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Kyle C. Kurek

Kyle C. Kurek, MD

Languages spoken: English

Clinical Locations

ARUP

801-581-2121

University of Utah Hospital

Pathology
801-581-2121
  • Specialties

    Board Certification

    American Board of Pathology (Clinical Path)
    American Board of Pathology (Sub: Anatomic Path)
  • Board Certification and Academic Information

    Academic Departments Pathology -Primary
    Board Certification
    American Board of Pathology (Clinical Path)
    American Board of Pathology (Sub: Anatomic Path)

    Education history

    Fellowship Molecular Genetics - Harvard Medical School Postdoctoral Fellow
    Pediatric Pathology - Harvard Medical School Chief Fellow
    Residency Anatomic & Clinical Pathology - Warren Alpert Medical School of Brown University Resident
    Pediatrics - University of Wisconsin School of Medicine and Public Health Intern
    Fellowship Infectious Disease - Duke University Research Fellow
    Medicine - Warren Alpert Medical School of Brown University M.D.
    Research Fellow Cell & Molecular Biology - University of Oxford Research Fellow
    Biochemistry - Warren Alpert Medical School of Brown University M.M.Sc.
    Undergraduate Major: Biology; Minors: Chemistry, Mathematics - Rhode Island College B.A.

    Selected Publications

    Journal Article

    1. Wright JR Jr, Chan S, Morgen EK, Maung RTA, and the Canadian Association of Pathologists Pan-Canadian Pediatric-Perinatal Pathology Workload Committee, Brundler MA, El Demellawy D, Fraser RB, Kurek KC, Magee F, Nizalik E, Oligny LL, Somers GR, Stefanovici C, Terry J (2022). Workload Measurement in Subspecialty Placental Pathology in Canada. Pediatr Dev Pathol, 25(6), 604-610.
    2. Park PC, Kurek KC, DeCoteau J, Howlett CJ, Hawkins C, Izevbaye I, Carter MD, Redpath M, Lo B, Alex D, Yousef G, Yip S, Maung R (2021). CAP-ACP Workload Model for Advanced Diagnostics in Precision Medicine. Am J Clin Pathol, 158(1), 105-111.
    3. Perez-Atayde AR, Debelenko L, Al-Ibraheemi A, Eng W, Ruiz-Gutierrez M, OHare M, Croteau SE, Trenor CC 3rd, Boyer D, Balkin DM, Barclay SF, Hsi Dickie B, Liang MG, Chaudry G, Alomari AI, Mulliken JB, Adams DM, Kurek KC, Fishman SJ, Kozakewich HPW (2022). Kaposiform Lymphangiomatosis: Pathologic Aspects in 43 Patients. Am J Surg Pathol, 46(7), 963-976.
    4. Slack JC, Kurek KC, Fraulin FOG, Brundler MA (2020). Cutaneous B-Cell Pseudolymphoma (Lymphocytoma Cutis) of the Earlobe: A Poorly Recognized Complication of Ear Piercing in Children. Fetal Pediatr Pathol, 41(3), 486-492.
    5. Slack JC, Brndler MA, Nohr E, McIntyre JB, Kurek KC (2021). Molecular Alterations in Pediatric Fibroblastic/Myofibroblastic Tumors: An Appraisal of a Next Generation Sequencing Assay in a Retrospective Single Centre Study. Pediatr Dev Pathol, 24(5), 405-421.
    6. Chang CA, Perrier R, Kurek KC, Estrada-Veras J, Lehman A, Yip S, Hendson G, Diamond C, Pinchot JW, Tran JM, Arkin LM, Drolet BA, Napier MP, ONeill SA, Balci TB, Keppler-Noreuil KM (2021). Novel findings and expansion of phenotype in a mosaic RASopathy caused by somatic KRAS variants. Am J Med Genet A, 185(9), 2829-2845.
    7. Gharial J, Ganesh A, Curtis C, Pauranik A, Chan J, Kurek K, Lafay-Cousin L (2020). Neuroimaging and Pathology Findings Associated With Rapid Onset Obesity, Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) Syndrome. J Pediatr Hematol Oncol, 43(4), e571-e576.
    8. Slack JC, Brndler MA, Chang CA, Perrier R, Lafay-Cousin L, Kurek KC (2021). Bilateral Nephroblastic Tumors and a Complex Renal Vascular Anomaly in a Patient With a Mosaic RASopathy: Novel Histopathologic Features and Molecular Insights. Pediatr Dev Pathol, 24(3), 235-240.
    9. Bakker A, Slack JC, Caragea M, Kurek KC, Brndler MA (2020). Adipocyte-rich CTNNB1-mutated Intramuscular Gardner Fibroma Progressing to Desmoid Fibromatosis. Pediatr Dev Pathol, 24(1), 62-67.
    10. Maximov VV, Akkawi R, Khawaled S, Salah Z, Jaber L, Barhoum A, Or O, Galasso M, Kurek KC, Yavin E, Aqeilan RI (2019). MiR-16-1-3p and miR-16-2-3p possess strong tumor suppressive and antimetastatic properties in osteosarcoma. Int J Cancer, 145(11), 3052-3063.
    11. Barclay SF, Inman KW, Luks VL, McIntyre JB, Al-Ibraheemi A, Church AJ, Perez-Atayde AR, Mangray S, Jeng M, Kreimer SR, Walker L, Fishman SJ, Alomari AI, Chaudry G, Trenor Iii CC, Adams D, Kozakewich HPW, Kurek KC (2018). A somatic activating NRAS variant associated with kaposiform lymphangiomatosis. Genet Med, 21(7), 1517-1524.
