Christian Con Yost
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Christian Con Yost, MD

Languages spoken: English

Clinical Locations

Primary Location

University of Utah Hospital

Newborn Intensive Care Unit
50 N Medical Dr
Salt Lake City , UT 84132
801-581-2745
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Primary Children's Hospital - Lehi

Pediatric Neonatology
2250 N Miller Campus Dr
Lehi , UT 84043
385-531-3000
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Intermountain Medical Center

5121 Cottonwood Street
Murray , UT 84107
801-507-7000
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Primary Children's Hospital

Newborn Intensive Care Unit
100 N Mario Capecchi Drive
Salt Lake City , UT 84113
801-662-4000
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  • Christian Con Yost, MD, is a tenured Professor in the Department of Pediatrics within the University of Utah School of Medicine. Dr. Yost serves as the Director for the Neonatal ExtraCorporeal Membrane Oxygenation (ECMO) program at Primary Children’s Hospital – Salt Lake Campus. He provides clinical care as an attending physician to critically ill patients admitted to the newborn intensive care units at the University of Utah Medical Center, Primary Children’s Hospital – Salt Lake and Miller campuses, and Intermountain Medical Center. His clinical areas of expertise include all aspects of neonatal care with a particular interest in improving clinical outcomes for patients with necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and all neonatal patients requiring ECMO as treatment for cardio-respiratory failure. His translational research program uses preclinical models and clinical samples to determine the beneficial and pathogenic effects of neutrophil extracellular traps (NETs) in inflammatory syndromes affecting patients of all ages including sepsis, ischemic stroke, and hypertensive disorders of pregnancy. His research laboratory discovered NET-Inhibitory Peptides, generated by the placenta, which modulate NET formation during human gestation.

    Specialties

    Board Certification

    American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine)
    American Board of Pediatrics (Pediatrics)

  • Christian Con Yost, MD, is a tenured Professor in the Department of Pediatrics within the University of Utah School of Medicine. Dr. Yost serves as the Director for the Neonatal ExtraCorporeal Membrane Oxygenation (ECMO) program at Primary Children’s Hospital – Salt Lake Campus. He provides clinical care as an attending physician to critically ill patients admitted to the newborn intensive care units at the University of Utah Medical Center, Primary Children’s Hospital – Salt Lake and Miller campuses, and Intermountain Medical Center. His clinical areas of expertise include all aspects of neonatal care with a particular interest in improving clinical outcomes for patients with necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and all neonatal patients requiring ECMO as treatment for cardio-respiratory failure. His translational research program uses preclinical models and clinical samples to determine the beneficial and pathogenic effects of neutrophil extracellular traps (NETs) in inflammatory syndromes affecting patients of all ages including sepsis, ischemic stroke, and hypertensive disorders of pregnancy. His research laboratory discovered NET-Inhibitory Peptides, generated by the placenta, which modulate NET formation during human gestation.

    Board Certification and Academic Information

    Academic Departments Pediatrics -Professor
    Academic Divisions Neonatology
    Board Certification
    American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine)
    American Board of Pediatrics (Pediatrics)

    Education history

    Undergraduate Biology - University of Utah B.S.
    Professional Medical University of Utah School of Medicine M.D.
    Internship Pediatrics - University of Vermont College of Medicine Intern
    Residency Pediatrics - University of Vermont College of Medicine Resident
    Fellowship Neonatology - University of Utah School of Medicine Fellow

