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John F. Valentine
( out of 45 reviews )

John F. Valentine, MD

Languages spoken: English

Clinical Locations

Primary Location

South Jordan Health Center

5126 West Daybreak Parkway
South Jordan , UT 84009

University of Utah Hospital

Gastroenterology Endoscopy Center
50 N Medical Dr
Salt Lake City , UT 84132

Gastroenterology /GI Clinic UUH

Gastroenterology, Area E
50 N Medical Dr
Salt Lake City , UT 84132

John F. Valentine, MD, is a Professor of Medicine at the University of Utah School of Medicine in the Division of Gastroenterology, Hepatology and Nutrition and specializes in ulcerative colitis and Crohn's disease. His clinical interests and expertise are in inflammatory diseases of the intestinal tract that include inflammatory bowel disease (ulcerative colitis and Crohn's disease) and celiac disease.

Dr. Valentine received his M.D. degree from the University of Texas Medical School at Houston in 1985. He received his training in Internal Medicine at the Medical College of Virginia-Virginia Commonwealth University Medical Center and his training in Gastroenterology at the University of Florida. While on faculty at the University of Florida, he rose to the position of Professor of Medicine, served as the Chief of the Gastroenterology Section at the Malcom Randal Veterans Administration Medical Center, and founded the Southeastern Center for Inflammatory Bowel Disease. He remains active with the Crohn's and Colitis Foundation of America and has served a Co-Chair of the CCFA patient education committee and was a member of the editorial board for the journal Inflammatory Bowel Disease. Dr. Valentine is a Fellow in the American Gastroenterological Association and the director of the University of Utah Inflammatory Bowel Disease Center. Dr. Valentine has extensive experience with treating patients with inflammatory bowel disease and he is developing laboratory research and clinical trials in ulcerative colitis and Crohn's disease in order to expand the understanding and treatment options for patients with these diseases.

Board Certification

American Board of Internal Medicine

Patient Rating

Patients consistently describe Dr. Valentine as knowledgeable and highly skilled, noting thorough evaluations and clear treatment plans. Many highlight his attentive listening, clear explanations of conditions and options, and willingness to collaborate with patients and other specialists. Commenters also emphasize his compassion and professionalism, saying he inspires confidence and is easy to recommend.

Generated via Patient Reviews

4.9 /5
( out of 45 reviews )

The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers. The scale on which responses are measured is 1 to 5 with 5 being the best score.


May 08, 2026
UNIVERSITY HOSPITAL

He is the deeply knowledge & passionate for what he does everyday..

May 03, 2026
UNIVERSITY HOSPITAL

I am so blessed to have dr. Valentine as my gastroenterologist and ,more importantly, as an excellent person who respects people .

Apr 20, 2026
UNIVERSITY HOSPITAL

An absolute professional. Has it all: Friendliness, understanding, compassion, directness, and the complete knowledge of his craft. I hope to be his patient all the way to his retirement. I don't dread going to see him; he has always made me feel better about my situation.

Apr 03, 2026
UNIVERSITY HOSPITAL

I am glad I got Dr. Valentine as my doctor. He came highly recommended by my old Doctor.

Mar 02, 2026
UNIVERSITY HOSPITAL

Excellent physician who is knowledgeable, supportive, and clearly cares about the health of his patients. I trust his expertise completely.

Oct 27, 2025
UNIVERSITY HOSPITAL

Great Doctor, communication skills are great at explaining details needed!

Oct 21, 2025
UNIVERSITY HOSPITAL

Dr. Valentine is a sagacious and assiduous professional who has always provided and shared great medical insight and options for me regarding my condition. Additionally, I get the impression he is always continuing to grow his knowledge in the field to provide me (his patient) the best options for treatment with cogent expectations.

Jul 12, 2025
UNIVERSITY HOSPITAL

Provides exceptional medical care for the IBD patient

Jul 06, 2025
UNIVERSITY HOSPITAL

He is so knowledgeable and caring, I hope he never retires

Jun 30, 2025
UNIVERSITY HOSPITAL

He Cares a great deal and will go to any length to help me feel Better and always has!

Jun 17, 2025
UNIVERSITY HOSPITAL

Dr Valentine has always been very positive to me. He treats me with respect and shares his Knowledge well!

May 19, 2025
UNIVERSITY HOSPITAL

Knowledgeable, thorough, compassionate

May 11, 2025
UNIVERSITY HOSPITAL

He is the most amazingly excellent physician and I have had many very good ones

Apr 19, 2025
UNIVERSITY HOSPITAL

He's great!

Apr 03, 2025
UNIVERSITY HOSPITAL

Dr Valentine is always kind and listens to my concerns and answers all of my questions so that I understand my disease and the plan for treatment. He spends time with me and does not make me feel like he is in a rush. He is also very knowledgeable about my disease and my options.

Mar 16, 2025
UNIVERSITY HOSPITAL

Highly recommend

Feb 28, 2025
UNIVERSITY HOSPITAL

Doctor Valentine is an exceptional physician. His knowledge, empathy, and compassion for patient health concerns are very much appreciated.

