Vaia Florou, MD, MS

Journal Article

1. Nevala-Plagemann C, Sama S, Ying J, Shen J, Haaland B, Florou V, Garrido-Laguna I (2022). A Real-World Comparison of Regorafenib and Trifluridine/Tipiracil in Refractory Metastatic Colorectal Cancer in the United States. J Natl Compr Canc Netw, 21(3), 257-264. (Read full article)
2. Miotke L, Nevala-Plagemann C, Ying J, Florou V, Haaland B, Garrido-Laguna I (2022). Treatment outcomes in recurrent versus de novo metastatic pancreatic adenocarcinoma: a real world study. BMC Cancer, 22(1), 1054. (Read full article)
3. Pauley K, Koptiuch C, Greenberg S, Kohlmann W, Jeter J, Colonna S, Werner T, Kinsey C, Gilcrease G, Weis J, Whisenant J, Florou V, Garrido-Laguna I (2022). Discrepancies between tumor genomic profiling and germline genetic testing. ESMO Open, 7(4), 100526. (Read full article)
4. Kourouni I, Aesif SW, Tamarkin SW, Bolen M, Sivak E, Shaman Z, Tamaskar I, Florou V (2021). A 51-year-old man with chronic cough and left hilar prominence. Breathe (Sheff), 17(2), 210018. (Read full article)
5. Azeem Khan M, Florou V, Swami U (2021). Immunotherapy and fatigue: what we know and what we don't know. Oncotarget, 12(8), 719-720. (Read full article)
6. Florou V, Jarboe E, Deftereos G (2020). Intravenous Leiomyomatosis: A Rare Diagnosis With Aggressive Potential. JCO Oncol Pract, 17(4), 206-208. (Read full article)
7. Naqash AR, Ricciuti B, Owen DH, Florou V et al (2020). Outcomes associated with immune-related adverse events in metastatic non-small cell lung cancer treated with nivolumab: a pooled exploratory analysis from a global cohort. Cancer Immunol Immunother, s00262-020-02536-5(10.1007), 1177-1187.
8. Naqash AR, Ricciuti B, Owen DH, Florou V, Toi Y, Cherry C, Hafiz M, De Giglio A, Muzaffar M, Patel SH, Sugawara S, Burkart J, Park W, Chiari R, Sugisaka J, Otterson GA, de Lima Lopes G, Walker PR (2020). Outcomes associated with immune-related adverse events in metastatic non-small cell lung cancer treated with nivolumab: a pooled exploratory analysis from a global cohort. Cancer Immunol Immunother, 69(7), 1177-1187. (Read full article)
9. Florou V, Rosenberg AE, Wieder E, Komanduri K V, Kolonias D, Uduman M, Castle JC, Buell JS, Trent JC, Wilky BA (2019). Angiosarcoma patients treated with immune checkpoint inhibitors: a case series of seven patients from a single institution. J Immunother Cancer.
10. Chae YK, Viveiros P, Lopes G, Sukhadia B, Sheikh MM, Saravia D, Florou V, Sokol ES, Frampton GM, Chalmers ZR, Ali SM, Ross JS, Chang S, Wang S, Chiec L, Rahbari A, Mohindra N, Villaflor V, Shin SH, Oh M, Anker J, Park LC, Wang V, Chuang J, Park W (2019). Clinical and immunological implications of frameshift mutations in lung cancer. J Thorac Oncol, (10.1016).
11. Wilky BA, Trucco MM, Subhawong TK, Florou V, Park W, Kwon D, Wieder ED, Kolonias D, Rosenberg AE, Kerr DA, Sfakianaki E, Foley M, Merchan JR, Komanduri KV, Trent JC (2019). Axitinib plus pembrolizumab in patients with advanced sarcomas including alveolar soft-part sarcoma: a single-centre, single-arm, phase 2 trial. Lancet Oncol, (10.1016), 30153-6.
12. Florou V, Ramdial JL, Trent JC (2018). Use of Tyrosine Kinase Inhibitors in Patients With GI Stromal Tumor Who Are Pregnant or Considering Pregnancy: Driver Mutations and Circulating Tumor DNA. J Clin Oncol, 36(25), 2659-60. (Read full article)
13. Florou V, Ramdial J, Trent JC (2017). GIST in Pregnancy: The Role of Circulating Tumor DNA to Define the Assessment of Risk of Rapid Progression and Response to Imatinib. Am J Hematol Oncol, 13(11), 37-40.

