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Specialties
Board Certification
American Board of Internal Medicine (Internal Medicine)American Board of Internal Medicine (Sub: Medical Oncology)National Board of Medical Examiners -
Board Certification and Academic Information
Academic Departments Internal Medicine -Primary Academic Divisions Oncology
Board Certification American Board of Internal Medicine (Internal Medicine)American Board of Internal Medicine (Sub: Medical Oncology)National Board of Medical ExaminersEducation history
Postdoctoral Fellowship Huntsman Cancer Institute Postdoctoral Research Fellow Hematology & Medical Oncology - Huntsman Cancer Institute Fellow Residency Internal Medicine - University of Utah School of Medicine Resident Internal Medicine - University of Utah School of Medicine Intern/Resident Professional Medical Microbiology & Immunology - SUNY Upstate Medical University Norton College of Medicine M.D., Ph.D. Microbiology & Immunology - Kalamazoo College B.S. Selected Publications
Journal Article
- Gumbleton M, Allan S, Conway H, Boucher K, Marvin J, Hawks J, Burnett W, Van Brocklin M, Whisenant J, Gilcrease G, Gupta S (2023). A phase I open-label study of the safety and efficacy of apatinib (rivoceranib) administered to patients with advanced malignancies to improve sensitivity to pembrolizumab in the second- or later-line setting (APPEASE). BMC Res Notes, 16(1), 16.
- Gumbleton M, Sudan R, Fernandes S, Engelman RW, Russo CM, Chisholm JD, Kerr WG (2017). Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival. Sci Signal, 10(500).
- Iyer S, Brooks R, Gumbleton M, Kerr WG (2015). SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging. Stem Cells Dev, 24(9), 1073-81.
- Gumbleton M, Vivier E, Kerr WG (2015). SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice. J Immunol, 194(6), 2847-54.
- Fernandes S, Brooks R, Gumbleton M, Park MY, Russo CM, Howard KT, Chisholm JD, Kerr WG (2015). SHIPi Enhances Autologous and Allogeneic Hematolymphoid Stem Cell Transplantation. EBioMedicine, 2(3), 205-213.
- Gumbleton M, Kerr WG (2013). Role of inositol phospholipid signaling in natural killer cell biology. Front Immunol, 4, 47.
- Fuhler GM, Brooks R, Toms B, Iyer S, Gengo EA, Park MY, Gumbleton M, Viernes DR, Chisholm JD, Kerr WG (2012). Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer. Mol Med, 18(1), 65-75.
- Puel A, Cypowyj S, Bustamante J, Wright JF, Liu L, Lim HK, Migaud M, Israel L, Chrabieh M, Audry M, Gumbleton M, Toulon A, Bodemer C, El-Baghdadi J, Whitters M, Paradis T, Brooks J, Collins M, Wolfman NM, Al-Muhsen S, Galicchio M, Abel L, Picard C, Casanova JL (2011). Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science, 332(6025), 65-8.
Patent
- William K, Gumbleton M (2020). Ship inhibition to induce activation of natural killer cells. U.S. Patent No. WO2015195812. Washington, D.C.:U.S. Patent and Trademark Office.