Rachna Malani, MD

Journal Article

1. Ferraro E, Singh J, Patil S, Razavi P, Modi S, Chandarlapaty S, Barrio AV, Malani R, Mellinghoff IK, Boire A, Wen HY, Brogi E, Seidman AD, Norton L, Robson ME, Dang CT (2022). Incidence of brain metastases in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy with trastuzumab and pertuzumab. NPJ Breast Cancer, 8(1), 37.
2. Ho KG, Bale T, Grommes C, Bhatia A, Malani R (2021). Use of circulating tumor DNA to guide treatment of primary central nervous system lymphoma: a case report. Neurooncol Adv, 3(1), vdab143.
3. Wijetunga NA, Boire A, Young RJ, Yamada Y, Wolden S, Yu H, Kris M, Seidman A, Betof-Warner A, Diaz M, Reiner A, Malani R, Pentsova E, Yang JT (2021). Quantitative cerebrospinal fluid circulating tumor cells are a potential biomarker of response for proton craniospinal irradiation for leptomeningeal metastasis. Neurooncol Adv, 3(1), vdab181.
4. Malani R, Fleisher M, Kumthekar P, Lin X, Omuro A, Groves MD, Lin NU, Melisko M, Lassman AB, Jeyapalan S, Seidman A, Skakodub A, Boire A, DeAngelis LM, Rosenblum M, Raizer J, Pentsova E (2020). Cerebrospinal fluid circulating tumor cells as a quantifiable measurement of leptomeningeal metastases in patients with HER2 positive cancer. J Neurooncol, 148(3), 599-606.
5. Gusdon AM, Cho SM, Mayasi Y, Malani R, Püttgen HA, Duffield A, Bolaños-Meade J, Lim M (2020). Chronic Lymphocytic Leukemia Resulting in Hemorrhagic Brain Masses After Sepsis. Neurohospitalist, 10(1), 64-68.
6. Gusdon AM, Nyquist PA, Torres-Lopez VM, Leasure AC, Falcone GJ, Sheth KN, Sansing LH, Hanley DF, Malani R (2020). Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy. Stroke, 51(1), 129-136.
7. Bhatia A, Birger M, Veeraraghavan H, Um H, Tixier F, McKenney AS, Cugliari M, Caviasco A, Bialczak A, Malani R, Flynn J, Zhang Z, Yang TJ, Santomasso BD, Shoushtari AN, Young RJ (2019). MRI radiomic features are associated with survival in melanoma brain metastases treated with immune checkpoint inhibitors. Neuro Oncol, 21(12), 1578-1586.
8. Sener U, Matin N, Yu H, Lin A, Yang TJ, Malani R (2019). Radiographic appearance of leptomeningeal disease in patients with EGFR-mutated non-small-cell lung carcinoma treated with tyrosine kinase inhibitors: a case series. CNS Oncol, 8(4), CNS42.
9. Malani R, Bhatia A, Wolfe J, Grommes C (2019). Staging identifies non-CNS malignancies in a large cohort with newly diagnosed lymphomatous brain lesions. Leuk Lymphoma, 60(9), 2278-2282.
10. Gusdon AM, Malani R, Chen X (2019). Clinical and EEG Characteristics of Ifosfamide-Related Encephalopathy. J Clin Neurophysiol, 36(2), 150-154.
11. Malani R, Bhatia A, Warner AB, Yang JT (2023). Leptomeningeal Carcinomatosis from Solid Tumor Malignancies: Treatment Strategies and Biomarkers. Seminars in Neurology, 43(6), 859-866.
12. Bhatia A, Moreno R, Reiner AS, Nandakumar S, Walch HS, Thomas TM, Nicklin PJ, Choi Y, Skakodub A, Malani R, Prabhakaran V, Tiwari P, Diaz M, Panageas KS, Mellinghoff IK, Bale TA, Young RJ (2023). Tumor Volume Growth Rates and Doubling Times during Active Surveillance of IDH-mutant Low-Grade Glioma.(Epub ahead of print). Clin Cancer Res.
13. Huang Y, Moreno R, Malani R, Meng A, Swinburne N, Holodny AI, Choi Y, Rusinek H, Golomb JB, George A, Parra LC, Young RJ (2022). Deep Learning Achieves Neuroradiologist-Level Performance in Detecting Hydrocephalus Requiring Treatment. J Digit Imaging, 35(6), 1662-1672.
