John Hyngstrom
( out of 413 reviews )

John Hyngstrom, MD

Languages spoken: English

Clinical Locations

Huntsman Cancer Institute - Cancer Hospital South

801-587-8808

  • Dr. Hyngstrom is an Associate Professor in the section of Surgical Oncology, division of General Surgery within the department of Surgery at the University of Utah. His medical practice is in general surgical oncology with a focus on melanoma and sarcoma, treating patients at the Huntsman Cancer Institute. His research interests include immunotherapy clinical trial development and survivorship issues in cancer patients. He currently serves as the site primary investigator at HCI on multiple therapeutic cooperative group and industry sponsored clinical trials focusing on improving care for patients with advanced melanoma and other solid tumors. He is physician lead of the melanoma Clinical Trials Research Group and the clinical lead of the Melanoma Disease Center at HCI. He also serves as the Surgery Chair of the Melanoma Working Group of the Southwest Oncology Cooperative Group through the NCI.

    Dr. Hyngstrom earned his Bachelor of Arts degree from Washington University in St. Louis, Missouri. He earned his Doctor of Medicine from the University of Chicago Pritzker School of Medicine and completed his general surgery residency at the University of Chicago Medical Center. During his residency, he completed a two-year clinical research fellowship in surgical oncology and tumor immunology at the Surgery Branch of the NCI/NIH in Bethesda, Maryland. After finishing his general surgery training, Dr. Hyngstrom completed a complex general surgical oncology fellowship at the University of Texas MD Anderson Cancer Center. Since 2012, he has worked as a faculty surgeon at the University of Utah Huntsman Cancer Institute, and as a contracted surgeon at Intermountain Medical Center.

    Specialties

    Board Certification

    American Board of Surgery

    Patient Rating

    4.9 /5
    ( out of 413 reviews )

    The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers.

    The scale on which responses are measured is 1 to 5 with 5 being the best score.

    Patient Comments

    Patient comments are gathered from our patient experience survey and displayed in their entirety.
    Patients are de-identified for confidentiality and patient privacy.

    September 29, 2023
    HUNTSMAN CANCER CENTER

    He made me feel welcome and cared about

    September 27, 2023
    HUNTSMAN CANCER CENTER

    Helpful and knowledgeable

    September 27, 2023
    HUNTSMAN CANCER CENTER

    Dr. Hyngstrom cared for me exceptionally well and is very competent and caring.

    September 25, 2023
    HUNTSMAN CANCER CENTER

    He is a very good Surgeon. He did a great job with my operation.

    September 23, 2023
    HUNTSMAN CANCER CENTER

    Since I found out about my cancer I've had scans MRIs and blood tests. This was the first I felt anyone really cared.

    September 15, 2023
    HUNTSMAN CANCER CENTER

    Very nice and compassionate. Explained condition in a way of understanding.

    September 15, 2023
    HUNTSMAN CANCER CENTER

    My experiences with Dr. Hyngstrom are always positive, professional, and yet personal, comprehensive, and encouraging.

    September 14, 2023
    HUNTSMAN CANCER CENTER

    He's a very knowledgeable, compassionate, friendly doctor and didn't act like he was too busy or rushed to spend time explaining everything to me.

    September 08, 2023
    HUNTSMAN CANCER CENTER

    He was so kind. He took the time to discuss everything I needed to ask about. Very skilled and I felt great trust in his expertise.

    See More Patient Comments

  • Dr. Hyngstrom is an Associate Professor in the section of Surgical Oncology, division of General Surgery within the department of Surgery at the University of Utah. His medical practice is in general surgical oncology with a focus on melanoma and sarcoma, treating patients at the Huntsman Cancer Institute. His research interests include immunotherapy clinical trial development and survivorship issues in cancer patients. He currently serves as the site primary investigator at HCI on multiple therapeutic cooperative group and industry sponsored clinical trials focusing on improving care for patients with advanced melanoma and other solid tumors. He is physician lead of the melanoma Clinical Trials Research Group and the clinical lead of the Melanoma Disease Center at HCI. He also serves as the Surgery Chair of the Melanoma Working Group of the Southwest Oncology Cooperative Group through the NCI.

