Specialties
Board Certification
|
American Board of Pediatrics (Sub: Pediatric Hematology-Oncology)
American Board of Pediatrics (Pediatrics)
|
Board Certification and Academic Information
| Academic Departments |
Pediatrics
-Associate Professor (Clinical) |
|---|---|
| Academic Divisions |
Hematology/Oncology
|
| Board Certification |
American Board of Pediatrics (Sub: Pediatric Hematology-Oncology)
American Board of Pediatrics (Pediatrics)
|
Education history
| Undergraduate | Biological and Physical Sciences - Northeast Mississippi Community College | A.A. |
|---|---|---|
| Undergraduate | English - University of Mississippi | B.A. |
| Professional Medical | Medicine - University of Mississippi School of Medicine | M.D. |
| Residency | Pediatrics - University of Utah School of Medicine | Resident |
| Fellowship | Pediatric Hematology/Oncology - St. Jude Children¿s Research Hospital | Fellow |
| Graduate Training | Emphasis: Epidemiology and Global Health - George Washington University | M.P.H. |
| Fellowship | Pediatric Neuro-Oncology - St. Jude Children¿s Research Hospital | Fellow |
Selected Publications
Journal Article
- Mondal G, Lee JC, Ravindranathan A, Villanueva-Meyer JE, Tran QT, Allen SJ, Barreto J, Gupta R, Doo P, Van Ziffle J, Onodera C, Devine P, Grenert JP, Samuel D, Li R, Metrock LK, Jin LW, Antony R, Alashari M, Cheshier S, Whipple NS, Bruggers C, Raffel C, Gupta N, Kline CN, Reddy A, Banerjee A, Hall MD, Mehta MP, Khatib Z, Maher OM, Brathwaite C, Pekmezci M, Phillips JJ, Bollen AW, Tihan T, Lucas JT Jr, Broniscer A, Berger MS, Perry A, Orr BA, Solomon DA (2020). Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition. Acta Neuropathol, 139(6), 1071-1088.
- Whipple NS, Schwartz JR, Nottage KA (2017). DAT-positive Plasmodium ovale malaria presenting in a child with sickle cell anemia. Am J Hematol, 92(7), 722.
- Whipple NS, Marion LL, Dansie DM, Murina AT, Megason GC, Vijayakumar V, Herrington BL (2018). [18F]FDG-PET for evaluating pediatric Rosai-Dorfman disease. Pediatr Hematol Oncol, 35(3), 177-180.
- Whipple NS, Naik RJ, Kang G, Moen J, Govindaswamy SD, Fowler JA, Dowdy J, Penkert R, Joshi VM, Hankins JS (2018). Ventricular global longitudinal strain is altered in children with sickle cell disease. Br J Haematol, 183(5), 796-806.
- Lucas CG, Villanueva-Meyer JE, Whipple N, Oberheim Bush NA, Cooney T, Chang S, McDermott M, Berger M, Cham E, Sun PP, Putnam A, Zhou H, Bollo R, Cheshier S, Poppe MM, Fung KM, Sung S, Glenn C, Fan X, Bannykh S, Hu J, Danielpour M, Li R, Alva E, Johnston J, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA (2020). Myxoid glioneuronal tumor, PDGFRA p.K385-mutant: clinical, radiologic, and histopathologic features. Brain Pathol, 30(3), 479-494.
- McClain KL, Picarsic J, Chakraborty R, Zinn D, Lin H, Abhyankar H, Scull B, Shih A, Lim KPH, Eckstein O, Lubega J, Peters TL, Olea W, Burke T, Ahmed N, Hicks MJ, Tran B, Jones J, Dauser R, Jeng M, Baiocchi R, Schiff D, Goldman S, Heym KM, Wilson H, Carcamo B, Kumar A, Rodriguez-Galindo C, Whipple NS, Campbell P, Murdoch G, Kofler J, Heales S, Malone M, Woltjer R, Quinn JF, Orchard P, Kruer MC, Jaffe R, Manz MG, Lira SA, Parsons DW, Merad M, Man TK, Allen CE (2018). CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions. Cancer, 124(12), 2607-2620.