14. Yang JT, Wijetunga NA, Pentsova E, Wolden S, Young RJ, Correa D, Zhang Z, Zheng J, Steckler A, Bucwinska W, Bernstein A, Betof Warner A, Yu H, Kris MG, Seidman AD, Wilcox JA, Malani R, Lin A, DeAngelis LM, Lee NY, Powell SN, Boire A (2022). Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis. J Clin Oncol, 40(33), 3858-3867.
15. Bhatia A, Moreno R, Reiner AS, Nandakumar S, Walch HS, Malani R, Panageas KS, Mellinghoff IK, Bale TA, Young RJ (2024). Tumor Volume Growth as Surrogate Endpoint in IDH-mt Glioma-Response. Clin Cancer Res, 30(3), 639.
16. Puri S, Malani R, Chalmers A, Kerrigan K, Patel SB, Monynahan K, Cannon L, Blouw B, Akerley W (2023). Keeping a track on leptomeningeal disease in non-small cell lung cancer: A single-institution experience with CNSide(TM). Neurooncol Adv, 6(1), vdad150.
17. Valerius AR, Webb MJ, Hammad N, Sener U, Malani R (2024). Cerebrospinal Fluid Liquid Biopsies in the Evaluation of Adult Gliomas. Curr Oncol Rep, 26(4), 377-390.
18. Bian DJH, Lazaratos AM, Maritan SM, Quaiattini A, Zeng Z, Zhu Z, Sener U, Malani R, Kim YJ, Ichihara E, Cohen V, Rose AAN, Bouganim N, Dankner M (2024). Osimertinib is associated with improved outcomes in pre-treated non-small cell lung cancer leptomeningeal metastases: A systematic review and meta-analysis. Heliyon, 10(9), e29668.
19. Schaff LR, Piotrowski AF, Pentsova E, Gavrilovic IT, Lin A, Kaley TJ, Wongchai V, Emadi-Paramkouhi L, Madzsar J, Quinn L, Gonzalez A, Breakey L, Tang SS, Mendez JS, Malani R, Nolan C, Hatzoglou V, Young RJ, DeAngelis LM, Reiner AS, Panageas KS, Francis JH, Mellinghoff IK, Grommes (2025). Phase Ib study with expansion of ibrutinib, lenalidomide and rituximab in patients with relapsed/refractory CNS lymphoma. Neuro-oncology,
20. Hongsermeier-Graves N, Hasen M, Yaffe N, Ajisebutu A, Malani (2025). Liquid biopsy in early detection and monitoring of CNS metastases. Advances in cancer research, 165, 255-290.
21. Sharma A, Boyce Kennedy L, Van Swearingen AED, Ahluwalia MS, Bagley SJ, Chiang VL, Chung C, Cittelly DM, Daras M, Davies MA, Fecci PE, Haas-Kogan DA, Hattangadi-Gluth JA, Jerzak KJ, Kim MM, Malani R, Mehta MP, Moss NS, Neman J, Nguyen DX, Priceman SJ, Sahebjam S, Shih HA, Soffietti R, Wang N, Zimmer A, Goldberg S, Khasraw M, Anders CK, Lin N (2025). SNO/ASCO Brain Metastasis Collaborative Think Tanks, Intracranial metastases from solid tumors: Call to Action and Consensus from the Society for Neuro-Oncology and American Society of Clinical Oncology Collaborative. Neuro-Oncology, noaf226,
22. Schaff LR, Piotrowski AF, Pentsova E, Gavrilovic IT, Lin A, Kaley TJ, Wongchai V, Emadi-Paramkouhi L, Madzsar J, Quinn L, Gonzalez A, Breakey L, Tang SS, Mendez JS, Malani R, Nolan C, Hatzoglou V, Young RJ, DeAngelis LM, Reiner AS, Panageas KS, Francis JH, Mellinghoff IK, Grommes (2025). Phase Ib study with expansion of ibrutinib, lenalidomide, and rituximab in patients with relapsed/refractory central nervous system lymphoma. Neuro-Oncology, 27(8), 2107-2116.
23. Sharma A, Boyce Kennedy L, Van Swearingen AED, Ahluwalia MS, Bagley SJ, Chiang VL, Chung C, Cittelly DM, Daras M, Davies MA, Fecci PE, Haas-Kogan DA, Hattangadi-Gluth JA, Jerzak KJ, Kim MM, Malani R, Mehta MP, Moss NS, Neman J, Nguyen DX, Priceman SJ, Sahebjam S, Shih HA, Soffietti R, Wang N, Zimmer A, Goldberg S, Khasraw M, Anders CK, Lin NU, SNO/ASCO Brain Metastasis Collaborative Think Tank (2026). Intracranial metastases from solid tumors: Call to Action and Consensus from the Society for Neuro-Oncology and American Society of Clinical Oncology Collaborative. Neuro-oncology, 28(2), 319-333.

