Nirupama Ramkumar

Nirupama Ramkumar, MD, MPH

Languages spoken: Hindi, English, Tamil

Clinical Locations

University of Utah Hospital

Kidney and Liver Clinic
801-581-2772

  • Dr.Ramkumar is an Assistant Professor at the University of Utah School of Medicine. She received her medical degree from Bangalore University, India and obtained her Master's degree in Public Health from the University of Utah. She completed her residency training in Internal Medicine at UCSF-Fresno and Nephrology fellowship training at University of Utah. Her clinical interests include hypertension, polycystic kidney disease and glomerulonephritis. She oversees Nephrology fellows in training in the outpatient and inpatient settings.

    Specialties

  • Dr.Ramkumar is an Assistant Professor at the University of Utah School of Medicine. She received her medical degree from Bangalore University, India and obtained her Master's degree in Public Health from the University of Utah. She completed her residency training in Internal Medicine at UCSF-Fresno and Nephrology fellowship training at University of Utah. Her clinical interests include hypertension, polycystic kidney disease and glomerulonephritis. She oversees Nephrology fellows in training in the outpatient and inpatient settings.

    Board Certification and Academic Information

    Academic Departments Internal Medicine -Primary
    Academic Divisions Nephrology

    Education history

    Fellowship Nephrology - University of Utah Fellow
    Internal Medicine - UCSF-Fresno Resident
    Internship Family Medicine - UCSF-Fresno Intern
    Public Health - University of Utah M.P.H.
    Professional Medical Medicine - Bangalore University M.B.B.S.

