Kyle C. Kurek
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Kyle C. Kurek, MD

Languages spoken: English

Clinical Locations

Primary Location

Huntsman Cancer Institute - Cancer Hospital South

1950 Circle of Hope
Salt Lake City , UT 84112
801-581-2121
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ARUP

500 Chipeta Way
Salt Lake City , UT 84108
801-581-2121
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University of Utah Hospital

Pathology
50 N Medical Dr
Salt Lake City , UT 84132
801-581-2121
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Specialties

Board Certification

American Board of Pathology (Clinical Path)
American Board of Pathology (Sub: Anatomic Path)

Board Certification and Academic Information

Academic Departments Pathology -Professor
Board Certification
American Board of Pathology (Clinical Path)
American Board of Pathology (Sub: Anatomic Path)

Education history

Undergraduate Major: Biology; Minors: Chemistry, Mathematics - Rhode Island College B.A.
Professional Medical Biochemistry - Warren Alpert Medical School of Brown University M.M.Sc.
Research Fellow Cell & Molecular Biology - University of Oxford Research Fellow
Fellowship Infectious Disease - Duke University Research Fellow
Professional Medical Medicine - Warren Alpert Medical School of Brown University M.D.
Internship Pediatrics - University of Wisconsin School of Medicine and Public Health Intern
Residency Anatomic & Clinical Pathology - Warren Alpert Medical School of Brown University Resident
Fellowship Pediatric Pathology - Harvard Medical School Chief Fellow
Fellowship Molecular Genetics - Harvard Medical School Postdoctoral Fellow

