Karl A. Sanders
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Karl A. Sanders, MD

Languages spoken: English

Clinical Locations

Primary Location

University of Utah Hospital

Pulmonary, Clinic 3
50 N Medical Dr
Salt Lake City , UT 84132
801-581-7806
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Dr. Karl Sanders is a member of the Division of Respiratory, Critical Care and Occupational Pulmonary Medicine in the Department of Internal Medicine, University of Utah School of Medicine. He serves as the Pulmonary and Critical Care Medicine Fellowship Training Program Director at the University of Utah. He is an associate professor of medicine (clinical) within the Department of Medicine. Dr. Sanders coordinates the efforts of the Division in its mission to educate and train future clinicians, investigators, and educators in the practice of pulmonary and critical care medicine.

Dr. Sanders is engaged in education of medical students, house officers and fellows in clinical aspects of pulmonary and critical care medicine. All of his clinical work occurs at the George E. Wahlen VA Medical center where he cares for critically ill individuals in the medical intensive care unit and sees patients with a variety of pulmonary diseases in the outpatient clinics.

Specialties

Board Certification

American Board of Internal Medicine (Sub: Pulmonary Disease)
American Board of Internal Medicine (Sub: Critical Care Medicine)

Dr. Karl Sanders is a member of the Division of Respiratory, Critical Care and Occupational Pulmonary Medicine in the Department of Internal Medicine, University of Utah School of Medicine. He serves as the Pulmonary and Critical Care Medicine Fellowship Training Program Director at the University of Utah. He is an associate professor of medicine (clinical) within the Department of Medicine. Dr. Sanders coordinates the efforts of the Division in its mission to educate and train future clinicians, investigators, and educators in the practice of pulmonary and critical care medicine.

Dr. Sanders is engaged in education of medical students, house officers and fellows in clinical aspects of pulmonary and critical care medicine. All of his clinical work occurs at the George E. Wahlen VA Medical center where he cares for critically ill individuals in the medical intensive care unit and sees patients with a variety of pulmonary diseases in the outpatient clinics.

Board Certification and Academic Information

Academic Departments Internal Medicine -Professor (Clinical)
Academic Divisions Public Health
Board Certification
American Board of Internal Medicine (Sub: Pulmonary Disease)
American Board of Internal Medicine (Sub: Critical Care Medicine)

Education history

Undergraduate History - University of Kansas B.A.
Professional Medical Medicine - University of Kansas M.D.
Residency Internal Medicine - University of Minnesota Hospitals Resident
Fellowship Pulmonary Medicine - University of Utah School of Medicine Fellow

Selected Publications

Journal Article

  1. Kwon OS, Decker ST, Zhao J, Hoidal JR, Heuckstadt T, Sanders KA, Richardson RS, Layec (2023). The receptor for advanced glycation end products (RAGE) is involved in mitochondrial function and cigarette smoke-induced oxidative stress. Free radical biology & medicine, 195, 261-269.
  2. Decker ST, Kwon OS, Zhao J, Hoidal JR, Heuckstadt T, Richardson RS, Sanders KA, Layec (2021). Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure. American journal of physiology. Endocrinology and metabolism, 321(1), E80-E89.
  3. Trivedi S, Labuz D, Deering-Rice CE, Kim CU, Christensen H, Aamodt S, Huecksteadt T, Sanders K, Warren K (2022). IL-33 induces NF-¿B activation in ILC2 that can be suppressed by in vivo and ex vivo 17ß-estradiol. Frontiers in allergy, 3, 1062412.
  4. Wuren T, Huecksteadt T, Beck E, Warren K, Hoidal J, Ostrand-Rosenberg S, Sanders (2021). The receptor for advanced glycation endproducts (RAGE) decreases survival of tumor-bearing mice by enhancing the generation of lung metastasis-associated myeloid-derived suppressor cells. Cellular immunology, 365, 104379.
  5. DeCato TW, Burk RE, Mir-Kasimov M, Shigeoka JW, Hegewald MJ, Sanders (2019). A 73-Year-Old Man With Progressive Whole Body Subcutaneous Gas After Pleural Catheter Removal. Chest, 155(4), e97-e100.
  6. Sturrock A, Woller D, Freeman A, Sanders K, Paine R 3r (2018). Consequences of Hypoxia for the Pulmonary Alveolar Epithelial Cell Innate Immune Response. Journal of immunology (Baltimore, Md., 201(11), 3411-3420.
  7. Reynolds PR, Schmitt RE, Kasteler SD, Sturrock A, Sanders K, Bierhaus A, Nawroth PP, Paine R 3rd, Hoidal J (2010). Receptors for advanced glycation end-products targeting protect against hyperoxia-induced lung injury in mice. American journal of respiratory cell and molecular biology, 42(5), 545-51.
  8. Ismail S, Sturrock A, Wu P, Cahill B, Norman K, Huecksteadt T, Sanders K, Kennedy T, Hoidal (2009). NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3. American journal of physiology. Lung cellular and molecular physiology, 296(3), L489-99.
  9. Farmer CG, Uriona TJ, Olsen DB, Steenblik M, Sanders (2008). The right-to-left shunt of crocodilians serves digestion. Physiological and biochemical zoology, 81(2), 125-37.
  10. Sturrock A, Huecksteadt TP, Norman K, Sanders K, Murphy TM, Chitano P, Wilson K, Hoidal JR, Kennedy T (2007). Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology, 292(6), L1543-55.
  11. He L, Dinger B, Sanders K, Hoidal J, Obeso A, Stensaas L, Fidone S, Gonzalez (2005). Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells. American journal of physiology. Lung cellular and molecular physiology, 289(6), L916-24.
  12. Yang T, Zhang A, Honeggar M, Kohan DE, Mizel D, Sanders K, Hoidal JR, Briggs JP, Schnermann J (2005). Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin. The Journal of biological chemistry, 280(41), 34966-73.
  13. He L, Chen J, Dinger B, Sanders K, Sundar K, Hoidal J, Fidone (2003). Carotid body chemoreceptor activity in mice deficient in selected subunits of NADPH oxidase. Advances in experimental medicine and biology, 536, 41-6.
  14. He L, Chen J, Dinger B, Sanders K, Sundar K, Hoidal J, Fidone (2002). Characteristics of carotid body chemosensitivity in NADPH oxidase-deficient mice. American journal of physiology. Cell physiology, 282(1), C27-33.
  15. Warren KJ, Deering-Rice C, Huecksteadt T, Trivedi S, Venosa A, Reilly C, Sanders K, Clayton F, Wyatt TA, Poole JA, Heller NM, Leung D, Paine R 3r (2023). Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance. Biology of sex differences, 14(1), 2.

Review

  1. Ostrand-Rosenberg S, Huecksteadt T, Sanders (2023). The Receptor for Advanced Glycation Endproducts (RAGE) and Its Ligands S100A8/A9 and High Mobility Group Box Protein 1 (HMGB1) Are Key Regulators of Myeloid-Derived Suppressor Cells. Cancers, 15(4),
  2. Dinger B, He L, Chen J, Liu X, Gonzalez C, Obeso A, Sanders K, Hoidal J, Stensaas L, Fidone (2007). The role of NADPH oxidase in carotid body arterial chemoreceptors. Respiratory physiology & neurobiology, 157(1), 45-54.