Changhong Xing
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Changhong Xing, MD, PhD

Languages spoken: English

Clinical Locations

Primary Location

ARUP

500 Chipeta Way
Salt Lake City , UT 84108
801-581-2121
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University of Utah Hospital

Pathology
50 N Medical Dr
Salt Lake City , UT 84132
801-581-2121
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  • Specialties

    • Pathology, Anatomical

    Board Certification

    American Board of Pathology (Sub: Anatomic Path)

  • Board Certification and Academic Information

    Academic Departments Pathology -Assistant Professor (Clinical)
    Board Certification
    American Board of Pathology (Sub: Anatomic Path)

    Education history

    Fellowship Neuropathology - University of Texas Southwestern Medical Center Fellow
    Residency Pathology - University of Texas Southwestern Medical Center Resident
    Research Fellow Massachusetts General Hospital Harvard Medical School Research Fellow
    Doctoral Training Neurobiology - Tsinghua University Ph.D.
    Professional Medical Pathology - Peking University Health Science Center MMed
    Undergraduate Medicine - Hebei Medical University BMed

    Selected Publications

    Journal Article

    1. Lokken A, Goold E, Comstock JM, Xing C (2025). Mevalonate kinase deficiency: Neuropathologic findings in an autopsy brain. J Neuropathol Exp Neurol. (Read full publication)
    2. Allsop VL, Gaumnitz J, Xing C, Goold E, Thomas J (2025). Myositis Due to Parvovirus B19: A Case Report and Literature Review. Cureus, 17(5), e83683. (Read full publication)
    3. Xing C, Trivedi J, Bitencourt N, Burns DK, Reisch JS, Cai C (2024). Myxovirus resistance protein A (MxA) expression in myositides: Sarcoplasmic expression is common in both dermatomyositis and lupus myositis. Muscle Nerve, 69(5), 548-555. (Read full publication)
    4. Robinson LJ, Goold E, Anderson D, Rennert RC, Couldwell WT, Xing C (2024). A mass in the pineal region of a young woman. Brain Pathol, 34(3), e13258. (Read full publication)
    5. Li W, Mandeville ET, Durn-Laforet V, Fukuda N, Yu Z, Zheng Y, Held A, Park JH, Nakano T, Tanaka M, Shi J, Esposito E, Niu W, Xing C, Hayakawa K, Lizasoain I, van Leyen K, Ji X, Wainger BJ, Moro MA, Lo EH (2022). Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke. Nat Commun, 13(1), 7812. (Read full publication)
    6. Yu F, Saand A, Xing C, Lee JW, Hsu L, Palmer OP, Jackson V, Tang L, Ning M, Du R, Kochanek PM, Lo EH, Chou SH (2021). CSF lipocalin-2 increases early in subarachnoid hemorrhage are associated with neuroinflammation and unfavorable outcome. J Cereb Blood Flow Metab, 41(10), 2524-2533. (Read full publication)
    7. Deng W, Mandeville E, Terasaki Y, Li W, Holder J, Chuang AT, Ning M, Arai K, Lo EH, Xing C (2020). Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. J Cereb Blood Flow Metab, 40(1_suppl), S34-S48. (Read full publication)
    8. Takase H, Chou SH, Hamanaka G, Ohtomo R, Islam MR, Lee JW, Hsu L, Mathew J, Reyes-Bricio E, Hayakawa K, Xing C, Ning MM, Wang X, Arai K, Lo EH, Lok J (2020). Soluble vascular endothelial-cadherin in CSF after subarachnoid hemorrhage. Neurology, 94(12), e1281-e1293. (Read full publication)
    9. Deng W, Xing C, David R, Mastroeni D, Ning M, Lo EH, Coleman PD (2019). AmpliSeq Transcriptome of Laser Captured Neurons from Alzheimer Brain: Comparison of Single Cell Versus Neuron Pools. Aging Dis, 10(6), 1146-1158. (Read full publication)
    10. Du Y, Li W, Lin L, Lo EH, Xing C (2019). Effects of lipocalin-2 on brain endothelial adhesion and permeability. PLoS One, 14(7), e0218965. (Read full publication)
    11. Guo S, Deng W, Xing C, Zhou Y, Ning M, Lo EH (2018). Effects of aging, hypertension and diabetes on the mouse brain and heart vasculomes. Neurobiol Dis, 126, 117-123. (Read full publication)
    12. Zhao Q, Yu Z, Zhang F, Huang L, Xing C, Liu N, Xu Y, Wang X (2018). HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation-induced transendothelial permeability by elevating PPARγ activity in vitro. J Neurochem, 149(2), 298-310. (Read full publication)
    13. Guo S, Tjrnlund-Wolf A, Deng W, Tejima-Mandeville E, Lo LJ, Xing C, Arai K, Ning M, Zhou Y, Lo EH (2018). Comparative transcriptome of neurons after oxygen-glucose deprivation: Potential differences in neuroprotection versus reperfusion. J Cereb Blood Flow Metab, 38(12), 2236-2250. (Read full publication)
    14. Lei H, Zhang Y, Huang L, Xu S, Li J, Yang L, Wang L, Xing C, Wang X, Peng Y (2018). L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway. Neurotox Res, 34(3), 477-488. (Read full publication)