    Selected Publications

    Journal Article

    1. Yost CC, Weyrich AS, Zimmerman GA (2010). The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Biochimie, 92(6), 692-7. (Read full publication)
    2. Yost CC, Cody MJ, Harris ES, Thornton NL, McInturff AM, Martinez ML, Chandler NB, Rodesch CK, Albertine KH, Petti CA, Weyrich AS, Zimmerman GA (2009). Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood, 113(25), 6419-27. (Read full publication)
    3. Rowley JW, Oler AJ, Tolley ND, Hunter BN, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich AS (2011). Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood, 118(14), e101-11. (Read full publication)
    4. McInturff AM, Cody MJ, Elliott EA, Glenn JW, Rowley JW, Rondina MT, Yost CC (2012). Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 ¿. Blood, 120(15), 3118-25. (Read full publication)
    5. Yost CC (2014). Toward the "ideal" inhibitor of NETs. Blood, 123(16), 2439-40. (Read full publication)
    6. Morales-Ortíz J, Deal V, Reyes F, Maldonado-Martínez G, Ledesma N, Staback F, Croft C, Pacheco A, Ortiz-Zuazaga H, Yost CC, Rowley JW, Madera B, John AS, Chen J, Lopez J, Rondina MT, Hunter R, Gibson A, Washington AV (2018). Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model. Blood, 132(23), 2495-2505. (Read full publication)
    7. Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell R (2020). Platelet gene expression and function in patients with COVID-19. Blood, 136(11), 1317-1329. (Read full publication)
    8. Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost C (2020). Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 136(10), 1169-1179. (Read full publication)
    9. Campbell RA, Campbell HD, Bircher JS, de Araujo CV, Denorme F, Crandell JL, Rustad JL, Monts J, Cody MJ, Kosaka Y, Yost C (2021). Placental HTRA1 cleaves alpha-1-antitrypsin to generate a NET-Inhibitory Peptide. Blood, 138(11), 977-988. (Read full publication)
    10. Yost C (2021). Neutrophils clear sterile inflammatory debris. Blood, 137(3), 293-294. (Read full publication)
    11. Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, Yost CC, Rubner FJ, Albertine KH, Swoboda KJ, Fratto CM, Tolley E, Kraiss LW, McIntyre TM, Zimmerman GA, Weyrich A (2005). Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell, 122(3), 379-91. (Read full publication)
    12. Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman G (2016). Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. The Journal of clinical investigation, 126(10), 3783-3798. (Read full publication)
    13. Yost CC, Denis MM, Lindemann S, Rubner FJ, Marathe GK, Buerke M, McIntyre TM, Weyrich AS, Zimmerman G (2004). Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. The Journal of experimental medicine, 200(5), 671-80. (Read full publication)
    14. Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daßler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, Salvatore S, Schwartz RE, Spicer JD, Yost CC, Weber A, Zuo Y, Egeblad (2020). Targeting potential drivers of COVID-19: Neutrophil extracellular traps. The Journal of experimental medicine, 217(6), (Read full publication)
    15. Sumanth MS, Jacob SP, Abhilasha KV, Manne BK, Basrur V, Lehoux S, Campbell RA, Yost CC, McIntyre TM, Cummings RD, Weyrich AS, Rondina MT, Marathe G (2021). Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils. Journal of leukocyte biology, 109(5), 915-930. (Read full publication)
    16. MacQueen BC, Christensen RD, Yost CC, Lambert DK, Baer VL, Sheffield MJ, Gordon PV, Cody MJ, Gerday E, Schlaberg R, Lowe J, Shepherd J (2016). Elevated fecal calprotectin levels during necrotizing enterocolitis are associated with activated neutrophils extruding neutrophil extracellular traps. Journal of perinatology, 36(10), 862-9. (Read full publication)
    17. MacQueen BC, Christensen RD, Yost CC, Gordon PV, Baer VL, Schlaberg R, Lowe (2018). Reference intervals for stool calprotectin in preterm neonates and their utility for the diagnosis of necrotizing enterocolitis. Journal of perinatology, 38(10), 1379-1385. (Read full publication)
    18. Yang MJ, Fenton S, Russell K, Yost CC, Yoder B (2020). Left-sided congenital diaphragmatic hernia: can we improve survival while decreasing ECMO?. Journal of perinatology, 40(6), 935-942. (Read full publication)
    19. Bloom R, Yost C (2004). A consideration of neonatal resuscitation. Pediatric clinics of North America, 51(3), 669-84, ix. (Read full publication)
    20. Campbell RA, Cody MJ, Manne BK, Zimmerman GA, Yost C (2019). Interleukin 6 receptor alpha expression in PMNs isolated from prematurely born neonates: decreased expression is associated with differential mTOR signaling. Pediatric research, 86(1), 55-62. (Read full publication)
    21. Yost C (2019). Pediatric immunothrombosis-Understudied¿ but what potential!. Pediatric research, 86(1), 17-18. (Read full publication)
