Kevin J. Whitehead, MD

Journal Article

1. Al-Samkari H, Kasthuri RS, Iyer VN, Pishko AM, Decker JE, Weiss CR, Whitehead KJ, Conrad MB, Zumberg MS, Zhou JY, Parambil J, Marsh D, Clancy M, Bradley L, Wisniewski L, Carper BA, Thomas SM, McCrae KR (2024). Pomalidomide for Epistaxis in Hereditary Hemorrhagic Telangiectasia. N Engl J Med, 391(11), 1015-1027. (Read full article)
2. Steinberg BA, Tandar A, Whitehead KJ (2024). Helix-fixed leadless pacemaker implantation through a valve-in-valve tricuspid prosthesis via the femoral approach. J Interv Card Electrophysiol, 67(5), 915-917. (Read full article)
3. Beslow LA, Vossough A, Kim H, Nelson J, Lawton MT, Pollak J, Lin DDM, Ratjen F, Hammill AM, Hetts SW, Gossage JR, Whitehead KJ, Faughnan ME, Krings T, Atherton ME, Chakinala MM, Clancy MS, Henderson K, Hetts SW, Hountras P, Iyer V, Kasthuri RS, Lin D, Mager JJ, Marchuk DA, McWilliams JP, McDonald J, Pawlikowska L, Swanson K, Vethanayagam D, Weinsheimer S, White AJ, Wilcox P (2024). Brain AVM compactness score in children with hereditary hemorrhagic telangiectasia. Childs Nerv Syst, 40(7), 2101-2108. (Read full article)
4. Whitehead KJ, Toydemir D, Wooderchak-Donahue W, Oakley GM, McRae B, Putnam A, McDonald J, Bayrak-Toydemir P (2024). Investigation of the Genetic Determinants of Telangiectasia and Solid Organ Arteriovenous Malformation Formation in Hereditary Hemorrhagic Telangiectasia (HHT). Int J Mol Sci, 25(14). (Read full article)
5. Beslow LA, Krings T, Kim H, Hetts SW, Lawton MT, Ratjen F, Whitehead KJ, Gossage JR, McCulloch CE, Clancy M, Bagheri N, Faughnan ME, Faughnan ME, Chakinala MM, Clancy M, Hammill AM, Henderson K, Hetts SW, Hountras P, Iyer V, Kasthuri RS, Lin D, Mager JJ, Marchuk DA, McWilliams JP, McDonald J, Pawlikowska L, Pollak J, Swanson K, Vethanayagam D, Weinsheimer S, White AJ, Wilcox P (2024). De Novo Brain Vascular Malformations in Hereditary Hemorrhagic Telangiectasia. Pediatr Neurol, 155, 120-125. (Read full article)
6. Landstrom AP, Spears T, DOttavio A, Chiswell K, Sommerhalter K, Soim A, Farr SL, Crume T, Book WM, Whitehead K, Botto LD, Li JS, Hsu DT (2024). Cardiovascular disease risk factors in congenital heart disease survivors are associated with heart failure. Pediatr Res. (Read full article)
7. Kilian A, Latino GA, White AJ, Ratjen F, McDonald J, Whitehead KJ, Gossage JR, Krings T, Lawton MT, Kim H, Faughnan ME, The Brain Vascular Malformation Consortium Hht Investigator Group (2023). Reply to Eker et al. Comment on "Kilian et al. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J. Clin. Med. 2023, 12, 2704". J Clin Med, 12(23). (Read full article)
8. Sun B, Rouzbehani OMT, Kramer RJ, Ghosh R, Perelli RM, Atkins S, Fatahian AN, Davis K, Szulik MW, Goodman MA, Hathaway MA, Chi E, Word TA, Tunuguntla H, Denfield SW, Wehrens XHT, Whitehead KJ, Abdelnasser HY, Warren JS, Wu M, Franklin S, Boudina S, Landstrom AP (2023). Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-β Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice. Circ Heart Fail, 16(12), e010351. (Read full article)
9. McDonald J, Kornish J, Stevenson DA, Hanson-Kahn A, Balch H, James J, Naik H, Whitehead KJ (2023). Frequency of epistaxis and telangiectasia in patients with hereditary hemorrhagic telangiectasia (HHT) in comparison with the general population: Curaçao diagnostic criteria revisited. Genet Med, 25(8), 100865. (Read full article)
10. Kilian A, Latino GA, White AJ, Ratjen F, McDonald J, Whitehead KJ, Gossage JR, Krings T, Lawton MT, Kim H, Faughnan ME, The Brain Vascular Malformation Consortium Hht Investigator Group (2023). Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J Clin Med, 12(7). (Read full article)