Feb 23, 2025
UNIVERSITY HOSPITAL

In the years of treatment for my Crohn's Dr Valentine and his staff rank at the top for the care I have received

Jan 24, 2025
UNIVERSITY HOSPITAL

I really appreciate Dr. Valentine's thoughtfulness and thoroughness in making plans for my care. I've had him for a few years now and will stay with him for as long as I can!

Jan 17, 2025
UNIVERSITY HOSPITAL

Dr. Valentine, and all of his staff, are so good to me as a friend and as my doctors. I am amazed at the personal attention they give to me even though they are very busy.

Dec 17, 2024
UH HOSPITALS AND CLINICS

Easy to talk to. Very knowledgeable and concerned

Nov 27, 2024
UH HOSPITALS AND CLINICS

Dr Valentine is very kind and respectful. I trust him with my care.

Nov 15, 2024
UH HOSPITALS AND CLINICS

He is very professional he explains everything to you that you need to hear

Nov 04, 2024
UH HOSPITALS AND CLINICS

I have appreciated his medical help since 2018. I am on a wonderful path and able to stay free of flareups. Dr. Valentine and his staff are helpful and accurate with their decisions. Thanks to all.

Jul 25, 2024
UH HOSPITALS AND CLINICS

I am very impressed with Dr. Valentine and his thoroughness in understanding my medical history of 42 years with Crohn's. He is very meticulous in record keeping and helping me understand challenges that have plagued me from the shortened bowel and what to look for.

Jul 13, 2024
UH HOSPITALS AND CLINICS

Dr. Valentine provides exceptional medical care and he is a very caring and compassionate physician.

Jun 30, 2024
UH HOSPITALS AND CLINICS

I've experienced significant improvement under Dr Valentine's care.

Jun 28, 2024
UH HOSPITALS AND CLINICS

Dr Valentine if one of the best doctors I've ever had!

Mar 30, 2024
UH HOSPITALS AND CLINICS

Fantastic and caring doctor

Jan 13, 2024
UH HOSPITALS AND CLINICS

Dr, Valentine is a wonderful doctor and I highly recommend him if you are looking for a Gastroenterologist. He listens to you; he makes sure to explain things clearly and he follows through on his plan. I had a great experience with him.

Jan 12, 2024
UH HOSPITALS AND CLINICS

If anyone has gastro problems like mine, I will recommend Dr, Valentine to them.

Dec 05, 2023
SUGAR HOUSE HEALTH CENTER

I have confidence in Dr Valentine. I feel that he is very knowledgeable, and he doesn't rush when we are in an appointment. He listens for my input and always explains things thoroughly. I feel like I am getting the very best care.

Dec 02, 2023
UH HOSPITALS AND CLINICS

Best doctor I have ever had treating me and my Crohn's

Nov 28, 2023
SUGAR HOUSE HEALTH CENTER

Dr Valentine is wonderful! He saved My life!

Nov 09, 2023
SUGAR HOUSE HEALTH CENTER

Dr. Valentine is fantastic! I have previously been treated by 3 other gastroenterologists . He is the best at listening, checking every aspect of the symptoms throughly and discussing and explaing a plan going forward. I was so impressed when I first started as his patient. I had been told by other gastroenterologists that I would have to stay on medicarion forever. His response was that our goal is to get you to the point you won't need medication. How refreshing!

Nov 01, 2023
SUGAR HOUSE HEALTH CENTER

Already answered this question.

Oct 29, 2023
UH HOSPITALS AND CLINICS

I was very impressed with how thorough Dr Valentine was and the care that I received. I was also impressed with the support offered the incase future complications.

Oct 14, 2023
UH HOSPITALS AND CLINICS

I was heard about my concerns and provided a remedy that was explained clearly

Aug 14, 2023
UH HOSPITALS AND CLINICS

Very positive.

Aug 05, 2023
UH HOSPITALS AND CLINICS

Highly recommended

Aug 04, 2023
SUGAR HOUSE HEALTH CENTER

Excellent doctor. Cares about patients.

Jul 08, 2023
UH HOSPITALS AND CLINICS

An exceptional experience

May 31, 2023
UH HOSPITALS AND CLINICS

Ive been dealing with Crohns for over 15 years at this point and he told me things Ive never heard from any other doctor. Eager to try out a new approach, but really havent moved forward with anything yet. Seems promising though!

May 21, 2023
UH HOSPITALS AND CLINICS

Great Dr.he really Listen to all my questions give me answers.

Apr 27, 2023
SUGAR HOUSE HEALTH CENTER

Great healthcare provider. Not only does Dr Valentine provide great medical care, he does so with a caring manner.

Apr 17, 2023
UH HOSPITALS AND CLINICS

Dr is so kind and helpful.

Apr 11, 2023
SUGAR HOUSE HEALTH CENTER

He is one of the best doctors I have ever had. He cares very much and he is very thorough.

Mar 31, 2023
UH HOSPITALS AND CLINICS

Very professional and concerned with patients well being.

Feb 13, 2023
SUGAR HOUSE HEALTH CENTER

Dr. Valentine was kind and professional. He took his time to explain things to me and was thorough in answering the questions I had.