    Selected Publications

    Journal Article

    1. Ramkumar N, Stuart D, Peterson CS, Hu C, Wheatley W, Min Cho J, Symons JD, Kohan DE (2021). Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury. Circ Res, 129(1), 50-62.
    2. Nicholson RJ, Ramkumar N, Summers SA (2021). Gain of 'FAOnction', Loss of Fibrosis. Trends Endocrinol Metab, 32(6), 333-334.
    3. Al-Rabadi LF, Caza T, Trivin-Avillach C, Rodan AR, Andeen N, Hayashi N, Williams B, Revelo MP, Clayton F, Abraham J, Lin E, Liou W, Zou CJ, Ramkumar N, Cummins T, Wilkey DW, Kawalit I, Herzog C, Storey A, Edmondson R, Sjoberg R, Yang T, Chien J, Merchant M, Arthur J, Klein J, Larsen C, Beck LH Jr (2021). Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy. J Am Soc Nephrol, 32, 1666-1681.
    4. Cho ME, Sweeney C, Fino N, Greene T, Ramkumar N, Huang Y, Ricardo AC, Shafi T, Deo R, Anderson A, Mills KT, Cheung AK, CRIC Study Investigators (2021). Longitudinal Changes in Prorenin and Renin in the Chronic Renal Insufficiency Cohort. Am J Nephrol, 52(2), 141-151.
    5. Lazaro-Guevara J, Fierro-Morales J, Wright AH, Gunville R, Simeone C, Frodsham SG, Pezzolesi MH, Zaffino CA, Al-Rabadi L, Ramkumar N, Pezzolesi MG (2021). Targeted Next-Generation Sequencing Identifies Pathogenic Variants in Diabetic Kidney Disease. Am J Nephrol, 52(3), 239-249.
    6. Lakshmipathi J, Gao Y, Hu C, Stuart D, Genzen J, Ramkumar N, Kohan DE (2020). Nephron-Specific Disruption of Polycystin-1 Induces Cyclooxygenase-2-Mediated Blood Pressure Reduction Independent of Cystogenesis. J Am Soc Nephrol, 31(6), 1243-1254.
    7. Nelson MD, Ramkumar N, Gale BK (2019). Flexible, transparent, sub-100 um microfluidic channels with FDM 3D-printed thermoplastic polyurethane . J Micromech Microeng, 29(095010).
    8. Wang F, Xu C, Luo R, Peng K, Ramkumar N, Xie S, Lu X, Zhao L, Zuo CJ, Kohan DE, Yang T (2019). Site-1 protease-derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability. JCI Insight, 4(7).
    9. Ramkumar N, Stuart D, Mironova E, Abraham N, Gao Y, Wang S, Lakshmipathi J, Stockand JD, Kohan DE (2018). Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion. Am J Physiol Renal Physiol, 315(3), F607-F617.
    10. Quadri SS, Culver S, Ramkumar N, Kohan DE, Siragy HM (2018). (Pro)Renin receptor mediates obesity-induced antinatriuresis and elevated blood pressure via upregulation of the renal epithelial sodium channel. PLoS One, 13(8), e0202419.
    11. Ramkumar N, Stuart D, Abraham N, Kohan DE (2018). Nephron prorenin receptor deficiency alters renal medullary endothelin-1 and endothelin receptor expression. Physiol Res, 67(Suppl 1), S127-S136.
    12. Ramkumar N, Stuart D, Yang T, Kohan DE (2016). Aldosterone does not alter endothelin B receptor signaling in the inner medullary collecting duct. Physiol Rep, 5(5).
    13. Ramkumar N, Gao Y, Kohan DE (2017). Characterization of flow-regulated cortical collecting duct endothelin-1 production. Physiol Rep, 5(4).
    14. Song K, Stuart D, Abraham N, Wang F, Wang S, Yang T, Sigmund CD, Kohan DE, Ramkumar N (2016). Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury. PLoS One, 11(7), e0159872.
    15. Ramkumar N, Stuart D, Mironova E, Bugay V, Wang S, Abraham N, Ichihara A, Stockand JD, Kohan DE (2016). Renal tubular epithelial cell prorenin receptor regulates blood pressure and sodium transport. Am J Physiol Renal Physiol, 311(1), F186-94.
    16. Ramkumar N, Stuart D, Calquin M, Wang S, Niimura F, Matsusaka T, Kohan DE (2016). Possible role for nephron-derived angiotensinogen in angiotensin-II dependent hypertension. Physiol Rep, 4(1).
    17. Ramkumar N, Stuart D, Calquin M, Wang S, Niimura F, Matsusaka T, Kohan DE (2016). Possible role for nephron-derived angiotensinogen in angiotensin-II dependent hypertension . Physiol Rep, 4(1), e12675.
    18. Ramkumar N, Stuart D, Calquin M, Quadri S, Wang S, Van Hoek AN, Siragy HM, Ichihara A, Kohan DE (2015). Nephron-specific deletion of the prorenin receptor causes a urine concentration defect. Am J Physiol Renal Physiol, 309(1), F48-56.
    19. Ramkumar N, Stuart D, Rees S, Hoek AV, Sigmund CD, Kohan DE (2014). Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension. Am J Physiol Renal Physiol, 307(8), F931-8.
    20. Ramkumar N, Ying J, Stuart D, Kohan DE (2013). Overexpression of Renin in the collecting duct causes elevated blood pressure. Am J Hypertens, 26(8), 965-72.
    21. Ramkumar N, Kohan DE (2013). Role of collecting duct renin in blood pressure regulation. Am J Physiol Regul Integr Comp Physiol, 305(2), R92-4.
    22. Ramkumar N, Stuart D, Ying J, Kohan DE (2013). A possible interaction between systemic and renal angiotensinogen in the control of blood pressure. Am J Hypertens, 26(4), 473-80.
    23. Roos KP, Bugaj V, Mironova E, Stockand JD, Ramkumar N, Rees S, Kohan DE (2013). Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity. J Am Soc Nephrol, 24(2), 218-27.
    24. Ying J, Stuart D, Hillas E, Gociman BR, Ramkumar N, Lalouel JM, Kohan DE (2012). Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice. Am J Hypertens, 25(6), 684-9.
    25. Hawkes CH, Ramkumar N, Baker R, Lyon JL (2007). Multiple sclerosis in Latter Day Saints (Mormons). Acta Neurol Scand, 115(4), 260-4.
    26. Ramkumar N, Murtaugh MA, Cheung AK, Beddhu S (2007). Lack of synergistic effects of metabolic syndrome and plasma fibrinogen on coronary events and mortality in moderate CKD. Am J Kidney Dis, 49(3), 356-64.
    27. Beddhu S, Ramkumar N, Pappas LM (2005). Normalization of protein intake by body weight and the associations of protein intake with nutritional status and survival. J Ren Nutr, 15(4), 387-97.
    28. Beddhu S, Kimmel PL, Ramkumar N, Cheung AK (2005). Associations of metabolic syndrome with inflammation in CKD: results From the Third National Health and Nutrition Examination Survey (NHANES III). Am J Kidney Dis, 46(4), 577-86.
    29. Ramkumar N, Pappas LM, Beddhu S (2005). Effect of body size and body composition on survival in peritoneal dialysis patients. Perit Dial Int, 25(5), 461-9.
    30. Ramkumar N, Beddhu S, Eggers P, Pappas LM, Cheung AK (2005). Patient preferences for in-center intense hemodialysis. Hemodial Int, 9(3), 281-95.
    31. Morris D, Samore MH, Pappas LM, Ramkumar N, Beddhu S (2005). Nutrition and racial differences in cardiovascular events and survival in elderly dialysis patients. Am J Med, 118(6), 671-5.
    32. Logar CM, Pappas LM, Ramkumar N, Beddhu S (2005). Surgical revascularization versus amputation for peripheral vascular disease in dialysis patients: a cohort study. BMC Nephrol, 6, 3.
    33. Ramkumar N, Cheung AK, Pappas LM, Roberts WL, Beddhu S (2004). Association of obesity with inflammation in chronic kidney disease: a cross-sectional study. J Ren Nutr, 14(4), 201-7.
    34. Beddhu S, Pappas LM, Ramkumar N, Samore MH (2004). Malnutrition and atherosclerosis in dialysis patients. J Am Soc Nephrol, 15(3), 733-42.
    35. Beddhu S, Pappas LM, Ramkumar N, Samore M (2003). Effects of body size and body composition on survival in hemodialysis patients. J Am Soc Nephrol, 14(9), 2366-72.
    36. Beddhu S, Samore MH, Roberts MS, Stoddard GJ, Ramkumar N, Pappas LM, Cheung AK (2003). Impact of timing of initiation of dialysis on mortality. J Am Soc Nephrol, 14(9), 2305-12.

