Christian Con Yost
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Christian Con Yost, MD

Languages spoken: English, German

Clinical Locations

Intermountain Medical Center

Murray
801-507-7000

Primary Children's Hospital

Newborn Intensive Care Unit
Salt Lake City
801-662-4100

University of Utah Hospital

Newborn Intensive Care Unit
Salt Lake City
801-581-2745

  • Christian Con Yost, MD is a tenured Associate Professor in the Department of Pediatrics within the University of Utah School of Medicine. He serves as the Director of the Neonatal-Perinatal Medicine Fellowship Training Program at the University of Utah. He provides clinical care as an attending physician to critically ill patients admitted to the newborn intensive care units at the University of Utah Medical Center, Primary Children’s Hospital, and Intermountain Medical Center. His clinical areas of expertise include all aspects of neonatal care with a particular interest in improving clinical outcomes for patients with necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and all neonatal patients requiring extracorporeal membrane oxygenation (ECMO) as treatment for cardio-respiratory failure.

    Specialties

    Board Certification

    American Board of Pediatrics (Pediatrics)
    American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine)

  • Christian Con Yost, MD is a tenured Associate Professor in the Department of Pediatrics within the University of Utah School of Medicine. He serves as the Director of the Neonatal-Perinatal Medicine Fellowship Training Program at the University of Utah. He provides clinical care as an attending physician to critically ill patients admitted to the newborn intensive care units at the University of Utah Medical Center, Primary Children’s Hospital, and Intermountain Medical Center. His clinical areas of expertise include all aspects of neonatal care with a particular interest in improving clinical outcomes for patients with necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and all neonatal patients requiring extracorporeal membrane oxygenation (ECMO) as treatment for cardio-respiratory failure.

    Board Certification and Academic Information

    Academic Departments Pediatrics -Primary
    Academic Divisions Neonatology
    Board Certification
    American Board of Pediatrics (Pediatrics)
    American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine)

    Education history

    Fellowship Neonatology - University of Utah School of Medicine Fellow
    Internship Pediatrics - University of Vermont College of Medicine Intern
    Residency Pediatrics - University of Vermont College of Medicine Resident
    Professional Medical University of Utah School of Medicine M.D.
    Undergraduate Biology - University of Utah B.S.

