Selected Publications

    Journal Article

    1. Li W, Mandeville ET, Durn-Laforet V, Fukuda N, Yu Z, Zheng Y, Held A, Park JH, Nakano T, Tanaka M, Shi J, Esposito E, Niu W, Xing C, Hayakawa K, Lizasoain I, van Leyen K, Ji X, Wainger BJ, Moro MA, Lo EH (2022). Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke. Nat Commun, 13(1), 7812. (Read full article)
    2. Yu F, Saand A, Xing C, Lee JW, Hsu L, Palmer OP, Jackson V, Tang L, Ning M, Du R, Kochanek PM, Lo EH, Chou SH (2021). CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome. J Cereb Blood Flow Metab, 41(10), 2524-2533. (Read full article)
    3. Deng W, Mandeville E, Terasaki Y, Li W, Holder J, Chuang AT, Ning M, Arai K, Lo EH, Xing C (2020). Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. J Cereb Blood Flow Metab, 40(1_suppl), S34-S48. (Read full article)
    4. Takase H, Chou SH, Hamanaka G, Ohtomo R, Islam MR, Lee JW, Hsu L, Mathew J, Reyes-Bricio E, Hayakawa K, Xing C, Ning MM, Wang X, Arai K, Lo EH, Lok J (2020). Soluble vascular endothelial-cadherin in CSF after subarachnoid hemorrhage. Neurology, 94(12), e1281-e1293. (Read full article)
    5. Deng W, Xing C, David R, Mastroeni D, Ning M, Lo EH, Coleman PD (2019). AmpliSeq Transcriptome of Laser Captured Neurons from Alzheimer Brain: Comparison of Single Cell Versus Neuron Pools. Aging Dis, 10(6), 1146-1158. (Read full article)
    6. Du Y, Li W, Lin L, Lo EH, Xing C (2019). Effects of lipocalin-2 on brain endothelial adhesion and permeability. PLoS One, 14(7), e0218965. (Read full article)
    7. Guo S, Deng W, Xing C, Zhou Y, Ning M, Lo EH (2018). Effects of aging, hypertension and diabetes on the mouse brain and heart vasculomes. Neurobiol Dis, 126, 117-123. (Read full article)
    8. Zhao Q, Yu Z, Zhang F, Huang L, Xing C, Liu N, Xu Y, Wang X (2018). HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation-induced transendothelial permeability by elevating PPARγ activity in vitro. J Neurochem, 149(2), 298-310. (Read full article)
    9. Guo S, Tjrnlund-Wolf A, Deng W, Tejima-Mandeville E, Lo LJ, Xing C, Arai K, Ning M, Zhou Y, Lo EH (2018). Comparative transcriptome of neurons after oxygen-glucose deprivation: Potential differences in neuroprotection versus reperfusion. J Cereb Blood Flow Metab, 38(12), 2236-2250. (Read full article)
    10. Lei H, Zhang Y, Huang L, Xu S, Li J, Yang L, Wang L, Xing C, Wang X, Peng Y (2018). L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway. Neurotox Res, 34(3), 477-488. (Read full article)
    11. Huang L, Wang S, Ma F, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y (2018). From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Pharmacol Res, 135, 201-211. (Read full article)
    12. Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH (2018). Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem, 146(2), 160-172. (Read full article)
    13. Xing C, Li W, Deng W, Ning M, Lo EH (2018). A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes. J Neuroinflammation, 15(1), 143. (Read full article)
    14. Wang S, Ma F, Huang L, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y (2018). Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke. CNS Neurol Disord Drug Targets, 17(5), 338-347. (Read full article)
    15. Cheng C, Yu Z, Zhao S, Liao Z, Xing C, Jiang Y, Yang YG, Whalen MJ, Lo EH, Sun X, Wang X (2017). Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice. Int J Med Sci, 14(10), 927-936. (Read full article)
    16. Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K (2017). A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev, 26(14), 1078-1085. (Read full article)
    17. Zhao C, Hou W, Lei H, Huang L, Wang S, Cui D, Xing C, Wang X, Peng Y (2017). Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice. Acta Pharm Sin B, 7(4), 470-478. (Read full article)
    18. Lin L, Desai R, Wang X, Lo EH, Xing C (2017). Characteristics of primary rat microglia isolated from mixed cultures using two different methods. J Neuroinflammation, 14(1), 101. (Read full article)
    19. Xing C, Lo EH (2016). Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery. Prog Neurobiol, 152, 181-199. (Read full article)
    20. Du Y, Deng W, Wang Z, Ning M, Zhang W, Zhou Y, Lo EH, Xing C (2016). Differential subnetwork of chemokines/cytokines in human, mouse, and rat brain cells after oxygen-glucose deprivation. J Cereb Blood Flow Metab, 37(4), 1425-1434. (Read full article)
    21. Xing C, Hayakawa K, Lo EH (2016). Mechanisms, Imaging, and Therapy in Stroke Recovery. Transl Stroke Res, 8(1), 1-2. (Read full article)
    22. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH (2016). Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med, 22(11), 1335-1341. (Read full article)
    23. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH (2016). Transfer of mitochondria from astrocytes to neurons after stroke. Nature, 535(7613), 551-5. (Read full article)
    24. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH (2016). Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma, 33(14), 1303-16. (Read full article)
    25. Jeong SY, Jeon R, Choi YK, Jung JE, Liang A, Xing C, Wang X, Lo EH, Song YS (2015). Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia. J Neurochem, 136(4), 851-858. (Read full article)
    26. Chen F, Du Y, Esposito E, Liu Y, Guo S, Wang X, Lo EH, Xing C, Ji X (2015). Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126. Transl Stroke Res, 6(6), 478-84. (Read full article)
    27. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY (2014). Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther, 21(4), 304-8. (Read full article)