Feb 03, 2023
UH HOSPITALS AND CLINICS

I have been with him a long time. I trust him with my issues completely.

Jan 14, 2023
SUGAR HOUSE HEALTH CENTER

Excellent physician. Very detail oriented.

Jan 12, 2023
SUGAR HOUSE HEALTH CENTER

I have had a serious chronic disorder of 50 years duration and have been cared for at the 4 of the finest hospitals in the US. Doctor John Valentine is the absolute best doctor I have ever had.

Jan 12, 2023
SUGAR HOUSE HEALTH CENTER

I have the upmost confidence in Doctor Valentine.

Dec 17, 2022
UH HOSPITALS AND CLINICS

Dr Valentine has been my doctor for almost 10 years and he is very good at what he does. He is on the quiet side, but he is always taking everything in and processing them so he can help you in the best way. I would not trust any other doctor with my care as much as I do him.

Dec 16, 2022
SUGAR HOUSE HEALTH CENTER

He is very patient, kind and helpful. He is an expert in his field of medicine.

Oct 30, 2022
University Hospital

Very informative and caring.

Jul 12, 2022
UH HOSPITALS AND CLINICS

My Doctor is the best

Apr 20, 2022
UH HOSPITALS AND CLINICS

Dr. Valentine great to work with.Thanks

Apr 09, 2022
SUGAR HOUSE HEALTH CENTER

Dr. Valentine is a peach, love the guy.

Mar 29, 2022
UH HOSPITALS AND CLINICS

Dr. Valentine is one best doctor I've been in contact with. He is direct and to the point, kind and considerate, friendly and very professional.

Mar 21, 2022
UH HOSPITALS AND CLINICS

Understood my concerns and knew exactly what I was talking about

Mar 03, 2022
SUGAR HOUSE HEALTH CENTER

Loved Dr. Valentine and associates!

Feb 13, 2022
UH HOSPITALS AND CLINICS

Exceptional care

Dec 09, 2021
SUGAR HOUSE HEALTH CENTER

There is never enough time to cover everything. Now my next appointment is in a year except for an emergency or with hands on treatment. He is a very knowledgeable physician and I appreciate his care and expert knowledge. Modern medicine, I guess.

Nov 20, 2021
SUGAR HOUSE HEALTH CENTER

I love Dr Valentine!

Nov 11, 2021
SUGAR HOUSE HEALTH CENTER

DrValentine is super

Nov 10, 2021
UH HOSPITALS AND CLINICS

It is apparent that Dr. Valentine is a thoughtful and caring physician. I appreciated his willingness to answer my questions and make a plan that I was comfortable with.

Jun 28, 2021
SUGAR HOUSE HEALTH CENTER

Dr. Valentine is exceptional. I appreciate his assertiveness.

Jun 20, 2021
UH HOSPITALS AND CLINICS

my meeting was very thorough with full explanations and resources. my comments were listened to and responded to clearly

Jun 01, 2021
UH HOSPITALS AND CLINICS

very satisfied

May 16, 2021
UH HOSPITALS AND CLINICS

Dr. Valentine has shared more knowledge and understanding of my condition then any other DR. or specialist has been able to in the last 7 years. I have already been recommending U of U medical to anybody that will listen!

May 15, 2021
SUGAR HOUSE HEALTH CENTER

Dr. Valentine is wonderful.

May 02, 2021
UH HOSPITALS AND CLINICS

Dr.Valentine is truly professional. but show a high degree of caring in his professional interactions.

Apr 02, 2021
SUGAR HOUSE HEALTH CENTER

Dr. Valentine is is excellent in his approach to my healthcare.

Mar 15, 2021
UH HOSPITALS AND CLINICS

Dr. Valentine had someone he was mentoring talk to me. She asked good questions and was specific abt my situation. Dr. Valentine was in the background but actively participating, coaching her as needed. I had a question abt an over the counter medicine that I had started taking which was related to my condition and asked his advice abt it's efficacy. Dr. Valentine gave his opinion which was very helpful!

Mar 08, 2021
SUGAR HOUSE HEALTH CENTER

Dr. Valentine is amazing. He displays genuine concern for my health and wellbeing.

Feb 14, 2021
UH HOSPITALS AND CLINICS

excellent care

Feb 09, 2021
UH HOSPITALS AND CLINICS

Dr Valentine is excellent -Would highly recommend

Feb 07, 2021
UH HOSPITALS AND CLINICS

It was all well done.

Jan 17, 2021
UH HOSPITALS AND CLINICS

Always very professional

Jan 14, 2021
UH HOSPITALS AND CLINICS

If there is a little bit more explanation about my situation will be perfect.

Dec 15, 2020
UH HOSPITALS AND CLINICS

Dr. Valentine is exceptional. I have been impressed with his care and concern and overall treatment plan progression for my diagnosis.

Oct 31, 2020
SUGAR HOUSE HEALTH CENTER

Have already recommended

Sep 10, 2020
SUGAR HOUSE HEALTH CENTER

good experience

Sep 02, 2020
UH HOSPITALS AND CLINICS

Dr. Valentine is great. He listened to my questions and answered them thoroughly.