- Mueller S, Taitt JM, Villanueva-Meyer JE, Bonner ER, Nejo T, Lulla RR, Goldman S, Banerjee A, Chi SN, Whipple NS, Crawford JR, Gauvain K, Nazemi KJ, Watchmaker PB, Almeida ND, Okada K, Salazar AM, Gilbert RD, Nazarian J, Molinaro AM, Butterfield LH, Prados MD, Okada H (2020). Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma. J Clin Invest, 130(12), 6325-6337.
- Whipple N (2011). Remembering Peru: what those who made the journey had to say. J Miss State Med Assoc, 52(9), 289-92.
- Desai AV, Robinson GW, Gauvain K, Basu EM, Macy ME, Maese L, Whipple NS, Sabnis AJ, Foster JH, Shusterman S, Yoon J, Weiss BD, Abdelbaki MS, Armstrong AE, Cash T, Pratilas CA, Corradini N, Marshall LV, Farid-Kapadia M, Chohan S, Devlin C, Meneses-Lorente G, Cardenas A, Hutchinson KE, Bergthold G, Caron H, Maneval EC, Gajjar A, Fox (2022). Entrectinib in children, adolescents, and young adults with solid tumours or primary CNS tumours harbouring NTRK, ROS1 or ALK aberrations: phase 1 and interim phase 2 results from STARTRK-NG. Journal of clinical oncology,
- Parsons MW, Whipple NS, Poppe MM, Mendez JS, Cannon DM, Burt L (2021). The use and efficacy of chemotherapy and radiotherapy in children and adults with pilocytic astrocytoma. Journal of neuro-oncology, 151(2), 93-101.
- Whipple NS, Bennett EE, Kaza E, O'Connor (2016). Umbilical Cord Pseudocyst in a Newborn. The Journal of pediatrics, 177, 333.
- Abdullah R, Shukla M, Whipple N, Gordon C, Majumdar S, Duchan E, Feinberg (2010). Index of suspicion. Pediatrics in review, 31(5), 211-5.
- Ku E, Thomas M, Ho CH, Whipple NS, Abdul-Rahman O, Megason GC, Herrington BL, Carmody JB, Charlton J (2014). Index of suspicion. Case 1: fever, diarrhea, jaundice, and confusion in an 18-year-old male. Case 2: severe anemia in a 6-month-old girl. Case 3: red urine in a 4-month-old boy. Pediatrics in review, 35(3), 129-35.
- Mukkada S, Bhakta N, Chantada GL, Chen Y, Vedaraju Y, Faughnan L, Homsi MR, Muniz-Talavera H, Ranadive R, Metzger M, Friedrich P, Agulnik A, Jeha S, Lam C, Dalvi R, Hessissen L, Moreira DC, Santana VM, Sullivan M, Bouffet E, Caniza MA, Devidas M, Pritchard-Jones K, Rodriguez-Galindo C, Global Registry of COVID-19 in Childhood Cancer (2021). Global characteristics and outcomes of SARS-CoV-2 infection in children and adolescents with cancer (GRCCC): a cohort study. The Lancet. Oncology, 22(10), 1416-1426.
- Whipple NS, Joshi VM, Naik RJ, Mentnech T, McFarland MM, Nolan VG, Hankins J (2021). Sickle cell disease and ventricular myocardial strain: A systematic review. Pediatric blood & cancer, 68(6), e28973.
- Lucas CG, Abdullaev Z, Bruggers CS, Mirchia K, Whipple NS, Alashari MM, Lowichik A, Cheshier S, Phillips JJ, Devine P, Solomon DA, Quezado M, Aldape KD, Perry (2022). Activating NTRK2 and ALK receptor tyrosine kinase fusions extend the molecular spectrum of pleomorphic xanthoastrocytomas of early childhood: a diagnostic overlap with infant-type hemispheric glioma. Acta neuropathologica, 143(2), 283-286.
- Johnston EE, Martinez I, Davis ES, Caudill C, Richman J, Brackett J, Dickens DS, Kahn A, Schwalm C, Sharma A, Patel PA, Bhatia S, Levine JM, Wolfson JA, POCC Consortium (2021). SARS-CoV-2 in Childhood Cancer in 2020: A Disease of Disparities. (Whipple, NS, Member of POCC Consortium). Journal of clinical oncology, 39(34), 3778-3788.