    Selected Publications

    Journal Article

    1. Bruno AM, Allshouse AA, Benson AE, Yost CC, Metz TD, Varner MW, Silver RM, Branch DW (2023). Thrombotic Markers in Pregnant Patients with and without SARS-CoV-2 Infection. Am J Perinatol. (Read full article)
    2. Denorme F, Armstrong ND, Stoller ML, Portier I, Tugolukova EA, Tanner RM, Montenont E, Bhatlekar S, Cody M, Rustad JL, Ajanel A, Tolley ND, Murray DC, Boyle JL, Nieman MT, McKenzie SE, Yost CC, Lange LA, Cushman M, Irvin MR, Bray PF, Campbell RA (2023). The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. J Clin Invest, 133(18). (Read full article)
    3. Krinsky N, Sizikov S, Nissim S, Dror A, Sas A, Prinz H, Pri-Or E, Perek S, Raz-Pasteur A, Lejbkowicz I, Cohen-Matsliah SI, Almog R, Chen N, Kurd R, Jarjoui A, Rokach A, Ben-Chetrit E, Schroeder A, Caulin AF, Yost CC, Schiffman JD, Goldfeder M, Martinod K (2023). NETosis induction reflects COVID-19 severity and Long COVID: insights from a two-center patient cohort study in Israel. J Thromb Haemost. (Read full article)
    4. Owen LA, Zhang C, Shirer K, Carroll L, Wood B, Szczotka K, Cornia C, Stubben C, Fung C, Yost CC, Katikaneni LD, DeAngelis MM, Comstock J (2023). Placental Inflammation Significantly Correlates with Reduced Risk for Retinopathy of Prematurity. Am J Pathol, 193(11), 1776-1788. (Read full article)
    5. de Araujo CV, Denorme F, Stephens WZ, Li Q, Cody MJ, Crandell JL, Petrey AC, Queisser KA, Rustad JL, Evangelista JL, Kay MS, Schiffman JD, Campbell RA, Yost CC (2023). Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial by inhibiting neutrophil extracellular traps. Front Immunol, 13, 1046574. (Read full article)
    6. Denorme F, Rustad JL, Portier I, Crandell JL, de Araujo CV, Cody MJ, Campbell RA, Yost CC (2022). Neutrophil extracellular trap inhibition improves survival in neonatal mouse infectious peritonitis. Pediatr Res, 93(4), 862-869. (Read full article)
    7. Denorme F, Portier I, Rustad JL, Cody MJ, de Araujo CV, Hoki C, Alexander MD, Grandhi R, Dyer MR, Neal MD, Majersik JJ, Yost CC, Campbell RA (2022). Neutrophil extracellular traps regulate ischemic stroke brain injury. J Clin Invest, 132(10). (Read full article)
    8. Cox KJ, Yang MJ, Fenton SJ, Russell KW, Yost CC, Yoder BA (2022). Operative repair in congenital diaphragmatic hernia: How long do we really need to wait? J Pediatr Surg, 57(9), 17-23. (Read full article)
    9. Stoller ML, Basak I, Denorme F, Rowley JW, Alsobrooks J, Parsawar K, Nieman MT, Yost CC, Hamilton JR, Bray PF, Campbell RA (2021). Neutrophil Cathepsin G Proteolysis of Protease Activated Receptor 4 Generates a Novel, Functional Tethered Ligand. Blood Adv, 6(7), 2303-2308. (Read full article)
    10. Campbell RA, Campbell HD, Bircher JS, de Araujo CV, Denorme F, Crandell JL, Rustad JL, Monts J, Cody MJ, Kosaka Y, Yost CC (2021). Placental HTRA1 cleaves alpha-1-antitrypsin to generate a NET-Inhibitory Peptide. Blood, 138(11), 977-988. (Read full article)
    11. Trivedi S, Grossmann AH, Jensen O, Cody MJ, Wahlig TA, Hayakawa Serpa P, Langelier C, Warren KJ, Yost CC, Leung DT (2021). Intestinal Infection Is Associated With Impaired Lung Innate Immunity to Secondary Respiratory Infection. Open Forum Infect Dis, 8(6), ofab237. (Read full article)
    12. Sumanth MS, Jacob SP, Abhilasha KV, Manne BK, Basrur V, Lehoux S, Campbell RA, Yost CC, McIntyre TM, Cummings RD, Weyrich AS, Rondina MT, Marathe GK (2020). Different glycoforms of alpha-1-acid glycoprotein contribute to its functional alterations in platelets and neutrophils. J Leukoc Biol, 109(5), 915-930. (Read full article)
    13. Yost CC (2021). Neutrophils clear sterile inflammatory debris. Blood, 137(3), 293-294. (Read full article)
    14. Bouck EG, Denorme F, Holle LA, Middelton EA, Blair AM, de Laat B, Schiffman JD, Yost CC, Rondina MT, Wolberg AS, Campbell RA (2020). COVID-19 and Sepsis Are Associated With Different Abnormalities in Plasma Procoagulant and Fibrinolytic Activity. Arterioscler Thromb Vasc Biol, 41(1), 401-414. (Read full article)
    15. Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, Petrey AC, Tolley ND, Guo L, Cody M, Weyrich AS, Yost CC, Rondina MT, Campbell RA (2020). Platelet gene expression and function in patients with COVID-19. Blood, 136(11), 1317-1329. (Read full article)
    16. Middleton EA, He XY, Denorme F, Campbell RA, Ng D, Salvatore SP, Mostyka M, Baxter-Stoltzfus A, Borczuk AC, Loda M, Cody MJ, Manne BK, Portier I, Harris ES, Petrey AC, Beswick EJ, Caulin AF, Iovino A, Abegglen LM, Weyrich AS, Rondina MT, Egeblad M, Schiffman JD, Yost CC (2020). Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome. Blood, 136(10), 1169-1179. (Read full article)
    17. Yang MJ, Fenton S, Russell K, Yost CC, Yoder BA (2020). Left-sided congenital diaphragmatic hernia: can we improve survival while decreasing ECMO? J Perinatol, 40(6), 935-942. (Read full article)
    18. Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, Salvatore S, Schwartz RE, Spicer JD, Yost CC, Weber A, Zuo Y, Egeblad M (2020). Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J Exp Med, 217(6). (Read full article)
    19. Yost CC (2019). Pediatric immunothrombosis-Understudied… but what potential! Pediatr Res, 86(1), 17-18. (Read full article)