    22. Lindemann SW, Yost CC, Denis MM, McIntyre TM, Weyrich AS, Zimmerman G (2004). Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proceedings of the National Academy of Sciences of the United States of America, 101(18), 7076-81. (Read full publication)
    23. Araújo CV, Campbell C, Gonçalves-de-Albuquerque CF, Molinaro R, Cody MJ, Yost CC, Bozza PT, Zimmerman GA, Weyrich AS, Castro-Faria-Neto HC, Silva A (2016). A PPAR¿ AGONIST ENHANCES BACTERIAL CLEARANCE THROUGH NEUTROPHIL EXTRACELLULAR TRAP FORMATION AND IMPROVES SURVIVAL IN SEPSIS. Shock (Augusta, Ga.), 45(4), 393-403. (Read full publication)
    24. Bouck EG, Denorme F, Holle LA, Middelton EA, Blair AM, de Laat B, Schiffman JD, Yost CC, Rondina MT, Wolberg AS, Campbell R (2021). COVID-19 and Sepsis Are Associated With Different Abnormalities in Plasma Procoagulant and Fibrinolytic Activity. Arteriosclerosis, thrombosis, and vascular biology, 41(1), 401-414. (Read full publication)
    25. Yost CC, Soll R (2000). Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. The Cochrane database of systematic reviews, (2), CD001456. (Read full publication)
    26. Yost C (2005). Neonatal necrotizing enterocolitis: diagnosis, management, and pathogenesis. Journal of infusion nursing, 28(2), 130-4. (Read full publication)
    27. McKnight RA, Yost CC, Yu X, Wiedmeier JE, Callaway CW, Brown AS, Lane RH, Fung C (2015). Intrauterine growth restriction perturbs nucleosome depletion at a growth hormone-responsive element in the mouse IGF-1 gene. Physiological genomics, 47(12), 634-43. (Read full publication)
    28. McKnight RA, Yost CC, Zinkhan EK, Fu Q, Callaway CW, Fung C (2016). Intrauterine growth restriction inhibits expression of eukaryotic elongation factor 2 kinase, a regulator of protein translation. Physiological genomics, 48(8), 616-25. (Read full publication)
    29. Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich A (2011). Novel anti-bacterial activities of ß-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS pathogens, 7(11), e1002355. (Read full publication)
    30. Thornton NL, Cody MJ, Yost C (2012). Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants. Neonatology, 101(2), 140-6. (Read full publication)
    31. Murphy J, Yost CC, Short S, Alashari M, Chan B (2018). Black eschar on a 4 day old preterm infant. NeoReviews, 19(9), e564-e568.
    32. Glenn JW, Cody MJ, McManus MP, Pulsipher MA, Schiffman JD, Yost C (2016). Deficient Neutrophil Extracellular Trap Formation in Patients Undergoing Bone Marrow Transplantation. Frontiers in immunology, 7, 250. (Read full publication)
    33. Brunelli L, Jenkins SM, Gudgeon JM, Bleyl SB, Miller CE, Tvrdik T, Dames SA, Ostrander B, Daboub JAF, Zielinski BA, Zinkhan EK, Underhill HR, Wilson T, Bonkowsky JL, Yost CC, Botto LD, Jenkins J, Pysher TJ, Bayrak-Toydemir P, Mao (2019). Targeted gene panel sequencing for the rapid diagnosis of acutely ill infants. Molecular genetics & genomic medicine, 7(7), e00796. (Read full publication)
    34. Trivedi S, Grossmann AH, Jensen O, Cody MJ, Wahlig TA, Hayakawa Serpa P, Langelier C, Warren KJ, Yost CC, Leung D (2021). Intestinal Infection Is Associated With Impaired Lung Innate Immunity to Secondary Respiratory Infection. Open forum infectious diseases, 8(6), ofab237. (Read full publication)
    35. Stoller ML, Basak I, Denorme F, Rowley JW, Alsobrooks J, Parsawar K, Nieman MT, Yost CC, Hamilton JR, Bray PF, Campbell R (2021). Neutrophil Cathepsin G Proteolysis of Protease Activated Receptor 4 Generates a Novel, Functional Tethered Ligand. Blood advances, 6(7), 2303-2308. (Read full publication)
    36. Denorme F, Portier I, Rustad JL, Cody MJ, de Araujo CV, Hoki C, Alexander MD, Grandhi R, Dyer MR, Neal MD, Majersik JJ, Yost CC, Campbell R (2022). Neutrophil extracellular traps regulate ischemic stroke brain injury. The Journal of clinical investigation, 132(10), (Read full publication)
    37. Cox KJ, Yang MJ, Fenton SJ, Russell KW, Yost CC, Yoder B (2022). Operative repair in congenital diaphragmatic hernia: How long do we really need to wait?. Journal of pediatric surgery, 57(9), 17-23. (Read full publication)
    38. Denorme F, Rustad JL, Portier I, Crandell JL, de Araujo CV, Cody MJ, Campbell RA, Yost C (2022). Neutrophil extracellular trap inhibition improves survival in neonatal mouse infectious peritonitis. Pediatric research, 93(4), 862-869. (Read full publication)
    39. Owen LA, Zhang C, Shirer K, Carroll L, Wood B, Szczotka K, Cornia C, Stubben C, Fung C, Yost CC, Katikaneni LD, DeAngelis MM, Comstock (2023). Placental Inflammation Significantly Correlates with Reduced Risk for Retinopathy of Prematurity. The American journal of pathology, 193(11), 1776-1788. (Read full publication)
    40. de Araujo CV, Denorme F, Stephens WZ, Li Q, Cody MJ, Crandell JL, Petrey AC, Queisser KA, Rustad JL, Evangelista JL, Kay MS, Schiffman JD, Campbell RA, Yost C (2023). Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial by inhibiting neutrophil extracellular traps. Frontiers in immunology, 13, 1046574. (Read full publication)
