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Shelley M. Lawrence
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Shelley M. Lawrence, MD

Languages spoken: English

Clinical Locations

Primary Location

Primary Children's Hospital

100 N Mario Capecchi Drive
Salt Lake City , UT 84113

Dr. Lawrence received her medical degree from the University of Oklahoma College of Medicine and completed her Pediatric residency and Neonatal-Perinatal Medicine Fellowship at the Oklahoma Children’s Hospital. Following fellowship, she spent the first six years of her professional career in a high acuity, tertiary referral, and private practice facility. Upon returning to academics in 2010, she received a Master of Science degree in Clinical and Translational Sciences (2013). She is board-certified in Pediatrics and Neonatal-Perinatal Medicine.

She is currently an Associate Professor of Pediatrics at the University of Utah and is in the Division of Neonatal-Perinatal Medicine at Primary Children’s Medical Center. Her clinical interests include neonatal sepsis, antibiotic stewardship, and the epidemiology of congenital cytomegalovirus, neonatal herpesvirus, and congenital syphilis infections. She is also working towards universal newborn screening for congenital cytomegalovirus infection to enable rapid identification and intervention services to children at risk for sensorineural hearing loss.

Her research interests lie in understanding the fundamental mechanisms of bacterial pathogenesis and the neonatal innate immune system, with particular focus on neonatal neutrophil function. She is also skilled at designing and successfully completing large clinical studies, with primary goals of translating innovative diagnostics and therapeutics from the bench to bedside. She has active NIH-funded research in the validation of new technology by MelioLabs in the rapid and low-cost detection and identification of pathogens (bacterial, fungal, and viral) in a single, low volume patient sample. She is also nationally funded in the investigation of host cell-membrane wrapped nanoparticles, engineered by Cellics Therapeutics, as a novel adjunctive therapeutic for neonatal sepsis.

Specialties

Board Certification

American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine)

Dr. Lawrence received her medical degree from the University of Oklahoma College of Medicine and completed her Pediatric residency and Neonatal-Perinatal Medicine Fellowship at the Oklahoma Children’s Hospital. Following fellowship, she spent the first six years of her professional career in a high acuity, tertiary referral, and private practice facility. Upon returning to academics in 2010, she received a Master of Science degree in Clinical and Translational Sciences (2013). She is board-certified in Pediatrics and Neonatal-Perinatal Medicine.

She is currently an Associate Professor of Pediatrics at the University of Utah and is in the Division of Neonatal-Perinatal Medicine at Primary Children’s Medical Center. Her clinical interests include neonatal sepsis, antibiotic stewardship, and the epidemiology of congenital cytomegalovirus, neonatal herpesvirus, and congenital syphilis infections. She is also working towards universal newborn screening for congenital cytomegalovirus infection to enable rapid identification and intervention services to children at risk for sensorineural hearing loss.

Her research interests lie in understanding the fundamental mechanisms of bacterial pathogenesis and the neonatal innate immune system, with particular focus on neonatal neutrophil function. She is also skilled at designing and successfully completing large clinical studies, with primary goals of translating innovative diagnostics and therapeutics from the bench to bedside. She has active NIH-funded research in the validation of new technology by MelioLabs in the rapid and low-cost detection and identification of pathogens (bacterial, fungal, and viral) in a single, low volume patient sample. She is also nationally funded in the investigation of host cell-membrane wrapped nanoparticles, engineered by Cellics Therapeutics, as a novel adjunctive therapeutic for neonatal sepsis.

Board Certification and Academic Information

Academic Departments Pediatrics -Associate Professor
Academic Divisions Neonatology
Board Certification
American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Neonatal-Perinatal Medicine)

Education history

Undergraduate Zoology - University of Oklahoma B.S.
Professional Medical Medicine - University of Oklahoma Health Sciences Center M.D.
Residency Pediatrics - University of Oklahoma Health Sciences Center Resident
Fellowship Neonatal-Perinatal Medicine - University of Texas Health Science Center at San Antonio Fellow
Other Training Biostatistics and Epidemiology - University of Oklahoma Health Sciences Center College of Public Health
Fellowship Neonatal-Perinatal Medicine - University of Oklahoma Health Sciences Center Fellow
Graduate Training Clinical and Translational Sciences - University of Oklahoma Health Sciences Center M.S.