Aug 02, 2020
SUGAR HOUSE HEALTH CENTER

I am a physician myself, Dr. Valentine is an ideal physician in all ways

Jul 24, 2020
UH HOSPITALS AND CLINICS

the virtual visit was super easy. I was contacted well ahead of time that it would be virtual

Jul 03, 2020
UH HOSPITALS AND CLINICS

I think he is very professional because he and his assistant asked a lot of questions and he knew every detail he needs to know about me. Literally, he did not show enough concern and give enough explanation, but I understood and appreciated what he has done. I hope every doctor can give patients an overall evaluation after interview and tell them what their current situation are, what they should do after interview, and why the proposed treatments are best for them.

Jun 09, 2020
UH HOSPITALS AND CLINICS

good discussion

May 19, 2020
UH HOSPITALS AND CLINICS

Dr. Valentine is a very attentive listener and answers all questions with expertise.

Apr 27, 2020
UH HOSPITALS AND CLINICS

doctor is likeable, knowledgeable and proctive

Mar 29, 2020
UH HOSPITALS AND CLINICS

Dr Valentine is great to work with, & it feels like he is really collaborating with me with an open mind to my concerns.

Mar 10, 2020
UH HOSPITALS AND CLINICS

Dr. Valentine and Julie were both very informative, looked after my needs as a patient, helpful, on time and always helping to do whats best for me. They are always amazing!

Feb 16, 2020
UH HOSPITALS AND CLINICS

Wow! I am super impressed with Dr. Valentine and his staff. Everyone was compassionate and caring. Dr. Valentine was very thorough, as I am a complicated patient. He even called my other specialist to coordinate care while I was in the room. He listened and answered all of my questions. He is the epitome of a great doctor!

Feb 10, 2020
UH HOSPITALS AND CLINICS

Dr. Valentine is a top-notch doctor. I trust him in every aspect of my care with regard to Crohns disease. He is very pleasant to talk to and I am so glad that he is treating me. I have been trying to get my grandson to come in, and he is thinking about it.

Feb 08, 2020
UH HOSPITALS AND CLINICS

Dr. Valentin is a very caring doctor. and I would recommend him for sure.


Patient comments are gathered from our patient experience survey and displayed in their entirety. For the convenience of our visitors, some patient comments have been translated from their original language into English while preserving their original meaning as accurately as possible. Patients are de-identified for confidentiality and patient privacy.

John F. Valentine, MD, is a Professor of Medicine at the University of Utah School of Medicine in the Division of Gastroenterology, Hepatology and Nutrition and specializes in ulcerative colitis and Crohn's disease. His clinical interests and expertise are in inflammatory diseases of the intestinal tract that include inflammatory bowel disease (ulcerative colitis and Crohn's disease) and celiac disease.

Dr. Valentine received his M.D. degree from the University of Texas Medical School at Houston in 1985. He received his training in Internal Medicine at the Medical College of Virginia-Virginia Commonwealth University Medical Center and his training in Gastroenterology at the University of Florida. While on faculty at the University of Florida, he rose to the position of Professor of Medicine, served as the Chief of the Gastroenterology Section at the Malcom Randal Veterans Administration Medical Center, and founded the Southeastern Center for Inflammatory Bowel Disease. He remains active with the Crohn's and Colitis Foundation of America and has served a Co-Chair of the CCFA patient education committee and was a member of the editorial board for the journal Inflammatory Bowel Disease. Dr. Valentine is a Fellow in the American Gastroenterological Association and the director of the University of Utah Inflammatory Bowel Disease Center. Dr. Valentine has extensive experience with treating patients with inflammatory bowel disease and he is developing laboratory research and clinical trials in ulcerative colitis and Crohn's disease in order to expand the understanding and treatment options for patients with these diseases.

Board Certification and Academic Information

Academic Departments Internal Medicine -Professor
Academic Divisions Gastroenterology
Board Certification
American Board of Internal Medicine

Education history

Undergraduate Microbiology - University of Texas at Arlington B.S.
Professional Medical Medicine - University of Texas Medical School at Houston M.D.
Internship/Residency Internal Medicine - Medical College of Virginia Intern/Resident
Fellowship Gastroenterology - University of Florida College of Medicine Fellow