Review

1. Florou V, Garrido-Laguna I (2022). Clinical Development of Anti-TIGIT Antibodies for Immunotherapy of Cancer. [Review]. Curr Oncol Rep, 24(9), 1107-1112. (Read full article)
2. Florou V, Wilky BA (2022). Emerging mechanisms of immunotherapy resistance in sarcomas. [Review]. Cancer Drug Resist, 5(1), 199-213. (Read full article)
3. Mittra A, Takebe N, Florou V, Chen AP, Naqash AR (2020). The emerging landscape of immune checkpoint inhibitor based clinical trials in adults with advanced rare tumors. [Review]. Hum Vaccin Immunother, 17(7), 1935-1939. (Read full article)
4. Florou V, Wilky BA (2021). Current Management of Angiosarcoma: Recent Advances and Lessons From the Past. [Review]. Curr Treat Options Oncol, 22(7), 61. (Read full article)
5. Florou V, Puri S, Garrido-Laguna I, Wilky BA (2020). Considerations for immunotherapy in patients with cancer and comorbid immune dysfunction. [Review]. Ann Transl Med, 9(12), 1035. (Read full article)
6. Bindal P, Gray JE, Boyle TA, Florou V, Puri S (2020). Biomarkers of therapeutic response with immune checkpoint inhibitors. [Review]. Ann Transl Med, 9(12), 1040. (Read full article)
7. Marron TU, Ryan AE, Reddy SM, Kaczanowska S, Younis RH, Thakkar D, Zhang J, Bartkowiak T, Howard R, Anderson KG, Olson D, Naqash AR, Patel RB, Sachdev E, Rodriguez-Ruiz ME, Sheffer M, Church S, Fuhrman C, Overacre-Delgoffe A, Nguyen R, Florou V, Thaxton JE, Aggen DH, Guerriero JL (2021). Considerations for treatment duration in responders to immune checkpoint inhibitors. [Review]. J Immunother Cancer, 9(3). (Read full article)
8. Florou V, Trent JC, Wilky BA (2020). Precision medicine in gastrointestinal stromal tumors. [Review]. Discov Med, 28(155), 267-276. (Read full article)
9. Florou V, Wilky BA (2018 Mar 8). Current and Future Directions for Angiosarcoma Therapy. [Review]. Curr Treat Options Oncol, 19(3), 14. (Read full article)
10. Alavi SN, Florou V, Tinoco G, Trent JC, Wilky BA (2018). A precision medicine approach in sarcoma: identification of patients who may benefit from early use of pazopanib. [Review]. Discov Med, 25(137), 131-44. (Read full article)
11. Florou V, Wilky BA, Trent JC (2017). Latest advances in adult gastrointestinal stromal tumors. [Review]. Future Oncol, 13(24), 2183-93. (Read full article)
12. Warner K, Crispatzu G, Al-Ghaili N, Weit N, Florou V, You MJ, Newrzela S, Herling M (2013). Models for mature T-cell lymphomas--a critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts. [Review]. Crit Rev Oncol Hematol, 88(3), 680-95. (Read full article)

Book Chapter

1. Florou V, Nascimento AG, Gulia A, de Lima Lopes Jr G (2018). Global Health Perspective in Sarcomas and Other Rare Cancers. In American Society of Clinical Oncology, Educational Book (38, pp. 916-24).

Case Report

1. Florou V, Nevala-Plagemann C, Whisenant J, Maeda P, Gilcrease GW, Garrido-Laguna I (2021). Clinical Activity of Selitrectinib in a Patient With Mammary Analogue Secretory Carcinoma of the Parotid Gland With Secondary Resistance to Entrectinib. J Natl Compr Canc Netw, 19(5), 478-482. (Read full article)
2. Florou V, Nevala-Plagemann C, Barber KE, Mastroianni JN, Cavalieri CC, Garrido-Laguna I (2020). Treatment Rechallenge With Checkpoint Inhibition in Patients With Mismatch Repair-Deficient Pancreatic Cancer After Planned Treatment Interruption. JCO Precis Oncol, 4. (Read full article)
3. Cioffi JH, Estes DJ, Florou V, Ardalan B (2017). Treatment of advanced colorectal cancer in a patient with cardiotoxic reactions to 5-fluorouracil and capecitabine using suboptimal doses.LID - bcr-2017-220952 [pii]LID - 10.1136/bcr-2017-220952 [doi]. BMJ Case Rep, 2017. (Read full article)

Editorial

1. Florou V, Garrido-Laguna I (2019). Cancer immunotherapy in the immunosuppressed patients and its relevance to clinical practice. J Immunother Precis Oncol 2:127. J Immunother Precis Oncol.

• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• A Phase Ib, Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
• Randomized Phase II Clinical Trial of Olaparib plus Pembrolizumab versus Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations
• Randomized Phase II Clinical Trial of Olaparib plus Pembrolizumab versus Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations
• Randomized Phase II Clinical Trial of Olaparib plus Pembrolizumab versus Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations
• Randomized Phase II Clinical Trial of Olaparib plus Pembrolizumab versus Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations
• Randomized Phase II Clinical Trial of Olaparib plus Pembrolizumab versus Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations
• Randomized Phase II Clinical Trial of Olaparib plus Pembrolizumab versus Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations
• Randomized Phase II Clinical Trial of Olaparib plus Pembrolizumab versus Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations
• Randomized Phase II Clinical Trial of Olaparib plus Pembrolizumab versus Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations
• Phase I/IB study of DS-8201a in combination with ATR Inhibition (AZD6738) in advanced solid tumors with HER2 expression (DASH Trial)
• Phase I/IB study of DS-8201a in combination with ATR Inhibition (AZD6738) in advanced solid tumors with HER2 expression (DASH Trial)
• Randomized Phase II Double-Blind Study of Olaparib versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
• Randomized Phase II Double-Blind Study of Olaparib versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
• Randomized Phase II Double-Blind Study of Olaparib versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
• Randomized Phase II Double-Blind Study of Olaparib versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
• Randomized Phase II Double-Blind Study of Olaparib versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
• Randomized Phase II Double-Blind Study of Olaparib versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
• Phase I First-Time-in-Human, Open-Label Study of GSK4381562 Administered as Monotherapy and in Combination with Anticancer Agents in Participants with Selected Advanced Solid Tumors
• Phase I First-Time-in-Human, Open-Label Study of GSK4381562 Administered as Monotherapy and in Combination with Anticancer Agents in Participants with Selected Advanced Solid Tumors
• Phase I First-Time-in-Human, Open-Label Study of GSK4381562 Administered as Monotherapy and in Combination with Anticancer Agents in Participants with Selected Advanced Solid Tumors
• Phase I First-Time-in-Human, Open-Label Study of GSK4381562 Administered as Monotherapy and in Combination with Anticancer Agents in Participants with Selected Advanced Solid Tumors
• Phase I First-Time-in-Human, Open-Label Study of GSK4381562 Administered as Monotherapy and in Combination with Anticancer Agents in Participants with Selected Advanced Solid Tumors
• Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
• Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
• Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
• Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
• Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
• Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
• Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
• Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
• Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
• A Phase I/IIa, Multi-Center, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of JAB-2485 in Adult Patients with Advanced Solid Tumors
• Phase 1/2 dose escalation and cohort expansion study evaluating MCLA-158(petosemtamab) as single agent or in combination in advanced solid tumors
• Phase 1/2 dose escalation and cohort expansion study evaluating MCLA-158(petosemtamab) as single agent or in combination in advanced solid tumors
• Phase 1/2 dose escalation and cohort expansion study evaluating MCLA-158(petosemtamab) as single agent or in combination in advanced solid tumors
• Phase 1/2 dose escalation and cohort expansion study evaluating MCLA-158(petosemtamab) as single agent or in combination in advanced solid tumors
• Phase 1/2 dose escalation and cohort expansion study evaluating MCLA-158(petosemtamab) as single agent or in combination in advanced solid tumors
• Phase 1/2 dose escalation and cohort expansion study evaluating MCLA-158(petosemtamab) as single agent or in combination in advanced solid tumors
• Phase I Study of SGN-EGFRd2 in Advanced Solid Tumors
• Phase II Trial of the Combination of the BET inhibitor, ZEN003694 (ZEN-3694), and the PARP Inhibitor Talazoparib, in Patients with Molecularly-Selected Solid Tumors (ComBET)
• Phase II Trial of the Combination of the BET inhibitor, ZEN003694 (ZEN-3694), and the PARP Inhibitor Talazoparib, in Patients with Molecularly-Selected Solid Tumors (ComBET)
• Phase II Trial of the Combination of the BET inhibitor, ZEN003694 (ZEN-3694), and the PARP Inhibitor Talazoparib, in Patients with Molecularly-Selected Solid Tumors (ComBET)
• A Phase 1 Study of the Polymerase Theta (POLθ) Inhibitor Novobiocin in BRCA-mutant and Other DNA Damage Repair-Deficient Solid Tumors
• Platform Study of RAS(ON) Inhibitors in Patients with Gastrointestinal Solid Tumors