    15. Huang L, Wang S, Ma F, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y (2018). From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Pharmacol Res, 135, 201-211. (Read full publication)
    16. Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH (2018). Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem, 146(2), 160-172. (Read full publication)
    17. Xing C, Li W, Deng W, Ning M, Lo EH (2018). A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes. J Neuroinflammation, 15(1), 143. (Read full publication)
    18. Wang S, Ma F, Huang L, Zhang Y, Peng Y, Xing C, Feng Y, Wang X, Peng Y (2018). Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke. CNS Neurol Disord Drug Targets, 17(5), 338-347. (Read full publication)
    19. Cheng C, Yu Z, Zhao S, Liao Z, Xing C, Jiang Y, Yang YG, Whalen MJ, Lo EH, Sun X, Wang X (2017). Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice. Int J Med Sci, 14(10), 927-936. (Read full publication)
    20. Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K (2017). A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev, 26(14), 1078-1085. (Read full publication)
    21. Zhao C, Hou W, Lei H, Huang L, Wang S, Cui D, Xing C, Wang X, Peng Y (2017). Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice. Acta Pharm Sin B, 7(4), 470-478. (Read full publication)
    22. Lin L, Desai R, Wang X, Lo EH, Xing C (2017). Characteristics of primary rat microglia isolated from mixed cultures using two different methods. J Neuroinflammation, 14(1), 101. (Read full publication)
    23. Xing C, Lo EH (2016). Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery. Prog Neurobiol, 152, 181-199. (Read full publication)
    24. Du Y, Deng W, Wang Z, Ning M, Zhang W, Zhou Y, Lo EH, Xing C (2016). Differential subnetwork of chemokines/cytokines in human, mouse, and rat brain cells after oxygen-glucose deprivation. J Cereb Blood Flow Metab, 37(4), 1425-1434. (Read full publication)
    25. Xing C, Hayakawa K, Lo EH (2016). Mechanisms, Imaging, and Therapy in Stroke Recovery. Transl Stroke Res, 8(1), 1-2. (Read full publication)
    26. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH (2016). Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med, 22(11), 1335-1341. (Read full publication)
    27. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH (2016). Transfer of mitochondria from astrocytes to neurons after stroke. Nature, 535(7613), 551-5. (Read full publication)
    28. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH (2016). Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma, 33(14), 1303-16. (Read full publication)
    29. Jeong SY, Jeon R, Choi YK, Jung JE, Liang A, Xing C, Wang X, Lo EH, Song YS (2015). Activation of microglial Toll-like receptor 3 promotes neuronal survival against cerebral ischemia. J Neurochem, 136(4), 851-858. (Read full publication)
    30. Chen F, Du Y, Esposito E, Liu Y, Guo S, Wang X, Lo EH, Xing C, Ji X (2015). Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126. Transl Stroke Res, 6(6), 478-84. (Read full publication)
    31. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY (2014). Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther, 21(4), 304-8. (Read full publication)
    32. Wu L, Du Y, Lok J, Lo EH, Xing C (2015). Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms. J Neurochem, 132(6), 622-8. (Read full publication)
    33. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH (2014). Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke, 45(7), 2085-92. (Read full publication)
    34. Guo S, Lok J, Liu Y, Hayakawa K, Leung W, Xing C, Ji X, Lo EH (2014). Assays to examine endothelial cell migration, tube formation, and gene expression profiles. Methods Mol Biol, 1135, 393-402. (Read full publication)
    35. Navaratna D, Fan X, Leung W, Lok J, Guo S, Xing C, Wang X, Lo EH (2013). Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain. J Clin Invest, 123(8), 3373-7. (Read full publication)
    36. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K (2012). Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets, 12(3), 302-15. (Read full publication)
    37. Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K (2012). Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J, 27(2), 437-45. (Read full publication)
    38. Xing C, Arai K, Lo EH, Hommel M (2012). Pathophysiologic cascades in ischemic stroke. Int J Stroke, 7(5), 378-85. (Read full publication)