Selected Publications

Journal Article

  1. Lawrence SM, Eckert J, Makoni M, Pereira HA (2015). Is the Use of Complete Blood Counts with Manual Differentials an Antiquated Method of Determining Neutrophil Composition in Newborns? Ann Clin Lab Sci, 45(4), 403-13.
  2. Lawrence SM, Wynn JL (2018). Chorioamnionitis, IL-17A, and fetal origins of neurologic disease. Am J Reprod Immunol, 79(5), e12803.
  3. Lawrence SM, Ruoss JL, Wynn JL (2018). IL-17 in neonatal health and disease. Am J Reprod Immunol, 79(5), e12800.
  4. Lammers EM, Johnson PN, Ernst KD, Hagemann TM, Lawrence SM, Williams PK, Anderson MP, Miller JL (2014). Association of fentanyl with neurodevelopmental outcomes in very-low-birth-weight infants. Ann Pharmacother, 48(3), 335-42.
  5. Sinha M, Jupe J, Mack H, Coleman TP, Lawrence SM, Fraley SI (2018). Emerging Technologies for Molecular Diagnosis of Sepsis. Clin Microbiol Rev, 31(2).
  6. Makoni M, Eckert J, Anne Pereira H, Nizet V, Lawrence SM (2016). Alterations in neonatal neutrophil function attributable to increased immature forms. Early Hum Dev, 103, 1-7.
  7. Aralar A, Yuan Y, Chen K, Geng Y, Ortiz Velez D, Sinha M, Lawrence SM, Fraley SI (2020). Improving Quantitative Power in Digital PCR through Digital High-Resolution Melting. J Clin Microbiol, 58(6).
  8. Major V, Lenaerts CH, Cowan JS, Lawrence SM, Mannel (2002). Breastfeeding: a public health challenge. The Journal of the Oklahoma State Medical Association, 95(11), 711-5.
  9. Lawrence SM, Corriden R, Nizet (2018). The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis. Microbiology and molecular biology reviews, 82(1),
  10. Langouche L, Aralar A, Sinha M, Lawrence SM, Fraley SI, Coleman T (2020). Data-driven noise modeling of digital DNA melting analysis enables prediction of sequence discriminating power. Bioinformatics (Oxford, England), 36(22-23), 5337-43.
  11. Lawrence SM, Corriden R, Nizet (2020). How Neutrophils Meet Their End. Trends in immunology, 41(6), 531-544.
  12. Lawrence S, Tang Y, Frank MB, Dozmorov I, Jiang K, Chen Y, Cadwell C, Turner S, Centola M, Jarvis J (2007). A dynamic model of gene expression in monocytes reveals differences in immediate/early response genes between adult and neonatal cells. Journal of inflammation (London, England), 4, 4.
  13. Lawrence SM, Nandyal R, Hallford G, Anderson M, Hart (2014). Changes in hematocrit following a blood transfusion does not influence the risk for necrotizing enterocolitis: A case-control study. Journal of neonatal-perinatal medicine, 7(1), 21-7.
  14. Eckert J, Scott B, Lawrence SM, Ihnat M, Chaaban (2017). FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis. Journal of inflammation research, 10, 75-81.
  15. Velez DO, Mack H, Jupe J, Hawker S, Kulkarni N, Hedayatnia B, Zhang Y, Lawrence S, Fraley S (2017). Massively parallel digital high resolution melt for rapid and absolutely quantitative sequence profiling. Scientific reports, 7, 42326.
  16. Koo J, Escajadillo T, Zhang L, Nizet V, Lawrence S (2019). Erythrocyte-Coated Nanoparticles Block Cytotoxic Effects of Group B Streptococcus ß-Hemolysin/Cytolysin. Frontiers in pediatrics, 7, 410.
  17. Lawrence SM, Corriden R, Nizet (2017). Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil. Frontiers in pediatrics, 5, 23.
  18. Reiss J, Sinha M, Gold J, Bykowski J, Lawrence S (2019). Outcomes of Infants with Mild Hypoxic Ischemic Encephalopathy Who Did Not Receive Therapeutic Hypothermia. Biomedicine hub, 4(3), 1-9.
  19. Bahr TM, Ohls RK, Baserga MC, Lawrence SM, Winter SL, Christensen R (2022). Implications of an Elevated Nucleated Red Blood Cell Count in Neonates with Moderate to Severe Hypoxic-Ischemic Encephalopathy. The Journal of pediatrics, 246, 12-18.e2.
  20. Bahr TM, Lawrence SM, Henry E, Ohls RK, Li S, Christensen R (2022). Severe Anemia at Birth-Incidence and Implications. The Journal of pediatrics, 248, 39-45.e2.
  21. Barnette BW, Schumacher BT, Armenta RF, Wynn JL, Richardson A, Bradley JS, Lazar S, Lawrence S (2021). Contribution of Concurrent Comorbidities to Sepsis-Related Mortality in Preterm Infants ¿32 Weeks of Gestation at an Academic Neonatal Intensive Care Network. American journal of perinatology,
  22. Aralar A, Goshia T, Ramchandar N, Lawrence SM, Karmakar A, Sharma A, Sinha M, Pride DT, Kuo P, Lecrone K, Chiu M, Mestan KK, Sajti E, Vanderpool M, Lazar S, Crabtree M, Tesfai Y, Fraley S (2024). Universal Digital High-Resolution Melt Analysis for the Diagnosis of Bacteremia. The Journal of molecular diagnostics, 26(5), 349-363.
  23. Gupta A, Lawrence SM, Fraley S (2023). A broad-based probe-free qPCR assay for detection and discrimination of three human herpes viruses. Journal of virological methods, 322, 114824.
  24. Bahr TM, Christensen TR, Henry E, Judkins AJ, Bennett ST, Pysher TJ, Lawrence SM, Ohls RK, Christensen R (2023). Fragmented red blood cell counts of neonates with new-onset gastrointestinal disturbances. Journal of perinatology, 43(9), 1173-1175.