Selected Publications

Journal Article

  1. Slack JC, Kurek KC, Fraulin FOG, Brundler M (2022). Cutaneous B-Cell Pseudolymphoma (Lymphocytoma Cutis) of the Earlobe: A Poorly Recognized Complication of Ear Piercing in Children. Fetal and pediatric pathology, 41(3), 486-492.
  2. Perez-Atayde AR, Debelenko L, Al-Ibraheemi A, Eng W, Ruiz-Gutierrez M, O'Hare M, Croteau SE, Trenor CC 3rd, Boyer D, Balkin DM, Barclay SF, Hsi Dickie B, Liang MG, Chaudry G, Alomari AI, Mulliken JB, Adams DM, Kurek KC, Fishman SJ, Kozakewich HP (2022). Kaposiform Lymphangiomatosis: Pathologic Aspects in 43 Patients. The American journal of surgical pathology, 46(7), 963-976.
  3. Park PC, Kurek KC, DeCoteau J, Howlett CJ, Hawkins C, Izevbaye I, Carter MD, Redpath M, Lo B, Alex D, Yousef G, Yip S, Maung (2022). CAP-ACP Workload Model for Advanced Diagnostics in Precision Medicine. American journal of clinical pathology, 158(1), 105-111.
  4. Wright JR Jr, Chan S, Morgen EK, Maung RTA, and the Canadian Association of Pathologists¿ Pan-Canadian Pediatric-Perinatal Pathology Workload Committee, Brundler MA, El Demellawy D, Fraser RB, Kurek KC, Magee F, Nizalik E, Oligny LL, Somers GR, Stefanovici C, Terry (2022). Workload Measurement in Subspecialty Placental Pathology in Canada. Pediatric and developmental pathology, 25(6), 604-610.
  5. Slack JC, Bründler MA, Chang CA, Perrier R, Lafay-Cousin L, Kurek K (2021). Bilateral Nephroblastic Tumors and a Complex Renal Vascular Anomaly in a Patient With a Mosaic RASopathy: Novel Histopathologic Features and Molecular Insights. Pediatric and developmental pathology, 24(3), 235-240.
  6. Slack JC, Bründler MA, Nohr E, McIntyre JB, Kurek K (2021). Molecular Alterations in Pediatric Fibroblastic/Myofibroblastic Tumors: An Appraisal of a Next Generation Sequencing Assay in a Retrospective Single Centre Study. Pediatric and developmental pathology, 24(5), 405-421.
  7. Chang CA, Perrier R, Kurek KC, Estrada-Veras J, Lehman A, Yip S, Hendson G, Diamond C, Pinchot JW, Tran JM, Arkin LM, Drolet BA, Napier MP, O'Neill SA, Balci TB, Keppler-Noreuil K (2021). Novel findings and expansion of phenotype in a mosaic RASopathy caused by somatic KRAS variants. American journal of medical genetics. Part A, 185(9), 2829-2845.
  8. Gharial J, Ganesh A, Curtis C, Pauranik A, Chan J, Kurek K, Lafay-Cousin (2021). Neuroimaging and Pathology Findings Associated With Rapid Onset Obesity, Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) Syndrome. Journal of pediatric hematology/oncology, 43(4), e571-e576.
  9. Bakker A, Slack JC, Caragea M, Kurek KC, Bründler M (2021). Adipocyte-rich CTNNB1-mutated Intramuscular Gardner Fibroma Progressing to Desmoid Fibromatosis. Pediatric and developmental pathology, 24(1), 62-67.
  10. Barclay SF, Inman KW, Luks VL, McIntyre JB, Al-Ibraheemi A, Church AJ, Perez-Atayde AR, Mangray S, Jeng M, Kreimer SR, Walker L, Fishman SJ, Alomari AI, Chaudry G, Trenor Iii CC, Adams D, Kozakewich HPW, Kurek K (2019). A somatic activating NRAS variant associated with kaposiform lymphangiomatosis. Genetics in medicine, 21(7), 1517-1524.
  11. Maximov VV, Akkawi R, Khawaled S, Salah Z, Jaber L, Barhoum A, Or O, Galasso M, Kurek KC, Yavin E, Aqeilan R (2019). MiR-16-1-3p and miR-16-2-3p possess strong tumor suppressive and antimetastatic properties in osteosarcoma. International journal of cancer, 145(11), 3052-3063.
  12. Brundler MA, Kurek KC, Patel K, Jester (2018). Submucosal Colonic Lipoblastoma Presenting With Colo-colonic Intussusception in an Infant. Pediatric and developmental pathology, 21(4), 401-405.
  13. Lam JY, Lopushinsky SR, Kurek KC, Beaudry (2018). Unusual case of coronal complete bladder duplication associated with rectoprostatic fistula to duplicated prostatic urethra. Pediatric surgery international, 34(1), 105-108.
  14. Tachibana N, Touahri Y, Dixit R, David LA, Adnani L, Cantrup R, Aavani T, Wong RO, Logan C, Kurek KC, Schuurmans (2018). Hamartoma-like lesions in the mouse retina: an animal model of Pten hamartoma tumour syndrome. Disease models & mechanisms, 11(5),
  15. Maclellan RA, Hassanein AH, Kurek KC, Mulliken JB, Rogers GF, Greene A (2016). An Experimental Study of Particulate Bone Graft for Secondary Inlay Cranioplasty Over Scarred Dura. Annals of plastic surgery, 76(4), 438-41.