Selected Publications

Journal Article

  1. Peterson LK, Nandakumar V, Valentine JF, Delgado JC, Saadalla A (2025). The Utility of the Immunoglobulin A Flag Used in Celiac Disease Serology Testing on a Particle-Based Multianalyte Technology Platform. Clinical chemistry, 71(7), 818-820.
  2. Mellema RA, Queisser KA, Ajanel A, Albtoush N, Smith L, Rondina M, Will J, Valentine JF, Petrey A (2025). Layilin inhibits integrin activation, and its loss results in platelet hyperactivation via Rac1 in inflammatory bowel disease. Blood, 146(24), 2979-2992.
  3. Tsai HY, Chen MH, Yun J, Lai LA, Valentine JF, Bronner MP, Brentnall TA, Pan S, Chen (2025). Restricting metabolic plasticity enhances stress adaptation through the modulation of PDH and HIF1A in TRAP1-depleted colon cancer. Cancer letters, 632, 217977.
  4. Melmed GY, Oliver B, Kennedy A, Hou JK, Lum D, Singh S, van Deen WK, Oberai R, Weaver SA, Testaverde J, Siegel CA, IBD Qoru (2025). Long-Term Sustained Improvement in Unplanned Healthcare Utilization in Patients With Inflammatory Bowel Disease. The American journal of gastroenterology, 120(11), 2714-2718.
  5. Chulkina M, Rohmer C, McAninch S, Panganiban RP, Villéger R, Portolese A, Ciocirlan J, Yang W, Cohen C, Koltun W, Valentine JF, Cong Y, Yochum G, Beswick EJ, Pinchuk I (2024). Increased activity of MAPKAPK2 within mesenchymal cells as a target for inflammation associated fibrosis in Crohn's Disease. Journal of Crohn's & colitis, 18(7), 1147-1161.
  6. Lewis JD, Daniel SG, Li H, Hao F, Patterson AD, Hecht A, Brensinger CM, Wu GD, Bittinger K, DINE-CD and SPARC IBD Investigators, Kaur M, Dassopoulos T, Snapper SB, Korzenik JR, Bohm M, Raffals L, Beniwal-Patel P, Hudesman D, Russ K, Brook L, Pekow J, Cross R, Wong U, Bishu S, Bewtra M, Lewis JD, Duerr R, Saha S, Caldera F, Scoville E, Deepak P, Ciorba (2024). Surgery for Crohn's Disease Is Associated with a Dysbiotic Microbiome and Metabolome: Results from Two Prospective Cohorts. Cellular and molecular gastroenterology and hepatology, 18(3), 101357.
  7. Colombel JF, Ungaro RC, Sands BE, Siegel CA, Wolf DC, Valentine JF, Feagan BG, Neustifter B, Kadali H, Nazarey P, James A, Jairath V, Qasim Khan R (2024). Vedolizumab, Adalimumab, and Methotrexate Combination Therapy in Crohn's Disease (EXPLORER). Clinical gastroenterology and hepatology, 22(7), 1487-1496.e12.
  8. Lee YJ, Li D, Mujukian A, Debbas P, Hampton M, Mengesha E, Cheng S, Ebinger JE, Chiorean M, Lum D, Damas OM, Braun J, McGovern DPB, Melmed GY, CORALE-IBD Study Grou (2024). Postvaccination Symptoms After a Fourth Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease. Inflammatory bowel diseases, 30(8), 1430-1434.
  9. Chulkina M, Rohmer C, McAninch S, Panganiban RP, Villéger R, Portolese A, Ciocirlan J, Yang W, Cohen C, Koltun W, Valentine JF, Cong Y, Yochum G, Beswick EJ, Pinchuk I (2024). Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target for Inflammation-Associated Fibrosis in Crohn's Disease. Journal of Crohn's & colitis, 18(7), 1147-1161.
  10. Levic DS, Niedzwiecki D, Kandakatla A, Karlovich NS, Juneja A, Park J, Stolarchuk C, Adams S, Willer JR, Schaner MR, Lian G, Beasley C, Marjoram L, Flynn AD, Valentine JF, Onken JE, Sheikh SZ, Davis EE, Evason KJ, Garman KS, Bagnat (2024). TNF promoter hypomethylation is associated with mucosal inflammation in IBD and anti-TNF response.
  11. Lewis JD, Daniel SG, Li H, Hao F, Patterson AD, Hecht AL, Brensinger CM, Wu GD, Bittinger K, DINE-CD, SPARC IBD Investigator (2024). Surgery for Crohn's Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts. Cellular and molecular gastroenterology and hepatology, 18(3), 101357.
  12. Levic DS, Niedzwiecki D, Kandakatla A, Karlovich NS, Juneja A, Park J, Stolarchuk C, Adams S, Willer JR, Schaner MR, Lian G, Beasley C, Marjoram L, Flynn AD, Valentine JF, Onken JE, Sheikh SZ, Davis EE, Evason KJ, Garman KS, Bagnat (2024). TNF Promoter Hypomethylation Is Associated With Mucosal Inflammation in IBD and Anti-TNF Response. Gastro hep advances, 3(7), 888-898.
  13. Danese S, Rothenberg ME, Lim JJ, Ding HT, McBride JM, Chen Y, Dash A, Mar JS, Keir M, Peyrin-Biroulet L, Panes J, Colombel JF, Feagan B, Valentine JF, Schreiber (2024). A Randomized Phase II Study of Efmarodocokin Alfa, an interleukin-22 Agonist, Versus Vedolizumab in Patients With Ulcerative Colitis. Clinical gastroenterology and hepatology,