11. Kilian A, Latino GA, White AJ, Ratjen F, McDonald J, Whitehead KJ, Gossage JR, Krings T, Lawton MT, Kim H, Faughnan ME (2023). Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J Clin Med, 12(7). (Read full article)
12. Kaufman CS, McDonald J, Balch H, Whitehead K (2022). Pulmonary Arteriovenous Malformations: What the Interventional Radiologist Should Know. Semin Intervent Radiol, 39(3), 261-270. (Read full article)
13. Son SL, Hosek LL, Stein MC, Allshouse AA, Catino AB, Hoskoppal AK, Cox DA, Whitehead KJ, Lindsay IM, Esplin S, Metz TD (2021). Association between pregnancy and long-term cardiac outcomes in individuals with congenital heart disease. Am J Obstet Gynecol, 226(1), 124.e1-124.e8. (Read full article)
14. Cho JM, Park SK, Ghosh R, Ly K, Ramous C, Thompson L, Hansen M, Mattera MSLC, Pires KM, Ferhat M, Mookherjee S, Whitehead KJ, Carter K, Buffolo M, Boudina S, Symons JD (2021). Late-in-life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts. Aging Cell, 20(10), e13467. (Read full article)
15. Shankar TS, Ramadurai DKA, Steinhorst K, Sommakia S, Badolia R, Thodou Krokidi A, Calder D, Navankasattusas S, Sander P, Kwon OS, Aravamudhan A, Ling J, Dendorfer A, Xie C, Kwon O, Cheng EHY, Whitehead KJ, Gudermann T, Richardson RS, Sachse FB, Schredelseker J, Spitzer KW, Chaudhuri D, Drakos SG (2021). Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis. Nat Commun, 12(1), 4583. (Read full article)
16. Andrade L, Hoskoppal A, Hunt Martin M, Whitehead K, Ou Z, Kuang J, Cox D (2020). Intracranial aneurysm and coarctation of the aorta: prevalence in the current era. Cardiol Young, 31(2), 229-232. (Read full article)
17. Hart BL, Mabray MC, Morrison L, Whitehead KJ, Kim H (2021). Systemic and CNS manifestations of inherited cerebrovascular malformations. Clin Imaging, 75, 55-66. (Read full article)
18. Faughnan ME, Mager JJ, Hetts SW, Palda VA, Lang-Robertson K, Buscarini E, Deslandres E, Kasthuri RS, Lausman A, Poetker D, Ratjen F, Chesnutt MS, Clancy M, Whitehead KJ, Al-Samkari H, Chakinala M, Conrad M, Cortes D, Crocione C, Darling J, de Gussem E, Derksen C, Dupuis-Girod S, Foy P, Geisthoff U, Gossage JR, Hammill A, Heimdal K, Henderson K, Iyer VN, Kjeldsen AD, Komiyama M, Korenblatt K, McDonald J, McMahon J, McWilliams J, Meek ME, Mei-Zahav M, Olitsky S, Palmer S, Pantalone R, Piccirillo JF, Plahn B, Porteous MEM, Post MC, Radovanovic I, Rochon PJ, Rodriguez-Lopez J, Sabba C, Serra M, Shovlin C, Sprecher D, White AJ, Winship I, Zarrabeitia R (2020). Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic Telangiectasia. Ann Intern Med, 173(12), 989-1001. (Read full article)
19. Kilian A, Latino GA, White AJ, Clark D, Chakinala MM, Ratjen F, McDonald J, Whitehead K, Gossage JR, Lin D, Henderson K, Pollak J, McWilliams JP, Kim H, Lawton MT, Faughnan ME, Chakinala M, Clancy MS, Gossage JR, Henderson K, Iyer V, Kasthuri RS, Kim H, Krings T, Lawton MT, Lin D, Mager JJ, Marchuk DA, McWilliams JP, McDonald J, Pawlikowska L, Pollak J, Ratjen F, Swanson K, Vethanayagam D, Wilcox P (2020). Genotype–phenotype correlations in children with hht. J Clin Med, 9(9), 1-9. (Read full article)
20. Kilian A, Latino GA, White AJ, Clark D, Chakinala MM, Ratjen F, McDonald J, Whitehead K, Gossage JR, Lin D, Henderson K, Pollak J, McWilliams JP, Kim H, Lawton MT, Faughnan ME, the Brain Vascular Malformation Consortium HHT Investigator Group (2020). Genotype-Phenotype Correlations in Children with HHT. J Clin Med, 9(9). (Read full article)
21. McDonald J, Bayrak-Toydemir P, DeMille D, Wooderchak-Donahue W, Whitehead K (2020). Curaçao diagnostic criteria for hereditary hemorrhagic telangiectasia is highly predictive of a pathogenic variant in ENG or ACVRL1 (HHT1 and HHT2). Genet Med, 22(7), 1201-1205. (Read full article)
22. Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal JR, Kensler TW, DellItalia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Rajasekaran NS (2021). Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxid Redox Signal, 32(18), 1293-1312. (Read full article)
23. Flemming KD, Kumar S, Brown RD Jr, Singh RJ, Whitehead K, McCreath L, Lanzino G (2020). Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level. Cerebrovasc Dis, 49(2), 216-222. (Read full article)
24. Polster SP, Stadnik A, Akers AL, Cao Y, Christoforidis GA, Fam MD, Flemming KD, Girard R, Hobson N, Koenig JI, Koskimki J, Lane K, Liao JK, Lee C, Lyne SB, McBee N, Morrison L, Piedad K, Shenkar R, Sorrentino M, Thompson RE, Whitehead KJ, Zeineddine HA, Hanley DF, Awad IA (2018). Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial. Neurosurgery, 85(6), 843-853. (Read full article)
25. Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Roedel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML (2018). Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Sci Transl Med, 11(520). (Read full article)
26. Gonzalez CD, Cipriano SD, Topham CA, Stevenson DA, Whitehead KJ, Vanderhooft S, Presson AP, McDonald J (2019). Localization and age distribution of telangiectases in children and adolescents with hereditary hemorrhagic telangiectasia: A retrospective cohort study. J Am Acad Dermatol, 81(4), 950-955. (Read full article)
27. Wooderchak-Donahue WL, Akay G, Whitehead K, Briggs E, Stevenson DA, OFallon B, Velinder M, Farrell A, Shen W, Bedoukian E, Skrabann CM, Antaya RJ, Henderson K, Pollak J, Treat J, Day R, Jacher JE, Hannibal M, Bontempo K, Marth G, Bayrak-Toydemir P, McDonald J (2019). Phenotype of CM-AVM2 caused by variants in EPHB4: how much overlap with hereditary hemorrhagic telangiectasia (HHT)? Genet Med, 21(9), 2007-2014. (Read full article)
28. Balakrishnan B, Verheijen J, Lupo A, Raymond K, Turgeon C, Yang Y, Carter KL, Whitehead KJ, Kozicz T, Morava E, Lai K (2019). A novel phosphoglucomutase-deficient mouse model reveals aberrant glycosylation and early embryonic lethality. J Inherit Metab Dis, 42(5), 998-1007. (Read full article)
29. Lyne SB, Girard R, Koskimki J, Zeineddine HA, Zhang D, Cao Y, Li Y, Stadnik A, Moore T, Lightle R, Shi C, Shenkar R, Carrin-Penagos J, Polster SP, Romanos S, Akers A, Lopez-Ramirez M, Whitehead KJ, Kahn ML, Ginsberg MH, Marchuk DA, Awad IA (2019). Biomarkers of cavernous angioma with symptomatic hemorrhage. JCI Insight, 4(12). (Read full article)
30. Wooderchak-Donahue WL, McDonald J, Farrell A, Akay G, Velinder M, Johnson P, VanSant-Webb C, Margraf R, Briggs E, Whitehead KJ, Thomson J, Lin AE, Pyeritz RE, Marth G, Bayrak-Toydemir P (2018). Genome sequencing reveals a deep intronic splicing ACVRL1 mutation hotspot in Hereditary Haemorrhagic Telangiectasia. J Med Genet, 55(12), 824-830. (Read full article)
31. Girard R, Zeineddine HA, Koskimki J, Fam MD, Cao Y, Shi C, Moore T, Lightle R, Stadnik A, Chaudagar K, Polster S, Shenkar R, Duggan R, Leclerc D, Whitehead KJ, Li DY, Awad IA (2018). Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth. Circ Res, 122(12), 1716-1721. (Read full article)
32. Thomson RS, Molin NL, Whitehead KJ, Ashby S, Johnson L, Ward PD, McRae BR, Wilson KF, McDonald J (2018). The effects of nasal closure on quality of life in patients with hereditary hemorrhagic telangiectasia. Laryngoscope Investig Otolaryngol, 3(3), 178-181. (Read full article)
33. Thomson RS, Molin NL, Whitehead KJ, Ashby S, Johnson L, Ward PD, McRae BR, Wilson KF, McDonald J (2018). The effects of nasal closure on quality of life in patients with hereditary hemorrhagic telangiectasia. Laryngoscope Investig Otolaryngol, 3(3), 178-181. (Read full article)