  16. Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, de Soysa Y, Cahan P, Theißen J, Tu HC, Han A, Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M, Collins JJ, Berthold F, Daley G (2016). Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature, 535(7611), 246-51.
  17. Padwa BL, Dentino K, Robson CD, Woo SB, Kurek K, Resnick C (2016). Pediatric Chronic Nonbacterial Osteomyelitis of the Jaw: Clinical, Radiographic, and Histopathologic Features. Journal of oral and maxillofacial surgery, 74(12), 2393-2402.
  18. Shillingford NM, Calicchio ML, Teot LA, Boyd T, Kurek KC, Goldsmith JD, Bousvaros A, Perez-Atayde AR, Kozakewich H (2015). Villin immunohistochemistry is a reliable method for diagnosing microvillus inclusion disease. The American journal of surgical pathology, 39(2), 245-50.
  19. Luks VL, Kamitaki N, Vivero MP, Uller W, Rab R, Bovée JV, Rialon KL, Guevara CJ, Alomari AI, Greene AK, Fishman SJ, Kozakewich HP, Maclellan RA, Mulliken JB, Rahbar R, Spencer SA, Trenor CC 3rd, Upton J, Zurakowski D, Perkins JA, Kirsh A, Bennett JT, Dobyns WB, Kurek KC, Warman ML, McCarroll SA, Murillo (2015). Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA. The Journal of pediatrics, 166(4), 1048-54.e1-5.
  20. Ai M, Cui Y, Sy MS, Lee DM, Zhang LX, Larson KM, Kurek KC, Jay GD, Warman M (2015). Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints. PloS one, 10(2), e0116237.
  21. Maclellan RA, Luks VL, Vivero MP, Mulliken JB, Zurakowski D, Padwa BL, Warman ML, Greene AK, Kurek K (2014). PIK3CA activating mutations in facial infiltrating lipomatosis. Plastic and reconstructive surgery, 133(1), 12e-19e.
  22. Bowen ME, Ayturk UM, Kurek KC, Yang W, Warman M (2014). SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates. PLoS genetics, 10(5), e1004364.
  23. Crompton BD, Stewart C, Taylor-Weiner A, Alexe G, Kurek KC, Calicchio ML, Kiezun A, Carter SL, Shukla SA, Mehta SS, Thorner AR, de Torres C, Lavarino C, Suñol M, McKenna A, Sivachenko A, Cibulskis K, Lawrence MS, Stojanov P, Rosenberg M, Ambrogio L, Auclair D, Seepo S, Blumenstiel B, DeFelice M, Imaz-Rosshandler I, Schwarz-Cruz Y Celis A, Rivera MN, Rodriguez-Galindo C, Fleming MD, Golub TR, Getz G, Mora J, Stegmaier (2014). The genomic landscape of pediatric Ewing sarcoma. Cancer discovery, 4(11), 1326-41.
  24. Maclellan RA, Luks VL, Vivero MP, Mulliken JB, Zurakowski D, Padwa BL, Warman ML, Greene AK, Kurek K (2014). PIK3CA activating mutations in facial infiltrating lipomatosis. Plastic and reconstructive surgery, 133(1), 12e-19e.
  25. Hassanein AH, Couto RA, Kurek KC, Rogers GF, Mulliken JB, Greene A (2013). Experimental Comparison of Cranial Particulate Bone Graft, rhBMP-2, and Split Cranial Bone Graft for Inlay Cranioplasty. The Cleft palate-craniofacial journal, 50(3), 358-62.
  26. Routh JC, Grundy PE, Anderson JR, Retik AB, Kurek K (2013). B7-h1 as a biomarker for therapy failure in patients with favorable histology Wilms tumor. The Journal of urology, 189(4), 1487-92.
  27. Kurek KC, Pansuriya TC, van Ruler MA, van den Akker B, Luks VL, Verbeke SL, Kozakewich HP, Sciot R, Lev D, Lazar AJ, Fletcher CD, Bovée J (2013). R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. The American journal of pathology, 182(5), 1494-500.
  28. Kelly AD, Haibe-Kains B, Janeway KA, Hill KE, Howe E, Goldsmith J, Kurek K, Perez-Atayde AR, Francoeur N, Fan JB, April C, Schneider H, Gebhardt MC, Culhane A, Quackenbush J, Spentzos (2013). MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32. Genome medicine, 5(1), 2.
  29. Kurek KC, Luks VL, Ayturk UM, Alomari AI, Fishman SJ, Spencer SA, Mulliken JB, Bowen ME, Yamamoto GL, Kozakewich HP, Warman M (2012). Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome. American journal of human genetics, 90(6), 1108-15.
  30. Kurek KC, Howard E, Tennant LB, Upton J, Alomari AI, Burrows PE, Chalache K, Harris DJ, Trenor CC 3rd, Eng C, Fishman SJ, Mulliken JB, Perez-Atayde AR, Kozakewich H (2012). PTEN hamartoma of soft tissue: a distinctive lesion in PTEN syndromes. The American journal of surgical pathology, 36(5), 671-87.