    Dr. Hyngstrom earned his Bachelor of Arts degree from Washington University in St. Louis, Missouri. He earned his Doctor of Medicine from the University of Chicago Pritzker School of Medicine and completed his general surgery residency at the University of Chicago Medical Center. During his residency, he completed a two-year clinical research fellowship in surgical oncology and tumor immunology at the Surgery Branch of the NCI/NIH in Bethesda, Maryland. After finishing his general surgery training, Dr. Hyngstrom completed a complex general surgical oncology fellowship at the University of Texas MD Anderson Cancer Center. Since 2012, he has worked as a faculty surgeon at the University of Utah Huntsman Cancer Institute, and as a contracted surgeon at Intermountain Medical Center.

    Board Certification and Academic Information

    Academic Departments Surgery -Primary
    Academic Divisions General Surgery
    Board Certification
    American Board of Surgery

    Education history

    Fellowship Surgical Oncology, Program Director: Jason Fleming, MD - The University of Texas MD Anderson Cancer Center Fellow
    Surgical Oncology Clinical Research, Program Director: Steven Rosenberg, MD PhD - National Cancer Institute, Surgery Branch Fellow
    Residency General Surgery, Program Director: Mitchell Posner, MD - University of Chicago Medical Center, the Pritzker School of Medicine Resident
    Medicine - The University of Chicago Pritzker School of Medicine M.D.
    Undergraduate Biology and History - Washington University B.A.