- Desai AV, Robinson GW, Gauvain K, Basu EM, Macy ME, Maese L, Whipple NS, Sabnis AJ, Foster JH, Shusterman S, Yoon J, Weiss BD, Abdelbaki MS, Armstrong AE, Cash T, Pratilas CA, Corradini N, Marshall LV, Farid-Kapadia M, Chohan S, Devlin C, Meneses-Lorente G, Cardenas A, Hutchinson KE, Bergthold G, Caron H, Chow Maneval E, Gajjar A, Fox (2022). Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG). Neuro-oncology, 24(10), 1776-1789.
- Lucas CG, Davidson CJ, Alashari M, Putnam AR, Whipple NS, Bruggers CS, Mendez JS, Cheshier SH, Walker JB, Ramani B, Cadwell CR, Sullivan DV, Lu R, Mirchia K, Van Ziffle J, Devine P, Goldschmidt E, Hervey-Jumper SL, Gupta N, Oberheim Bush NA, Raleigh DR, Bollen A, Tihan T, Pekmezci M, Solomon DA, Phillips JJ, Perry (2022). Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma. Journal of neuropathology and experimental neurology, 81(8), 650-657.
- Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu R, Mirchia K, Sullivan DV, Pekmezci M, Tihan T, Bollen AW, Perry A, Banerjee A, Mueller S, Gupta N, Hervey-Jumper SL, Oberheim Bush NA, Daras M, Taylor JW, Butowski NA, de Groot J, Clarke JL, Raleigh DR, Costello JF, Phillips JJ, Reddy AT, Chang SM, Berger MS, Solomon D (2022). Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1. Acta neuropathologica, 144(4), 747-765.
- Pratt D, Lucas CG, Selvam PP, Abdullaev Z, Ketchum C, Quezado M, Armstrong TS, Gilbert MR, Papanicolau-Sengos A, Raffeld M, Choo-Wosoba H, Chan P, Whipple N, Nasrallah M, Santi M, Ramaswamy V, Giannini C, Ritzmann TA, Grundy RG, Burford A, Jones C, Hawkins C, Venneti S, Solomon DA, Aldape (2022). Recurrent ACVR1 mutations in posterior fossa ependymoma. Acta neuropathologica, 144(2), 373-376.
- Baker C, Crevelt J, Whipple N, Bollo RJ, Cheshier (2022). Treatment of a symptomatic thalamic pilocytic astrocytoma with reservoir placement and laser interstitial thermal therapy: illustrative case. Journal of neurosurgery. Case lessons, 3(11),
- Gajjar A, Mahajan A, Abdelbaki M, Anderson C, Antony R, Bale T, Bindra R, Bowers DC, Cohen K, Cole B, Dorris K, Ermoian R, Franson A, Helgager J, Landi D, Lin C, Metrock L, Nanda R, Palmer J, Partap S, Plant A, Pruthi S, Reynolds R, Ruggieri P, Stearns D, Storm P, Wang A, Warren K, Whipple N, Zaky W, McMillian NR, Pluchino L (2022). Pediatric Central Nervous System Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network, 20(12), 1339-1362.
- Mueller S, Taitt JM, Villanueva-Meyer JE, Bonner ER, Nejo T, Lulla RR, Goldman S, Banerjee A, Chi SN, Whipple NS, Crawford JR, Gauvain K, Nazemi KJ, Watchmaker PB, Almeida ND, Okada K, Salazar AM, Gilbert RD, Nazarian J, Molinaro AM, Butterfield LH, Prados MD, Okada (2022). Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma. The Journal of clinical investigation, 132(12),
- Kilburn LB, Khuong-Quang DA, Hansford JR, Landi D, van der Lugt J, Leary SES, Driever PH, Bailey S, Perreault S, McCowage G, Waanders AJ, Ziegler DS, Witt O, Baxter PA, Kang HJ, Hassall TE, Han JW, Hargrave D, Franson AT, Yalon Oren M, Toledano H, Larouche V, Kline C, Abdelbaki MS, Jabado N, Gottardo NG, Gerber NU, Whipple NS, Segal D, Chi SN, Oren L, Tan EEK, Mueller S, Cornelio I, McLeod L, Zhao X, Walter A, Da Costa D, Manley P, Blackman SC, Packer RJ, Nysom (2023). The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial. Nature medicine,
- Martin SD, Davis ES, Dai C, Boal LH, Araya B, Brackett J, Dickens D, Kahn A, Martinez I, Sharma A, Schwalm C, Aguayo-Hiraldo P, Bhatia S, Levine JM, Johnston EE, Wolfson JA, Pediatric Oncology COVID-19 Case Consortiu (2023). Clinical Features and Risk Factors Associated With Multisystem Inflammatory Syndrome in Children With Cancer and COVID-19. (Whipple, NS, Member of POCC Consortium) . JAMA oncology, 9(8), 1108-1112.