    12. Brundler MA, Kurek KC, Patel K, Jester I (2017). Submucosal Colonic Lipoblastoma Presenting With Colo-colonic Intussusception in an Infant. Pediatr Dev Pathol, 21(4), 401-405.
    13. Tachibana N, Touahri Y, Dixit R, David LA, Adnani L, Cantrup R, Aavani T, Wong RO, Logan C, Kurek KC, Schuurmans C (2018). Hamartoma-like lesions in the mouse retina: an animal model of Pten hamartoma tumour syndrome. Dis Model Mech, 11(5).
    14. Lam JY, Lopushinsky SR, Kurek KC, Beaudry P (2017). Unusual case of coronal complete bladder duplication associated with rectoprostatic fistula to duplicated prostatic urethra. Pediatr Surg Int, 34(1), 105-108.
    15. Padwa BL, Dentino K, Robson CD, Woo SB, Kurek K, Resnick CM (2016). Pediatric Chronic Nonbacterial Osteomyelitis of the Jaw: Clinical, Radiographic, and Histopathologic Features. J Oral Maxillofac Surg, 74(12), 2393-2402.
    16. Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, de Soysa Y, Cahan P, Theien J, Tu HC, Han A, Kurek KC, LaPier GS, Osborne JK, Ross SJ, Cesana M, Collins JJ, Berthold F, Daley GQ (2016). Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature, 535(7611), 246-51.
    17. Maclellan RA, Hassanein AH, Kurek KC, Mulliken JB, Rogers GF, Greene AK (2015). An Experimental Study of Particulate Bone Graft for Secondary Inlay Cranioplasty Over Scarred Dura. Ann Plast Surg, 76(4), 438-41.
    18. Luks VL, Kamitaki N, Vivero MP, Uller W, Rab R, Bove JV, Rialon KL, Guevara CJ, Alomari AI, Greene AK, Fishman SJ, Kozakewich HP, Maclellan RA, Mulliken JB, Rahbar R, Spencer SA, Trenor CC 3rd, Upton J, Zurakowski D, Perkins JA, Kirsh A, Bennett JT, Dobyns WB, Kurek KC, Warman ML, McCarroll SA, Murillo R (2015). Lymphatic and other vascular malformative/overgrowth disorders are caused by somatic mutations in PIK3CA. J Pediatr, 166(4), 1048-54.e1-5.
    19. Ai M, Cui Y, Sy MS, Lee DM, Zhang LX, Larson KM, Kurek KC, Jay GD, Warman ML (2015). Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints. PLoS One, 10(2), e0116237.
    20. Shillingford NM, Calicchio ML, Teot LA, Boyd T, Kurek KC, Goldsmith JD, Bousvaros A, Perez-Atayde AR, Kozakewich HP (2014). Villin immunohistochemistry is a reliable method for diagnosing microvillus inclusion disease. Am J Surg Pathol, 39(2), 245-50.
    21. Crompton BD, Stewart C, Taylor-Weiner A, Alexe G, Kurek KC, Calicchio ML, Kiezun A, Carter SL, Shukla SA, Mehta SS, Thorner AR, de Torres C, Lavarino C, Suol M, McKenna A, Sivachenko A, Cibulskis K, Lawrence MS, Stojanov P, Rosenberg M, Ambrogio L, Auclair D, Seepo S, Blumenstiel B, DeFelice M, Imaz-Rosshandler I, Schwarz-Cruz Y Celis A, Rivera MN, Rodriguez-Galindo C, Fleming MD, Golub TR, Getz G, Mora J, Stegmaier K (2014). The genomic landscape of pediatric Ewing sarcoma. Cancer Discov, 4(11), 1326-41.
    22. Bowen ME, Ayturk UM, Kurek KC, Yang W, Warman ML (2014). SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates. PLoS Genet, 10(5), e1004364.
    23. Maclellan RA, Luks VL, Vivero MP, Mulliken JB, Zurakowski D, Padwa BL, Warman ML, Greene AK, Kurek KC (2013). PIK3CA activating mutations in facial infiltrating lipomatosis. Plast Reconstr Surg, 133(1), 12e-19e.
    24. Maclellan RA, Luks VL, Vivero MP, Mulliken JB, Zurakowski D, Padwa BL, Warman ML, Greene AK, Kurek KC (2013). PIK3CA activating mutations in facial infiltrating lipomatosis. Plast Reconstr Surg, 133(1), 12e-19e.
    25. Hassanein AH, Couto RA, Kurek KC, Rogers GF, Mulliken JB, Greene AK (2012). Experimental Comparison of Cranial Particulate Bone Graft, rhBMP-2, and Split Cranial Bone Graft for Inlay Cranioplasty. Cleft Palate Craniofac J, 50(3), 358-62.
    26. Kurek KC, Pansuriya TC, van Ruler MA, van den Akker B, Luks VL, Verbeke SL, Kozakewich HP, Sciot R, Lev D, Lazar AJ, Fletcher CD, Bove JV (2013). R132C IDH1 mutations are found in spindle cell hemangiomas and not in other vascular tumors or malformations. Am J Pathol, 182(5), 1494-500.
    27. Routh JC, Grundy PE, Anderson JR, Retik AB, Kurek KC (2012). B7-h1 as a biomarker for therapy failure in patients with favorable histology Wilms tumor. J Urol, 189(4), 1487-92.
    28. Kelly AD, Haibe-Kains B, Janeway KA, Hill KE, Howe E, Goldsmith J, Kurek K, Perez-Atayde AR, Francoeur N, Fan JB, April C, Schneider H, Gebhardt MC, Culhane A, Quackenbush J, Spentzos D (2013). MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32. Genome Med, 5(1), 2.