  14. Mohan BP, Fatima N, Khan SR, Kassab L, Chandan S, Asokkumar R, Valentine JF, Navaneethan U, Kochhar GS, Ma C, Jairath V, Singh (2023). Early Remission With Induction Therapy Predicts Long-Term Remission in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis. PMID: 37207296 DOI: 10.14309/ajg.0000000000002328. The American journal of gastroenterology,
  15. Toy G, Colletier K, Hale G, Valentine J, Gawron AJ, Sossenheimer M, Peterson K, Aparicio R, Fang J (2023). Incidence of retained biopsy specimens after esophagogastroduodenoscopy and colonoscopy. Endoscopy international open, 11(7), E653-E659.
  16. Colombel JF, Ungaro RC, Sands BE, Siegel CA, Wolf DC, Valentine JF, Feagan BG, Neustifter B, Kadali H, Nazarey P, James A, Jairath V, Qasim Khan R (2023). Vedolizumab, Adalimumab, and Methotrexate Combination Therapy in Crohn's Disease (EXPLORER). Clinical gastroenterology and hepatology, 22(7), 1487-1496.e12.
  17. Papamichael K, Jairath V, Zou G, Cohen B, Ritter T, Sands B, Siegel C, Valentine J, Smith M, Vande Casteele N, Dubinsky M, Cheifetz (2022). Proactive infliximab optimisation using a pharmacokinetic dashboard versus standard of care in patients with Crohn's disease: study protocol for a randomised, controlled, multicentre, open-label study (the OPTIMIZE trial). BMJ open, 12(4), e057656.
  18. Tse CS, Van Citters AD, Ricci B, Freundlich NZ, Lee M, Shah SA, Melmed GY, Siegel CA, van Deen WK, IBD Qorus (2022). Identifying and Predicting the Goals and Concerns Prioritised by Individuals with Inflammatory Bowel Disease. Journal of Crohn's & colitis, 16(3), 379-388.
  19. Peyrin-Biroulet L, Hart A, Bossuyt P, Long M, Allez M, Juillerat P, Armuzzi A, Loftus EV Jr, Ostad-Saffari E, Scalori A, Oh YS, Tole S, Chai A, Pulley J, Lacey S, Sandborn WJ, HICKORY Study Group (2022). Etrolizumab as induction and maintenance therapy for ulcerative colitis in patients previously treated with tumour necrosis factor inhibitors (HICKORY): a phase 3, randomised, controlled trial. The lancet. Gastroenterology & hepatology, 7(2), 128-140.
  20. Vermeire S, Lakatos PL, Ritter T, Hanauer S, Bressler B, Khanna R, Isaacs K, Shah S, Kadva A, Tyrrell H, Oh YS, Tole S, Chai A, Pulley J, Eden C, Zhang W, Feagan BG, LAUREL Study Group (2022). Etrolizumab for maintenance therapy in patients with moderately to severely active ulcerative colitis (LAUREL): a randomised, placebo-controlled, double-blind, phase 3 study. The lancet. Gastroenterology & hepatology, 7(1), 28-37.
  21. Rubin DT, Dotan I, DuVall A, Bouhnik Y, Radford-Smith G, Higgins PDR, Mishkin DS, Arrisi P, Scalori A, Oh YS, Tole S, Chai A, Chamberlain-James K, Lacey S, McBride J, Panés J, HIBISCUS Study Group (2022). Etrolizumab versus adalimumab or placebo as induction therapy for moderately to severely active ulcerative colitis (HIBISCUS): two phase 3 randomised, controlled trials. The lancet. Gastroenterology & hepatology, 7(1), 17-27.
  22. Tsai HY, Bronner MP, March JK, Valentine JF, Shroyer NF, Lai LA, Brentnall TA, Pan S, Chen (2022). Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer. Cancer letters, 549, 215915.
  23. Sandborn WJ, Panés J, Danese S, Sharafali Z, Hassanali A, Jacob-Moffatt R, Eden C, Daperno M, Valentine JF, Laharie D, Baía C, Atreya R, Panaccione R, Rydzewska G, Aguilar H, Vermeire S, BERGAMOT Study Group (2022). Etrolizumab as induction and maintenance therapy in patients with moderately to severely active Crohn's disease (BERGAMOT): a randomised, placebo-controlled, double-blind, phase 3 trial. The lancet. Gastroenterology & hepatology,
  24. Lebish EJ, Morgan NJ, Valentine JF, Beswick E (2022). MK2 Inhibitors as a Potential Crohn's Disease Treatment Approach for Regulating MMP Expression, Cleavage of Checkpoint Molecules and T Cell Activity. Pharmaceuticals (Basel, Switzerland), 15(12),
  25. Somineni HK, Nagpal S, Venkateswaran S, Cutler DJ, Okou DT, Haritunians T, Simpson CL, Begum F, Datta LW, Quiros AJ, Seminerio J, Mengesha E, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Iskandar H, Dryden GW, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kuemmerle JF, Lazarev M, Li E, Mannon P, Moulton DE, Newberry RD, Patel AS, Pekow J, Saeed SA, Valentine JF, Wang MH, McCauley JL, Abreu MT, Jester T, Molle-Rios Z, Palle S, Scherl EJ, Kwon J, Rioux JD, Duerr RH, Silverberg MS, Zwick ME, Stevens C, Daly MJ, Cho JH, Gibson G, McGovern DPB, Brant SR, Kugathasan (2021). Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. American journal of human genetics, 108(3), 431-445.
