Kimberley J. Evason

Kimberley J. Evason, MD, PhD

Languages spoken: English

  • Dr. Evason is an assistant professor of pathology at the University of Utah School of Medicine and currently serves as head of Hepatobiliary Pathology. Dr. Evason also directs a basic science research program at the Huntsman Cancer Institute. The overarching goal of the Evason laboratory is to define mechanisms involved in liver tumorigenesis in order to develop improved therapies to treat hepatocellular carcinoma and other hepatobiliary malignancies. Dr. Evason received her MD/PhD from Washington University in St. Louis. She completed her anatomic pathology residency, along with fellowship training in surgical pathology and liver/gastrointestinal pathology, at University of California, San Francisco (UCSF). She then remained at UCSF as a clinical instructor while completing post-doctoral research funded by a Damon Runyon Cancer Research Fellowship Award and a K08 award from the NIH/NCI.

    Specialties

    • Pathology, Anatomical

    Board Certification

    American Board of Pathology (Sub: Anatomic Path)

  • Dr. Evason is an assistant professor of pathology at the University of Utah School of Medicine and currently serves as head of Hepatobiliary Pathology. Dr. Evason also directs a basic science research program at the Huntsman Cancer Institute. The overarching goal of the Evason laboratory is to define mechanisms involved in liver tumorigenesis in order to develop improved therapies to treat hepatocellular carcinoma and other hepatobiliary malignancies. Dr. Evason received her MD/PhD from Washington University in St. Louis. She completed her anatomic pathology residency, along with fellowship training in surgical pathology and liver/gastrointestinal pathology, at University of California, San Francisco (UCSF). She then remained at UCSF as a clinical instructor while completing post-doctoral research funded by a Damon Runyon Cancer Research Fellowship Award and a K08 award from the NIH/NCI.

    Board Certification and Academic Information

    Academic Departments Pathology -Primary
    Oncological Sciences -Adjunct
    Board Certification
    American Board of Pathology (Sub: Anatomic Path)

    Education history

    Fellowship GI/Liver Pathology - University of California, San Francisco Clinical Research Fellow
    Laboratories of Didier Stainier, Andrei Goga, and Mike Bishop - University of California, San Francisco Postdoctoral Fellow
    Chief Resident Anatomic Pathology - University of California, San Francisco Chief Resident
    Anatomic Pathology - University of California, San Francisco Resident
    Professional Medical Medicine/Developmental Biology - Washington University School of Medicine M.D., Ph.D.
    Biomedical Engineering - University of Iowa B.S.

    Selected Publications

    Journal Article

    1. Boylan KE, Kanth P, Delker D, Hazel MW, Boucher KM, Affolter K, Clayton F, Evason KJ, Jedrzkiewicz J, Pletneva M, Samowitz W, Swanson E, Bronner MP (2023). Three pathologic criteria for reproducible diagnosis of colonic sessile serrated lesion versus hyperplastic polyp. Hum Pathol, 137, 25-35.
    2. Ong AJS, Bladen CE, Tigani TA, Karamalakis AP, Evason KJ, Brown KK, Cox AG (2023). The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis. Proc Natl Acad Sci U S A, 120(22), e2217425120.
    3. Leonard NB, Hale GL, Boylan KE, Ou Z, Zhang C, Kim R, Chandna S, Dong ZM, Evason KJ (2023). Histologic features of allograft livers in patients treated for rejection before biopsy. Hum Pathol, 135, 11-21.
    4. Bowman KER, Ahne L, OBrien L, Vander Mause ER, Lu P, Wallis B, Evason KJ, Lim CS (2022). p53-Bad* Fusion Gene Therapy Induces Apoptosis In Vitro and Reduces Zebrafish Tumor Burden in Hepatocellular Carcinoma. Mol Pharm, 20(1), 331-340.
    5. Ellis JL, Evason KJ, Zhang C, Fourman MN, Liu J, Ninov N, Delous M, Vanhollebeke B, Fiddes I, Otis JP, Houvras Y, Farber SA, Xu X, Lin X, Stainier DYR, Yin C (2022). A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatol Commun, 6(11), 3083-3097.
    6. Pham DH, Kudira R, Xu L, Valencia CA, Ellis JL, Shi T, Evason KJ, Osuji I, Matuschek N, Pfuher L, Mullen M, Mohanty SK, Husami A, Bull LN, Zhang K, Wali S, Yin C, Miethke A (2021). Deleterious variants in ABCC12 are detected in idiopathic chronic cholestasis and cause intrahepatic bile duct loss in model organisms: ABCC12 pathogenic variants lead to cholestasis. Gastroenterology, 161, 287-300.e16.
    7. Kalasekar SM, Garrido-Laguna I, Evason KJ (2021). Immune Checkpoint Inhibitors in Novel Combinations for Hepatocellular Carcinoma. Hepatology, 73(6), 2591-2593.
    8. Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vzquez-Arregun K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J (2019). Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. Cell Metab, 31(2), 284-300.e7.
    9. Kotiyal S, Fulbright A, OBrien LK, Evason KJ (2020). Quantifying Liver Size in Larval Zebrafish Using Brightfield Microscopy. J Vis Exp, (156).
    10. Kalasekar SM, Kotiyal S, Conley C, Phan C, Young A, Evason KJ (2019). Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish. Biol Open, 8(10).
    11. Dubey JP, Evason KJ, Walther Z (2019). Endogenous development of Cystoisospora belli in intestinal and biliary epithelium of humans. Parasitology, 146(7), 865-872.
    12. Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, OConnell RM (2019). Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease. PLoS Genet, 15(2), e1007970.
    13. Swanson EA, March JK, Clayton F, Couturier MR, Arcega R, Smith R, Evason KJ (2018). Epithelial Inclusions in Gallbladder Specimens Mimic Parasite Infection: Histologic and Molecular Examination of Reported Cystoisospora belli Infection in Gallbladders of Immunocompetent Patients. Am J Surg Pathol, 42(10), 1346-1352.
    14. So J, Khaliq M, Evason K, Ninov N, Martin BL, Stainier DYR, Shin D (4/19/2018). Wnt/β-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating Notch activity. Hepatology.
    15. Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A (2017). MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer. EMBO Rep, 18(4), 569-585.
    16. Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W (2016). Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci U S A, 113(38), E5562-71.
    17. Cox AG, Hwang KL, Brown KK, Evason K, Beltz S, Tsomides A, OConnor K, Galli GG, Yimlamai D, Chhangawala S, Yuan M, Lien EC, Wucherpfennig J, Nissim S, Minami A, Cohen DE, Camargo FD, Asara JM, Houvras Y, Stainier DYR, Goessling W (2016). Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat Cell Biol, 18(8), 886-896.
    18. Juric V, Ruffell B, Evason KJ, Hu J, Che L, Wang L, Chen X, Bishop JM (2015). Monocytes promote liver carcinogenesis in an oncogene-specific manner. J Hepatol, 64(4), 881-90.

    Review

    1. Kalasekar SM, VanSant-Webb CH, Evason KJ (2021). Intratumor Heterogeneity in Hepatocellular Carcinoma: Challenges and Opportunities. [Review]. Cancers (Basel), 13(21).
    2. Kotiyal S, Evason KJ (2021). Exploring the Interplay of Telomerase Reverse Transcriptase and β-Catenin in Hepatocellular Carcinoma. [Review]. Cancers (Basel), 13(16).