    39. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X (2012). Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci, 13, 67. (Read full publication)
    40. Xing C, Levchenko T, Guo S, Stins M, Torchilin VP, Lo EH (2012). Delivering minocycline into brain endothelial cells with liposome-based technology. J Cereb Blood Flow Metab, 32(6), 983-8. (Read full publication)
    41. Xing C, Hayakawa K, Lok J, Arai K, Lo EH (2012). Injury and repair in the neurovascular unit. Neurol Res, 34(4), 325-30. (Read full publication)
    42. Liu N, Yu Z, Xiang S, Zhao S, Tjrnlund-Wolf A, Xing C, Zhang J, Wang X (2012). Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression. Biochem J, 443(1), 153-64. (Read full publication)
    43. Guo S, Zhou Y, Xing C, Lok J, Som AT, Ning M, Ji X, Lo EH (2012). The vasculome of the mouse brain. PLoS One, 7(12), e52665. (Read full publication)
    44. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH (2011). Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol, 26(9), 1193-8. (Read full publication)
    45. Xing C, Arai K, Park KP, Lo EH (2010). Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res, 35(7), 1092-7. (Read full publication)
    46. Peng Y, Xing C, Xu S, Lemere CA, Chen G, Liu B, Wang L, Feng Y, Wang X (2009). L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats. Eur J Pharmacol, 621(1-3), 38-45. (Read full publication)
    47. Yu Z, Liu J, Guo S, Xing C, Fan X, Ning M, Yuan JC, Lo EH, Wang X (2009). Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation. Neuroscience, 162(2), 396-403. (Read full publication)
    48. Xing C, Lee S, Kim WJ, Wang H, Yang YG, Ning M, Wang X, Lo EH (2009). Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro. J Neurosci Res, 87(11), 2571-7. (Read full publication)
    49. Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH (2009). Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke, 40(8), 2836-42. (Read full publication)
    50. Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH (2009). CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol, 217(1), 165-70. (Read full publication)
    51. Zhao WH, Ji XM, Ling F, Ding YC, Xing CH, Wu H, Guo M, Xuan Y, Guan B, Jiang LL (2008). Local mild hypothermia induced by intra-arterial cold saline infusion prolongs the time window of onset of reperfusion injury after transient focal ischemia in rats. Neurol Res, 31(1), 43-51. (Read full publication)
    52. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X (2008). Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res, 87(1), 164-70. (Read full publication)
    53. Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH (2008). Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem, 108(2), 430-6. (Read full publication)
    54. Peng Y, Xing C, Lemere CA, Chen G, Wang L, Feng Y, Wang X (2008). l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells. Neurosci Lett, 434(2), 224-9. (Read full publication)
    55. Xing C, Yin Y, Chang R, Gong X, He X, Xie Z (2007). Effects of insulin-like growth factor 1 on synaptic excitability in cultured rat hippocampal neurons. Exp Neurol, 205(1), 222-9. (Read full publication)
    56. Xing C, Yin Y, He X, Xie Z (2006). Effects of insulin-like growth factor 1 on voltage-gated ion channels in cultured rat hippocampal neurons. Brain Res, 1072(1), 30-5. (Read full publication)
    57. Xing C, Peng Y, Chang R, Yin Y, Xie Z (2005). Effects of insulin-like growth factor-1 on okadaic acid-induced apoptosis in SH-SY5Y cells. Cell Biol Int, 29(9), 803-8. (Read full publication)
    58. Xing C, Yin Y, Chang R, He X, Xie Z (2005). A role of insulin-like growth factor 1 in beta amyloid-induced disinhibition of hippocampal neurons. Neurosci Lett, 384(1-2), 93-7. (Read full publication)
    59. Gong H, Shen P, Jin L, Xing C, Tang F (2005). Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice. Cancer Biother Radiopharm, 20(2), 155-62. (Read full publication)
    60. Hai-Yang G, Ping S, Li JI, Chang-Hong X, Fu T (2005). Therapeutic effects of Lycium barbarum polysaccharide (LBP) on mitomycin C (MMC)-induced myelosuppressive mice. J Exp Ther Oncol, 4(3), 181-7. (Read full publication)
    61. Han J, Xia C, Gao J, Xing C, Yang X, Tang X, Qiu F, Du Y (2002). [Expression of vascular endothelial growth factor in colorectal cancer and its clinical significance]. Zhonghua Yi Xue Za Zhi, 82(7), 481-3. (Read full publication)
    62. Xing C, Gong E (1998). Detection of hepatitis C virus RNA in liver tissues by in situ hybridization. Cell Vis, 5(1), 80-2. (Read full publication)