  26. Lewis JD, Sandler R, Brotherton C, Brensinger C, Li H, Kappelman MD, Daniel SG, Bittinger K, Albenberg L, Valentine JF, Hanson J, Suskind D, Meyer A, Compher CW, Bewtra M, Saxena A, Dobes A, Cohen B, Flynn AD, Fischer M, Saha S, Swaminath A, Yacyshyn B, Scherl E, Horst S, Curtis JR, Braly K, Nessel L, McCauley M, McKeever L, Herfarth H, DINE-CD Study Group (2021). A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults with Crohn's Disease. Gastroenterology, 161, 837-852.e9.
  27. Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round J (2021). Adaptive immunity induces mutualism between commensal eukaryotes. Nature, 596(7870), 114-118.
  28. Samadder NJ, Valentine JF, Guthery S, Singh H, Bernstein CN, Leighton JA, Wan Y, Wong J, Boucher K, Pappas L, Rowe K, Burt RW, Curtin K, Smith K (2019). Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases. Clinical gastroenterology and hepatology, 17(9), 1807-1813.e1.
  29. Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, O'Connell R, Jacob V, Scherl E, Crawford C, Stephens WZ, Casjens SR, Longman RS, Round J (2019). Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Cell host & microbe, 25(2), 285-299.e8.
  30. Herfarth H, Barnes EL, Valentine JF, Hanson J, Higgins PDR, Isaacs KL, Jackson S, Osterman MT, Anton K, Ivanova A, Long MD, Martin C, Sandler RS, Abraham B, Cross RK, Dryden G, Fischer M, Harlan W, Levy C, McCabe R, Polyak S, Saha S, Williams E, Yajnik V, Serrano J, Sands BE, Lewis JD, Clinical Research Alliance of the Crohn's and Colitis Foundation (2018). Methotrexate Is Not Superior to Placebo in Maintaining Steroid-Free Response or Remission in Ulcerative Colitis. Gastroenterology, 155(4), 1098-1108.e9.
  31. Johnson J, Affolter K, Boynton K, Chen X, Valentine J, Peterson (2018). CMV Disease in IBD: Comparison of Diagnostic Tests and Correlation with Disease Outcome. Inflammatory bowel diseases, 24(7), 1539-1546.
  32. Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, Herrinton LJ, Klapproth JA, Quiros AJ, Seminerio J, Liu Z, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Dryden GW, Hanson JS, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kwon JH, Lazarev M, Li E, Mack D, Mannon P, Moulton DE, Newberry RD, Osuntokun BO, Patel AS, Saeed SA, Targan SR, Valentine JF, Wang MH, Zonca M, Rioux JD, Duerr RH, Silverberg MS, Cho JH, Hakonarson H, Zwick ME, McGovern DP, Kugathasan (2017). Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology, 152(1), 206-217.e2.
  33. Huang C, Haritunians T, Okou DT, Cutler DJ, Zwick ME, Taylor KD, Datta LW, Maranville JC, Liu Z, Ellis S, Chopra P, Alexander JS, Baldassano RN, Cross RK, Dassopoulos T, Dhere TA, Duerr RH, Hanson JS, Hou JK, Hussain SZ, Isaacs KL, Kachelries KE, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kumar A, Kwon JH, Lazarev M, Mannon P, Moulton DE, Osuntokun BO, Patel A, Rioux JD, Rotter JI, Saeed S, Scherl EJ, Silverberg MS, Silverman A, Targan SR, Valentine JF, Wang MH, Simpson CL, Bridges SL, Kimberly RP, Rich SS, Cho JH, Rienzo AD, Kao LWH, McGovern DPB, Brant SR, Kugathasan (2015). Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans. Gastroenterology, 149(6), 1575-1586.
  34. Melmed GY, Pandak WM, Casey K, Abraham B, Valentine J, Schwartz D, Awais D, Bassan I, Lichtiger S, Sands B, Hanauer S, Richards R, Oikonomou I, Parekh N, Targan S, Johnson K, Hariri R, Fischkoff (2015). Human Placenta-derived Cells (PDA-001) for the Treatment of Moderate-to-severe Crohn's Disease: A Phase 1b/2a Study. Inflammatory bowel diseases, 21(8), 1809-16.
  35. Panaccione R, Sandborn WJ, Gordon GL, Lee SD, Safdi A, Sedghi S, Feagan BG, Hanauer S, Reinisch W, Valentine JF, Huang B, Carcereri (2015). Briakinumab for treatment of Crohn's disease: results of a randomized trial. Inflammatory bowel diseases, 21(6), 1329-40.
  36. Koboziev I, Jones-Hall Y, Valentine JF, Webb CR, Furr KL, Grisham M (2015). Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases. Inflammatory bowel diseases, 21(7), 1652-73.
  37. Runtsch MC, Hu R, Alexander M, Wallace J, Kagele D, Petersen C, Valentine JF, Welker NC, Bronner MP, Chen X, Smith DP, Ajami NJ, Petrosino JF, Round JL, O'Connell R (2015). MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis. Oncotarget, 6(30), 28556-72.