    41. Krinsky N, Sizikov S, Nissim S, Dror A, Sas A, Prinz H, Pri-Or E, Perek S, Raz-Pasteur A, Lejbkowicz I, Cohen-Matsliah SI, Almog R, Chen N, Kurd R, Jarjou'i A, Rokach A, Ben-Chetrit E, Schroeder A, Caulin AF, Yost CC, Schiffman JD, Goldfeder M, Martinod (2023). NETosis induction reflects COVID-19 severity and Long COVID: insights from a two-center patient cohort study in Israel. Journal of thrombosis and haemostasis, 21(9), 2569-2584. (Read full publication)
    42. Denorme F, Armstrong ND, Stoller ML, Portier I, Tugolukova EA, Tanner RM, Montenont E, Bhatlekar S, Cody M, Rustad JL, Ajanel A, Tolley ND, Murray DC, Boyle JL, Nieman MT, McKenzie SE, Yost CC, Lange LA, Cushman M, Irvin MR, Bray PF, Campbell R (2023). The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. The Journal of clinical investigation, 133(18), (Read full publication)
    43. Bruno AM, Allshouse AA, Benson AE, Yost CC, Metz TD, Varner MW, Silver RM, Branch D (2023). Thrombotic Markers in Pregnant Patients with and without SARS-CoV-2 Infection. American journal of perinatology, 41(S 01), e3202-e3209. (Read full publication)
    44. Weber Z, Yost CC, Cody M, King JM, Henderson C, Christensen RD, Carr N (2024). Acquired ineffective erythropoiesis in pediatric ECMO patients: Higher than anticipated serum EPO levels and lower than anticipated reticulocytes counts were associated with mortality. Perfusion, 2676591241300956. (Read full publication)
    45. Nelson MD, Tresco PA, Yost CC, Gale B (2024). Achieving biocompatibility and tailoring mechanical properties of SLA 3D printed devices for microfluidic and cell culture applications. Lab on a chip, 24(19), 4632-4638. (Read full publication)
    46. Jones MD Jr, Guiton G, Yost CC, Torr CB, Gong J, Parker T (2024). Structured Debriefing to Assess Performance of Entrustable Professional Activities. Journal of graduate medical education, 16(5), 607-610. (Read full publication)
    47. Yang MJ, Ellsworth TS, Woodward PJ, Kennedy AM, Fenton SJ, Russell KW, Byrne JLB, Yost CC, Yoder B (2024). Comparison of current to past outcomes in congenital diaphragmatic hernia using MRI observed-to-expected total fetal lung volume. Journal of perinatology, 44(9), 1347-1352. (Read full publication)
    48. Bircher JS, Denorme F, Cody MJ, de Araujo CV, Petrey AC, Middleton EA, Campbell RA, Yost C (2024). Neonatal NET-inhibitory factor inhibits macrophage extracellular trap formation. Blood advances, 8(14), 3686-3690. (Read full publication)
    49. Aoki JA, Denorme F, Cody MJ, Perry DP, Rustad JL, Brown SM, Goldstein SA, Middleton EA, Yost CC, Harris ES, NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigator (2025). Plasma surrogate markers of neutrophil extracellular traps correlate with disease severity in patients with moderate to severe acute respiratory distress syndrome. Journal of inflammation (London, England), 22(1), 22. (Read full publication)
    50. Yang MJ, Carpenter RJ, Russell KW, Fenton SJ, Yost CC, Yoder B (2025). Are Early, Frequent Echocardiograms Necessary to Improve Outcomes of Neonates with Congenital Diaphragmatic Hernia?. The Journal of pediatrics, 280, 114510. (Read full publication)
    51. Yang MJ, Yost CC, Monson M, Woodward PJ, Kennedy AM, Fenton SJ, Russell KW, Byrne JLB, Yoder B (2025). Concurrent Bronchopulmonary Sequestration in Congenital Diaphragmatic Hernia: Is Frequency Increasing or Are We Better at Diagnosis?. Journal of pediatrics. Clinical practice, 15, 200141. (Read full publication)
    52. Yang MJ, Yost CC, Carpenter RJ, Kahn AM, Fenton SJ, Russell KW, Yoder B (2025). Congenital diaphragmatic hernia: exclusion criteria for repair or ECMO?. Journal of pediatric surgery, 162721. (Read full publication)
    53. Kahan AM, Glasgow SL, Yoder BA, Yang M, Yost CC, Peterson K, Scaife JH, Clinker CE, Arnold E, Fenton SJ, Kastenberg ZJ, Swendiman RA, Russell K (2025). Long-term outcomes after muscle flap repair in congenital diaphragmatic hernia: A retrospective study at a single institution. Journal of pediatric surgery, 162572. (Read full publication)
    54. Kahan AM, Glasgow SL, Yoder BA, Yang M, Yost CC, Peterson K, Scaife JH, Clinker CE, Arnold E, Fenton SJ, Kastenberg ZJ, Swendiman RA, Short SS, Russell K (2025). Less is more: ECMO utilization and outcomes in congenital diaphragmatic hernia. Journal of pediatric surgery, 162571. (Read full publication)
    55. Ellsworth TS, Carpenter RJ, Yost CC, Yoder BA, Yang M (2025). Oxygenation Index and Oxygen Saturation Index in Congenital Diaphragmatic Hernia: Do Management Guidelines Make a Difference?. Neonatology, 1-9. (Read full publication)
    56. Davenport P, Feldman HA, Young V, Soule-Albridge E, Kerper R, Kinlay S, Nolton E, Stoeckel A, Denorme F, Cody MJ, de Menezes EM, Norris P, Yost CC, Sola-Visner (2025). Effects of platelet transfusions on neonatal bleeding and inflammation. Pediatric research, (Read full publication)