- Moreira DC, Qaddoumi I, Chen Y, Bhakta N, Chantada GL, Santana VM, Caniza MA, Devidas M, Pritchard-Jones K, Rodriguez-Galindo C, Bouffet E, Mukkada S, Global Registry of COVID-19 in Childhood Cance (2023). Outcomes of SARS-CoV-2 infection in 126 children and adolescents with central nervous system tumors. Pediatric blood & cancer, 70(8), e30402.
- Chan PP, Whipple NS, Ramani B, Solomon DA, Zhou H, Linscott LL, Kestle JRW, Bruggers C (2023). Patterns of Extraneural Metastases in Children With Ependymoma. Journal of pediatric hematology/oncology, 45(2), e272-e278.
- Kahn AR, Davis ES, Dai C, Caudill CV, Martinez I, Brackett J, Sharma A, Schwalm C, Kebede A, Dickens DS, Richman J, Colace S, POCC Consortium, Araya B, Bhatia S, Wolfson JA, Levine JM, Johnston E (2024). COVID-19 Disease in Children With ALL Receiving Maintenance Therapy: Do Not Discount the Risk. (Whipple, NS, Member of POCC Consortium). JCO oncology practice, OP2300631.
- Foxworthy B, Dai C, Davis EC, Xavier AC, Brackett J, Dickens D, Kahn A, Martinez I, Sharma A, Schwalm C, Foley J, Wilkes J, POCC Consortium, Bhatia S, Levine JM, Johnston EE, Wolfson J (2024). COVID-19 infection in children, adolescents, and young adults with Down syndrome and hematologic malignancies. (Whipple, NS, Member of POCC Consortium) . Pediatric blood & cancer, 71(8), e31082.
- Wolfson JA, Davis ES, Saha A, Martinez I, McCall D, Kothari P, Brackett J, Dickens DS, Kahn AR, Schwalm C, Sharma A, Richman J, Cuglievan B, POCC Consortium, Bhatia S, Dai C, Levine JM, Johnston E (2024). Adolescents and young adults with cancer: the clinical course of COVID-19 infections. (Whipple, NS, Member of POCC Consortium). Journal of the National Cancer Institute, 116(8), 1366-1373.
- Nysom K, Kilburn LB, Leary SES, Landi DB, de Vos-Kerkhof E, Perreault S, Witt O, Ziegler DS, Hernáiz Driever P, Franson AT, Baxter PA, Whipple NS, Kline C, Segal D, Jabado N, Bailey S, McCowage G, Hansford JR, Khuong-Quang DA, Gottardo NG, Hassall T, Han JW, Yalon Oren M, Chi SN, Qiu J, Da Costa D, Govinda Raju S, Manley P, Hargrave (2024). Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial. Neuro-oncology,
- Yu B, Kline C, Hoare O, Jung J, Knowles T, Ranavaya A, Minturn J, Banerjee A, Leary S, Crotty E, Abdelbaki M, Whipple N, Goldman S, Margol A, Bhatia A, Dababo N, George E, Nabavizadeh A, Pampaloni MH, Inagaki A, Collins S, Chuntova P, Barcova M, Patel TS, Phillips J, Prados M, Molinaro A, Gupta N, Raffel C, Cole K, Kasahara N, Diaz AA, Mueller (2025). Measles Oncolytic Virus as an Immunotherapy for Recurrent/Refractory Pediatric Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor: Results from PNOC005. Clinical cancer research, 31(16), 3463-3475.