    29. Kentsis A, Ahmed S, Kurek K, Brennan E, Bradwin G, Steen H, Bachur R (2012). Detection and diagnostic value of urine leucine-rich α-2-glycoprotein in children with suspected acute appendicitis. Ann Emerg Med, 60(1), 78-83.e1.
    30. Kurek KC, Luks VL, Ayturk UM, Alomari AI, Fishman SJ, Spencer SA, Mulliken JB, Bowen ME, Yamamoto GL, Kozakewich HP, Warman ML (2012). Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome. Am J Hum Genet, 90(6), 1108-15.
    31. Kurek KC, Howard E, Tennant LB, Upton J, Alomari AI, Burrows PE, Chalache K, Harris DJ, Trenor CC 3rd, Eng C, Fishman SJ, Mulliken JB, Perez-Atayde AR, Kozakewich HP (2012). PTEN hamartoma of soft tissue: a distinctive lesion in PTEN syndromes. Am J Surg Pathol, 36(5), 671-87.
    32. Pansuriya TC, van Eijk R, dAdamo P, van Ruler MA, Kuijjer ML, Oosting J, Cleton-Jansen AM, van Oosterwijk JG, Verbeke SL, Meijer D, van Wezel T, Nord KH, Sangiorgi L, Toker B, Liegl-Atzwanger B, San-Julian M, Sciot R, Limaye N, Kindblom LG, Daugaard S, Godfraind C, Boon LM, Vikkula M, Kurek KC, Szuhai K, French PJ, Bove JV (2011). Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. Nat Genet, 43(12), 1256-61.
    33. Olson JC, Kurek KC, Mehta HP, Warman ML, Snyder BD (2011). Expansion thoracoplasty affects lung growth and morphology in a rabbit model: a pilot study. Clin Orthop Relat Res, 469(5), 1375-82.
    34. Spencer RJ, Kurek KC, Laufer MR (2010). Ovarian dermoid cyst super-infected with methicillin-sensitive Staphylococcus aureus leading to the misdiagnosis of appendicitis in an adolescent. J Pediatr Adolesc Gynecol, 24(2), e25-8.
    35. Bowen ME, Boyden ED, Holm IA, Campos-Xavier B, Bonaf L, Superti-Furga A, Ikegawa S, Cormier-Daire V, Bove JV, Pansuriya TC, de Sousa SB, Savarirayan R, Andreucci E, Vikkula M, Garavelli L, Pottinger C, Ogino T, Sakai A, Regazzoni BM, Wuyts W, Sangiorgi L, Pedrini E, Zhu M, Kozakewich HP, Kasser JR, Seidman JG, Kurek KC, Warman ML (2011). Loss-of-function mutations in PTPN11 cause metachondromatosis, but not Ollier disease or Maffucci syndrome. PLoS Genet, 7(4), e1002050.
    36. Kasliwal MK, Rogers GF, Ramkissoon S, Moses-Gardner A, Kurek KC, Smith ER (2011). A rare case of psammomatoid ossifying fibroma in the sphenoid bone reconstructed using autologous particulate exchange cranioplasty. J Neurosurg Pediatr, 7(3), 238-43.
    37. Del Mare S, Kurek KC, Stein GS, Lian JB, Aqeilan RI (2011). Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma. Am J Cancer Res, 1(5), 585-94.
    38. Hassanein AH, Fishman SJ, Mulliken JB, Alomari AI, Kurek KC, Padua HM, Greene AK (2010). Metastatic neuroblastoma mimicking infantile hemangioma. J Pediatr Surg, 45(10), 2045-9.
    39. Kurek KC, Del Mare S, Salah Z, Abdeen S, Sadiq H, Lee SH, Gaudio E, Zanesi N, Jones KB, DeYoung B, Amir G, Gebhardt M, Warman M, Stein GS, Stein JL, Lian JB, Aqeilan RI (2010). Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. Cancer Res, 70(13), 5577-86.
    40. Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur R (2009). Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Ann Emerg Med, 55(1), 62-70.e4.
    41. Peritz DC, Duncan C, Kurek K, Perez-Atayde AR, Lehmann LE (2009). Visceral varicella zoster virus (VZV) after allogeneic hematopoietic stem cell transplant (HSCT) in pediatric patients with chronic graft-versus-host disease (cGVHD). J Pediatr Hematol Oncol, 30(12), 931-4.
    42. Fischer SA, Graham MB, Kuehnert MJ, Kotton CN, Srinivasan A, Marty FM, Comer JA, Guarner J, Paddock CD, DeMeo DL, Shieh WJ, Erickson BR, Bandy U, DeMaria A Jr, Davis JP, Delmonico FL, Pavlin B, Likos A, Vincent MJ, Sealy TK, Goldsmith CS, Jernigan DB, Rollin PE, Packard MM, Patel M, Rowland C, Helfand RF, Nichol ST, Fishman JA, Ksiazek T, Zaki SR, LCMV in Transplant Recipients Investigation Team (2006). Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med, 354(21), 2235-49.
    43. Matsumoto L, Kurek K, Larocque K, Gustafson G, Pires R, Zhang J, Tantravahi U, Suggs JW (1999). Biological effects of a bifunctional DNA crosslinker. I. Generation of triradial and quadriradial chromosomes. Mutat Res, 426(1), 79-87.
    44. Kurek K, Matsumoto L, Gustafson G, Pires R, Tantravahi U, Suggs JW (1999). Biological effects of a bifunctional DNA cross-linker. II. Generation of micronuclei and attached micronuclear-like structures. Mutat Res, 426(1), 89-94.
    45. Kurek KC, Matsumoto L (1995). Nonrandom arrangement of bovine satellite I DNA within the interphase nucleus of Madin-Darby bovine kidney cells. Exp Cell Res, 216(1), 187-90.