    Selected Publications

    Journal Article

    1. Dummer R, Gyorki DE, Hyngstrom JR, Ning M, Lawrence T, Ross MI (2024). Final 5-Year Follow-Up Results Evaluating Neoadjuvant Talimogene Laherparepvec Plus Surgery in Advanced Melanoma: A Randomized Clinical Trial. JAMA Oncol, 9(10), 1457-1459.
    2. Marsiglio J, McPherson JP, Kovacsovics-Bankowski M, Jeter J, Vaklavas C, Swami U, Grossmann D, Erickson-Wayman A, Soares HP, Kerrigan K, Gibson B, Doherty JA, Hyngstrom J, Hardikar S, Hu-Lieskovan S (2023). A single center case series of immune checkpoint inhibitor-induced type 1 diabetes mellitus, patterns of disease onset and long-term clinical outcome. Front Immunol, 14, 1229823.
    3. Brunsgaard EK, Bowles TL, Asare EA, Grossmann K, Boucher KM, Grossmann A, Jackson JA, Wada DA, Rathore R, Budde G, Grandemange A, Hyngstrom JR (2023). Feasibility of personalized circulating tumor DNA detection in stage II and III melanoma. Melanoma Res, 33(3), 184-191.
    4. Patel SP, Othus M, Chen Y, Wright GP Jr, Yost KJ, Hyngstrom JR, Hu-Lieskovan S, Lao CD, Fecher LA, Truong TG, Eisenstein JL, Chandra S, Sosman JA, Kendra KL, Wu RC, Devoe CE, Deutsch GB, Hegde A, Khalil M, Mangla A, Reese AM, Ross MI, Poklepovic AS, Phan GQ, Onitilo AA, Yasar DG, Powers BC, Doolittle GC, In GK, Kokot N, Gibney GT, Atkins MB, Shaheen M, Warneke JA, Ikeguchi A, Najera JE, Chmielowski B, Crompton JG, Floyd JD, Hsueh E, Margolin KA, Chow WA, Grossmann KF, Dietrich E, Prieto VG, Lowe MC, Buchbinder EI, Kirkwood JM, Korde L, Moon J, Sharon E, Sondak VK, Ribas A (2023). Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma. N Engl J Med, 388(9), 813-823.
    5. Kwon OS, Noh SG, Park SH, Andtbacka RHI, Hyngstrom JR, Richardson RS (2022). Ageing and endothelium-mediated vascular dysfunction: the role of the NADPH oxidases. J Physiol, 601(3), 451-467.
    6. Curti BD, Richards J, Hyngstrom JR, Daniels GA, Faries M, Feun L, Margolin KA, Hallmeyer S, Grose M, Zhang Y, Li A, Andtbacka RHI (2022). Intratumoral oncolytic virus V937 plus ipilimumab in patients with advanced melanoma: the phase 1b MITCI study. J Immunother Cancer, 10(12).
    7. Adams AM, Carpenter EL, Clifton GT, Vreeland TJ, Chick RC, OShea AE, McCarthy PM, Kemp Bohan PM, Hickerson AT, Valdera FA, Tiwari A, Hale DF, Hyngstrom JR, Berger AC, Jakub JW, Sussman JJ, Shaheen MF, Yu X, Wagner TE, Faries MB, Peoples GE (2022). Divergent clinical outcomes in a phase 2B trial of the TLPLDC vaccine in preventing melanoma recurrence and the impact of dendritic cell collection methodology: a randomized clinical trial. Cancer Immunol Immunother.
    8. Chesney JA, Ribas A, Long GV, Kirkwood JM, Dummer R, Puzanov I, Hoeller C, Gajewski TF, Gutzmer R, Rutkowski P, Demidov L, Arenberger P, Shin SJ, Ferrucci PF, Haydon A, Hyngstrom J, van Thienen JV, Haferkamp S, Guilera JM, Rapoport BL, VanderWalde A, Diede SJ, Anderson JR, Treichel S, Chan EL, Bhatta S, Gansert J, Hodi FS, Gogas H (2022). Randomized, Double-Blind, Placebo-Controlled, Global Phase III Trial of Talimogene Laherparepvec Combined With Pembrolizumab for Advanced Melanoma. J Clin Oncol, JCO2200343.
    9. Multicenter Selective Lymphadenectomy Trials Study Group, Crystal JS, Thompson JF, Hyngstrom J, Carac C, Zager JS, Jahkola T, Bowles TL, Pennacchioli E, Beitsch PD, Hoekstra HJ, Moncrieff M, Ingvar C, van Akkooi A, Sabel MS, Levine EA, Agnese D, Henderson M, Dummer R, Neves R, Rossi CR, Kane JM 3rd, Trocha S, Wright F, Byrd DR, Matter M, Hsueh EC, MacKenzie-Ross A, Kelley M, Terheyden P, Huston TL, Wayne JD, Neuman H, Smithers BM, Ariyan CE, Desai D, Gershenwald JE, Schneebaum S, Gesierich A, Jacobs LK, Lewis JM, McMasters KM, ODonoghue C, van der Westhuizen A, Sardi A, Barth R, Barone R, McKinnon JG, Slingluff CL, Farma JM, Schultz E, Scheri RP, Vidal-Sicart S, Molina M, Testori AAE, Foshag LJ, Van Kreuningen L, Wang HJ, Sim MS, Scolyer RA, Elashoff DE, Cochran AJ, Faries MB (2022). Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial. JAMA Surg, 157, 835-842.
    10. Dummer R, Gyorki DE, Hyngstrom J, Berger AC, Conry R, Demidov L, Sharma A, Treichel SA, Radcliffe H, Gorski KS, Anderson A, Chan E, Faries M, Ross MI (2021). Neoadjuvant talimogene laherparepvec plus surgery versus surgery alone for resectable stage IIIB-IVM1a melanoma: a randomized, open-label, phase 2 trial. Nat Med, 27(10), 1789-1796.
    11. Adams AM, Chick RC, Vreeland TJ, Clifton GT, Hale DF, McCarthy PM, OShea AE, Bohan PMK, Hickerson AT, Park H, Sloan AJ, Hyngstrom J, Berger AC, Jakub JW, Sussman JJ, Shaheen M, Wagner T, Faries MB, Peoples GE (2021). Safety and efficacy of autologous tumor lysate particle-loaded dendritic cell vaccination in combination with systemic therapies in patients with recurrent and metastatic melanoma. Melanoma Res, 31(4), 378-388.
    12. Walker HR, Evans E, Nirula R, Hyngstrom J, Matsen C, Nelson E, Pickron B, Zurbuchen E, Morrow EH (2021). "I need to have a fulfilling job": A qualitative study of surgeon well-being and professional fulfillment. Am J Surg, 223(1), 6-11.