    Review

    1. Ramkumar N, Kohan DE (2019). The (pro)renin receptor: emerging player in hypertension and metabolic syndrome . [Review]. Kidney Int, 95(5), 1041-1052.
    2. Ramkumar N, Kohan DE (2016). The nephron (pro)renin receptor: function and significance. [Review]. Am J Physiol Renal Physiol, 311(6), F1145-1148.
    3. Ramkumar N, Kohan DE (2016). Role of the collecting duct renin angiotensin system in regulation of blood pressure and renal function. [Review]. Curr Hypertens Rep, 18(4), 29.
    4. Ramkumar N, Kohan DE (2013). Proximal tubule angiotensinogen modulation of arterial pressure . [Review]. Curr Opin Nephrol Hypertens, 22(1), 32-36.

    Editorial

    1. Ramkumar N (2018). Return of the prorenin receptor: a novel role in macula dense signaling . 315(4), F913-914.

    Letter

    1. Beddhu S, Ramkumar N, Samore MH (2005). The paradox of the "body mass index paradox" in dialysis patients: associations of adiposity with inflammation. [Letter to the editor]. Am J Clin Nutr, 82(4), 909-10; author reply 910-11.
    2. Beddhu S, Pappas LM, Ramkumar N, Samore MH (2005). Body mass index and survival in incident dialysis patients: the answer depends on the question. [Letter to the editor]. Am J Clin Nutr, 81(2), 534-6; author reply 536.

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