34. Weber LM, McDonald J, Whitehead K (2018). Vitamin D levels are associated with epistaxis severity and bleeding duration in hereditary hemorrhagic telangiectasia. Biomark Med, 12(4), 365-371. (Read full article)
35. Girard R, Zeineddine HA, Fam MD, Mayampurath A, Cao Y, Shi C, Shenkar R, Polster SP, Jesselson M, Duggan R, Mikati AG, Christoforidis G, Andrade J, Whitehead KJ, Li DY, Awad IA (2017). Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations. Transl Stroke Res, 9(1), 34-43. (Read full article)
36. Akers A, Al-Shahi Salman R, A Awad I, Dahlem K, Flemming K, Hart B, Kim H, Jusue-Torres I, Kondziolka D, Lee C, Morrison L, Rigamonti D, Rebeiz T, Tournier-Lasserve E, Waggoner D, Whitehead K (2016). Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel. Neurosurgery, 80(5), 665-680. (Read full article)
37. Whitehead KJ, Sautter NB, McWilliams JP, Chakinala MM, Merlo CA, Johnson MH, James M, Everett EM, Clancy MS, Faughnan ME, Oh SP, Olitsky SE, Pyeritz RE, Gossage JR (2016). Effect of Topical Intranasal Therapy on Epistaxis Frequency in Patients With Hereditary Hemorrhagic Telangiectasia: A Randomized Clinical Trial. JAMA, 316(9), 943-51. (Read full article)
38. Hunter BN, Timmins BH, McDonald J, Whitehead KJ, Ward PD, Wilson KF (2016). An evaluation of the severity and progression of epistaxis in hereditary hemorrhagic telangiectasia 1 versus hereditary hemorrhagic telangiectasia 2. Laryngoscope, 126(4), 786-90. (Read full article)
39. McDonald J, Wooderchak-Donahue W, VanSant Webb C, Whitehead K, Stevenson DA, Bayrak-Toydemir P (2015). Hereditary hemorrhagic telangiectasia: genetics and molecular diagnostics in a new era. Front Genet, 6, 1. (Read full article)
40. Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY (2015). Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Circulation, 131(3), 289-99. (Read full article)
41. McDonald J, Wooderchak-Donahue W, VanSant Webb C, Whitehead K, Stevenson DA, Bayrak-Toydemir P (2015). Hereditary hemorrhagic telangiectasia: Genetics and molecular diagnostics in a new era. Front Genet, 5(JAN). (Read full article)
42. Mleynek TM, Chan AC, Redd M, Gibson CC, Davis CT, Shi DS, Chen T, Carter KL, Ling J, Blanco R, Gerhardt H, Whitehead K, Li DY (2014). Lack of CCM1 induces hypersprouting and impairs response to flow. Hum Mol Genet, 23(23), 6223-34. (Read full article)
43. Gounder SS, Kannan S, Devadoss D, Miller CJ, Whitehead KS, Odelberg SJ, Firpo MA, Paine R, Hoidal JR, Abel ED, Rajasekaran NS (2013). Correction: Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training. PLoS One, 8(6). (Read full article)
44. Chan AC, Drakos SG, Ruiz OE, Smith ACH, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY (2012). Erratum: Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice (Journal of Clinical Investigation (2011) 121, 5 (1871-1881) DOI: 10.1172/JCI44393). J Clin Invest, 122(5), 1948. (Read full article)
45. Whitehead KJ, Chan AC, Navankasattusas S, Koh W, London NR, Ling J, Mayo AH, Drakos SG, Jones CA, Zhu W, Marchuk DA, Davis GE, Li DY (2009). Erratum: The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases (Nature Medicine (2009) 15 (177-184)). Nat Med, 15(4), 462. (Read full article)

Letter

1. Kilian A, Latino GA, White AJ, Ratjen F, McDonald J, Whitehead KJ, Gossage JR, Krings T, Lawton MT, Kim H, Faughnan ME (2023). Reply to Eker et al. Comment on “Kilian et al. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J. Clin. Med. 2023, 12, 2704” [Letter to the editor]. J Clin Med, 12(23). (Read full article)

Video/Film/CD/Web/Podcast

1. Cure HHT (2019). Dr Whitehead's Interview Highlighting Utah HHT Center [Video]. Pompano Beach, Florida: Cure HHT.

News

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