    13. Chick RC, Faries MB, Hale DF, Kemp Bohan PM, Hickerson AT, Vreeland TJ, Myers JW 3rd, Cindass JL, Brown TA 2nd, Hyngstrom J, Berger AC, Jakub JW, Sussman JJ, Shaheen M, Clifton GT, Park H, Sloan AJ, Wagner T, Peoples GE (2021). Multi-institutional, prospective, randomized, double-blind, placebo-controlled phase IIb trial of the tumor lysate, particle-loaded, dendritic cell (TLPLDC) vaccine to prevent recurrence in high-risk melanoma patients: A subgroup analysis. Cancer Med, 10(13), 4302-4311.
    14. Baron K, Moser JC, Patel S, Grossmann KF, Colonna SV, Hyngstrom JR (2020). Comparative effectiveness of second-line ipilimumab vs. nivolumab in combination with ipilimumab in patients with advanced melanoma who received frontline anti-PD-1 antibodies. J Oncol Pharm Pract, 27(3), 555-559.
    15. Bleicher J, Asare EA, Flores S, Bowles TL, Bowen GM, Hyngstrom JR (2020). Oncologic outcomes of patients with Merkel Cell Carcinoma (MCC): A multi-institutional cohort study. Am J Surg, 221(4), 844-849.
    16. Bleicher J, Cohan JN, Huang LC, Peche W, Pickron TB, Scaife CL, Bowles TL, Hyngstrom JR, Asare EA (2020). Trends in the management of anorectal melanoma: A multi-institutional retrospective study and review of the world literature. World J Gastroenterol, 27(3), 267-280.
    17. Bleicher J, Swords DS, Mali ME, McGuire L, Pahlkotter MK, Asare EA, Bowles TL, Hyngstrom JR (2020). Recurrence patterns in patients with Stage II melanoma: The evolving role of routine imaging for surveillance. J Surg Oncol, 122(8), 1770-1777.
    18. Grossman D, Okwundu N, Bartlett EK, Marchetti MA, Othus M, Coit DG, Hartman RI, Leachman SA, Berry EG, Korde L, Lee SJ, Bar-Eli M, Berwick M, Bowles T, Buchbinder EI, Burton EM, Chu EY, Curiel-Lewandrowski C, Curtis JA, Daud A, Deacon DC, Ferris LK, Gershenwald JE, Grossmann KF, Hu-Lieskovan S, Hyngstrom J, Jeter JM, Judson-Torres RL, Kendra KL, Kim CC, Kirkwood JM, Lawson DH, Leming PD, Long GV, Marghoob AA, Mehnert JM, Ming ME, Nelson KC, Polsky D, Scolyer RA, Smith EA, Sondak VK, Stark MS, Stein JA, Thompson JA, Thompson JF, Venna SS, Wei ML, Swetter SM (2020). Prognostic Gene Expression Profiling in Cutaneous Melanoma: Identifying the Knowledge Gaps and Assessing the Clinical Benefit. JAMA Dermatol, 156(9), 1004-1011.
    19. Truong A, Hyngstrom JR, Andtbacka RHI, Noyes RD, Wright M, Snyder J, Winters A, Sause WT, Grossmann KF, Khong HT, Bowen GM, Hitchcock YJ, Grossman D, Bowles TL (2019). Recurrence risk of early-stage melanoma of the external ear: an investigation of surgical approach and sentinel lymph node status. Melanoma Res, 30(2), 173-178.
    20. Moser JC, Wei G, Colonna SV, Grossmann KF, Patel S, Hyngstrom JR (2020). Comparative-effectiveness of pembrolizumab vs. nivolumab for patients with metastatic melanoma. Acta Oncol, 59(4), 434-437.
    21. Park SH, Kwon OS, Park SY, Weavil JC, Hydren JR, Reese V, Andtbacka RHI, Hyngstrom JR, Richardson RS (2020). Vasodilatory and vascular mitochondrial respiratory function with advancing age: evidence of a free radically mediated link in the human vasculature. Am J Physiol Regul Integr Comp Physiol, 318(4), R701-R711.
    22. Moser JC, Chen D, Hu-Lieskovan S, Grossmann KF, Patel S, Colonna SV, Ying J, Hyngstrom JR (2019). Real-world survival of patients with advanced BRAF V600 mutated melanoma treated with front-line BRAF/MEK inhibitors, anti-PD-1 antibodies, or nivolumab/ipilimumab. Cancer Med, 8(18), 7637-7643.
    23. Grossman D, Farnham JM, Hyngstrom J, Klapperich ME, Secrest AM, Empey S, Bowen GM, Wada D, Andtbacka RHI, Grossmann K, Bowles TL, Cannon-Albright LA (2018). Similar survival of patients with multiple versus single primary melanomas based on Utah Surveillance, Epidemiology, and End Results data (1973-2011). J Am Acad Dermatol, 79(2), 238-244.
    24. Gardner LJ, Ward M, Andtbacka RHI, Boucher KM, Bowen GM, Bowles TL, Cohen AL, Grossmann K, Hitchcock YJ, Holmen SL, Hyngstrom J, Khong H, McMahon M, Monroe MM, Ross CB, Suneja G, Wada D, Grossman D (2017). Risk factors for development of melanoma brain metastasis and disease progression: a single-center retrospective analysis. Melanoma Res, 27(5), 477-484.
    25. Ray A, Williams MA, Meek SM, Bowen RC, Grossmann KF, Andtbacka RH, Bowles TL, Hyngstrom JR, Leachman SA, Grossman D, Bowen GM, Holmen SL, VanBrocklin MW, Suneja G, Khong HT (2016). A phase I study of intratumoral ipilimumab and interleukin-2 in patients with advanced melanoma. Oncotarget, 7(39), 64390-64399.
    26. Hyngstrom JR, Tzeng CW, Beddar S, Das P, Krishnan S, Delclos ME, Crane CH, Chang GJ, You YN, Feig BW, Skibber JM, Rodriguez-Bigas MA (2014). Intraoperative radiation therapy for locally advanced primary and recurrent colorectal cancer: ten-year institutional experience. J Surg Oncol, 109(7), 652-8.
    27. Hyngstrom JR, Chiang YJ, Cromwell KD, Ross MI, Xing Y, Mungovan KS, Lee JE, Gershenwald JE, Royal RE, Lucci A, Armer JM, Cormier JN (8/23/2013). Prospective assessment of lymphedema incidence and lymphedema-associated symptoms following lymph node surgery for melanoma. Melanoma Res, 23(4), 290--7.
    28. Hyngstrom JR, Hu CY, Xing Y, You YN, Feig BW, Skibber JM, Rodriguez-Bigas MA, Cormier JN, Chang GJ (2012). Clinicopathology and outcomes for mucinous and signet ring colorectal adenocarcinoma: analysis from the National Cancer Data Base. Ann Surg Oncol, 19(9), 2814-21.