  31. Kentsis A, Ahmed S, Kurek K, Brennan E, Bradwin G, Steen H, Bachur (2012). Detection and diagnostic value of urine leucine-rich ¿-2-glycoprotein in children with suspected acute appendicitis. Annals of emergency medicine, 60(1), 78-83.e1.
  32. Bowen ME, Boyden ED, Holm IA, Campos-Xavier B, Bonafé L, Superti-Furga A, Ikegawa S, Cormier-Daire V, Bovée JV, Pansuriya TC, de Sousa SB, Savarirayan R, Andreucci E, Vikkula M, Garavelli L, Pottinger C, Ogino T, Sakai A, Regazzoni BM, Wuyts W, Sangiorgi L, Pedrini E, Zhu M, Kozakewich HP, Kasser JR, Seidman JG, Kurek KC, Warman M (2011). Loss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome. PLoS genetics, 7(4), e1002050.
  33. Kasliwal MK, Rogers GF, Ramkissoon S, Moses-Gardner A, Kurek KC, Smith E (2011). A rare case of psammomatoid ossifying fibroma in the sphenoid bone reconstructed using autologous particulate exchange cranioplasty. Journal of neurosurgery. Pediatrics, 7(3), 238-43.
  34. Olson JC, Kurek KC, Mehta HP, Warman ML, Snyder B (2011). Expansion thoracoplasty affects lung growth and morphology in a rabbit model: a pilot study. Clinical orthopaedics and related research, 469(5), 1375-82.
  35. Spencer RJ, Kurek KC, Laufer M (2011). Ovarian dermoid cyst super-infected with methicillin-sensitive Staphylococcus aureus leading to the misdiagnosis of appendicitis in an adolescent. Journal of pediatric and adolescent gynecology, 24(2), e25-8.
  36. Del Mare S, Kurek KC, Stein GS, Lian JB, Aqeilan R (2011). Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma. American journal of cancer research, 1(5), 585-94.
  37. Pansuriya TC, van Eijk R, d'Adamo P, van Ruler MA, Kuijjer ML, Oosting J, Cleton-Jansen AM, van Oosterwijk JG, Verbeke SL, Meijer D, van Wezel T, Nord KH, Sangiorgi L, Toker B, Liegl-Atzwanger B, San-Julian M, Sciot R, Limaye N, Kindblom LG, Daugaard S, Godfraind C, Boon LM, Vikkula M, Kurek KC, Szuhai K, French PJ, Bovée J (2011). Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. Nature genetics, 43(12), 1256-61.
  38. Hassanein AH, Fishman SJ, Mulliken JB, Alomari AI, Kurek KC, Padua HM, Greene A (2010). Metastatic neuroblastoma mimicking infantile hemangioma. Journal of pediatric surgery, 45(10), 2045-9.
  39. Kurek KC, Del Mare S, Salah Z, Abdeen S, Sadiq H, Lee SH, Gaudio E, Zanesi N, Jones KB, DeYoung B, Amir G, Gebhardt M, Warman M, Stein GS, Stein JL, Lian JB, Aqeilan R (2010). Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. Cancer research, 70(13), 5577-86.
  40. Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur (2010). Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Annals of emergency medicine, 55(1), 62-70.e4.
  41. Peritz DC, Duncan C, Kurek K, Perez-Atayde AR, Lehmann L (2008). Visceral varicella zoster virus (VZV) after allogeneic hematopoietic stem cell transplant (HSCT) in pediatric patients with chronic graft-versus-host disease (cGVHD). Journal of pediatric hematology/oncology, 30(12), 931-4.
  42. Fischer SA, Graham MB, Kuehnert MJ, Kotton CN, Srinivasan A, Marty FM, Comer JA, Guarner J, Paddock CD, DeMeo DL, Shieh WJ, Erickson BR, Bandy U, DeMaria A Jr, Davis JP, Delmonico FL, Pavlin B, Likos A, Vincent MJ, Sealy TK, Goldsmith CS, Jernigan DB, Rollin PE, Packard MM, Patel M, Rowland C, Helfand RF, Nichol ST, Fishman JA, Ksiazek T, Zaki SR, LCMV in Transplant Recipients Investigation Tea (2006). Transmission of lymphocytic choriomeningitis virus by organ transplantation. The New England journal of medicine, 354(21), 2235-49.
  43. Kurek K, Matsumoto L, Gustafson G, Pires R, Tantravahi U, Suggs J (1999). Biological effects of a bifunctional DNA cross-linker. II. Generation of micronuclei and attached micronuclear-like structures. Mutation research, 426(1), 89-94.
  44. Matsumoto L, Kurek K, Larocque K, Gustafson G, Pires R, Zhang J, Tantravahi U, Suggs J (1999). Biological effects of a bifunctional DNA crosslinker. I. Generation of triradial and quadriradial chromosomes. Mutation research, 426(1), 79-87.
  45. Kurek KC, Matsumoto (1995). Nonrandom arrangement of bovine satellite I DNA within the interphase nucleus of Madin-Darby bovine kidney cells. Experimental cell research, 216(1), 187-90.

