Changhong Xing
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Changhong Xing, MD, PhD

Languages spoken: English

Clinical Locations

Primary Location

University of Utah Hospital

Pathology
50 N Medical Dr
Salt Lake City , UT 84132
801-581-2121
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ARUP

500 Chipeta Way
Salt Lake City , UT 84108
801-581-2121
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Specialties

  • Pathology, Anatomical

Board Certification

American Board of Pathology (Sub: Anatomic Path)
American Board of Pathology (Sub: Neuropathology)

Board Certification and Academic Information

Academic Departments Pathology -Assistant Professor (Clinical)
Board Certification
American Board of Pathology (Sub: Anatomic Path)
American Board of Pathology (Sub: Neuropathology)

Education history

Undergraduate Medicine - Hebei Medical University BMed
Professional Medical Pathology - Peking University Health Science Center MMed
Doctoral Training Neurobiology - Tsinghua University Ph.D.
Research Fellow Massachusetts General Hospital Harvard Medical School Research Fellow
Residency Pathology - University of Texas Southwestern Medical Center Resident
Fellowship Neuropathology - University of Texas Southwestern Medical Center Fellow

Selected Publications

Journal Article

  1. Li W, Mandeville ET, Durán-Laforet V, Fukuda N, Yu Z, Zheng Y, Held A, Park JH, Nakano T, Tanaka M, Shi J, Esposito E, Niu W, Xing C, Hayakawa K, Lizasoain I, van Leyen K, Ji X, Wainger BJ, Moro MA, Lo EH (2022). Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke. Nat Commun, 13(1), 7812.
  2. Xing C, Gong E (1998). Detection of hepatitis C virus RNA in liver tissues by in situ hybridization. Cell Vis, 5(1), 80-2.
  3. Han J, Xia C, Gao J, Xing C, Yang X, Tang X, Qiu F, Du Y (2002). [Expression of vascular endothelial growth factor in colorectal cancer and its clinical significance]. Zhonghua Yi Xue Za Zhi, 82(7), 481-3.
  4. Xing C, Arai K, Park KP, Lo EH (2010). Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res, 35(7), 1092-7.
  5. Takase H, Chou SH, Hamanaka G, Ohtomo R, Islam MR, Lee JW, Hsu L, Mathew J, Reyes-Bricio E, Hayakawa K, Xing C, Ning MM, Wang X, Arai K, Lo EH, Lok J (2020). Soluble vascular endothelial-cadherin in CSF after subarachnoid hemorrhage. Neurology, 94(12), e1281-e1293.
  6. Gong H, Shen P, Jin L, Xing C, Tang F (2005). Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice. Cancer Biother Radiopharm, 20(2), 155-62.
  7. Xing C, Yin Y, Chang R, He X, Xie Z (2005). A role of insulin-like growth factor 1 in beta amyloid-induced disinhibition of hippocampal neurons. Neurosci Lett, 384(1-2), 93-7.
  8. Xing C, Yin Y, He X, Xie Z (2006). Effects of insulin-like growth factor 1 on voltage-gated ion channels in cultured rat hippocampal neurons. Brain Res, 1072(1), 30-5.
  9. Xing C, Yin Y, Chang R, Gong X, He X, Xie Z (2007). Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons. Exp Neurol, 205(1), 222-9.
  10. Xing C, Peng Y, Chang R, Yin Y, Xie Z (2005). Effects of insulin-like growth factor-1 on okadaic acid-induced apoptosis in SH-SY5Y cells. Cell Biol Int, 29(9), 803-8.
  11. Peng Y, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X (2008). l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells. Neurosci Lett, 434(2), 224-9.
  12. Peng Y, Xing C, Xu S, Lemere CA, Chen G, Liu B, Wang L, Feng Y, Wang X (2009). L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. Eur J Pharmacol, 621(1-3), 38-45.
  13. Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH (2009). Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke, 40(8), 2836-42.
  14. Xing C, Lee S, Kim WJ, Wang H, Yang YG, Ning M, Wang X, Lo EH (2009). Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro. J Neurosci Res, 87(11), 2571-7.
  15. Yu Z, Liu J, Guo S, Xing C, Fan X, Ning M, Yuan JC, Lo EH, Wang X (2009). Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation. Neuroscience, 162(2), 396-403.
  16. Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH (2009). CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol, 217(1), 165-70.