    20. Campbell RA, Cody MJ, Manne BK, Zimmerman GA, Yost CC (2019). Interleukin 6 receptor alpha expression in PMNs isolated from prematurely born neonates: decreased expression is associated with differential mTOR signaling. Pediatr Res, 86(1), 55-62. (Read full article)
    21. Brunelli L, Jenkins SM, Gudgeon JM, Bleyl SB, Miller CE, Tvrdik T, Dames SA, Ostrander B, Daboub JAF, Zielinski BA, Zinkhan EK, Underhill HR, Wilson T, Bonkowsky JL, Yost CC, Botto LD, Jenkins J, Pysher TJ, Bayrak-Toydemir P, Mao R (2019). Targeted gene panel sequencing for the rapid diagnosis of acutely ill infants. Mol Genet Genomic Med, 7(7), e00796. (Read full article)
    22. Morales-Ortz J, Deal V, Reyes F, Maldonado-Martnez G, Ledesma N, Staback F, Croft C, Pacheco A, Ortiz-Zuazaga H, Yost CC, Rowley JW, Madera B, John AS, Chen J, Lopez J, Rondina MT, Hunter R, Gibson A, Washington AV (2018). Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model. Blood, 132(23), 2495-2505. (Read full article)
    23. MacQueen BC, Christensen RD, Yost CC, Gordon PV, Baer VL, Schlaberg R, Lowe J (2018). Reference intervals for stool calprotectin in preterm neonates and their utility for the diagnosis of necrotizing enterocolitis. J Perinatol, 38(10), 1379-1385. (Read full article)
    24. Murphy J, Yost CC, Short S, Alashari M, Chan B (Sep 2018). Black eschar on a 4 day old preterm infant. Neoreviews, 19(9), e564-e568.
    25. Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman GA (2016). Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. J Clin Invest, 126(10), 3783-3798. (Read full article)
    26. MacQueen BC, Christensen RD, Yost CC, Lambert DK, Baer VL, Sheffield MJ, Gordon PV, Cody MJ, Gerday E, Schlaberg R, Lowe J, Shepherd JG (2016). Elevated fecal calprotectin levels during necrotizing enterocolitis are associated with activated neutrophils extruding neutrophil extracellular traps. J Perinatol, 36(10), 862-9. (Read full article)
    27. McKnight RA, Yost CC, Zinkhan EK, Fu Q, Callaway CW, Fung CM (2016). Intrauterine growth restriction inhibits expression of eukaryotic elongation factor 2 kinase, a regulator of protein translation. Physiol Genomics, 48(8), 616-25. (Read full article)
    28. Glenn JW, Cody MJ, McManus MP, Pulsipher MA, Schiffman JD, Yost CC (2016). Deficient Neutrophil Extracellular Trap Formation in Patients Undergoing Bone Marrow Transplantation. Front Immunol, 7, 250. (Read full article)
    29. Arajo CV, Campbell C, Gonalves-de-Albuquerque CF, Molinaro R, Cody MJ, Yost CC, Bozza PT, Zimmerman GA, Weyrich AS, Castro-Faria-Neto HC, Silva AR (2016). A PPARγ AGONIST ENHANCES BACTERIAL CLEARANCE THROUGH NEUTROPHIL EXTRACELLULAR TRAP FORMATION AND IMPROVES SURVIVAL IN SEPSIS. Shock, 45(4), 393-403. (Read full article)
    30. McKnight RA, Yost CC, Yu X, Wiedmeier JE, Callaway CW, Brown AS, Lane RH, Fung CM (2015). Intrauterine growth restriction perturbs nucleosome depletion at a growth hormone-responsive element in the mouse IGF-1 gene. Physiol Genomics, 47(12), 634-43. (Read full article)
    31. Yost CC (2014). Toward the "ideal" inhibitor of NETs. Blood, 123(16), 2439-40. (Read full article)
    32. McInturff AM, Cody MJ, Elliott EA, Glenn JW, Rowley JW, Rondina MT, Yost CC (2012). Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α. Blood, 120(15), 3118-25. (Read full article)
    33. Thornton NL, Cody MJ, Yost CC (2011). Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants. Neonatology, 101(2), 140-6. (Read full article)
    34. Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS (2011). Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog, 7(11), e1002355. (Read full article)
    35. Rowley JW, Oler AJ, Tolley ND, Hunter BN, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich AS (2011). Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood, 118(14), e101-11. (Read full article)
    36. Yost CC, Weyrich AS, Zimmerman GA (2010). The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Biochimie, 92(6), 692-7. (Read full article)
    37. Yost CC, Cody MJ, Harris ES, Thornton NL, McInturff AM, Martinez ML, Chandler NB, Rodesch CK, Albertine KH, Petti CA, Weyrich AS, Zimmerman GA (2009). Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood, 113(25), 6419-27. (Read full article)
    38. Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, Yost CC, Rubner FJ, Albertine KH, Swoboda KJ, Fratto CM, Tolley E, Kraiss LW, McIntyre TM, Zimmerman GA, Weyrich AS (2005). Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell, 122(3), 379-91. (Read full article)
    39. Yost CC (2005). Neonatal necrotizing enterocolitis: diagnosis, management, and pathogenesis. J Infus Nurs, 28(2), 130-4. (Read full article)
    40. Yost CC, Denis MM, Lindemann S, Rubner FJ, Marathe GK, Buerke M, McIntyre TM, Weyrich AS, Zimmerman GA (2004). Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. J Exp Med, 200(5), 671-80. (Read full article)
    41. Bloom R, Yost CC (2004). A consideration of neonatal resuscitation. Pediatr Clin North Am, 51(3), 669-84, ix. (Read full article)
    42. Lindemann SW, Yost CC, Denis MM, McIntyre TM, Weyrich AS, Zimmerman GA (2004). Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proc Natl Acad Sci U S A, 101(18), 7076-81. (Read full article)
    43. Yost CC, Soll RF (2000). Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. Cochrane Database Syst Rev, (2), CD001456. (Read full article)