Review

  1. Lawrence SM, Wynn JL, Kimberlin DW, Cantey J (2025). Investigating antibiotics in the NICU and patient safety. Frontiers in cellular and infection microbiology, 15, 1563940.
  2. Lawrence S (2025). Should granulocyte transfusion therapy for septic neutropenic neonates be resurrected?. Seminars in fetal & neonatal medicine, 30(1), 101616.
  3. Lawrence S (2024). Human cytomegalovirus and neonatal infection. Current research in microbial sciences, 7, 100257.
  4. Lawrence SM, Goshia T, Sinha M, Fraley SI, Williams (2024). Decoding human cytomegalovirus for the development of innovative diagnostics to detect congenital infection. Pediatric research, 95(2), 532-542.

Case Report

  1. Kreshak AA, Lawrence SM, Ontiveros ST, Castellano T, VanHoesen K (2022). Perinatal Carbon Monoxide Poisoning: Treatment of a 2-Hour-Old Neonate with Hyperbaric Oxygen. AJP reports, 12(1), e113-e116.
  2. Hooper SM, Fung CM, Torr C, Lawrence S (2025). Case Report: Delayed recurrence of staphylococcal scalded skin syndrome in an extremely low birth weight infant. Frontiers in pediatrics, 13, 1564633.
  3. Nelson BD, Lawrence SM, Simek K, Stowers KB, Morales Moreno JE, Prince JS, Mehra (2025). Are We Playing It Fast and Loose With the Serofast?. The Pediatric infectious disease journal, 44(2), 174-179.

Editorial

  1. Chavez-Bueno S, Lawrence S (2025). Editorial: Advancing understanding of neonatal bacterial infections. Frontiers in cellular and infection microbiology, 15, 1746698.