    28. Wu L, Du Y, Lok J, Lo EH, Xing C (2015). Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms. J Neurochem, 132(6), 622-8. (Read full article)
    29. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH (2014). Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke, 45(7), 2085-92. (Read full article)
    30. Guo S, Lok J, Liu Y, Hayakawa K, Leung W, Xing C, Ji X, Lo EH (2014). Assays to examine endothelial cell migration, tube formation, and gene expression profiles. Methods Mol Biol, 1135, 393-402. (Read full article)
    31. Navaratna D, Fan X, Leung W, Lok J, Guo S, Xing C, Wang X, Lo EH (2013). Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain. J Clin Invest, 123(8), 3373-7. (Read full article)
    32. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K (2012). Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets, 12(3), 302-15. (Read full article)
    33. Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K (2012). Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J, 27(2), 437-45. (Read full article)
    34. Xing C, Arai K, Lo EH, Hommel M (2012). Pathophysiologic cascades in ischemic stroke. Int J Stroke, 7(5), 378-85. (Read full article)
    35. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X (2012). Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci, 13, 67. (Read full article)
    36. Xing C, Levchenko T, Guo S, Stins M, Torchilin VP, Lo EH (2012). Delivering minocycline into brain endothelial cells with liposome-based technology. J Cereb Blood Flow Metab, 32(6), 983-8. (Read full article)
    37. Xing C, Hayakawa K, Lok J, Arai K, Lo EH (2012). Injury and repair in the neurovascular unit. Neurol Res, 34(4), 325-30. (Read full article)
    38. Liu N, Yu Z, Xiang S, Zhao S, Tjrnlund-Wolf A, Xing C, Zhang J, Wang X (2012). Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression. Biochem J, 443(1), 153-64. (Read full article)
    39. Guo S, Zhou Y, Xing C, Lok J, Som AT, Ning M, Ji X, Lo EH (2012). The vasculome of the mouse brain. PLoS One, 7(12), e52665. (Read full article)
    40. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH (2011). Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol, 26(9), 1193-8. (Read full article)
    41. Xing C, Arai K, Park KP, Lo EH (2010). Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res, 35(7), 1092-7. (Read full article)
    42. Peng Y, Xing C, Xu S, Lemere CA, Chen G, Liu B, Wang L, Feng Y, Wang X (2009). L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. Eur J Pharmacol, 621(1-3), 38-45. (Read full article)
    43. Yu Z, Liu J, Guo S, Xing C, Fan X, Ning M, Yuan JC, Lo EH, Wang X (2009). Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation. Neuroscience, 162(2), 396-403. (Read full article)
    44. Xing C, Lee S, Kim WJ, Wang H, Yang YG, Ning M, Wang X, Lo EH (2009). Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro. J Neurosci Res, 87(11), 2571-7. (Read full article)
    45. Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH (2009). Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke, 40(8), 2836-42. (Read full article)
    46. Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH (2009). CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol, 217(1), 165-70. (Read full article)
    47. Zhao WH, Ji XM, Ling F, Ding YC, Xing CH, Wu H, Guo M, Xuan Y, Guan B, Jiang LL (2008). Local mild hypothermia induced by intra-arterial cold saline infusion prolongs the time window of onset of reperfusion injury after transient focal ischemia in rats. Neurol Res, 31(1), 43-51. (Read full article)
    48. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X (2008). Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res, 87(1), 164-70. (Read full article)
    49. Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH (2008). Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem, 108(2), 430-6. (Read full article)
    50. Peng Y, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X (2008). l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells. Neurosci Lett, 434(2), 224-9. (Read full article)
    51. Xing C, Yin Y, Chang R, Gong X, He X, Xie Z (2007). Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons. Exp Neurol, 205(1), 222-9. (Read full article)
    52. Xing C, Yin Y, He X, Xie Z (2006). Effects of insulin-like growth factor 1 on voltage-gated ion channels in cultured rat hippocampal neurons. Brain Res, 1072(1), 30-5. (Read full article)
    53. Xing C, Peng Y, Chang R, Yin Y, Xie Z (2005). Effects of insulin-like growth factor-1 on okadaic acid-induced apoptosis in SH-SY5Y cells. Cell Biol Int, 29(9), 803-8. (Read full article)
    54. Xing C, Yin Y, Chang R, He X, Xie Z (2005). A role of insulin-like growth factor 1 in beta amyloid-induced disinhibition of hippocampal neurons. Neurosci Lett, 384(1-2), 93-7. (Read full article)
    55. Gong H, Shen P, Jin L, Xing C, Tang F (2005). Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice. Cancer Biother Radiopharm, 20(2), 155-62. (Read full article)
    56. Hai-Yang G, Ping S, Li JI, Chang-Hong X, Fu T (2005). Therapeutic effects of Lycium barbarum polysaccharide (LBP) on mitomycin C (MMC)-induced myelosuppressive mice. J Exp Ther Oncol, 4(3), 181-7. (Read full article)
    57. Han J, Xia C, Gao J, Xing C, Yang X, Tang X, Qiu F, Du Y (2002). [Expression of vascular endothelial growth factor in colorectal cancer and its clinical significance]. Zhonghua Yi Xue Za Zhi, 82(7), 481-3. (Read full article)
    58. Xing C, Gong E (1998). Detection of hepatitis C virus RNA in liver tissues by in situ hybridization. Cell Vis, 5(1), 80-2. (Read full article)