  38. Xia CQ, Peng R, Chernatynskaya AV, Yuan L, Carter C, Valentine J, Sobel E, Atkinson MA, Clare-Salzler MJ (2014). Increased IFN-¿-producing plasmacytoid dendritic cells (pDCs) in human Th1-mediated type 1 diabetes: pDCs augment Th1 responses through IFN-¿ production. Journal of immunology (Baltimore, Md., 193(3), 1024-34.
  39. Faubion WA Jr, Fletcher JG, O'Byrne S, Feagan BG, de Villiers WJ, Salzberg B, Plevy S, Proctor DD, Valentine JF, Higgins PD, Harris JM, Diehl L, Wright L, Tew GW, Luca D, Basu K, Keir M (2013). EMerging BiomARKers in Inflammatory Bowel Disease (EMBARK) study identifies fecal calprotectin, serum MMP9, and serum IL-22 as a novel combination of biomarkers for Crohn's disease activity: role of cross-sectional imaging. The American journal of gastroenterology, 108(12), 1891-900.
  40. Mahadevan U, Wolf DC, Dubinsky M, Cortot A, Lee SD, Siegel CA, Ullman T, Glover S, Valentine JF, Rubin DT, Miller J, Abreu M (2013). Placental transfer of anti-tumor necrosis factor agents in pregnant patients with inflammatory bowel disease. Clinical gastroenterology and hepatology, 11(3), 286-92; quiz e24.
  41. Wang MH, Okazaki T, Kugathasan S, Cho JH, Isaacs KL, Lewis JD, Smoot DT, Valentine JF, Kader HA, Ford JG, Harris ML, Oliva-Hemker M, Cuffari C, Torbenson MS, Duerr RH, Silverberg MS, Rioux JD, Taylor KD, Nguyen GC, Wu Y, Datta LW, Hooker S, Dassopoulos T, Kittles RA, Kao LW, Brant S (2012). Contribution of higher risk genes and European admixture to Crohn's disease in African Americans. Inflammatory bowel diseases, 18(12), 2277-87.
  42. Ukhanova M, Culpepper T, Baer D, Gordon D, Kanahori S, Valentine J, Neu J, Sun Y, Wang X, Mai (2012). Gut microbiota correlates with energy gain from dietary fiber and appears to be associated with acute and chronic intestinal diseases. Clinical microbiology and infection, 18, 62-66.
  43. Dassopoulos T, Nguyen GC, Talor MV, Datta LW, Isaacs KL, Lewis JD, Gold MS, Valentine JF, Smoot DT, Harris ML, Oliva-Hemker M, Bayless TM, Burek CL, Brant S (2010). NOD2 mutations and anti-Saccharomyces cerevisiae antibodies are risk factors for Crohn's disease in African Americans. The American journal of gastroenterology, 105(2), 378-86.
  44. Davis MK, Valentine JF, Weinstein DA, Polyak (2010). Antibodies to CBir1 are associated with glycogen storage disease type Ib. Journal of pediatric gastroenterology and nutrition, 51(1), 14-8.
  45. Ahmadi A, Li Q, Muller K, Collins D, Valentine JF, Drane W, Polyak (2010). Diagnostic value of noninvasive combined fluorine-18 labeled fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography enterography in active Crohn's disease. Inflammatory bowel diseases, 16(6), 974-81.
  46. Valentine JF, Fedorak RN, Feagan B, Fredlund P, Schmitt R, Ni P, Humphries T (2009). Steroid-sparing properties of sargramostim in patients with corticosteroid-dependent Crohn's disease: a randomised, double-blind, placebo-controlled, phase 2 study. Gut, 58(10), 1354-62.
  47. Korzenik JR, Dieckgraefe BK, Valentine JF, Hausman DF, Gilbert M (2005). Sargramostim for active Crohn's disease. The New England journal of medicine, 352(21), 2193-201.
  48. Naser SA, Ghobrial G, Romero C, Valentine J (2004). Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease. Lancet (London, England), 364(9439), 1039-44.
  49. Valentine J (2001). Mesalamine induces manganese superoxide dismutase in rat intestinal epithelial cell lines and in vivo. American journal of physiology. Gastrointestinal and liver physiology, 281(4), G1044-50.
  50. Levic DS, Niedzwiecki D, Kandakatla A, Karlovich NS, Juneja A, Park J, Stolarchuk C, Adams S, Willer JR, Schaner MR, Lian G, Beasley C, Marjoram L, Flynn AD, Valentine JF, Onken JE, Sheikh SZ, Davis EE, Evason KJ, Garman KS, Bagnat M TNF promoter hypomethylation is associated with mucosal inflammation in IBD and anti-TNF response. medRxiv (Preprint) 2024 Feb 6:2024. medRxiv,

Abstract

  1. Mach A, Glover S, Valentine J (2012). GM-CSF and IL23 Protect the Intestinal Epithelial Barrier from Disruption by IFN Treatment.
  2. Gaidos JKJ, Sultan S, Dahl W, Valentine J (2010). Vitamin D Deficiency in Inflammatory Bowel Disease. Advances in IBD Annual CCFA Meeting. Ft. Lauderdale, FL.