- Gajjar A, Mahajan A, Bale T, Bowers DC, Canan L, Chi S, Cluster A, Cohen K, Cole B, Coven S, Darlington W, Dorris K, Elster J, Ermoian R, Franson A, George E, Helgager J, Landi D, Lin C, Metrock L, Nanda R, Palmer J, Partap S, Plant A, Pruthi S, Reynolds R, Stearns D, Storm P, Wang A, Wang LD, Whipple N, Zaky W, McMillian N, Ramakrishnan (2025). Pediatric Central Nervous System Cancers, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology. Journal of the National Comprehensive Cancer Network, 23(3), 113-130.
Book Chapter
- Whipple NS, Gajjar A (2019). Chapter 33: Targeted Therapies for Pediatric Central Nervous System Tumors. In: Predictive Biomarkers in Oncology: Applications in Precision Medicine. Sunil Badve and George Kumar, editors. Springer International Publishing (2019). 375-382. doi:10.1007/978-3-319-95228-4.
Case Report
- Whipple NS, Whipple PD, Nelson CR, Bollo RJ (2011). Puzzler: Three-year-old with upper extremity hemiparesis. Contemp Pediatr, 28(9), 75-84.
- Whipple NS, Moreau DA, Moulds JM, Hankins JS, Wang WC, Nottage K (2015). Paroxysmal cold hemoglobinuria due to an IgA Donath-Landsteiner antibody. Pediatric blood & cancer, 62(11), 2044-6.
- Baker C, Crevelt J, Whipple NS, Bollo R, Cheshier (2022). Treatment of a symptomatic thalamic pilocytic astrocytoma with reservoir placement and laser interstitial thermal therapy. Journal of neurosurgery. Pediatrics,
Newspaper
- Whipple (2005). NICHOLAS WHIPPLE: Community college route was the right choice.
Other
- Kilburn LB, Khuong-Quang DA, Hansford JR, Landi D, van der Lugt J, Leary SES, Driever PH, Bailey S, Perreault S, McCowage G, Waanders AJ, Ziegler DS, Witt O, Baxter PA, Kang HJ, Hassall TE, Han JW, Hargrave D, Franson AT, Yalon Oren M, Toledano H, Larouche V, Kline C, Abdelbaki MS, Jabado N, Gottardo NG, Gerber NU, Whipple NS, Segal D, Chi SN, Oren L, Tan EEK, Mueller S, Cornelio I, McLeod L, Zhao X, Walter A, Da Costa D, Manley P, Blackman SC, Packer RJ, Nysom (2024). Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial. Nature medicine, 30(5), 1500.
- Kilburn LB, Khuong-Quang DA, Hansford JR, Landi D, van der Lugt J, Leary SES, Driever PH, Bailey S, Perreault S, McCowage G, Waanders AJ, Ziegler DS, Witt O, Baxter PA, Kang HJ, Hassall TE, Han JW, Hargrave D, Franson AT, Yalon Oren M, Toledano H, Larouche V, Kline C, Abdelbaki MS, Jabado N, Gottardo NG, Gerber NU, Whipple NS, Segal D, Chi SN, Oren L, Tan EEK, Mueller S, Cornelio I, McLeod L, Zhao X, Walter A, Da Costa D, Manley P, Blackman SC, Packer RJ, Nysom (2025). Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial. Nature medicine, 31(7), 2454.
Video/Film/CD/Web/Podcast
- Whipple N (2021). A Career in Pediatric Hematology-Oncology. Video recorded for University of Utah medical students to view for career planning and decision making. .
- Whipple NS, Wirkus (2021). Pediatric Central Nervous System Tumors. The Virtual Curbside Podcast. Utah Chapter of the American Academy of Pediatrics.
- Whipple NS, Wirkus (2021). Cancer Therapies in a Nutshell. The Virtual Curbside Podcast. Utah Chapter of the American Academy of Pediatrics.
- Nicholas S. Whipple, Priya P. Chan, Samuel H. Cheshie (2025). Inside the Clinic: Advances in the Management of Pediatric Low-Grade Glioma. A Focus on Biomarker-Driven Treatment Strategies.
- Nicholas S. Whippl (2025). Case Presentation: BRAF-Mutated Pilocytic Astrocytoma.
- Nicholas S. Whippl (2025). REACHMD: Clinical Stability Post-Tovorafenib in Pediatric Low-Grade Glioma: FIREFLY1 Results.