    Book Chapter

    1. Yost CC, Bloom RS (2004). Neonatal Resucitation.
    2. Whitley Hulse, Christian Con Yos Disorders of Glucose, Electrolytes, and Acid-Base Balance.

    Case Report

    1. Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Yost CC, Li P, Reading NS, Prchal JT, Christensen R (2020). A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity. Neonatology, 117(4), 532-535. (Read full publication)

    Letter

    1. Yang MJ, Carpenter RJ, Russell KW, Fenton SJ, Yost CC, Yoder B (2025). Reply. The Journal of pediatrics, 283, 114580. (Read full publication)
    2. Yang MJ, Carpenter RJ, Russell KW, Fenton SJ, Yost CC, Yoder B (2025). Reply. The Journal of pediatrics, 291, 114955. (Read full publication)

    Other

    1. de Araujo CV, Denorme F, Stephens WZ, Li Q, Cody MJ, Crandell JL, Petrey AC, Queisser KA, Rustad JL, Fulcher JM, Evangelista JL, Kay MS, Schiffman JD, Campbell RA, Yost C (2023). Corrigendum: Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps. Frontiers in immunology, 14, 1171222. (Read full publication)
    2. Davenport P, Feldman HA, Young V, Soule-Albridge E, Kerper R, Kinlay S, Nolton E, Stoeckel A, Denorme F, Cody MJ, de Menezes EM, Norris P, Yost CC, Sola-Visner (2025). Correction: Effects of platelet transfusions on neonatal bleeding and inflammation. Pediatric research, (Read full publication)

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