Review

1. Kaplan A, Li MJ, Malani R (2022). Treatments on the Horizon: Breast Cancer Patients with Central Nervous System Metastases. [Review]. Curr Oncol Rep, 24, (3), 343-350.
2. Dominguez M, Malani R (2021). Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome: A Comprehensive Review. [Review]. Curr Pain Headache Rep, 25, (5), 33.
3. Warstadt MB, Richards TJ, Shah LM, Kohler ME, Mendez JS, Malani R, Salzman K (2025). Glioneuronal and Neuronal Tumors in Adults: WHO 2021 Imaging and Molecular Updates. AJNR. American journal of neuroradiology,

Book Chapter

1. Malani R, Schaff L (2018). Paraneoplastic Syndromes. In Drilon A, Postow M, Vasan N, Carlo MI (Eds.), Pocket Oncology (2nd edition). Wolters Kluwer.
2. Diwas G, Malani R (2023). Introduction to FDA Processes: Biologic Agents. Translational Neurosurgery.
3. Hansen A, Malani R (2023). Introduction to the FDA. Translational Neurosurgery.
4. Hongsermeier-Graves N, Hasen M, Yaffe N, Ajisebutu A, Malani (2025). Liquid biopsy in early detection and monitoring of CNS metastases. 165, 255-290.

Editorial

1. Malani R (2020). A view on the landscape of breast cancer brain metastases. CNS Oncol, 9(3), CNS59.

Abstract

1. Kelly F, Malani R (2024). MMOD-11 Radiation necrosis after concomitant EGFR-TKI and radiation: a case series and consideration for future patients [Abstract]. Neuro-Oncology Advances, 6(Supplement_1), i17-i18.
2. Imber B, Ravichandran V, Rao P, Casanova H, Friend J, Simpson J, Pike L, Zinovoy M, Mitchell R, Chacko C, Kotecha R, Somai S, Boire A, Gavrilovic I, Piotrowski A, Wilcox J, Malani R, Young R, Offin M, Diamond E, Yang J (2023). CTNI-07. Phase I study of paxalisib and radiotherapy for CNS disease harboring PI3K pathway mutations: pilot analysis of circulating tumor DNA for patient eligibility confirmation and post-treatment response [Abstract]. Neuro-Oncology, 25(Supplement_5), v74.
3. Kropp S, Tenoheve S, Mendez J, Malani R, Zhao Y, Chen A (2024). The impact of distance in treating glioblastoma: a retrospective single center study [Abstract]. Neuro-Oncology.
4. Huang J, Boockvar J, Batiste J, Jaboin J, Halasz L, Ahluwalia M, Rammohan N, Ney D, Malani R, Chinnaiyan P, Mehta M, Marcus S (2024). Phase II study of azeliragon in combination with radiation therapy in newly diagnosed patients with MGMT-unmethylated glioblastoma [Abstract]. Neuro-Oncology.
5. Malani R, Zhang Y, Dean C, Boatz L, Harrison B, Wei M, Akerley W, Bronner MP, Underhill HR (2024). Low-Pass Whole Genome Sequencing of Cerebrospinal Fluid Identifies Tumor Agnostic TP53 Aberrations in Leptomeningeal Metastatic Disease [Abstract]. Neuro-Oncology.
6. Zhang Y, Malani R, Dean C, Boatz LA, Harrison BE, Wei M, Akerley W, Bronner MP, Underhill HR (2024). Molecular Profiling of Serially Collected Cerebrospinal Fluid Uncovers Therapy-Resistant Subclones in Recurrent Leptomeningeal Metastatic Disease [Abstract]. American Association for Cancer Research (AACR).
7. Schaff LR, Piotrowski AF, Pentsova E, Gavrilovic IT, Lin A, Kaley TJ, Wongchai V, Emadi-Paramkouhi L, Madzsar J, Quinn L, Gonzalez A, Breakey L, Tang SS, Mendez JS, Malani R, Nolan C, Hatzoglou V, Young RJ, DeAngelis LM, Reiner AS, Panageas KS, Francis JH, Mellinghoff IK, Grommes (2025). Phase Ib study with expansion of ibrutinib, lenalidomide and rituximab in patients with relapsed/refractory CNS lymphoma. noaf104,
8. Ngo R, Urias E, Nelson N, Hammond J, Malani M, Cannon D, DeCesaris (2025). Proton vs VMAT-based craniospinal irradiation for leptomeningeal carcinomatosis: an institutional dosimetric and hematologic toxicity analysis.
9. Ngo R, DeCesaris C, Malani R, Hammond J, Nelson (2025). Hematologic toxicities in adult patients with solid tumor leptomeningeal disease treated with proton- versus volumetric modulated arc therapy-based craniospinal irradiation. 48,

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