    Review

    1. Fastner S, Hieken TJ, McWilliams RR, Hyngstrom J (2023). Anorectal melanoma. [Review]. J Surg Oncol, 128(4), 635-644.

    Case Report

    1. Shah A, Hyngstrom J, Florell SR, Grossman D (2019). Use of the Pigmented Lesion Assay to rapidly screen a patient with numerous clinically atypical pigmented lesions. JAAD Case Rep, 5(12), 1048-1050.

    Letter

    1. Bilimoria KY, Russell MC, Hyngstrom J (2017). Melanoma Sentinel-Node Metastasis. [Letter to the editor]. N Engl J Med, 377(9), 891.
    2. Duffy KL, Truong A, Bowen GM, Andtbacka RH, Hyngstrom J, Bowles T, Grossmann K, Khong H, Hyde M, Florell SR, Bowen AR, Wada D, Grossman D (2014). Adequacy of 5-mm surgical excision margins for non-lentiginous melanoma in situ. [Letter to the editor]. J Am Acad Dermatol, 71(4), 835-8.

    Other

    1. Slingluff CL, Lewis KD, Andtbacka R, Hyngstrom J, Milhem M, Markovic SN, Bowles T, Hamid O, Hernandez-Aya L, Claveau J, Jang S, Philips P, Holtan SG, Shaheen MF, Curti B, Schmidt W, Butler MO, Paramo J, Lutzky J, Padmanabhan A, Thomas S, Milton D, Pecora A, Sato T, Hsueh E, Badarinath S, Keech J, Kalmadi S, Kumar P, Weber R, Levine E, Berger A, Bar A, Beck JT, Travers JB, Mihalcioiu C, Gastman B, Beitsch P, Rapisuwon S, Glaspy J, McCarron EC, Gupta V, Behl D, Blumenstein B, Peterkin JJ (2021). Multicenter, double-blind, placebo-controlled trial of seviprotimut-L polyvalent melanoma vaccine in patients with post-resection melanoma at high risk of recurrence. J Immunother Cancer (9(10)). England.
    2. Hyngstrom JR, Chiang YJ, Cromwell KD, Ross MI, Xing Y, Mungovan KS, Lee JE, Gershenwald JE, Royal RE, Lucci A, Armer JM, Cormier JN (2013). Prospective assessment of lymphedema incidence and lymphedema-associated symptoms following lymph node surgery for melanoma. Melanoma Res (23(4), pp. 290-7). England.