  17. Chen F, Du Y, Esposito E, Liu Y, Guo S, Wang X, Lo EH, Xing C, Ji X (2015). Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126. Transl Stroke Res, 6(6), 478-84.
  18. Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH (2009). Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem, 108(2), 430-6.
  19. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X (2009). Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res, 87(1), 164-70.
  20. Zhao WH, Ji XM, Ling F, Ding YC, Xing CH, Wu H, Guo M, Xuan Y, Guan B, Jiang LL (2009). Local mild hypothermia induced by intra-arterial cold saline infusion prolongs the time window of onset of reperfusion injury after transient focal ischemia in rats. Neurol Res, 31(1), 43-51.
  21. Liu N, Yu Z, Xiang S, Zhao S, Tjärnlund-Wolf A, Xing C, Zhang J, Wang X (2012). Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression. Biochem J, 443(1), 153-64.
  22. Xing C, Levchenko T, Guo S, Stins M, Torchilin VP, Lo EH (2012). Delivering minocycline into brain endothelial cells with liposome-based technology. J Cereb Blood Flow Metab, 32(6), 983-8.
  23. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X (2012). Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci, 13, 67.
  24. Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K (2013). Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J, 27(2), 437-45.
  25. Guo S, Zhou Y, Xing C, Lok J, Som AT, Ning M, Ji X, Lo EH (2012). The vasculome of the mouse brain. PLoS One, 7(12), e52665.
  26. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH (2016). Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma, 33(14), 1303-16.
  27. Navaratna D, Fan X, Leung W, Lok J, Guo S, Xing C, Wang X, Lo EH (2013). Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain. J Clin Invest, 123(8), 3373-7.
  28. Guo S, Lok J, Liu Y, Hayakawa K, Leung W, Xing C, Ji X, Lo EH (2014). Assays to examine endothelial cell migration, tube formation, and gene expression profiles. Methods Mol Biol, 1135, 393-402.
  29. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH (2014). Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke, 45(7), 2085-92.
  30. Wu L, Du Y, Lok J, Lo EH, Xing C (2015). Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms. J Neurochem, 132(6), 622-8.
  31. Jeong SY, Jeon R, Choi YK, Jung JE, Liang A, Xing C, Wang X, Lo EH, Song YS (2016). Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia. J Neurochem, 136(4), 851-858.
  32. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH (2016). Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med, 22(11), 1335-1341.
  33. Du Y, Deng W, Wang Z, Ning M, Zhang W, Zhou Y, Lo EH, Xing C (2017). Differential subnetwork of chemokines/cytokines in human, mouse, and rat brain cells after oxygen-glucose deprivation. J Cereb Blood Flow Metab, 37(4), 1425-1434.
  34. Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K (2017). A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev, 26(14), 1078-1085.
  35. Lin L, Desai R, Wang X, Lo EH, Xing C (2017). Characteristics of primary rat microglia isolated from mixed cultures using two different methods. J Neuroinflammation, 14(1), 101.
  36. Zhao C, Hou W, Lei H, Huang L, Wang S, Cui D, Xing C, Wang X, Peng Y (2017). Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice. Acta Pharm Sin B, 7(4), 470-478.
  37. Cheng C, Yu Z, Zhao S, Liao Z, Xing C, Jiang Y, Yang YG, Whalen MJ, Lo EH, Sun X, Wang X (2017). Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice. Int J Med Sci, 14(10), 927-936.
  38. Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH (2018). Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem, 146(2), 160-172.
  39. Lei H, Zhang Y, Huang L, Xu S, Li J, Yang L, Wang L, Xing C, Wang X, Peng Y (2018). L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway. Neurotox Res, 34(3), 477-488.
  40. Xing C, Li W, Deng W, Ning M, Lo EH (2018). A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes. J Neuroinflammation, 15(1), 143.
  41. Guo S, Deng W, Xing C, Zhou Y, Ning M, Lo EH (2019). Effects of aging, hypertension and diabetes on the mouse brain and heart vasculomes. Neurobiol Dis, 126, 117-123.