Review

  1. Khaytin I, Victor AK, Barclay SF, Benson LA, Slattery SM, Rand CM, Kurek KC, Weese-Mayer D (2023). Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD): a collaborative review of the current understanding. Clinical autonomic research, 33(3), 251-268.
  2. Slattery SM, Perez IA, Ceccherini I, Chen ML, Kurek KC, Yap KL, Keens TG, Khaytin I, Ballard HA, Sokol EA, Mittal A, Rand CM, Weese-Mayer D (2023). Transitional care and clinical management of adolescents, young adults, and suspected new adult patients with congenital central hypoventilation syndrome. Clinical autonomic research, 33(3), 231-249.
  3. Ceccherini I, Kurek KC, Weese-Mayer D (2022). Developmental disorders affecting the respiratory system: CCHS and ROHHAD. Handbook of clinical neurology, 189, 53-91.
  4. Slattery SM, Perez IA, Ceccherini I, Chen ML, Kurek KC, Yap KL, Keens TG, Khaytin I, Ballard HA, Sokol EA, Mittal A, Rand CM, Weese-Mayer D (2022). Transitional care and clinical management of adolescents, young adults, and suspected new adult patients with congenital central hypoventilation syndrome. Clinical autonomic research, 33(3), 231-249.
  5. Ceccherini I, Kurek KC, Weese-Mayer D (2022). Developmental disorders affecting the respiratory system: CCHS and ROHHAD. Handbook of clinical neurology, 189, 53-91.
  6. de Champlain K, Kurek KC, Yunker W (2018). Novel presentation of cranial fasciitis of the mandible: Case report and literature review. International journal of pediatric otorhinolaryngology, 115, 33-37.
  7. Barton SE, Kurek KC, Laufer M (2010). Recurrent bilateral serous cystadenomas in a premenarchal girl: a case report and literature review. Journal of pediatric and adolescent gynecology, 23(1), e27-9.

Letter

  1. Kryshtalskyj MT, Agi J, Ramien ML, Kurek KC, Kherani (2023). Lichen sclerosus of the upper eyelid in a paediatric patient: a novel presentation. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 58(6), e267-e268.
  2. AlTeneiji M, Brundler MA, Noseworthy M, Kurek K (2021). Unilateral congenital pulmonary lymphangiectasis presenting with pneumothorax and an NRAS variant. Pediatric pulmonology, 56(7), 2374-2376.