    Book Chapter

    1. Yost CC, Bloom RS (2004). Neonatal Resucitation. In Dildy GA, Belfort MA, Saade GR, et. al. (Eds.), Critical Care Obstetrics 4th Edition.

    Case Report

    1. Bahr TM, Lozano-Chinga M, Agarwal AM, Meznarich JA, Yost CC, Li P, Reading NS, Prchal JT, Christensen RD (2020). A Novel Variant in G6PD (c.1375C>G) Identified from a Hispanic Neonate with Extreme Hyperbilirubinemia and Low G6PD Enzymatic Activity. Neonatology, 117(4), 532-535. (Read full article)

    Other

    1. de Araujo CV, Denorme F, Stephens WZ, Li Q, Cody MJ, Crandell JL, Petrey AC, Queisser KA, Rustad JL, Fulcher JM, Evangelista JL, Kay MS, Schiffman JD, Campbell RA, Yost CC (2023). Corrigendum: Neonatal NET-Inhibitory Factor improves survival in the cecal ligation and puncture model of polymicrobial sepsis by inhibiting neutrophil extracellular traps. Front Immunol (14, p. 1171222). Switzerland. (Read full article)

    Patent

    1. Yost CC, Zimmerman GA, Weyrich AS, Schiffman JD. (2021). METHODS FOR TREATMENT OF AND PROPHYLAXIS AGAINST INFLAMMATORY DISORDERS. U.S. Patent No. EP3019188B1. Washington, D.C.:U.S. Patent and Trademark Office.
    2. Yost CC, Zimmerman GA, Weyrich AS, Schiffman JD. (2019). METHODS FOR TREATMENT OF AND PROPHYLAXIS AGAINST INFLAMMATORY DISORDERS. U.S. Patent No. 10,646,556. Washington, D.C.:U.S. Patent and Trademark Office.
    3. Yost CC, Zimmerman GA, Weyrich AS, Schiffman J. (2019). nNIF AND nNIF-RELATED PEPTIDES AND RELATED METHODS. U.S. Patent No. 10,857,201. Washington, D.C.:U.S. Patent and Trademark Office.
    4. Yost CC, Zimmerman GA, Weyrich AS. (2018). METHODS FOR TREATMENT OF AND PROPHYLAXIS AGAINST INFLAMMATORY DISORDERS. U.S. Patent No. 10,232,023. Washington, D.C.:U.S. Patent and Trademark Office.

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