  42. Guo S, Tjärnlund-Wolf A, Deng W, Tejima-Mandeville E, Lo LJ, Xing C, Arai K, Ning M, Zhou Y, Lo EH (2018). Comparative transcriptome of neurons after oxygen-glucose deprivation: Potential differences in neuroprotection versus reperfusion. J Cereb Blood Flow Metab, 38(12), 2236-2250.
  43. Zhao Q, Yu Z, Zhang F, Huang L, Xing C, Liu N, Xu Y, Wang X (2019). HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation-induced transendothelial permeability by elevating PPAR¿ activity in vitro. J Neurochem, 149(2), 298-310.
  44. Du Y, Li W, Lin L, Lo EH, Xing C (2019). Effects of lipocalin-2 on brain endothelial adhesion and permeability. PLoS One, 14(7), e0218965.
  45. Deng W, Xing C, David R, Mastroeni D, Ning M, Lo EH, Coleman PD (2019). AmpliSeq Transcriptome of Laser Captured Neurons from Alzheimer Brain: Comparison of Single Cell Versus Neuron Pools. Aging Dis, 10(6), 1146-1158.
  46. Deng W, Mandeville E, Terasaki Y, Li W, Holder J, Chuang AT, Ning M, Arai K, Lo EH, Xing C (2020). Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. J Cereb Blood Flow Metab, 40(1_suppl), S34-S48.
  47. Yu F, Saand A, Xing C, Lee JW, Hsu L, Palmer OP, Jackson V, Tang L, Ning M, Du R, Kochanek PM, Lo EH, Chou SH (2021). CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome. J Cereb Blood Flow Metab, 41(10), 2524-2533.
  48. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH (2011). Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol, 26(9), 1193-8.
  49. Xing C, Hayakawa K, Lok J, Arai K, Lo EH (2012). Injury and repair in the neurovascular unit. Neurol Res, 34(4), 325-30.
  50. Xing C, Arai K, Lo EH, Hommel M (2012). Pathophysiologic cascades in ischemic stroke. Int J Stroke, 7(5), 378-85.
  51. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K (2013). Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets, 12(3), 302-15.
  52. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY (2015). Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther, 21(4), 304-8.
  53. Xing C, Lo EH (2017). Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery. Prog Neurobiol, 152, 181-199.
  54. Xing C, Hayakawa K, Lo EH (2017). Mechanisms, Imaging, and Therapy in Stroke Recovery. Transl Stroke Res, 8(1), 1-2.
  55. Wang S, Ma F, Huang L, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y (2018). Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke. CNS Neurol Disord Drug Targets, 17(5), 338-347.
  56. Huang L, Wang S, Ma F, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y (2018). From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Pharmacol Res, 135, 201-211.
  57. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH (2016). Transfer of mitochondria from astrocytes to neurons after stroke. Nature, 535(7613), 551-5.
  58. Hai-Yang G, Ping S, Li JI, Chang-Hong X, Fu (2004). Therapeutic effects of Lycium barbarum polysaccharide (LBP) on mitomycin C (MMC)-induced myelosuppressive mice. Journal of experimental therapeutics & oncology, 4(3), 181-7.
  59. Xing C, Trivedi J, Bitencourt N, Burns DK, Reisch JS, Cai (2024). Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis. Muscle & nerve, 69(5), 548-555.
  60. Lokken A, Goold E, Comstock JM, Xing (2025). Mevalonate kinase deficiency: Neuropathologic findings in an autopsy brain. Journal of neuropathology and experimental neurology,
  61. Allsop VL, Gaumnitz J, Xing C, Goold E, Thomas (2025). Myositis Due to Parvovirus B19: A Case Report and Literature Review. Cureus, 17(5), e83683.
  62. Robinson LJ, Goold E, Anderson D, Rennert RC, Couldwell WT, Xing (2024). A mass in the pineal region of a young woman. Brain pathology (Zurich, Switzerland), 34(3), e13258.
  63. Jia L, Xing C, Kandathil A, Rosado F, Chen W, Ramakrishnan Geethakumari (2024). Fibrin-Associated Large B-Cell Lymphoma (FA-LBCL) Involving Solid Organs as Necrotic Cystic Lesions-A Rare Entity with Potential Diagnostic Pitfalls: A Two-Case Series and Review of the Literature. International journal of surgical pathology, 32(3), 543-550.