    Review

    1. Slattery SM, Perez IA, Ceccherini I, Chen ML, Kurek KC, Yap KL, Keens TG, Khaytin I, Ballard HA, Sokol EA, Mittal A, Rand CM, Weese-Mayer DE (2022). Transitional care and clinical management of adolescents, young adults, and suspected new adult patients with congenital central hypoventilation syndrome. [Review]. Clin Auton Res.
    2. Ceccherini I, Kurek KC, Weese-Mayer DE (2022). Developmental disorders affecting the respiratory system: CCHS and ROHHAD. [Review]. Handb Clin Neurol, 189, 53-91.
    3. de Champlain K, Kurek KC, Yunker WK (2018). Novel presentation of cranial fasciitis of the mandible: Case report and literature review. [Review]. Int J Pediatr Otorhinolaryngol, 115, 33-37.
    4. Barton SE, Kurek KC, Laufer MR (2009). Recurrent bilateral serous cystadenomas in a premenarchal girl: a case report and literature review. [Review]. J Pediatr Adolesc Gynecol, 23(1), e27-9.

    Letter

    1. AlTeneiji M, Brundler MA, Noseworthy M, Kurek KC (2021). Unilateral congenital pulmonary lymphangiectasis presenting with pneumothorax and an NRAS variant. [Letter to the editor]. Pediatr Pulmonol, 56(7), 2374-2376.
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